Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Anti-sigma-F factor RsbW (Anti-sigma-F factor UsfX) (Regulator of SigF) (Sigma-F anti-sigma factor RsbW)

 RSBW_MYCTU              Reviewed;         168 AA.
P9WGX7; Q798J8; Q7D5S1;
16-APR-2014, integrated into UniProtKB/Swiss-Prot.
02-NOV-2016, sequence version 2.
30-AUG-2017, entry version 24.
RecName: Full=Anti-sigma-F factor RsbW;
AltName: Full=Anti-sigma-F factor UsfX;
AltName: Full=Regulator of SigF;
AltName: Full=Sigma-F anti-sigma factor RsbW;
Name=rsbW; Synonyms=usfX; OrderedLocusNames=Rv3287c;
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
Mycobacterium; Mycobacterium tuberculosis complex.
NCBI_TaxID=83332;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 25618 / H37Rv;
PubMed=9634230; DOI=10.1038/31159;
Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M.,
Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III,
Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T.,
Connor R., Davies R.M., Devlin K., Feltwell T., Gentles S., Hamlin N.,
Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S.,
Murphy L.D., Oliver S., Osborne J., Quail M.A., Rajandream M.A.,
Rogers J., Rutter S., Seeger K., Skelton S., Squares S., Squares R.,
Sulston J.E., Taylor K., Whitehead S., Barrell B.G.;
"Deciphering the biology of Mycobacterium tuberculosis from the
complete genome sequence.";
Nature 393:537-544(1998).
[2]
SEQUENCE REVISION.
STRAIN=ATCC 25618 / H37Rv;
PubMed=12368430;
Camus J.-C., Pryor M.J., Medigue C., Cole S.T.;
"Re-annotation of the genome sequence of Mycobacterium tuberculosis
H37Rv.";
Microbiology 148:2967-2973(2002).
[3]
INDUCTION FOLLOWING STARVATION.
STRAIN=ATCC 25618 / H37Rv / NCTC 7416;
PubMed=11929527; DOI=10.1046/j.1365-2958.2002.02779.x;
Betts J.C., Lukey P.T., Robb L.C., McAdam R.A., Duncan K.;
"Evaluation of a nutrient starvation model of Mycobacterium
tuberculosis persistence by gene and protein expression profiling.";
Mol. Microbiol. 43:717-731(2002).
[4]
FUNCTION AS AN ANTI-SIGMA FACTOR, AND INTERACTION WITH SIGF; RSFA AND
RSFB.
PubMed=12354223; DOI=10.1046/j.1365-2958.2002.03135.x;
Beaucher J., Rodrigue S., Jacques P.E., Smith I., Brzezinski R.,
Gaudreau L.;
"Novel Mycobacterium tuberculosis anti-sigma factor antagonists
control sigmaF activity by distinct mechanisms.";
Mol. Microbiol. 45:1527-1540(2002).
[5]
POSSIBLE NUCLEOTIDE HYDROLYSIS, SUBUNIT, AND NUCLEOTIDE-BINDING.
PubMed=18722345; DOI=10.1016/j.bbrc.2008.08.043;
Malik S.S., Luthra A., Srivastava S.K., Ramachandran R.;
"Mycobacterium tuberculosis UsfX (Rv3287c) exhibits novel nucleotide
binding and hydrolysis properties.";
Biochem. Biophys. Res. Commun. 375:465-470(2008).
[6]
SUBUNIT, AND INTERACTION WITH SIGF AND RSFA.
PubMed=19130906; DOI=10.1016/j.bbapap.2008.11.007;
Malik S.S., Luthra A., Ramachandran R.;
"Interactions of the M. tuberculosis UsfX with the cognate sigma
factor SigF and the anti-anti sigma factor RsfA.";
Biochim. Biophys. Acta 1794:541-553(2009).
[7]
DISRUPTION PHENOTYPE.
STRAIN=ATCC 25618 / H37Rv;
PubMed=20729364; DOI=10.1128/JB.00687-10;
Hartkoorn R.C., Sala C., Magnet S.J., Chen J.M., Pojer F., Cole S.T.;
"Sigma factor F does not prevent rifampin inhibition of RNA polymerase
or cause rifampin tolerance in Mycobacterium tuberculosis.";
J. Bacteriol. 192:5472-5479(2010).
[8]
INTERACTION WITH SIGF.
PubMed=20600947; DOI=10.1016/j.pep.2010.06.018;
Thakur K.G., Jaiswal R.K., Shukla J.K., Praveena T., Gopal B.;
"Over-expression and purification strategies for recombinant multi-
protein oligomers: a case study of Mycobacterium tuberculosis
sigma/anti-sigma factor protein complexes.";
Protein Expr. Purif. 74:223-230(2010).
[9]
INTERACTION WITH OBG.
