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Anoctamin-8 (Transmembrane protein 16H)

 ANO8_MOUSE              Reviewed;        1060 AA.
Q6PB70; Q05CB5; Q69ZE4;
05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
13-OCT-2009, sequence version 3.
05-DEC-2018, entry version 98.
RecName: Full=Anoctamin-8;
AltName: Full=Transmembrane protein 16H;
Name=Ano8; Synonyms=Kiaa1623, Tmem16h;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J; TISSUE=Brain, and Mammary tumor;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1057.
TISSUE=Embryonic tail;
PubMed=15368895; DOI=10.1093/dnares/11.3.205;
Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S.,
Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H.,
Nagase T., Ohara O., Koga H.;
"Prediction of the coding sequences of mouse homologues of KIAA gene:
IV. The complete nucleotide sequences of 500 mouse KIAA-homologous
cDNAs identified by screening of terminal sequences of cDNA clones
randomly sampled from size-fractionated libraries.";
DNA Res. 11:205-218(2004).
[3]
IDENTIFICATION.
PubMed=15647853;
Katoh M., Katoh M.;
"Identification and characterization of TMEM16H gene in silico.";
Int. J. Mol. Med. 15:353-358(2005).
[4]
DEVELOPMENTAL STAGE.
PubMed=18729231; DOI=10.1002/dvdy.21676;
Rock J.R., Harfe B.D.;
"Expression of TMEM16 paralogs during murine embryogenesis.";
Dev. Dyn. 237:2566-2574(2008).
[5]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-318 AND SER-665, AND
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Brain;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and
expression.";
Cell 143:1174-1189(2010).
[6]
TISSUE SPECIFICITY.
PubMed=20056604; DOI=10.1074/jbc.M109.065367;
Schreiber R., Uliyakina I., Kongsuphol P., Warth R., Mirza M.,
Martins J.R., Kunzelmann K.;
"Expression and function of epithelial anoctamins.";
J. Biol. Chem. 285:7838-7845(2010).
[7]
REVIEW.
PubMed=22302790; DOI=10.1113/expphysiol.2011.058214;
Winpenny J.P., Gray M.A.;
"The anoctamin (TMEM16) gene family: calcium-activated chloride
channels come of age.";
Exp. Physiol. 97:175-176(2012).
[8]
METHYLATION [LARGE SCALE ANALYSIS] AT ARG-991 AND ARG-999, AND
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Brain, and Embryo;
PubMed=24129315; DOI=10.1074/mcp.O113.027870;
Guo A., Gu H., Zhou J., Mulhern D., Wang Y., Lee K.A., Yang V.,
Aguiar M., Kornhauser J., Jia X., Ren J., Beausoleil S.A., Silva J.C.,
Vemulapalli V., Bedford M.T., Comb M.J.;
"Immunoaffinity enrichment and mass spectrometry analysis of protein
methylation.";
Mol. Cell. Proteomics 13:372-387(2014).
-!- FUNCTION: Does not exhibit calcium-activated chloride channel
(CaCC) activity. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Note=Shows predominantly an intracellular localization with a weak
expression in the cell membrane. {ECO:0000250}.
-!- TISSUE SPECIFICITY: Predominant expression seen in epithelial
tissues. {ECO:0000269|PubMed:20056604}.
-!- DEVELOPMENTAL STAGE: Detected in the mantle layer of the neural
tube and in the dorsal root ganglia at E14.5.
{ECO:0000269|PubMed:18729231}.
-!- MISCELLANEOUS: The term 'anoctamin' was coined because these
channels are anion selective and have eight (OCT) transmembrane
segments. There is some dissatisfaction in the field with the Ano
nomenclature because it is not certain that all the members of
this family are anion channels or have the 8-transmembrane
topology.
-!- SIMILARITY: Belongs to the anoctamin family. {ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=BAD32500.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
-----------------------------------------------------------------------
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EMBL; BC027735; AAH27735.1; -; mRNA.
EMBL; BC059855; AAH59855.1; -; mRNA.
