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Apolipoprotein A-I (Apo-AI) (ApoA-I) (Apolipoprotein A1) [Cleaved into: Proapolipoprotein A-I (ProapoA-I); Truncated apolipoprotein A-I]

 APOA1_GORGO             Reviewed;         267 AA.
G3QY98;
21-MAR-2012, integrated into UniProtKB/Swiss-Prot.
16-NOV-2011, sequence version 1.
12-SEP-2018, entry version 50.
RecName: Full=Apolipoprotein A-I;
Short=Apo-AI;
Short=ApoA-I;
AltName: Full=Apolipoprotein A1;
Contains:
RecName: Full=Proapolipoprotein A-I;
Short=ProapoA-I;
Contains:
RecName: Full=Truncated apolipoprotein A-I;
Flags: Precursor;
Name=APOA1;
Gorilla gorilla gorilla (Western lowland gorilla).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Gorilla.
NCBI_TaxID=9595;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Scally A.;
"Insights into the evolution of the great apes provided by the gorilla
genome.";
Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
[2]
IDENTIFICATION BY MASS SPECTROMETRY.
PubMed=21298813; DOI=10.1016/j.cbd.2009.09.001;
Puppione D.L., Della Donna L., Laganowsky A.D., Bassilian S.,
Souda P., Ryder O.A., Whitelegge J.P.;
"Mass spectral analyses of the two major apolipoproteins of great ape
high density lipoproteins.";
Comp. Biochem. Physiol. 4:305-309(2009).
-!- FUNCTION: Participates in the reverse transport of cholesterol
from tissues to the liver for excretion by promoting cholesterol
efflux from tissues and by acting as a cofactor for the lecithin
cholesterol acyltransferase (LCAT). As part of the SPAP complex,
activates spermatozoa motility (By similarity). {ECO:0000250}.
-!- SUBUNIT: Interacts with APOA1BP and CLU. Component of a sperm
activating protein complex (SPAP), consisting of APOA1, an
immunoglobulin heavy chain, an immunoglobulin light chain and
albumin. Interacts with NDRG1. Interacts with SCGB3A2.
{ECO:0000250|UniProtKB:P02647}.
-!- SUBCELLULAR LOCATION: Secreted.
-!- TISSUE SPECIFICITY: Major protein of plasma HDL, also found in
chylomicrons.
-!- PTM: Glycosylated. {ECO:0000250}.
-!- PTM: Palmitoylated. {ECO:0000250}.
-!- PTM: Phosphorylation sites are present in the extracellular
medium. {ECO:0000250}.
-!- MASS SPECTROMETRY: Mass=28078.67; Mass_error=0.833;
Method=Electrospray; Range=25-267;
Evidence={ECO:0000269|PubMed:21298813};
-!- SIMILARITY: Belongs to the apolipoprotein A1/A4/E family.
{ECO:0000305}.
-----------------------------------------------------------------------
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RefSeq; XP_004052230.1; XM_004052182.2.
ProteinModelPortal; G3QY98; -.
SMR; G3QY98; -.
STRING; 9593.ENSGGOP00000007828; -.
PRIDE; G3QY98; -.
Ensembl; ENSGGOT00000008040; ENSGGOP00000007828; ENSGGOG00000008006.
Ensembl; ENSGGOT00000048162; ENSGGOP00000033442; ENSGGOG00000008006.
GeneID; 101137897; -.
KEGG; ggo:101137897; -.
CTD; 335; -.
GeneTree; ENSGT00530000063081; -.
InParanoid; G3QY98; -.
KO; K08757; -.
OMA; KDFATVY; -.
OrthoDB; EOG091G0IA5; -.
Proteomes; UP000001519; Chromosome 11.
Bgee; ENSGGOG00000008006; Expressed in 6 organ(s), highest expression level in liver.
GO; GO:0030139; C:endocytic vesicle; IEA:Ensembl.
GO; GO:0034366; C:spherical high-density lipoprotein particle; IEA:Ensembl.
GO; GO:0034361; C:very-low-density lipoprotein particle; IEA:Ensembl.
GO; GO:0001540; F:amyloid-beta binding; IEA:Ensembl.
GO; GO:0034191; F:apolipoprotein A-I receptor binding; IEA:Ensembl.
GO; GO:0045499; F:chemorepellent activity; IEA:Ensembl.
GO; GO:0015485; F:cholesterol binding; IEA:Ensembl.
GO; GO:0017127; F:cholesterol transporter activity; IEA:Ensembl.
GO; GO:0019899; F:enzyme binding; IEA:Ensembl.
GO; GO:0031072; F:heat shock protein binding; IEA:Ensembl.
GO; GO:0008035; F:high-density lipoprotein particle binding; IEA:Ensembl.
GO; GO:0070653; F:high-density lipoprotein particle receptor binding; IEA:Ensembl.
GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
GO; GO:0060228; F:phosphatidylcholine-sterol O-acyltransferase activator activity; IEA:Ensembl.
GO; GO:0005543; F:phospholipid binding; IEA:Ensembl.
GO; GO:0030325; P:adrenal gland development; IEA:Ensembl.
GO; GO:0043534; P:blood vessel endothelial cell migration; IEA:Ensembl.
GO; GO:0006695; P:cholesterol biosynthetic process; IEA:Ensembl.
GO; GO:0033344; P:cholesterol efflux; IEA:Ensembl.
GO; GO:0042632; P:cholesterol homeostasis; IEA:Ensembl.
GO; GO:0070508; P:cholesterol import; IEA:Ensembl.
GO; GO:0001935; P:endothelial cell proliferation; IEA:Ensembl.
GO; GO:0007186; P:G-protein coupled receptor signaling pathway; IEA:Ensembl.
GO; GO:0008211; P:glucocorticoid metabolic process; IEA:Ensembl.
GO; GO:0034380; P:high-density lipoprotein particle assembly; IEA:Ensembl.
GO; GO:0034375; P:high-density lipoprotein particle remodeling; IEA:Ensembl.
GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:Ensembl.
GO; GO:0019915; P:lipid storage; IEA:Ensembl.
GO; GO:0042158; P:lipoprotein biosynthetic process; IEA:Ensembl.
GO; GO:0060354; P:negative regulation of cell adhesion molecule production; IEA:Ensembl.
GO; GO:0002740; P:negative regulation of cytokine secretion involved in immune response; IEA:Ensembl.
GO; GO:0034115; P:negative regulation of heterotypic cell-cell adhesion; IEA:Ensembl.
GO; GO:0051346; P:negative regulation of hydrolase activity; IEA:Ensembl.
GO; GO:0050728; P:negative regulation of inflammatory response; IEA:Ensembl.
GO; GO:0050713; P:negative regulation of interleukin-1 beta secretion; IEA:Ensembl.
GO; GO:0010804; P:negative regulation of tumor necrosis factor-mediated signaling pathway; IEA:Ensembl.
GO; GO:0010903; P:negative regulation of very-low-density lipoprotein particle remodeling; IEA:Ensembl.
GO; GO:0018206; P:peptidyl-methionine modification; ISS:UniProtKB.
GO; GO:0006656; P:phosphatidylcholine biosynthetic process; IEA:Ensembl.
GO; GO:0033700; P:phospholipid efflux; IEA:Ensembl.
GO; GO:0055091; P:phospholipid homeostasis; IEA:Ensembl.
GO; GO:0010873; P:positive regulation of cholesterol esterification; IEA:Ensembl.
GO; GO:0051345; P:positive regulation of hydrolase activity; IEA:Ensembl.
GO; GO:0035025; P:positive regulation of Rho protein signal transduction; IEA:Ensembl.
GO; GO:0051496; P:positive regulation of stress fiber assembly; IEA:Ensembl.
GO; GO:1900026; P:positive regulation of substrate adhesion-dependent cell spreading; IEA:Ensembl.
GO; GO:0018158; P:protein oxidation; ISS:UniProtKB.
GO; GO:0050821; P:protein stabilization; IEA:Ensembl.
GO; GO:0032489; P:regulation of Cdc42 protein signal transduction; IEA:Ensembl.
GO; GO:0030300; P:regulation of intestinal cholesterol absorption; IEA:Ensembl.
GO; GO:0001932; P:regulation of protein phosphorylation; IEA:Ensembl.
GO; GO:0043691; P:reverse cholesterol transport; IEA:Ensembl.
GO; GO:0070328; P:triglyceride homeostasis; IEA:Ensembl.
GO; GO:0051180; P:vitamin transport; IEA:Ensembl.
InterPro; IPR000074; ApoA_E.
Pfam; PF01442; Apolipoprotein; 1.
1: Evidence at protein level;
Cholesterol metabolism; Complete proteome; Glycoprotein; HDL;
Lipid metabolism; Lipid transport; Lipoprotein; Oxidation; Palmitate;
Phosphoprotein; Reference proteome; Repeat; Secreted; Signal;
Steroid metabolism; Sterol metabolism; Transport.
SIGNAL 1 18 {ECO:0000255}.
CHAIN 19 267 Proapolipoprotein A-I.
/FTId=PRO_0000425321.
CHAIN 25 267 Apolipoprotein A-I.
/FTId=PRO_0000415938.
CHAIN 25 266 Truncated apolipoprotein A-I.
/FTId=PRO_0000416573.
REPEAT 68 89 1.
REPEAT 90 111 2.
REPEAT 112 122 3; half-length.
REPEAT 123 144 4.
REPEAT 145 166 5.
REPEAT 167 188 6.
REPEAT 189 210 7.
REPEAT 211 232 8.
REPEAT 233 243 9; half-length.
REPEAT 244 267 10.
REGION 68 267 10 X approximate tandem repeats.
MOD_RES 110 110 Methionine sulfoxide. {ECO:0000250}.
MOD_RES 136 136 Methionine sulfoxide. {ECO:0000250}.
SEQUENCE 267 AA; 30778 MW; 1A28B8366E620310 CRC64;
MKAAVLTLAV LFLTGSQARH FWQQDEPPQS PWDRVKDLAT VYVDVLKDSG RDYVSQFEGS
ALGKQLNLKL LDNWDSVTST FSKLREQLGP VTQEFWDNLE KETEGLRQEM SKDLEEVKAK
VQPYLDDFQK KWQEEMELYR QKVEPLRAEL QEGARQKLHE LQEKLSPLGE EMRDRARAHV
DALRTHLAPY SDELRQRLAA RLEALKENGG ARLAEYHAKA TEHLSTLSEK AKPALEDLRQ
GLLPVLESFK VSFLSALEEY TKKLNTQ


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