STRAIN=H37Rv;
PubMed=21352546; DOI=10.1186/1471-2180-11-43;
Sasindran S.J., Saikolappan S., Scofield V.L., Dhandayuthapani S.;
"Biochemical and physiological characterization of the GTP-binding
protein Obg of Mycobacterium tuberculosis.";
BMC Microbiol. 11:43-43(2011).
[10]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
STRAIN=ATCC 25618 / H37Rv;
PubMed=21969609; DOI=10.1074/mcp.M111.011627;
Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B.,
Yadav A.K., Shrivastava P., Marimuthu A., Anand S., Sundaram H.,
Kingsbury R., Harsha H.C., Nair B., Prasad T.S., Chauhan D.S.,
Katoch K., Katoch V.M., Kumar P., Chaerkady R., Ramachandran S.,
Dash D., Pandey A.;
"Proteogenomic analysis of Mycobacterium tuberculosis by high
resolution mass spectrometry.";
Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
-!- FUNCTION: A cognate anti-sigma factor for alternative sigma factor
SigF. Alternative sigma factors are held in an inactive form by an
anti-sigma factor. Binds ATP and GTP, may hydrolyze both.
{ECO:0000269|PubMed:12354223}.
-!- SUBUNIT: Homodimer (Probable). Interacts with cognate RNA
polymerase sigma factor SigF with a possible 2:1 RbsW:SigF
stoichiometry; this inhibits the interaction of SigF with the RNA
polymerase catalytic core. Interacts with anti-sigma-F factor
antagonist RsfA with a possible 2:1 RbsW:RsfA stoichiometry; this
blocks binding to SigF, thus indirectly activating transcription.
Interacts with GTPase Obg (PubMed:21352546).
{ECO:0000269|PubMed:12354223, ECO:0000269|PubMed:18722345,
ECO:0000269|PubMed:19130906, ECO:0000269|PubMed:20600947,
ECO:0000269|PubMed:21352546, ECO:0000305}.
-!- INDUCTION: 9-fold induced by starvation.
{ECO:0000269|PubMed:11929527}.
-!- DOMAIN: The cytosolic domain interacts with sigma factor SigF.
-!- DISRUPTION PHENOTYPE: A double rsbW-sigF disruption shows no
effect in the presence or absence of rifampicin.
{ECO:0000269|PubMed:20729364}.
-!- SIMILARITY: Belongs to the anti-sigma-factor family.
{ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=CCP46106.1; Type=Erroneous initiation; Note=Translation N-terminally extended.;
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; AL123456; CCP46106.1; ALT_INIT; Genomic_DNA.
RefSeq; NP_217804.4; NC_000962.3.
ProteinModelPortal; P9WGX7; -.
IntAct; P9WGX7; 6.
STRING; 83332.Rv3287c; -.
PaxDb; P9WGX7; -.
EnsemblBacteria; CCP46106; CCP46106; Rv3287c.
GeneID; 887977; -.
KEGG; mtu:Rv3287c; -.
TubercuList; Rv3287c; -.
eggNOG; ENOG4105XVZ; Bacteria.
eggNOG; COG2172; LUCA.
Proteomes; UP000001584; Chromosome.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
GO; GO:0000166; F:nucleotide binding; IDA:MTBBASE.
GO; GO:0016989; F:sigma factor antagonist activity; IDA:MTBBASE.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IDA:MTBBASE.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
1: Evidence at protein level;
ATP-binding; Complete proteome; Hydrolase; Nucleotide-binding;
Reference proteome; Transcription; Transcription regulation.
CHAIN 1 168 Anti-sigma-F factor RsbW.
/FTId=PRO_0000422955.
NP_BIND 124 128 ATP. {ECO:0000255}.