EMBL; AK173222; BAD32500.1; ALT_INIT; Transcribed_RNA.
CCDS; CCDS52585.1; -.
RefSeq; NP_001158151.1; NM_001164679.1.
UniGene; Mm.260360; -.
UniGene; Mm.475713; -.
ProteinModelPortal; Q6PB70; -.
STRING; 10090.ENSMUSP00000091157; -.
iPTMnet; Q6PB70; -.
PhosphoSitePlus; Q6PB70; -.
MaxQB; Q6PB70; -.
PaxDb; Q6PB70; -.
PeptideAtlas; Q6PB70; -.
PRIDE; Q6PB70; -.
Ensembl; ENSMUST00000093450; ENSMUSP00000091157; ENSMUSG00000034863.
GeneID; 382014; -.
KEGG; mmu:382014; -.
UCSC; uc009mdl.2; mouse.
CTD; 57719; -.
MGI; MGI:2687327; Ano8.
eggNOG; KOG2513; Eukaryota.
eggNOG; ENOG410XPYE; LUCA.
GeneTree; ENSGT00940000157019; -.
HOGENOM; HOG000033952; -.
HOVERGEN; HBG100443; -.
InParanoid; Q6PB70; -.
KO; K19502; -.
OMA; IMSHKSW; -.
OrthoDB; EOG091G06A3; -.
PhylomeDB; Q6PB70; -.
TreeFam; TF314265; -.
Reactome; R-MMU-2672351; Stimuli-sensing channels.
Reactome; R-MMU-381426; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).
Reactome; R-MMU-8957275; Post-translational protein phosphorylation.
PRO; PR:Q6PB70; -.
Proteomes; UP000000589; Chromosome 8.
Bgee; ENSMUSG00000034863; Expressed in 86 organ(s), highest expression level in dorsal root ganglion.
ExpressionAtlas; Q6PB70; baseline and differential.
Genevisible; Q6PB70; MM.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005886; C:plasma membrane; ISO:MGI.
GO; GO:0005229; F:intracellular calcium activated chloride channel activity; IEA:Ensembl.
GO; GO:0006821; P:chloride transport; ISO:MGI.
InterPro; IPR007632; Anoctamin.
InterPro; IPR031289; Anoctamin-8.
PANTHER; PTHR12308; PTHR12308; 1.
PANTHER; PTHR12308:SF33; PTHR12308:SF33; 1.
Pfam; PF04547; Anoctamin; 1.
1: Evidence at protein level;
Acetylation; Cell membrane; Complete proteome; Glycoprotein; Membrane;
Methylation; Phosphoprotein; Reference proteome; Transmembrane;
Transmembrane helix.
INIT_MET 1 1 Removed. {ECO:0000250|UniProtKB:Q9HCE9}.
CHAIN 2 1060 Anoctamin-8.
/FTId=PRO_0000249004.
TOPO_DOM 2 244 Cytoplasmic. {ECO:0000255}.
TRANSMEM 245 265 Helical. {ECO:0000255}.
TOPO_DOM 266 281 Extracellular. {ECO:0000255}.
TRANSMEM 282 302 Helical. {ECO:0000255}.
TOPO_DOM 303 356 Cytoplasmic. {ECO:0000255}.
TRANSMEM 357 377 Helical. {ECO:0000255}.
TOPO_DOM 378 400 Extracellular. {ECO:0000255}.
TRANSMEM 401 421 Helical. {ECO:0000255}.
TOPO_DOM 422 437 Cytoplasmic. {ECO:0000255}.
TRANSMEM 438 458 Helical. {ECO:0000255}.
TOPO_DOM 459 745 Extracellular. {ECO:0000255}.
TRANSMEM 746 766 Helical. {ECO:0000255}.
TOPO_DOM 767 802 Cytoplasmic. {ECO:0000255}.
TRANSMEM 803 823 Helical. {ECO:0000255}.
TOPO_DOM 824 836 Extracellular. {ECO:0000255}.
