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Antiholin

 A0A097J2H9_BPR06        Unreviewed;        97 AA.
A0A097J2H9;
07-JAN-2015, integrated into UniProtKB/TrEMBL.
07-JAN-2015, sequence version 1.
22-NOV-2017, entry version 8.
RecName: Full=Antiholin {ECO:0000256|HAMAP-Rule:MF_04105};
Name=rI {ECO:0000313|EMBL:AIT73388.1};
ORFNames=RB6_108 {ECO:0000313|EMBL:AIT73388.1};
Enterobacteria phage RB6 (Bacteriophage RB6).
Viruses; dsDNA viruses, no RNA stage; Caudovirales; Myoviridae;
Tevenvirinae; T4virus.
NCBI_TaxID=69610 {ECO:0000313|EMBL:AIT73388.1, ECO:0000313|Proteomes:UP000029936};
NCBI_TaxID=562; Escherichia coli.
[1] {ECO:0000313|EMBL:AIT73388.1, ECO:0000313|Proteomes:UP000029936}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Yaung S.J., Esvelt K.M., Church G.M.;
"Complete Genome Sequences of T4-like Bacteriophages RB3, RB5, RB6,
RB7, RB9, RB10, RB27, RB33, RB55, RB59, and RB68.";
Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Involved in lysis inhibition. Interacts with and
inhibits the holin thereby delaying the host cell lysis timing.
Lysis inhibition is imposed when a cell infected by a T4-like
virus is superinfected by new incoming viruses. This is probably
due to the capsid content of the new phage being released in the
periplasm because of blockage of entry due to superinfection
exclusion. These periplasmically released viral proteins must
somehow activate the periplasmic antiholin, which in turn will
block the holin multimerization. {ECO:0000256|HAMAP-
Rule:MF_04105}.
-!- SUBUNIT: Interacts (via C-terminus) with holin (via C-terminus);
this interaction blocks the holin homomultimerization and delays
the host cell lysis. {ECO:0000256|HAMAP-Rule:MF_04105}.
-!- SUBCELLULAR LOCATION: Host cell inner membrane {ECO:0000256|HAMAP-
Rule:MF_04105}; Single-pass type II membrane protein
{ECO:0000256|HAMAP-Rule:MF_04105}.
-!- DOMAIN: The transmembrane signal-anchor domain can escape
spontaneously from the cell inner membrane. It is called SAR for
signal-anchor-release for that reason and explains why the
antiholin is an extremly instable protein. Superinfection might
stabilize it so that it can inhibit holin multimerization and
delay lysis. {ECO:0000256|HAMAP-Rule:MF_04105}.
-!- PTM: Disulfide bond is required for functionality.
{ECO:0000256|HAMAP-Rule:MF_04105}.
-!- SIMILARITY: Belongs to the T4likevirus antiholin family.
{ECO:0000256|HAMAP-Rule:MF_04105}.
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EMBL; KM606996; AIT73388.1; -; Genomic_DNA.
Proteomes; UP000029936; Genome.
GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-UniRule.
GO; GO:0019835; P:cytolysis; IEA:UniProtKB-KW.
GO; GO:1901218; P:negative regulation of holin activity; IEA:UniProtKB-UniRule.
HAMAP; MF_04105; ANTIH_T4; 1.
InterPro; IPR034696; RI_T4.
3: Inferred from homology;
Complete proteome {ECO:0000313|Proteomes:UP000029936};
Cytolysis {ECO:0000256|HAMAP-Rule:MF_04105};
Disulfide bond {ECO:0000256|HAMAP-Rule:MF_04105};
Host cell inner membrane {ECO:0000256|HAMAP-Rule:MF_04105};
Host cell lysis by virus {ECO:0000256|HAMAP-Rule:MF_04105};
Host cell membrane {ECO:0000256|HAMAP-Rule:MF_04105};
Host membrane {ECO:0000256|HAMAP-Rule:MF_04105};
Membrane {ECO:0000256|HAMAP-Rule:MF_04105};
Signal-anchor {ECO:0000256|HAMAP-Rule:MF_04105};
Transmembrane {ECO:0000256|HAMAP-Rule:MF_04105};
Transmembrane helix {ECO:0000256|HAMAP-Rule:MF_04105};
Viral release from host cell {ECO:0000256|HAMAP-Rule:MF_04105}.
TOPO_DOM 25 97 Periplasmic. {ECO:0000256|HAMAP-
Rule:MF_04105}.
DISULFID 69 75 {ECO:0000256|HAMAP-Rule:MF_04105}.
SEQUENCE 97 AA; 11107 MW; 4D5CC9DF1539FADB CRC64;
MALKATALFA MLGLSFALSP PIEANVDPHF DKFMESGIRH VYMLFENKSV ESSEQFYSFM
RTTYKNDPCS SDFECIERGA EMAQSYARIM NIKLETE


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