Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Apolipoprotein A-I (Apo-AI) (ApoA-I) (Apolipoprotein A1) [Cleaved into: Proapolipoprotein A-I (ProapoA-I); Truncated apolipoprotein A-I]

 APOA1_PANTR             Reviewed;         267 AA.
P0DJG0;
18-APR-2012, integrated into UniProtKB/Swiss-Prot.
18-APR-2012, sequence version 1.
12-SEP-2018, entry version 51.
RecName: Full=Apolipoprotein A-I;
Short=Apo-AI;
Short=ApoA-I;
AltName: Full=Apolipoprotein A1;
Contains:
RecName: Full=Proapolipoprotein A-I;
Short=ProapoA-I;
Contains:
RecName: Full=Truncated apolipoprotein A-I;
Flags: Precursor;
Name=APOA1;
Pan troglodytes (Chimpanzee).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Pan.
NCBI_TaxID=9598;
[1]
IDENTIFICATION BY MASS SPECTROMETRY.
PubMed=21298813; DOI=10.1016/j.cbd.2009.09.001;
Puppione D.L., Della Donna L., Laganowsky A.D., Bassilian S.,
Souda P., Ryder O.A., Whitelegge J.P.;
"Mass spectral analyses of the two major apolipoproteins of great ape
high density lipoproteins.";
Comp. Biochem. Physiol. 4:305-309(2009).
-!- FUNCTION: Participates in the reverse transport of cholesterol
from tissues to the liver for excretion by promoting cholesterol
efflux from tissues and by acting as a cofactor for the lecithin
cholesterol acyltransferase (LCAT). As part of the SPAP complex,
activates spermatozoa motility (By similarity). {ECO:0000250}.
-!- SUBUNIT: Interacts with APOA1BP and CLU. Component of a sperm
activating protein complex (SPAP), consisting of APOA1, an
immunoglobulin heavy chain, an immunoglobulin light chain and
albumin. Interacts with NDRG1. Interacts with SCGB3A2.
{ECO:0000250|UniProtKB:P02647}.
-!- SUBCELLULAR LOCATION: Secreted.
-!- TISSUE SPECIFICITY: Major protein of plasma HDL, also found in
chylomicrons.
-!- PTM: Glycosylated. {ECO:0000250}.
-!- PTM: Palmitoylated. {ECO:0000250}.
-!- PTM: Phosphorylation sites are present in the extracellular
medium. {ECO:0000250}.
-!- MASS SPECTROMETRY: Mass=28079.33; Mass_error=1.258;
Method=Electrospray; Range=25-267;
Evidence={ECO:0000269|PubMed:21298813};
-!- MASS SPECTROMETRY: Mass=27953.3; Method=Electrospray; Range=25-
266; Evidence={ECO:0000269|PubMed:21298813};
-!- SIMILARITY: Belongs to the apolipoprotein A1/A4/E family.
{ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
RefSeq; XP_001153383.1; XM_001153383.4.
RefSeq; XP_001153517.1; XM_001153517.4.
RefSeq; XP_016777528.1; XM_016922039.1.
RefSeq; XP_016777529.1; XM_016922040.1.
RefSeq; XP_016777530.1; XM_016922041.1.
RefSeq; XP_508770.1; XM_508770.5.
ProteinModelPortal; P0DJG0; -.
SMR; P0DJG0; -.
STRING; 9598.ENSPTRP00000007404; -.
PaxDb; P0DJG0; -.
PRIDE; P0DJG0; -.
Ensembl; ENSPTRT00000008023; ENSPTRP00000007404; ENSPTRG00000004316.
Ensembl; ENSPTRT00000095290; ENSPTRP00000080550; ENSPTRG00000046016.
GeneID; 107967226; -.
KEGG; ptr:107967226; -.
CTD; 335; -.
VGNC; VGNC:10228; APOA1.
eggNOG; ENOG410IWKR; Eukaryota.
eggNOG; ENOG410YGQ6; LUCA.
GeneTree; ENSGT00530000063081; -.
InParanoid; P0DJG0; -.
KO; K08757; -.
OMA; KDFATVY; -.
OrthoDB; EOG091G0IA5; -.
TreeFam; TF334458; -.
Proteomes; UP000002277; Chromosome 11.
Bgee; ENSPTRG00000004316; Expressed in 6 organ(s), highest expression level in liver.
GO; GO:0072562; C:blood microparticle; IBA:GO_Central.
