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Anti-sigma-F factor antagonist RsfB (Anti-anti-sigma F factor RsfB)

 RSFB_MYCTU              Reviewed;         122 AA.
P9WGE1; F2GFD0; O69655; Q7D525;
16-APR-2014, integrated into UniProtKB/Swiss-Prot.
16-APR-2014, sequence version 1.
25-OCT-2017, entry version 23.
RecName: Full=Anti-sigma-F factor antagonist RsfB;
AltName: Full=Anti-anti-sigma F factor RsfB;
Name=rsfB; OrderedLocusNames=Rv3687c;
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
Mycobacterium; Mycobacterium tuberculosis complex.
NCBI_TaxID=83332;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 25618 / H37Rv;
PubMed=9634230; DOI=10.1038/31159;
Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M.,
Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III,
Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T.,
Connor R., Davies R.M., Devlin K., Feltwell T., Gentles S., Hamlin N.,
Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S.,
Murphy L.D., Oliver S., Osborne J., Quail M.A., Rajandream M.A.,
Rogers J., Rutter S., Seeger K., Skelton S., Squares S., Squares R.,
Sulston J.E., Taylor K., Whitehead S., Barrell B.G.;
"Deciphering the biology of Mycobacterium tuberculosis from the
complete genome sequence.";
Nature 393:537-544(1998).
[2]
FUNCTION AS AN ANTI-SIGMA-F FACTOR ANTAGONIST, INTERACTION WITH RSBW,
PHOSPHORYLATION AT SER-61, AND MUTAGENESIS OF SER-61.
PubMed=12354223; DOI=10.1046/j.1365-2958.2002.03135.x;
Beaucher J., Rodrigue S., Jacques P.E., Smith I., Brzezinski R.,
Gaudreau L.;
"Novel Mycobacterium tuberculosis anti-sigma factor antagonists
control sigmaF activity by distinct mechanisms.";
Mol. Microbiol. 45:1527-1540(2002).
[3]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
STRAIN=ATCC 25618 / H37Rv;
PubMed=21969609; DOI=10.1074/mcp.M111.011627;
Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B.,
Yadav A.K., Shrivastava P., Marimuthu A., Anand S., Sundaram H.,
Kingsbury R., Harsha H.C., Nair B., Prasad T.S., Chauhan D.S.,
Katoch K., Katoch V.M., Kumar P., Chaerkady R., Ramachandran S.,
Dash D., Pandey A.;
"Proteogenomic analysis of Mycobacterium tuberculosis by high
resolution mass spectrometry.";
Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
-!- FUNCTION: Positive regulator of sigma-F (SigF) activity. Binds to
anti-sigma-F factor RsbW (UsfX) preventing its binding to SigF,
thus activating transcription. {ECO:0000269|PubMed:12354223}.
-!- SUBUNIT: Interacts with anti-sigma-F factor RsbW (UsfX). Its
phosphorylation may prevent this interaction.
{ECO:0000269|PubMed:12354223}.
-!- PTM: Putative phosphorylation on Ser-61 may prevent interaction
with RsbW. {ECO:0000269|PubMed:12354223}.
-!- SIMILARITY: Belongs to the anti-sigma-factor antagonist family.
{ECO:0000305}.
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EMBL; AL123456; CCP46511.1; -; Genomic_DNA.
PIR; H70791; H70791.
RefSeq; NP_218204.1; NC_000962.3.
RefSeq; WP_003419762.1; NZ_KK339374.1.
ProteinModelPortal; P9WGE1; -.
SMR; P9WGE1; -.
IntAct; P9WGE1; 1.
STRING; 83332.Rv3687c; -.
iPTMnet; P9WGE1; -.
PaxDb; P9WGE1; -.
EnsemblBacteria; CCP46511; CCP46511; Rv3687c.
GeneID; 885599; -.
KEGG; mtu:Rv3687c; -.
TubercuList; Rv3687c; -.
eggNOG; COG1366; LUCA.
OMA; ATRRPIH; -.
PhylomeDB; P9WGE1; -.
Proteomes; UP000001584; Chromosome.
GO; GO:0043856; F:anti-sigma factor antagonist activity; IPI:MTBBASE.
GO; GO:0045152; F:antisigma factor binding; IEA:InterPro.
GO; GO:0006355; P:regulation of transcription, DNA-templated; IPI:MTBBASE.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
Gene3D; 3.30.750.24; -; 1.
InterPro; IPR003658; Anti-sigma_ant.
InterPro; IPR002645; STAS_dom.
InterPro; IPR036513; STAS_dom_sf.
Pfam; PF01740; STAS; 1.
SUPFAM; SSF52091; SSF52091; 1.
TIGRFAMs; TIGR00377; ant_ant_sig; 1.
PROSITE; PS50801; STAS; 1.
1: Evidence at protein level;
Complete proteome; Phosphoprotein; Reference proteome; Transcription;
Transcription regulation.
CHAIN 1 122 Anti-sigma-F factor antagonist RsfB.
/FTId=PRO_0000422956.
DOMAIN 7 115 STAS. {ECO:0000255|PROSITE-
ProRule:PRU00198}.
MOD_RES 61 61 Phosphoserine.
{ECO:0000305|PubMed:12354223}.
MUTAGEN 61 61 S->A: Still interacts with RsbW.
{ECO:0000269|PubMed:12354223}.
MUTAGEN 61 61 S->E: No longer interacts with RsbW.
{ECO:0000269|PubMed:12354223}.
SEQUENCE 122 AA; 12651 MW; 3F748FC41C6CCBB7 CRC64;
MSAPDSITVT VADHNGVAVL SIGGEIDLIT AAALEEAIGE VVADNPTALV IDLSAVEFLG
SVGLKILAAT SEKIGQSVKF GVVARGSVTR RPIHLMGLDK TFRLFSTLHD ALTGVRGGRI
DR


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