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Anti-sigma-E factor RseA (Regulator of SigE) (Sigma-E anti-sigma factor RseA)

 RSEA_MYCS2              Reviewed;         132 AA.
A0R2D3; I7FRJ7;
24-JUL-2013, integrated into UniProtKB/Swiss-Prot.
09-JAN-2007, sequence version 1.
20-JUN-2018, entry version 62.
RecName: Full=Anti-sigma-E factor RseA;
AltName: Full=Regulator of SigE;
AltName: Full=Sigma-E anti-sigma factor RseA;
Name=rseA; OrderedLocusNames=MSMEG_5071, MSMEI_4944;
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155).
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
Mycolicibacterium.
NCBI_TaxID=246196;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 700084 / mc(2)155;
Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C.,
Fraser C.M.;
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 700084 / mc(2)155;
PubMed=17295914; DOI=10.1186/gb-2007-8-2-r20;
Deshayes C., Perrodou E., Gallien S., Euphrasie D., Schaeffer C.,
Van-Dorsselaer A., Poch O., Lecompte O., Reyrat J.-M.;
"Interrupted coding sequences in Mycobacterium smegmatis: authentic
mutations or sequencing errors?";
Genome Biol. 8:R20.1-R20.9(2007).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 700084 / mc(2)155;
PubMed=18955433; DOI=10.1101/gr.081901.108;
Gallien S., Perrodou E., Carapito C., Deshayes C., Reyrat J.-M.,
Van Dorsselaer A., Poch O., Schaeffer C., Lecompte O.;
"Ortho-proteogenomics: multiple proteomes investigation through
orthology and a new MS-based protocol.";
Genome Res. 19:128-135(2009).
[4]
INTERACTION WITH SIGE, DISRUPTION PHENOTYPE, AND INDUCTION.
STRAIN=ATCC 700084 / mc(2)155;
PubMed=20025669; DOI=10.1111/j.1365-2958.2009.07008.x;
Barik S., Sureka K., Mukherjee P., Basu J., Kundu M.;
"RseA, the SigE specific anti-sigma factor of Mycobacterium
tuberculosis, is inactivated by phosphorylation-dependent ClpC1P2
proteolysis.";
Mol. Microbiol. 75:592-606(2010).
-!- FUNCTION: An anti-sigma factor for extracytoplasmic function (ECF)
sigma factor SigE. ECF sigma factors are held in an inactive form
by an anti-sigma factor (By similarity). {ECO:0000250}.
-!- COFACTOR:
Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250};
Note=Binds 1 Zn(2+) ion per subunit. {ECO:0000250};
-!- SUBUNIT: Interacts with ECF RNA polymerase sigma factor SigE,
interaction is abrogated by treatment of cells with H(2)O(2),
detergent or vancomycin (the latter 2 cause surface stress). This
probably inhibits the interaction of SigE with the RNA polymerase
catalytic core. {ECO:0000269|PubMed:20025669}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
-!- INDUCTION: Total levels of RseA decrease after detergent or
vancomycin treatment of whole cells (at protein level).
{ECO:0000269|PubMed:20025669}.
-!- PTM: Phosphorylated by PknB on Thr-36; can be dephosphorylated (at
least in vitro) by PstP. Phosphorylation is the signal for
subsequent degradation by the ClpC1-ClpP2 complex (By similarity).
{ECO:0000250}.
-!- PTM: Degraded following vancomycin treatment (surface stress) by a
ClpC1-ClpP2 complex. {ECO:0000250}.
-!- DISRUPTION PHENOTYPE: No phenotype upon growth in liquid culture.
{ECO:0000269|PubMed:20025669}.
-!- SIMILARITY: Belongs to the zinc-associated anti-sigma factor (ZAS)
superfamily. {ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=AFP41388.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
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EMBL; CP000480; ABK72380.1; -; Genomic_DNA.
EMBL; CP001663; AFP41388.1; ALT_INIT; Genomic_DNA.
RefSeq; WP_003896479.1; NZ_CP009494.1.
RefSeq; YP_889321.1; NC_008596.1.
ProteinModelPortal; A0R2D3; -.
SMR; A0R2D3; -.
STRING; 246196.MSMEG_5071; -.
EnsemblBacteria; ABK72380; ABK72380; MSMEG_5071.
EnsemblBacteria; AFP41388; AFP41388; MSMEI_4944.
GeneID; 4532491; -.
KEGG; msb:LJ00_25080; -.
KEGG; msg:MSMEI_4944; -.
KEGG; msm:MSMEG_5071; -.
PATRIC; fig|246196.19.peg.4949; -.
eggNOG; ENOG4106684; Bacteria.
eggNOG; ENOG41123YS; LUCA.
HOGENOM; HOG000053107; -.
OMA; FSWLPSQ; -.
OrthoDB; POG091H0AS5; -.
Proteomes; UP000000757; Chromosome.
Proteomes; UP000006158; Chromosome.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
1: Evidence at protein level;
Complete proteome; Cytoplasm; Metal-binding; Phosphoprotein;
Reference proteome; Transcription; Transcription regulation; Zinc.
CHAIN 1 132 Anti-sigma-E factor RseA.
/FTId=PRO_0000422951.
METAL 63 63 Zinc; via tele nitrogen. {ECO:0000250}.
METAL 67 67 Zinc. {ECO:0000250}.
METAL 70 70 Zinc. {ECO:0000250}.
MOD_RES 36 36 Phosphothreonine; by PknB. {ECO:0000250}.
SEQUENCE 132 AA; 14426 MW; 8F94510E3C8C5A1B CRC64;
MADPGHVFRR AFSWLPSQFA SQSDAPVGAP RQFGSTEHLS VEAIAAFVDG ELRMSAHLRA
AHHLSLCPEC AAEVDAQSQA RTALRESCPI AIPNSLLGML SQIPHRTPEV TPDVSEQAKF
ADDPTRGRRK RR


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