GO; GO:0042627; C:chylomicron; IBA:GO_Central.
GO; GO:0034364; C:high-density lipoprotein particle; IBA:GO_Central.
GO; GO:0015485; F:cholesterol binding; IBA:GO_Central.
GO; GO:0017127; F:cholesterol transporter activity; IBA:GO_Central.
GO; GO:0070653; F:high-density lipoprotein particle receptor binding; IBA:GO_Central.
GO; GO:0031210; F:phosphatidylcholine binding; IBA:GO_Central.
GO; GO:0060228; F:phosphatidylcholine-sterol O-acyltransferase activator activity; IBA:GO_Central.
GO; GO:0006695; P:cholesterol biosynthetic process; IBA:GO_Central.
GO; GO:0033344; P:cholesterol efflux; IBA:GO_Central.
GO; GO:0042632; P:cholesterol homeostasis; IBA:GO_Central.
GO; GO:0034380; P:high-density lipoprotein particle assembly; IBA:GO_Central.
GO; GO:0042157; P:lipoprotein metabolic process; IBA:GO_Central.
GO; GO:0031102; P:neuron projection regeneration; IBA:GO_Central.
GO; GO:0046470; P:phosphatidylcholine metabolic process; IBA:GO_Central.
GO; GO:0033700; P:phospholipid efflux; IBA:GO_Central.
GO; GO:0010873; P:positive regulation of cholesterol esterification; IBA:GO_Central.
GO; GO:0045723; P:positive regulation of fatty acid biosynthetic process; IBA:GO_Central.
GO; GO:0051006; P:positive regulation of lipoprotein lipase activity; IBA:GO_Central.
GO; GO:0010898; P:positive regulation of triglyceride catabolic process; IBA:GO_Central.
GO; GO:0030300; P:regulation of intestinal cholesterol absorption; IBA:GO_Central.
GO; GO:0043691; P:reverse cholesterol transport; IBA:GO_Central.
GO; GO:0019433; P:triglyceride catabolic process; IBA:GO_Central.
GO; GO:0070328; P:triglyceride homeostasis; IBA:GO_Central.
GO; GO:0034372; P:very-low-density lipoprotein particle remodeling; IBA:GO_Central.
InterPro; IPR000074; ApoA_E.
Pfam; PF01442; Apolipoprotein; 1.
1: Evidence at protein level;
Cholesterol metabolism; Complete proteome; Glycoprotein; HDL;
Lipid metabolism; Lipid transport; Lipoprotein; Oxidation; Palmitate;
Phosphoprotein; Reference proteome; Repeat; Secreted; Signal;
Steroid metabolism; Sterol metabolism; Transport.
SIGNAL 1 18 {ECO:0000255}.
CHAIN 19 267 Proapolipoprotein A-I.
/FTId=PRO_0000425330.
CHAIN 25 267 Apolipoprotein A-I.
/FTId=PRO_0000416563.
CHAIN 25 266 Truncated apolipoprotein A-I.
/FTId=PRO_0000416564.
REPEAT 68 89 1.
REPEAT 90 111 2.
REPEAT 112 122 3; half-length.
REPEAT 123 144 4.
REPEAT 145 166 5.
REPEAT 167 188 6.
REPEAT 189 210 7.
REPEAT 211 232 8.
REPEAT 233 243 9; half-length.
REPEAT 244 267 10.
REGION 68 267 10 X approximate tandem repeats.
MOD_RES 110 110 Methionine sulfoxide. {ECO:0000250}.
MOD_RES 136 136 Methionine sulfoxide. {ECO:0000250}.
