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Anti-sigma factor RshA (Regulator of SigH) (Sigma-H anti-sigma factor RshA)
RSHA_MYCS2 Reviewed; 101 AA.
A0QTP3; Q9XCD7;
16-OCT-2013, integrated into UniProtKB/Swiss-Prot.
09-JAN-2007, sequence version 1.
07-JUN-2017, entry version 65.
RecName: Full=Anti-sigma factor RshA;
AltName: Full=Regulator of SigH;
AltName: Full=Sigma-H anti-sigma factor RshA;
Name=rshA; OrderedLocusNames=MSMEG_1915, MSMEI_1875;
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155).
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
Mycobacterium.
NCBI_TaxID=246196;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND INDUCTION.
STRAIN=ATCC 700084 / mc(2)155;
PubMed=10400584;
Fernandes N.D., Wu Q.-L., Kong D., Puyang X., Garg S., Husson R.N.;
"A mycobacterial extracytoplasmic sigma factor involved in survival
following heat shock and oxidative stress.";
J. Bacteriol. 181:4266-4274(1999).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 700084 / mc(2)155;
Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C.,
Fraser C.M.;
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 700084 / mc(2)155;
PubMed=17295914; DOI=10.1186/gb-2007-8-2-r20;
Deshayes C., Perrodou E., Gallien S., Euphrasie D., Schaeffer C.,
Van-Dorsselaer A., Poch O., Lecompte O., Reyrat J.-M.;
"Interrupted coding sequences in Mycobacterium smegmatis: authentic
mutations or sequencing errors?";
Genome Biol. 8:R20.1-R20.9(2007).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 700084 / mc(2)155;
PubMed=18955433; DOI=10.1101/gr.081901.108;
Gallien S., Perrodou E., Carapito C., Deshayes C., Reyrat J.-M.,
Van Dorsselaer A., Poch O., Schaeffer C., Lecompte O.;
"Ortho-proteogenomics: multiple proteomes investigation through
orthology and a new MS-based protocol.";
Genome Res. 19:128-135(2009).
[5]
PROBABLE INTERACTION WITH SIGH, AND MUTAGENESIS OF CYS-25; CYS-40;
CYS-55; CYS-58 AND CYS-76.
STRAIN=ATCC 700084 / mc(2)155;
PubMed=14617153; DOI=10.1046/j.1365-2958.2003.03739.x;
Song T., Dove S.L., Lee K.H., Husson R.N.;
"RshA, an anti-sigma factor that regulates the activity of the
mycobacterial stress response sigma factor SigH.";
Mol. Microbiol. 50:949-959(2003).
[6]
POSSIBLE PHOSPHORYLATION, AND REGULATION.
PubMed=18728196; DOI=10.1073/pnas.0801143105;
Park S.T., Kang C.M., Husson R.N.;
"Regulation of the SigH stress response regulon by an essential
protein kinase in Mycobacterium tuberculosis.";
Proc. Natl. Acad. Sci. U.S.A. 105:13105-13110(2008).
-!- FUNCTION: A redox-regulated anti-sigma factor for cognate
extracytoplasmic function (ECF) sigma factor SigH. ECF sigma
factors are held in an inactive form by an anti-sigma factor
(Probable). Overexpression leads to increased susceptibility to
diamide. {ECO:0000305}.
-!- COFACTOR:
Name=iron-sulfur cluster; Xref=ChEBI:CHEBI:30408;
Evidence={ECO:0000305};
Note=Binds 1 iron-sulfur cluster per subunit. {ECO:0000305};
-!- SUBUNIT: Interacts with cognate ECF RNA polymerase sigma factor
SigH under reducing conditions; the complex is disrupted under
oxiding conditions or as temperatures rise. Binding inhibits the
interaction of SigH with the RNA polymerase catalytic core.
-!- INDUCTION: Induced after heat shock (50 degress Celsius). Part of
the sigH-rshA operon. {ECO:0000269|PubMed:10400584}.
-!- PTM: Phosphorylated, probably by PknB (Probable). Phosphorylation
decreases interaction with SigH, probably leading to increased
SigH-mediated transcription. {ECO:0000305}.
-!- SIMILARITY: Belongs to the zinc-associated anti-sigma factor (ZAS)
superfamily. {ECO:0000305}.
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EMBL; AF144091; AAD41811.1; -; Genomic_DNA.
