Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Apolipoprotein A-I (Apo-AI) (ApoA-I) (Apolipoprotein A1) [Cleaved into: Proapolipoprotein A-I (ProapoA-I); Truncated apolipoprotein A-I]

 APOA1_MESAU             Reviewed;         264 AA.
Q9Z2L4;
26-APR-2005, integrated into UniProtKB/Swiss-Prot.
01-MAY-1999, sequence version 1.
25-OCT-2017, entry version 67.
RecName: Full=Apolipoprotein A-I;
Short=Apo-AI;
Short=ApoA-I;
AltName: Full=Apolipoprotein A1;
Contains:
RecName: Full=Proapolipoprotein A-I;
Short=ProapoA-I;
Contains:
RecName: Full=Truncated apolipoprotein A-I;
Flags: Precursor;
Name=APOAI;
Mesocricetus auratus (Golden hamster).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Cricetidae; Cricetinae; Mesocricetus.
NCBI_TaxID=10036;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Syrian; TISSUE=Intestine;
PubMed=9843713;
Wu J.Y., Reaves S.K., Wang Y.R., Wu Y., Lei P.P., Lei K.Y.;
"Zinc deficiency decreases plasma level and hepatic mRNA abundance of
apolipoprotein A-I in rats and hamsters.";
Am. J. Physiol. 275:C1516-C1525(1998).
-!- FUNCTION: Participates in the reverse transport of cholesterol
from tissues to the liver for excretion by promoting cholesterol
efflux from tissues and by acting as a cofactor for the lecithin
cholesterol acyltransferase (LCAT). As part of the SPAP complex,
activates spermatozoa motility.
-!- SUBUNIT: Interacts with APOA1BP and CLU. Component of a sperm
activating protein complex (SPAP), consisting of APOA1, an
immunoglobulin heavy chain, an immunoglobulin light chain and
albumin. Interacts with NDRG1 (By similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Secreted.
-!- TISSUE SPECIFICITY: Major protein of plasma HDL, also found in
chylomicrons.
-!- PTM: Glycosylated. {ECO:0000250}.
-!- PTM: Palmitoylated. {ECO:0000250}.
-!- PTM: Phosphorylation sites are present in the extracellular
medium. {ECO:0000250}.
-!- SIMILARITY: Belongs to the apolipoprotein A1/A4/E family.
{ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; AF046919; AAC98484.1; -; mRNA.
RefSeq; NP_001268586.1; NM_001281657.1.
ProteinModelPortal; Q9Z2L4; -.
SMR; Q9Z2L4; -.
PRIDE; Q9Z2L4; -.
Ensembl; ENSMAUT00000023940; ENSMAUP00000019954; ENSMAUG00000018114.
GeneID; 101841336; -.
CTD; 335; -.
HOVERGEN; HBG105708; -.
OrthoDB; EOG091G0IA5; -.
Proteomes; UP000189706; Genome assembly.
GO; GO:0072562; C:blood microparticle; IEA:Ensembl.
GO; GO:0030139; C:endocytic vesicle; IEA:Ensembl.
GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
GO; GO:0031012; C:extracellular matrix; IEA:Ensembl.
GO; GO:0034366; C:spherical high-density lipoprotein particle; IEA:Ensembl.
GO; GO:0034361; C:very-low-density lipoprotein particle; IEA:Ensembl.
GO; GO:0001540; F:amyloid-beta binding; IEA:Ensembl.
GO; GO:0034191; F:apolipoprotein A-I receptor binding; IEA:Ensembl.
GO; GO:0045499; F:chemorepellent activity; IEA:Ensembl.
GO; GO:0015485; F:cholesterol binding; IEA:Ensembl.
GO; GO:0017127; F:cholesterol transporter activity; IEA:Ensembl.
GO; GO:0019899; F:enzyme binding; IEA:Ensembl.
GO; GO:0031072; F:heat shock protein binding; IEA:Ensembl.
GO; GO:0008035; F:high-density lipoprotein particle binding; IEA:Ensembl.
GO; GO:0070653; F:high-density lipoprotein particle receptor binding; IEA:Ensembl.
GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
GO; GO:0060228; F:phosphatidylcholine-sterol O-acyltransferase activator activity; IEA:Ensembl.
GO; GO:0005543; F:phospholipid binding; IEA:Ensembl.
GO; GO:0030325; P:adrenal gland development; IEA:Ensembl.
GO; GO:0043534; P:blood vessel endothelial cell migration; IEA:Ensembl.
GO; GO:0006695; P:cholesterol biosynthetic process; IEA:Ensembl.
GO; GO:0033344; P:cholesterol efflux; IEA:Ensembl.
GO; GO:0042632; P:cholesterol homeostasis; IEA:Ensembl.
GO; GO:0070508; P:cholesterol import; IEA:Ensembl.
GO; GO:0001935; P:endothelial cell proliferation; IEA:Ensembl.
GO; GO:0007186; P:G-protein coupled receptor signaling pathway; IEA:Ensembl.
GO; GO:0008211; P:glucocorticoid metabolic process; IEA:Ensembl.
GO; GO:0034380; P:high-density lipoprotein particle assembly; IEA:Ensembl.
GO; GO:0034375; P:high-density lipoprotein particle remodeling; IEA:Ensembl.
GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:Ensembl.
GO; GO:0019915; P:lipid storage; IEA:Ensembl.
GO; GO:0042158; P:lipoprotein biosynthetic process; IEA:Ensembl.
GO; GO:0060354; P:negative regulation of cell adhesion molecule production; IEA:Ensembl.
GO; GO:0002740; P:negative regulation of cytokine secretion involved in immune response; IEA:Ensembl.
GO; GO:0034115; P:negative regulation of heterotypic cell-cell adhesion; IEA:Ensembl.
GO; GO:0051346; P:negative regulation of hydrolase activity; IEA:Ensembl.
GO; GO:0050728; P:negative regulation of inflammatory response; IEA:Ensembl.
GO; GO:0050713; P:negative regulation of interleukin-1 beta secretion; IEA:Ensembl.
GO; GO:0010804; P:negative regulation of tumor necrosis factor-mediated signaling pathway; IEA:Ensembl.
GO; GO:0010903; P:negative regulation of very-low-density lipoprotein particle remodeling; IEA:Ensembl.
GO; GO:0018206; P:peptidyl-methionine modification; ISS:UniProtKB.
GO; GO:0006656; P:phosphatidylcholine biosynthetic process; IEA:Ensembl.
GO; GO:0033700; P:phospholipid efflux; IEA:Ensembl.
GO; GO:0055091; P:phospholipid homeostasis; IEA:Ensembl.
GO; GO:0010873; P:positive regulation of cholesterol esterification; IEA:Ensembl.
GO; GO:0051345; P:positive regulation of hydrolase activity; IEA:Ensembl.
GO; GO:0035025; P:positive regulation of Rho protein signal transduction; IEA:Ensembl.
GO; GO:0051496; P:positive regulation of stress fiber assembly; IEA:Ensembl.
GO; GO:1900026; P:positive regulation of substrate adhesion-dependent cell spreading; IEA:Ensembl.
GO; GO:0018158; P:protein oxidation; ISS:UniProtKB.
GO; GO:0050821; P:protein stabilization; IEA:Ensembl.
GO; GO:0032489; P:regulation of Cdc42 protein signal transduction; IEA:Ensembl.
GO; GO:0030300; P:regulation of intestinal cholesterol absorption; IEA:Ensembl.
GO; GO:0001932; P:regulation of protein phosphorylation; IEA:Ensembl.
GO; GO:0043691; P:reverse cholesterol transport; IEA:Ensembl.
GO; GO:0070328; P:triglyceride homeostasis; IEA:Ensembl.
GO; GO:0051180; P:vitamin transport; IEA:Ensembl.
InterPro; IPR000074; ApoA_E.
Pfam; PF01442; Apolipoprotein; 1.
2: Evidence at transcript level;
Cholesterol metabolism; Complete proteome; Glycoprotein; HDL;
Lipid metabolism; Lipid transport; Lipoprotein; Oxidation; Palmitate;
Phosphoprotein; Reference proteome; Repeat; Secreted; Signal;
Steroid metabolism; Sterol metabolism; Transport.
SIGNAL 1 18 {ECO:0000250}.
CHAIN 19 264 Proapolipoprotein A-I.
/FTId=PRO_0000425325.
CHAIN 25 264 Apolipoprotein A-I.
/FTId=PRO_0000001944.
CHAIN 25 263 Truncated apolipoprotein A-I.
{ECO:0000250}.
/FTId=PRO_0000416575.
REPEAT 67 88 1.
REPEAT 89 110 2.
REPEAT 111 121 3; half-length.
REPEAT 122 143 4.
REPEAT 144 165 5.
REPEAT 166 187 6.
REPEAT 188 207 7.
REPEAT 208 229 8.
REPEAT 230 240 9; half-length.
REPEAT 241 264 10.
REGION 67 264 10 X approximate tandem repeats.
MOD_RES 109 109 Methionine sulfoxide. {ECO:0000250}.
MOD_RES 193 193 Methionine sulfoxide. {ECO:0000250}.
MOD_RES 240 240 Methionine sulfoxide. {ECO:0000250}.
