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Anoctamin-9 (Transmembrane protein 16J)

 ANO9_MOUSE              Reviewed;         747 AA.
P86044;
04-NOV-2008, integrated into UniProtKB/Swiss-Prot.
04-NOV-2008, sequence version 1.
12-SEP-2018, entry version 58.
RecName: Full=Anoctamin-9 {ECO:0000250|UniProtKB:A1A5B4};
AltName: Full=Transmembrane protein 16J {ECO:0000250|UniProtKB:A1A5B4};
Name=Ano9 {ECO:0000250|UniProtKB:A1A5B4};
Synonyms=Tmem16j {ECO:0000250|UniProtKB:A1A5B4};
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=C57BL/6J;
PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
Lindblad-Toh K., Eichler E.E., Ponting C.P.;
"Lineage-specific biology revealed by a finished genome assembly of
the mouse.";
PLoS Biol. 7:E1000112-E1000112(2009).
[2] {ECO:0000305}
DEVELOPMENTAL STAGE.
PubMed=18729231; DOI=10.1002/dvdy.21676;
Rock J.R., Harfe B.D.;
"Expression of TMEM16 paralogs during murine embryogenesis.";
Dev. Dyn. 237:2566-2574(2008).
[3]
TISSUE SPECIFICITY.
PubMed=20056604; DOI=10.1074/jbc.M109.065367;
Schreiber R., Uliyakina I., Kongsuphol P., Warth R., Mirza M.,
Martins J.R., Kunzelmann K.;
"Expression and function of epithelial anoctamins.";
J. Biol. Chem. 285:7838-7845(2010).
[4]
REVIEW.
PubMed=22302790; DOI=10.1113/expphysiol.2011.058214;
Winpenny J.P., Gray M.A.;
"The anoctamin (TMEM16) gene family: calcium-activated chloride
channels come of age.";
Exp. Physiol. 97:175-176(2012).
[5]
FUNCTION, AND TISSUE SPECIFICITY.
PubMed=23532839; DOI=10.1074/jbc.M113.457937;
Suzuki J., Fujii T., Imao T., Ishihara K., Kuba H., Nagata S.;
"Calcium-dependent phospholipid scramblase activity of TMEM16 protein
family members.";
J. Biol. Chem. 288:13305-13316(2013).
-!- FUNCTION: Has calcium-dependent phospholipid scramblase activity;
scrambles phosphatidylserine, phosphatidylcholine and
galactosylceramide. Does not exhibit calcium-activated chloride
channel (CaCC) activity. Can inhibit the activity of ANO1 (By
similarity). {ECO:0000250|UniProtKB:A1A5B4,
ECO:0000269|PubMed:23532839}.
-!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Note=Shows predominantly an intracellular localization with a weak
expression in the cell membrane. {ECO:0000250}.
-!- TISSUE SPECIFICITY: Predominant expression seen in epithelial
tissues. {ECO:0000269|PubMed:20056604,
ECO:0000269|PubMed:23532839}.
-!- DEVELOPMENTAL STAGE: In the developing respiratory system,
expression is restricted to the lung epithelium at E14.5. At E14.5
and E16.5, expressed in the epithelium of the esophagus, small
intestine, stomach and pancreas. At E16.5, detected in bronchial
epithelium. In the developing skeleton, expressed in the
perichondria of developing ribs at E14.5. In developing skin,
expression is detected in the most suprabasal layers at E16.5.
{ECO:0000269|PubMed:18729231}.
-!- MISCELLANEOUS: The term 'anoctamin' was coined because these
channels are anion selective and have eight (OCT) transmembrane
segments. There is some dissatisfaction in the field with the Ano
nomenclature because it is not certain that all the members of
this family are anion channels or have the 8-transmembrane
topology.
-!- SIMILARITY: Belongs to the anoctamin family.
{ECO:0000250|UniProtKB:A1A5B4}.
-----------------------------------------------------------------------
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EMBL; AC109272; -; NOT_ANNOTATED_CDS; Genomic_DNA.
CCDS; CCDS52438.1; -.
RefSeq; NP_848468.2; NM_178381.3.
UniGene; Mm.235813; -.
ProteinModelPortal; P86044; -.
STRING; 10090.ENSMUSP00000067689; -.
SwissLipids; SLP:000000376; -.
iPTMnet; P86044; -.
PhosphoSitePlus; P86044; -.
PaxDb; P86044; -.
PeptideAtlas; P86044; -.
PRIDE; P86044; -.
Ensembl; ENSMUST00000067836; ENSMUSP00000067689; ENSMUSG00000054662.
GeneID; 71345; -.
KEGG; mmu:71345; -.
UCSC; uc012fwo.1; mouse.
CTD; 338440; -.
MGI; MGI:1918595; Ano9.
eggNOG; KOG2514; Eukaryota.
eggNOG; ENOG410XS4S; LUCA.
GeneTree; ENSGT00760000119015; -.
HOVERGEN; HBG100444; -.
InParanoid; P86044; -.
KO; K19503; -.
OMA; KLIAAWY; -.
OrthoDB; EOG091G02JM; -.
PhylomeDB; P86044; -.
TreeFam; TF314265; -.
Reactome; R-MMU-2672351; Stimuli-sensing channels.
PRO; PR:P86044; -.
Proteomes; UP000000589; Chromosome 7.
Bgee; ENSMUSG00000054662; Expressed in 96 organ(s), highest expression level in zone of skin.
Genevisible; P86044; MM.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005622; C:intracellular; IDA:MGI.
GO; GO:0005886; C:plasma membrane; ISO:MGI.
GO; GO:0005229; F:intracellular calcium activated chloride channel activity; IEA:Ensembl.
GO; GO:0017128; F:phospholipid scramblase activity; IDA:MGI.
GO; GO:0061591; P:calcium activated galactosylceramide scrambling; IDA:MGI.
GO; GO:0061590; P:calcium activated phosphatidylcholine scrambling; IDA:MGI.
GO; GO:0061589; P:calcium activated phosphatidylserine scrambling; IDA:MGI.
GO; GO:0006821; P:chloride transport; ISO:MGI.
GO; GO:1902939; P:negative regulation of intracellular calcium activated chloride channel activity; ISO:MGI.
InterPro; IPR007632; Anoctamin.
InterPro; IPR031290; Anoctamin-9.
PANTHER; PTHR12308; PTHR12308; 1.
PANTHER; PTHR12308:SF37; PTHR12308:SF37; 1.
Pfam; PF04547; Anoctamin; 1.
2: Evidence at transcript level;
Cell membrane; Complete proteome; Glycoprotein; Lipid transport;
Membrane; Reference proteome; Transmembrane; Transmembrane helix;
Transport.
CHAIN 1 747 Anoctamin-9.
/FTId=PRO_0000353191.
TOPO_DOM 1 193 Cytoplasmic. {ECO:0000255}.
TRANSMEM 194 214 Helical. {ECO:0000255}.
TOPO_DOM 215 259 Extracellular. {ECO:0000255}.
TRANSMEM 260 280 Helical. {ECO:0000255}.
TOPO_DOM 281 326 Cytoplasmic. {ECO:0000255}.
TRANSMEM 327 347 Helical. {ECO:0000255}.
TOPO_DOM 348 364 Extracellular. {ECO:0000255}.
TRANSMEM 365 385 Helical. {ECO:0000255}.
TOPO_DOM 386 414 Cytoplasmic. {ECO:0000255}.
TRANSMEM 415 435 Helical. {ECO:0000255}.
TOPO_DOM 436 543 Extracellular. {ECO:0000255}.
TRANSMEM 544 564 Helical. {ECO:0000255}.
TOPO_DOM 565 595 Cytoplasmic. {ECO:0000255}.
TRANSMEM 596 616 Helical. {ECO:0000255}.
TOPO_DOM 617 695 Extracellular. {ECO:0000255}.
TRANSMEM 696 716 Helical. {ECO:0000255}.
TOPO_DOM 717 747 Cytoplasmic. {ECO:0000255}.
CARBOHYD 630 630 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 643 643 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 665 665 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 681 681 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
SEQUENCE 747 AA; 87180 MW; 42B4CA02516A54C4 CRC64;
MQDDESSQIF MGPEGDQLPL VEMGSCKPEA SDQWDCVLVA DLQTLKIQKH AQKQLQFLEN
LESNGFHFKM LKDQKKVFFG IRADSDVIDK YRTLLMNPED SGSRDEQSFN IATTRIRIVS
FVVNNKLKPG DTFEDLVKDG VFETMFLLHK GEQNLKNIWA RWRNMFEPQP IDEIREYFGE
KVALYFTWLG WYTYMLVPAA VVGLIVFLSG FALFDSSQIS KEICSANDIF MCPLGDHSHR
YLRLSEMCTF AKLTHLFDNE GTVLFAIFMA LWATVFLEIW KRKRAHEVQS WKLYEWDEEE
EEMALELINS PHYKLKDHRH SYLSSTIILI LSLFMICLMI GMAHVLVVYR VLAGALFSSL
VKQQVTTAVV VTGAVVHYII IVIMTKVNKY VALKLCKFEE SGTFSEQERK FTVKFFILQF
FAHFSSLIYI AFILGRINGH PGKSTRLAGL WKLEECHLSG CMMDLFIQMA IIMGLKQTLS
NCVEYLCPLL AHKWRLMWAS KHGHMSKDPE LKEWQRNYYM NPINTFSLFD EFMEMMIQYG
FTTIFVAAFP LAPLLALFSN LVEIRLDAIK MVRLQRRLVP RKAKDIGTWL QVLETIGVLA
VIANGMVIAF TSEFIPRVVY KYHYGPCRTN RTFTDDCLTN YVNHSLSVFY TKHFNDHSRM
EGQENVTVCR YRDYRNEHDY NLSEQFWFIL AIRLTFVILF EHFALCIKLI AAWFVPDVPQ
KVKNEVLQEK YDRIRHRMRF SSRSTDV


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