EMBL; CP000480; ABK70150.1; -; Genomic_DNA.
EMBL; CP001663; AFP38347.1; -; Genomic_DNA.
RefSeq; WP_011728007.1; NZ_CP009494.1.
RefSeq; YP_886281.1; NC_008596.1.
ProteinModelPortal; A0QTP3; -.
STRING; 246196.MSMEG_1915; -.
EnsemblBacteria; ABK70150; ABK70150; MSMEG_1915.
EnsemblBacteria; AFP38347; AFP38347; MSMEI_1875.
GeneID; 4535149; -.
KEGG; msb:LJ00_09560; -.
KEGG; msg:MSMEI_1875; -.
KEGG; msm:MSMEG_1915; -.
PATRIC; fig|246196.19.peg.1897; -.
eggNOG; ENOG4105WMN; Bacteria.
eggNOG; ENOG41128S4; LUCA.
HOGENOM; HOG000247360; -.
OMA; PCLEKYG; -.
OrthoDB; POG091H09CC; -.
Proteomes; UP000000757; Chromosome.
Proteomes; UP000006158; Chromosome.
GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
InterPro; IPR024020; Anit_sigma_mycothiol_RsrA.
InterPro; IPR014295; Anti-sigma.
InterPro; IPR027383; Znf_put.
Pfam; PF13490; zf-HC2; 1.
TIGRFAMs; TIGR02949; anti_SigH_actin; 1.
TIGRFAMs; TIGR03988; antisig_RsrA; 1.
1: Evidence at protein level;
Complete proteome; Iron; Iron-sulfur; Metal-binding; Phosphoprotein;
Reference proteome; Transcription; Transcription regulation.
CHAIN 1 101 Anti-sigma factor RshA.
/FTId=PRO_0000423651.
METAL 25 25 Iron-sulfur. {ECO:0000255}.
METAL 51 51 Iron-sulfur. {ECO:0000255}.
METAL 55 55 Iron-sulfur. {ECO:0000250}.
METAL 58 58 Iron-sulfur. {ECO:0000250}.
MOD_RES 96 96 Phosphothreonine. {ECO:0000250}.
MUTAGEN 25 25 C->A: Slightly decreased inhibition of
SigH. {ECO:0000269|PubMed:14617153}.
MUTAGEN 40 40 C->A: No effect.
{ECO:0000269|PubMed:14617153}.
MUTAGEN 55 55 C->A: Decreased inhibition of SigH;
reduced interaction with SigH.
{ECO:0000269|PubMed:14617153}.
MUTAGEN 58 58 C->A: Decreased inhibition of SigH;
reduced interaction with SigH.
{ECO:0000269|PubMed:14617153}.
MUTAGEN 76 76 C->A: No effect.
{ECO:0000269|PubMed:14617153}.
SEQUENCE 101 AA; 11606 MW; 974265FA55D88790 CRC64;
MSETEREDER WTPPIGPIDP EHPECAAVIA EVWTLLDGEC TPETRDKLKQ HLEECPTCLR
HYGIEERVKR LIAAKCSGEK APDSLRERLR IQISRTTIIR G
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Pathways :
WP654: ATM
WP1046: Signaling of Hepatocyte Growth Factor Receptor
WP1162: Signaling of Hepatocyte Growth Factor Receptor
WP1206: Signaling of Hepatocyte Growth Factor Receptor
WP1235: Signaling of Hepatocyte Growth Factor Receptor
WP1789: Binding of RNA by Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs)
WP1899: Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
WP193: Signaling of Hepatocyte Growth Factor Receptor
WP1963: The effect of Glucocorticoids on target gene expression
WP1983: Splicing factor NOVA regulated synpatic proteins
WP2148: Brain derived neurotrophic factor
WP272: Blood Clotting Cascade
WP313: Signaling of Hepatocyte Growth Factor Receptor
WP444: Signaling of Hepatocyte Growth Factor Receptor
WP810: Signaling of Hepatocyte Growth Factor Receptor
WP927: Signaling of Hepatocyte Growth Factor Receptor
WP94: Signaling of Hepatocyte Growth Factor Receptor
WP1582: mycobacterial virulence
WP1689: Porphyrin and chlorophyll metabolism
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[rsiW ybbM BSU01740] Anti-sigma-W factor RsiW (Regulator of SigW) (Sigma-W anti-sigma factor RsiW)
