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Anti-Muellerian hormone type-2 receptor (EC 2.7.11.30) (Anti-Muellerian hormone type II receptor) (AMH type II receptor) (MIS type II receptor) (MISRII) (MRII)

 AMHR2_MOUSE             Reviewed;         568 AA.
Q8K592; Q0VDQ4;
28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
28-NOV-2006, sequence version 2.
25-OCT-2017, entry version 125.
RecName: Full=Anti-Muellerian hormone type-2 receptor;
EC=2.7.11.30;
AltName: Full=Anti-Muellerian hormone type II receptor;
Short=AMH type II receptor;
AltName: Full=MIS type II receptor;
Short=MISRII;
Short=MRII;
Flags: Precursor;
Name=Amhr2;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=9299437; DOI=10.1006/bbrc.1997.7224;
Mishina Y., Tizard R., Deng J.M., Pathak B.G., Copeland N.G.,
Jenkins N.A., Cate R.L., Behringer R.R.;
"Sequence, genomic organization, and chromosomal location of the mouse
Muellerian-inhibiting substance type II receptor gene.";
Biochem. Biophys. Res. Commun. 237:741-746(1997).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Testis;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and
expression.";
Cell 143:1174-1189(2010).
-!- FUNCTION: On ligand binding, forms a receptor complex consisting
of two type II and two type I transmembrane serine/threonine
kinases. Type II receptors phosphorylate and activate type I
receptors which autophosphorylate, then bind and activate SMAD
transcriptional regulators. Receptor for anti-Muellerian hormone.
-!- CATALYTIC ACTIVITY: ATP + [receptor-protein] = ADP + [receptor-
protein] phosphate.
-!- COFACTOR:
Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250};
-!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass type I
membrane protein {ECO:0000250}.
-!- SIMILARITY: Belongs to the protein kinase superfamily. TKL Ser/Thr
protein kinase family. TGFB receptor subfamily. {ECO:0000305}.
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EMBL; AF503863; AAM28608.1; -; mRNA.
EMBL; BC119571; AAI19572.1; -; mRNA.
CCDS; CCDS27882.1; -.
PIR; JC5629; JC5629.
RefSeq; NP_653130.2; NM_144547.2.
RefSeq; XP_006520356.1; XM_006520293.2.
UniGene; Mm.60331; -.
ProteinModelPortal; Q8K592; -.
SMR; Q8K592; -.
IntAct; Q8K592; 1.
STRING; 10090.ENSMUSP00000023809; -.
iPTMnet; Q8K592; -.
PhosphoSitePlus; Q8K592; -.
PaxDb; Q8K592; -.
PRIDE; Q8K592; -.
Ensembl; ENSMUST00000023809; ENSMUSP00000023809; ENSMUSG00000023047.
GeneID; 110542; -.
KEGG; mmu:110542; -.
UCSC; uc007xvq.2; mouse.
CTD; 269; -.
MGI; MGI:105062; Amhr2.
eggNOG; KOG3653; Eukaryota.
eggNOG; ENOG410XS2Z; LUCA.
GeneTree; ENSGT00900000140999; -.
HOGENOM; HOG000033920; -.
HOVERGEN; HBG097461; -.
InParanoid; Q8K592; -.
KO; K04672; -.
OMA; CCFGIWN; -.
OrthoDB; EOG091G05X7; -.
PhylomeDB; Q8K592; -.
TreeFam; TF314724; -.
Reactome; R-MMU-201451; Signaling by BMP.
PRO; PR:Q8K592; -.
Proteomes; UP000000589; Chromosome 15.
Bgee; ENSMUSG00000023047; -.
CleanEx; MM_AMHR2; -.
ExpressionAtlas; Q8K592; baseline and differential.
Genevisible; Q8K592; MM.
GO; GO:0005887; C:integral component of plasma membrane; ISO:MGI.
GO; GO:1990272; F:anti-Mullerian hormone receptor activity; IDA:MGI.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0042562; F:hormone binding; ISS:UniProtKB.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0004872; F:receptor activity; ISS:UniProtKB.
GO; GO:0004702; F:signal transducer, downstream of receptor, with serine/threonine kinase activity; IEA:InterPro.
GO; GO:0005026; F:transforming growth factor beta receptor activity, type II; ISO:MGI.
GO; GO:0005024; F:transforming growth factor beta-activated receptor activity; TAS:MGI.
GO; GO:1990262; P:anti-Mullerian hormone signaling pathway; IDA:MGI.
GO; GO:0008585; P:female gonad development; IEA:Ensembl.
GO; GO:0008584; P:male gonad development; IEA:Ensembl.
GO; GO:1902613; P:negative regulation of anti-Mullerian hormone signaling pathway; IDA:MGI.
GO; GO:0007548; P:sex differentiation; IMP:MGI.
GO; GO:0007165; P:signal transduction; ISS:UniProtKB.
GO; GO:0007179; P:transforming growth factor beta receptor signaling pathway; ISO:MGI.
InterPro; IPR000472; Activin_recp.
InterPro; IPR015771; Anti-muellerian_hrmn_rcpt_II.
InterPro; IPR011009; Kinase-like_dom.
InterPro; IPR000719; Prot_kinase_dom.
InterPro; IPR000333; TGFB_receptor.
PANTHER; PTHR23255; PTHR23255; 1.
Pfam; PF01064; Activin_recp; 1.
Pfam; PF00069; Pkinase; 1.
PIRSF; PIRSF037392; AMHRII; 1.
SUPFAM; SSF56112; SSF56112; 1.
PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
1: Evidence at protein level;
ATP-binding; Complete proteome; Disulfide bond; Glycoprotein; Kinase;
Magnesium; Manganese; Membrane; Metal-binding; Nucleotide-binding;
Receptor; Reference proteome; Serine/threonine-protein kinase; Signal;
Transferase; Transmembrane; Transmembrane helix.
SIGNAL 1 15 {ECO:0000255}.
CHAIN 16 568 Anti-Muellerian hormone type-2 receptor.
/FTId=PRO_0000260265.
TOPO_DOM 16 147 Extracellular. {ECO:0000255}.
TRANSMEM 148 168 Helical. {ECO:0000255}.
TOPO_DOM 169 568 Cytoplasmic. {ECO:0000255}.
DOMAIN 199 504 Protein kinase. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
NP_BIND 205 213 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
ACT_SITE 329 329 Proton acceptor. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
BINDING 226 226 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
CARBOHYD 66 66 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 119 119 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 55 79 {ECO:0000250|UniProtKB:P37023}.
DISULFID 92 109 {ECO:0000250|UniProtKB:P37023}.
CONFLICT 240 240 R -> G (in Ref. 1; AAM28608).
{ECO:0000305}.
SEQUENCE 568 AA; 61195 MW; AE89AA1727600E5E CRC64;
MLGTLGLWTL LPAAAQVSPN RRTCVFFEAP GVRGSTKTLG EMVDAGPGPP KGIRCLYSHC
CFGIWNLTHG RAQVEMQGCR DSDEPGCESL HCDPVPRAHP NPSSTLFTCS CGTDFCNANY
SHLPPSGNQG APGPQEPQAT PGGPVWMALL LLGMFLVLLL SSIILALLQR KACRVQGGSD
PEPGSGGDCS EELPELAELR FSQVIQEGGH AVVWAGRLQG EMVAIKAFPP RAVAQFRAER
AVYQLLGLQH DHIVRFITAG QGGPGPLPSG PLLVLELYPK GSLCHYLTQY TSDWGSSLRM
ALSLAEGLAF LHEERWQDGQ YKPGIAHRDL SSQNVLIRED RSCAIGDLGL ALVLPGLAQP
PALAPTQPRG PAAILEAGTQ RYMAPELLDK TLDLQDWGTA LQRADVYSLA LLLWEILSRC
SDLRPDHRPP PFQLAYEAEL GSNPSACELW ALAVEERKRP NIPSTWSCSA TDPRGLRELL
EDCWDADPEA RLTAECVQQR LAALAYPHGA SSFPESPQGC PENCLSAPAS AVFPCRPQQS
SCLLSVQQGP GSRSPDPVGD TVQVYVNE


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