SEQUENCE 168 AA; 17928 MW; D1E729A26DFD765E CRC64;
MTDQLEDQTQ GGSTVDRSLP GGCMADSDLP TKGRQRGVRA VELNVAARLE NLALLRTLVG
AIGTFEDLDF DAVADLRLAV DEVCTRLIRS ALPDATLRLV VDPRKDEVVV EASAACDTHD
VVAPGSFSWH VLTALADDVQ TFHDGRQPDV AGSVFGITLT ARRAASSR


Related products :

Catalog number Product name Quantity
15-288-22217F AP-3 complex subunit sigma-2 - Adapter-related protein complex 3 sigma-2 subunit; Sigma-adaptin 3b; AP-3 complex sigma-3B subunit; Sigma-3B-adaptin Polyclonal 0.05 mg
15-288-22217F AP-3 complex subunit sigma-2 - Adapter-related protein complex 3 sigma-2 subunit; Sigma-adaptin 3b; AP-3 complex sigma-3B subunit; Sigma-3B-adaptin Polyclonal 0.1 mg
10-288-22217F AP-3 complex subunit sigma-2 - Adapter-related protein complex 3 sigma-2 subunit; Sigma-adaptin 3b; AP-3 complex sigma-3B subunit; Sigma-3B-adaptin 0.1 mg
10-288-22217F AP-3 complex subunit sigma-2 - Adapter-related protein complex 3 sigma-2 subunit; Sigma-adaptin 3b; AP-3 complex sigma-3B subunit; Sigma-3B-adaptin 0.05 mg
AB2B201 Polyclonal Antibodies: Anti-RNA polymerase sigma factor RpoE Polyclonal Antibody; Specificity: Anti-RNA polymerase sigma factor RpoE Polyclonal Antibody ; Application: IHC 0.1mg
LF-MA10299 anti-14-3-3 σ (14-3-3 sigma) (3C3), Mouse monoclonal to 14-3-3 σ (14-3-3 sigma), Isotype IgG1, Host Mouse 100 ug
20-272-191003 14 - 3 - 3 sigma - Mouse monoclonal [1.T.28] to 14 - 3 - 3 sigma; Stratifin; Epithelial cell marker protein 1 Monoclonal 0.05 mg
20-272-191004 14 - 3 - 3 sigma - Mouse monoclonal [1.N.6] to 14 - 3 - 3 sigma; Stratifin; Epithelial cell marker protein 1 Monoclonal 0.25 ml
AHP1050 RABBIT ANTI 14_3_3 SIGMA, Product Type Polyclonal Antibody, Specificity 14_3_3 SIGMA, Target Species Sheep, Host Rabbit, Format Serum, Isotypes Polyclonal IgG, Applications WB, Clone 0.1 ml
SCH-AHP1050 RABBIT ANTI 14_3_3 SIGMA, Product Type Polyclonal Antibody, Specificity 14_3_3 SIGMA, Target Species Sheep, Host Rabbit, Format Serum, Isotypes Polyclonal IgG, Applications WB, Clone 0.1 ml
E1384146 RNA Polymerase sigma Factor (ECF) ELISA Kit
E1381258 RNA Polymerase sigma Factor (ECF) ELISA Kit 1
E1380079 Guinea pig RNA Polymerase sigma Factor (ECF) ELISA Kit
EIAAB38145 Oprs1,Rat,Rattus norvegicus,Sigma 1-type opioid receptor,Sigma non-opioid intracellular receptor 1,Sigma1R,Sigma1-receptor,Sigmar1
EIAAB38141 Bos taurus,Bovine,OPRS1,Sigma 1-type opioid receptor,Sigma non-opioid intracellular receptor 1,Sigma1R,Sigma1-receptor,SIGMAR1
EIAAB38144 Mouse,Mus musculus,Oprs1,Sigma 1-type opioid receptor,Sigma non-opioid intracellular receptor 1,Sigma1R,Sigma1-receptor,Sigmar1
MCA4035Z MOUSE ANTI HUMAN 14_3_3 SIGMA Azide Free, Product Type Monoclonal Antibody, Specificity 14_3_3 SIGMA, Target Species Human, Host Mouse, Format Azide Free, Isotypes IgG1, Applications P*, WB, Cl 0.1 mg
EIAAB38142 AAG8,Aging-associated gene 8 protein,Homo sapiens,hSigmaR1,Human,OPRS1,SIG-1R,Sigma 1-type opioid receptor,Sigma non-opioid intracellular receptor 1,Sigma1R,Sigma1-receptor,SIGMAR1,SR31747-binding pro
20-272-190999 14 - 3 - 3 sigma - BSA and Azide free - Mouse monoclonal [1.N.6] to 14 - 3 - 3 sigma - BSA and Azide free; Stratifin; Epithelial cell marker protein 1 Monoclonal 0.05 mg
PAB16007 Rhodopseudomonas palustris<_i> RNA polymerase sigma factor RpoE protein polyclonal antibody 50 ug
EIAAB38143 Chicken,Gallus gallus,OPRS1,RCJMB04_7e2,Sigma 1-type opioid receptor,Sigma non-opioid intracellular receptor 1,Sigma1R,Sigma1-receptor,SIGMAR1
20-272-190716 RNA polymerase sigma 70 - Mouse monoclonal [2G10] to RNA polymerase sigma 70 Monoclonal 0.05 ml
15-288-21486 Receptor-type tyrosine-protein phosphatase S - EC 3.1.3.48; R-PTP-S; Protein-tyrosine phosphatase sigma; R-PTP-sigma Polyclonal 0.1 mg
15-288-21486 Receptor-type tyrosine-protein phosphatase S - EC 3.1.3.48; R-PTP-S; Protein-tyrosine phosphatase sigma; R-PTP-sigma Polyclonal 0.05 mg
10-782-55100 Receptor-type tyrosine-protein phosphatase S - EC 3.1.3.48; R-PTP-S; Protein-tyrosine phosphatase sigma; R-PTP-sigma N_A 0.005 mg


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur