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Anterior gradient protein 1 (XAG-1) (XAG)

 AG1_XENLA               Reviewed;         183 AA.
P55868; Q5D0A7;
01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
01-NOV-1997, sequence version 1.
20-JUN-2018, entry version 62.
RecName: Full=Anterior gradient protein 1;
Short=XAG-1;
AltName: Full=XAG;
Flags: Precursor;
Name=ag1; Synonyms=ag;
Xenopus laevis (African clawed frog).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus;
Xenopus.
NCBI_TaxID=8355;
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
TISSUE=Embryonic head;
PubMed=2752418; DOI=10.1016/0092-8674(89)90413-3;
Sive H.L., Hattori K., Weintraub H.;
"Progressive determination during formation of the anteroposterior
axis in Xenopus laevis.";
Cell 58:171-180(1989).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Tail bud;
NIH - Xenopus Gene Collection (XGC) project;
Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
[3]
TISSUE SPECIFICITY.
PubMed=1723941;
Hemmati-Brivanlou A., Frank D., Bolce M.E., Brown B.D., Sive H.L.,
Harland R.M.;
"Localization of specific mRNAs in Xenopus embryos by whole-mount in
situ hybridization.";
Development 110:325-330(1990).
[4]
LACK OF FUNCTION IN CEMENT GLAND FORMATION.
PubMed=9533957; DOI=10.1016/S0925-4773(98)00021-5;
Aberger F., Weidinger G., Grunz H., Richter K.;
"Anterior specification of embryonic ectoderm: the role of the Xenopus
cement gland-specific gene XAG-2.";
Mech. Dev. 72:115-130(1998).
-!- FUNCTION: Does not appear to be required for cement gland
formation.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
-!- TISSUE SPECIFICITY: From stage 18 (neurula) onward, expressed in
the cement gland until it degenerates. More weakly expressed in
the adjacent hatching gland. {ECO:0000269|PubMed:1723941,
ECO:0000269|PubMed:2752418}.
-!- SIMILARITY: Belongs to the AGR family. {ECO:0000305}.
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EMBL; U76752; AAB18819.1; -; mRNA.
EMBL; BC046838; AAH46838.1; -; mRNA.
RefSeq; NP_001079667.1; NM_001086198.1.
UniGene; Xl.1076; -.
ProteinModelPortal; P55868; -.
GeneID; 379354; -.
KEGG; xla:379354; -.
CTD; 379354; -.
Xenbase; XB-GENE-5866216; ag1.
HOVERGEN; HBG006516; -.
KO; K20357; -.
GO; GO:0005576; C:extracellular region; ISS:UniProtKB.
InterPro; IPR036249; Thioredoxin-like_sf.
SUPFAM; SSF52833; SSF52833; 1.
1: Evidence at protein level;
Secreted; Signal.
SIGNAL 1 18 {ECO:0000255}.
CHAIN 19 183 Anterior gradient protein 1.
/FTId=PRO_0000001042.
SEQUENCE 183 AA; 20475 MW; 95E12B06FCB8DCE8 CRC64;
MQAGLSLVCL VLLCSALGEA VLKKPKKQAG TTDTKTDQEP APIKTKGLKT LDRGWGESIE
WVQTYEEGLA KARENNKPLM VIHHLEDCPY SIALKKAFVA DRMAQKLAQE DFIMLNLVHP
VADENQSPDG HYVPRVIFID PSLTVRSDLK GRYGNKMYAY DADDIPELIT NMKKAKSFLK
TEL


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