[rslA Rv0736] Anti-sigma-L factor RslA (Regulator of SigL) (Sigma-L anti-sigma factor RslA)
[rshA Rv3221A] Anti-sigma factor RshA (Regulator of SigH) (Sigma-H anti-sigma factor RshA)
[rseA Rv1222] Anti-sigma-E factor RseA (Regulator of SigE) (Sigma-E anti-sigma factor RseA)
[rsbW usfX Rv3287c] Anti-sigma-F factor RsbW (Anti-sigma-F factor UsfX) (Regulator of SigF) (Sigma-F anti-sigma factor RsbW)
[rseA STM14_3233] Anti-sigma-E factor RseA (Regulator of SigE) (Sigma-E anti-sigma factor RseA) (Sigma-E factor negative regulatory protein)
[rsdA Rv3413c MTCY78.16] Anti-sigma-D factor RsdA (Regulator of SigD) (Sigma-D anti-sigma factor RsdA)
[FLO11 MAL5 MUC1 S1 S2 YIR019C] Flocculation protein FLO11 (Flo11p) (Flocculin-11) (Mucin-like protein 1)
[rskA Rv0444c] Anti-sigma-K factor RskA (Regulator of SigK) (Sigma-K anti-sigma factor RskA)
[csfB gin yaaM BSU00240] Anti-sigma-G factor Gin (Protein CsfB)
[rshA MSMEG_1915 MSMEI_1875] Anti-sigma factor RshA (Regulator of SigH) (Sigma-H anti-sigma factor RshA)
[MEP2 AMT2 YNL142W N1207 N1820] Ammonium transporter MEP2
[sigF Rv3286c] RNA polymerase sigma factor SigF (Sigma factor SigF) (Alternative RNA polymerase sigma factor SigF) (RNA polymerase sigma-F factor) (Sigma-F factor) (Stress response/stationary phase sigma factor SigF)
[sigE Rv1221] ECF RNA polymerase sigma factor SigE (ECF sigma factor SigE) (Alternative RNA polymerase sigma factor SigE) (RNA polymerase sigma-E factor) (Sigma-E factor)
[sigH rpoE Rv3223c MTCY07D11.03] ECF RNA polymerase sigma factor SigH (ECF sigma factor SigH) (Alternative RNA polymerase sigma factor SigH) (RNA polymerase sigma-H factor) (Sigma-H factor)
[rpoE sigE b2573 JW2557] ECF RNA polymerase sigma-E factor (RNA polymerase sigma-E factor) (Sigma-24)
[sigR SCO5216] ECF RNA polymerase sigma factor SigR (ECF sigma factor SigR) (Alternative RNA polymerase sigma factor SigR) (RNA polymerase sigma-R factor) (Sigma-R factor)
[rsfB Rv3687c] Anti-sigma-F factor antagonist RsfB (Anti-anti-sigma F factor RsfB)
[sigD Rv3414c MTCY78.15] ECF RNA polymerase sigma factor SigD (ECF sigma factor SigD) (Alternative RNA polymerase sigma factor SigD) (RNA polymerase sigma-D factor) (Sigma-D factor)
[rsbW BSU04720] Serine-protein kinase RsbW (EC 2.7.11.1) (Anti-sigma-B factor) (Sigma-B negative effector RsbW)
[GPB2 KRH1 YAL056W] Guanine nucleotide-binding protein subunit beta 2 (Gbeta mimic kelch protein 2)
[rseA MSMEG_5071 MSMEI_4944] Anti-sigma-E factor RseA (Regulator of SigE) (Sigma-E anti-sigma factor RseA)
[sigC Rv2069 MTCY49.08] ECF RNA polymerase sigma factor SigC (ECF sigma factor SigC) (Alternative RNA polymerase sigma factor SigC) (RNA polymerase sigma-C factor) (Sigma-C factor)
[rsbV BSU04710] Anti-sigma-B factor antagonist (Anti-anti-sigma-B factor)
[PEA2 PPF2 YER149C] Protein PEA2 (Protein PPF2)
[rsfA Rv1365c MTCY02B10.29c] Anti-sigma-F factor antagonist RsfA (Anti-anti-sigma F factor RsfA)
[nrsF CCNA_03273] Anti-sigma-F factor NrsF (Negative regulator of sigma F) (Regulator of SigF) (Sigma-F anti-sigma factor NrsF)
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