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Anterior gradient protein 3

 AGR3_MOUSE              Reviewed;         165 AA.
Q8R3W7; A7NSI1; Q8BW95;
10-MAY-2005, integrated into UniProtKB/Swiss-Prot.
01-JUN-2002, sequence version 1.
25-APR-2018, entry version 104.
RecName: Full=Anterior gradient protein 3 {ECO:0000312|MGI:MGI:2685734};
Flags: Precursor;
Name=Agr3 {ECO:0000312|MGI:MGI:2685734};
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J; TISSUE=Lung;
PubMed=16141072; DOI=10.1126/science.1112014;
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=C57BL/6J;
PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
Lindblad-Toh K., Eichler E.E., Ponting C.P.;
"Lineage-specific biology revealed by a finished genome assembly of
the mouse.";
PLoS Biol. 7:E1000112-E1000112(2009).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=FVB/N-3; TISSUE=Mammary tumor;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
DISRUPTION PHENOTYPE, TISSUE SPECIFICITY, AND FUNCTION.
PubMed=25751668; DOI=10.1165/rcmb.2014-0318OC;
Bonser L.R., Schroeder B.W., Ostrin L.A., Baumlin N., Olson J.L.,
Salathe M., Erle D.J.;
"The ER resident protein AGR3 is required for regulation of ciliary
beat frequency in the airway.";
Am. J. Respir. Cell Mol. Biol. 53:536-543(2015).
-!- FUNCTION: Required for calcium-mediated regulation of ciliary beat
frequency and mucociliary clearance in the airway. Might be
involved in the regulation of intracellular calcium in tracheal
epithelial cells. {ECO:0000269|PubMed:25751668}.
-!- SUBUNIT: Interacts with LYPD3 and DAG1 (alphaDAG1).
{ECO:0000250|UniProtKB:Q8TD06}.
-!- SUBCELLULAR LOCATION: Endoplasmic reticulum
{ECO:0000250|UniProtKB:Q8TD06}. Cytoplasm
{ECO:0000250|UniProtKB:Q8TD06}.
-!- TISSUE SPECIFICITY: Expressed in the ciliated cells of the airway
epithelium. Not detected in the mucous cells.
{ECO:0000269|PubMed:25751668}.
-!- DISRUPTION PHENOTYPE: Knockout mice develop ciliated cells with
normal-appearing cilia and histology. However, ciliary beat
frequency was lower in airways from knockout mice compared with
control mice in presence of calcium (20% lower in the absence of
stimulation, 35% lower after ATP stimulation). Knockout mice show
reduced mucociliary clearance. Knockout mice do not seem to show
endoplasmic reticulum stress response.
{ECO:0000269|PubMed:25751668}.
-!- SIMILARITY: Belongs to the AGR family. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; AK053177; BAC35297.1; -; mRNA.
EMBL; CT030196; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BC023499; AAH23499.1; -; mRNA.
CCDS; CCDS25880.1; -.
RefSeq; NP_997414.2; NM_207531.3.
UniGene; Mm.190508; -.
ProteinModelPortal; Q8R3W7; -.
SMR; Q8R3W7; -.
iPTMnet; Q8R3W7; -.
PhosphoSitePlus; Q8R3W7; -.
MaxQB; Q8R3W7; -.
PaxDb; Q8R3W7; -.
PeptideAtlas; Q8R3W7; -.
PRIDE; Q8R3W7; -.
Ensembl; ENSMUST00000042101; ENSMUSP00000049212; ENSMUSG00000036231.
GeneID; 403205; -.
KEGG; mmu:403205; -.
UCSC; uc007njl.2; mouse.
CTD; 155465; -.
MGI; MGI:2685734; Agr3.
eggNOG; ENOG410IWAH; Eukaryota.
eggNOG; ENOG4111K70; LUCA.
GeneTree; ENSGT00530000063273; -.
HOGENOM; HOG000231100; -.
HOVERGEN; HBG006516; -.
InParanoid; Q8R3W7; -.
KO; K20357; -.
OMA; AQNNFIM; -.
OrthoDB; EOG091G0RHV; -.
PhylomeDB; Q8R3W7; -.
TreeFam; TF321449; -.
PRO; PR:Q8R3W7; -.
Proteomes; UP000000589; Chromosome 12.
Bgee; ENSMUSG00000036231; -.
CleanEx; MM_AGR3; -.
ExpressionAtlas; Q8R3W7; baseline and differential.
Genevisible; Q8R3W7; MM.
GO; GO:0005783; C:endoplasmic reticulum; ISO:MGI.
GO; GO:0043231; C:intracellular membrane-bounded organelle; ISO:MGI.
GO; GO:0002162; F:dystroglycan binding; ISO:MGI.
GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
GO; GO:0060548; P:negative regulation of cell death; IBA:GO_Central.
InterPro; IPR036249; Thioredoxin-like_sf.
SUPFAM; SSF52833; SSF52833; 1.
2: Evidence at transcript level;
Complete proteome; Cytoplasm; Endoplasmic reticulum;
Reference proteome; Signal.
SIGNAL 1 20 {ECO:0000255}.
CHAIN 21 165 Anterior gradient protein 3.
/FTId=PRO_0000001041.
MOTIF 162 165 Prevents secretion from ER.
{ECO:0000305}.
CONFLICT 90 90 A -> E (in Ref. 1; BAC35297).
{ECO:0000305}.
SEQUENCE 165 AA; 19081 MW; 39FBC7DCB36E122C CRC64;
MLHSALALCL LLITVSSNLA IAIKKEKRPP QTLSRGWGDD ITWVQTYEEG LFHARKSNKP
LMVIHHLEDC QYCQALKKEF AKNEEIQEMA QNDFIMLNLM HETTDKNLSP DGQYVPRIMF
VDPSLTVRAD ITGRYSNRLY TYEPQDLPML VDNMKKALRL IQSEL


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Catalog number Product name Quantity
orb80905 Human Anterior Gradient Protein Homolog protein Anterior Gradient Protein Homolog Human Recombinant fused to His-tag on N-terminal produced in E.coli is a single, non-glycosylated polypeptide chain co 10
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pro-242 Recombinant Human Anterior Gradient Protein 3 Homolog 1mg
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C424 Human Anterior Gradient Protein 2 Homolog AG-2 l0
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E92285Hu ELISA Kit for Anterior Gradient Protein 2 (AGR2) 96T/Kit
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E14113h Human Anterior Gradient Protein 3 ELISA Kit 96T
PRO-580 Recombinant Human Anterior Gradient Protein 2 Homolog 10µg
RP-990 Recombinant Human Anterior Gradient Protein 2 Homolog 10 ug


 

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