SEQUENCE 267 AA; 30778 MW; 1A28B8366E620310 CRC64;
MKAAVLTLAV LFLTGSQARH FWQQDEPPQS PWDRVKDLAT VYVDVLKDSG RDYVSQFEGS
ALGKQLNLKL LDNWDSVTST FSKLREQLGP VTQEFWDNLE KETEGLRQEM SKDLEEVKAK
VQPYLDDFQK KWQEEMELYR QKVEPLRAEL QEGARQKLHE LQEKLSPLGE EMRDRARAHV
DALRTHLAPY SDELRQRLAA RLEALKENGG ARLAEYHAKA TEHLSTLSEK AKPALEDLRQ
GLLPVLESFK VSFLSALEEY TKKLNTQ


Related products :

Catalog number Product name Quantity
E0604h ELISA kit APOA1,Apo-AI,ApoA-I,Apolipoprotein A1,Apolipoprotein A-I,Homo sapiens,Human 96T
E0604h ELISA APOA1,Apo-AI,ApoA-I,Apolipoprotein A1,Apolipoprotein A-I,Homo sapiens,Human 96T
E0604Rb ELISA kit APOA1,Apo-AI,ApoA-I,Apolipoprotein A1,Apolipoprotein A-I,Oryctolagus cuniculus,Rabbit 96T
U0604Rb CLIA APOA1,Apo-AI,ApoA-I,Apolipoprotein A1,Apolipoprotein A-I,Oryctolagus cuniculus,Rabbit 96T
E0604Rb ELISA APOA1,Apo-AI,ApoA-I,Apolipoprotein A1,Apolipoprotein A-I,Oryctolagus cuniculus,Rabbit 96T
U0604h CLIA APOA1,Apo-AI,ApoA-I,Apolipoprotein A1,Apolipoprotein A-I,Homo sapiens,Human 96T
E0604b ELISA kit APOA1,Apo-AI,ApoA-I,Apolipoprotein A1,Apolipoprotein A-I,Bos taurus,Bovine 96T
E0604m ELISA Apoa1,Apo-AI,ApoA-I,Apolipoprotein A1,Apolipoprotein A-I,Mouse,Mus musculus 96T
E0604r ELISA Apoa1,Apo-AI,ApoA-I,Apolipoprotein A1,Apolipoprotein A-I,Rat,Rattus norvegicus 96T
E0604r ELISA kit Apoa1,Apo-AI,ApoA-I,Apolipoprotein A1,Apolipoprotein A-I,Rat,Rattus norvegicus 96T
E0604m ELISA kit Apoa1,Apo-AI,ApoA-I,Apolipoprotein A1,Apolipoprotein A-I,Mouse,Mus musculus 96T
U0604r CLIA Apoa1,Apo-AI,ApoA-I,Apolipoprotein A1,Apolipoprotein A-I,Rat,Rattus norvegicus 96T
U0604m CLIA Apoa1,Apo-AI,ApoA-I,Apolipoprotein A1,Apolipoprotein A-I,Mouse,Mus musculus 96T
E0604b ELISA APOA1,Apo-AI,ApoA-I,Apolipoprotein A1,Apolipoprotein A-I,Bos taurus,Bovine 96T
U0604b CLIA APOA1,Apo-AI,ApoA-I,Apolipoprotein A1,Apolipoprotein A-I,Bos taurus,Bovine 96T
E0604p ELISA kit APOA1,Apo-AI,ApoA-I,Apolipoprotein A1,Apolipoprotein A-I,Pig,Sus scrofa 96T
E0604p ELISA APOA1,Apo-AI,ApoA-I,Apolipoprotein A1,Apolipoprotein A-I,Pig,Sus scrofa 96T
U0604p CLIA APOA1,Apo-AI,ApoA-I,Apolipoprotein A1,Apolipoprotein A-I,Pig,Sus scrofa 96T
U0604c CLIA APOA1,Apo-AI,ApoA-I,Apolipoprotein A1,Apolipoprotein A-I,Chicken,Gallus gallus 96T
E0604c ELISA APOA1,Apo-AI,ApoA-I,Apolipoprotein A1,Apolipoprotein A-I,Chicken,Gallus gallus 96T
E0604c ELISA kit APOA1,Apo-AI,ApoA-I,Apolipoprotein A1,Apolipoprotein A-I,Chicken,Gallus gallus 96T
E0604c ELISA APOA1,Apo-AI,ApoA-I,Apolipoprotein A1,Apolipoprotein A-I,Canis familiaris,Canis lupus familiaris,Dog 96T
U0604c CLIA APOA1,Apo-AI,ApoA-I,Apolipoprotein A1,Apolipoprotein A-I,Canis familiaris,Canis lupus familiaris,Dog 96T
E0604c ELISA kit APOA1,Apo-AI,ApoA-I,Apolipoprotein A1,Apolipoprotein A-I,Canis familiaris,Canis lupus familiaris,Dog 96T
20-272-192023 Apolipoprotein J - Mouse monoclonal [Hs - 3] to Apolipoprotein J; Complement-associated protein SP-40.40; Complement cytolysis inhibitor; CLI; NA1_NA2; Apolipoprotein J; Apo-J; Testosterone-repressed 0.05 mg


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48      &nb