TRANSMEM 837 857 Helical. {ECO:0000255}.
TOPO_DOM 858 1060 Cytoplasmic. {ECO:0000255}.
COMPBIAS 353 519 Leu-rich.
COMPBIAS 550 600 Glu-rich.
COMPBIAS 877 926 Arg-rich.
COMPBIAS 949 1013 Pro-rich.
MOD_RES 2 2 N-acetylalanine.
{ECO:0000250|UniProtKB:Q9HCE9}.
MOD_RES 318 318 Phosphoserine.
{ECO:0000244|PubMed:21183079}.
MOD_RES 665 665 Phosphoserine.
{ECO:0000244|PubMed:21183079}.
MOD_RES 796 796 Phosphoserine.
{ECO:0000250|UniProtKB:Q9HCE9}.
MOD_RES 991 991 Asymmetric dimethylarginine; alternate.
{ECO:0000244|PubMed:24129315}.
MOD_RES 991 991 Omega-N-methylarginine; alternate.
{ECO:0000244|PubMed:24129315}.
MOD_RES 999 999 Omega-N-methylarginine.
{ECO:0000244|PubMed:24129315}.
CARBOHYD 708 708 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CONFLICT 196 196 I -> AV (in Ref. 2; BAD32500).
{ECO:0000305}.
SEQUENCE 1060 AA; 119101 MW; B10687A73CD65802 CRC64;
MAEAASGAGD VTLEGERGKR PPPEGEPAAP ASGVLDKLFG KRLLQAGRYL VSHKAWMKTV
PTEDCDVLMT FPDTTDDHTL LWLLNHIRVG IPELIVQVRH HRHTRAYAFF VTATYESLLR
GADELGLRKA VKAEFGGGTR SFSCEEDFIY ENVESELRFF TSQERQSIIR FWLQNLRAKQ
GEALHNVRFL EDQPIIPELA ARGIIQQVFP VHEQRILNRL MKSWVQAVCE NQPLDDICDY
FGVKIAMYFA WLGFYTSAMV YPAVFGSVLY TFTEADQTSR DVSCVVFALF NVIWSTLFLE
EWKRRGAELA YKWGTLDSPG EAVEEPRPQF RGIRRISPIT RAEEFYYPPW KRLLFQLLVS
LPLCLACLIC VFILMLGCFQ LQELVLSVKG LPRLVRFLPK VMLALLVSVS AEGYKKLAVW
LNDMENYRLE STYERHLIIK VVLFQFVNSY LSLFYIGFYL KDMDRLKEML ATLLITRQLL
QNVREVLQPH LYRRLGSGEL GLRTILELAR ALLGLLNPLR PDPRRHLEAQ ADEGGAGSRR
CLGGGCGAPE EENEEEEEAA VERRPAGEGG EVPEGPRGGK EEDEEEDDDE DEDEEYEGEE
GSLLDCGLRL KKVSFAERGA GRRRPGPSPD GLLEEGSPTM VEKGLEPGVF TLAEEDDEPE
GPPGSPGPEP QTVLLRRARG EGRDQGPDGD RDTETGSGDA AGRQKRHNRS SWIDPPEEEH
SPQLTQAELE SCMKKYEDTF QDYQEMFVQF GYVVLFSSAF PLAALCALVN NLIEIRSDAF
KLCTGLQRPF GRRVESIGQW QKVMEAMGVL AIVVNCYLIG QCGQLQRLFP WLSPEAAIVS
VVVLEHLALL VKYLIHVAIP DIPGWVAEEM AKLEYQRREA FKRHERQAQQ RFQQQQRRRR
EEEERQRHAE QQARRERDTG GREEARAEAP GPDPVAERGA AKAKGSERPR RPGALLPPGP
VLRLKQIIPL QTRPPAPTGC APPPRSPADT RLPAFLSLRF LKAPERGPSP PRPGKLFAFS
AREPSANGAP GGGARAHRSA GDEPAAAEPE PRPEDAGHRP


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