SEQUENCE 264 AA; 30739 MW; 280B22F4C0F0B129 CRC64;
MKTVVLAVAV LFLTGSQARH FWQRDDPQTP WDRVKDFATV YVDAVKDSGR EYVSQFETSA
LGKQLNLNLL ENWDTLGSTV GRLQEQLGPV TQEFWDNLEK ETEWLRREMN KDLEEVKAKV
QPYLDQFQTK WQEEVALYRQ KMEPLGAELR DGARQKLQEL QEKLTPLGED LRDRMRHHVD
ALRTKMTPYS DQMRDRLAER LAQLKDSPTL AEYHTKAADH LKAFGEKAKP ALEDLRQGLM
PVFESFKTRI MSMVEEASKK LNAQ


Related products :

Catalog number Product name Quantity
E0604h ELISA kit APOA1,Apo-AI,ApoA-I,Apolipoprotein A1,Apolipoprotein A-I,Homo sapiens,Human 96T
E0604h ELISA APOA1,Apo-AI,ApoA-I,Apolipoprotein A1,Apolipoprotein A-I,Homo sapiens,Human 96T
E0604Rb ELISA kit APOA1,Apo-AI,ApoA-I,Apolipoprotein A1,Apolipoprotein A-I,Oryctolagus cuniculus,Rabbit 96T
U0604Rb CLIA APOA1,Apo-AI,ApoA-I,Apolipoprotein A1,Apolipoprotein A-I,Oryctolagus cuniculus,Rabbit 96T
E0604Rb ELISA APOA1,Apo-AI,ApoA-I,Apolipoprotein A1,Apolipoprotein A-I,Oryctolagus cuniculus,Rabbit 96T
U0604h CLIA APOA1,Apo-AI,ApoA-I,Apolipoprotein A1,Apolipoprotein A-I,Homo sapiens,Human 96T
E0604b ELISA kit APOA1,Apo-AI,ApoA-I,Apolipoprotein A1,Apolipoprotein A-I,Bos taurus,Bovine 96T
E0604m ELISA Apoa1,Apo-AI,ApoA-I,Apolipoprotein A1,Apolipoprotein A-I,Mouse,Mus musculus 96T
E0604r ELISA Apoa1,Apo-AI,ApoA-I,Apolipoprotein A1,Apolipoprotein A-I,Rat,Rattus norvegicus 96T
E0604r ELISA kit Apoa1,Apo-AI,ApoA-I,Apolipoprotein A1,Apolipoprotein A-I,Rat,Rattus norvegicus 96T
E0604m ELISA kit Apoa1,Apo-AI,ApoA-I,Apolipoprotein A1,Apolipoprotein A-I,Mouse,Mus musculus 96T
U0604r CLIA Apoa1,Apo-AI,ApoA-I,Apolipoprotein A1,Apolipoprotein A-I,Rat,Rattus norvegicus 96T
U0604m CLIA Apoa1,Apo-AI,ApoA-I,Apolipoprotein A1,Apolipoprotein A-I,Mouse,Mus musculus 96T
E0604b ELISA APOA1,Apo-AI,ApoA-I,Apolipoprotein A1,Apolipoprotein A-I,Bos taurus,Bovine 96T
U0604b CLIA APOA1,Apo-AI,ApoA-I,Apolipoprotein A1,Apolipoprotein A-I,Bos taurus,Bovine 96T
E0604p ELISA kit APOA1,Apo-AI,ApoA-I,Apolipoprotein A1,Apolipoprotein A-I,Pig,Sus scrofa 96T
E0604p ELISA APOA1,Apo-AI,ApoA-I,Apolipoprotein A1,Apolipoprotein A-I,Pig,Sus scrofa 96T
U0604p CLIA APOA1,Apo-AI,ApoA-I,Apolipoprotein A1,Apolipoprotein A-I,Pig,Sus scrofa 96T
U0604c CLIA APOA1,Apo-AI,ApoA-I,Apolipoprotein A1,Apolipoprotein A-I,Chicken,Gallus gallus 96T
E0604c ELISA APOA1,Apo-AI,ApoA-I,Apolipoprotein A1,Apolipoprotein A-I,Chicken,Gallus gallus 96T
E0604c ELISA kit APOA1,Apo-AI,ApoA-I,Apolipoprotein A1,Apolipoprotein A-I,Chicken,Gallus gallus 96T
E0604c ELISA APOA1,Apo-AI,ApoA-I,Apolipoprotein A1,Apolipoprotein A-I,Canis familiaris,Canis lupus familiaris,Dog 96T
U0604c CLIA APOA1,Apo-AI,ApoA-I,Apolipoprotein A1,Apolipoprotein A-I,Canis familiaris,Canis lupus familiaris,Dog 96T
E0604c ELISA kit APOA1,Apo-AI,ApoA-I,Apolipoprotein A1,Apolipoprotein A-I,Canis familiaris,Canis lupus familiaris,Dog 96T
20-272-192023 Apolipoprotein J - Mouse monoclonal [Hs - 3] to Apolipoprotein J; Complement-associated protein SP-40.40; Complement cytolysis inhibitor; CLI; NA1_NA2; Apolipoprotein J; Apo-J; Testosterone-repressed 0.05 mg


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur