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Apolipoprotein A-II (Apo-AII) (ApoA-II) (Apolipoprotein A2) [Cleaved into: Proapolipoprotein A-II (ProapoA-II); Truncated apolipoprotein A-II]

 APOA2_CHLSB             Reviewed;         100 AA.
P0DP84;
30-AUG-2017, integrated into UniProtKB/Swiss-Prot.
30-AUG-2017, sequence version 1.
25-APR-2018, entry version 7.
RecName: Full=Apolipoprotein A-II;
Short=Apo-AII;
Short=ApoA-II;
AltName: Full=Apolipoprotein A2;
Contains:
RecName: Full=Proapolipoprotein A-II;
Short=ProapoA-II;
Contains:
RecName: Full=Truncated apolipoprotein A-II;
Flags: Precursor;
Name=APOA2;
Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Cercopithecidae; Cercopithecinae; Chlorocebus.
NCBI_TaxID=60711;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Warren W., Wilson R.K.;
Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
[2]
IDENTIFICATION.
Puppione D.L.;
Unpublished observations (JUN-2017).
-!- FUNCTION: May stabilize HDL (high density lipoprotein) structure
by its association with lipids, and affect the HDL metabolism.
{ECO:0000250|UniProtKB:P18656}.
-!- SUBUNIT: Monomer. Interacts with APOA1BP and NDRG1.
{ECO:0000250|UniProtKB:P02652}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P02652}.
-!- SIMILARITY: Belongs to the apolipoprotein A2 family.
{ECO:0000305}.
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EMBL; AQIB01138703; -; NOT_ANNOTATED_CDS; Genomic_DNA.
RefSeq; XP_007974599.1; XM_007976408.1.
Ensembl; ENSCSAT00000000691; ENSCSAP00000015372; ENSCSAG00000002673.
GeneID; 103223686; -.
KEGG; csab:103223686; -.
CTD; 336; -.
GeneTree; ENSGT00390000003306; -.
KO; K08758; -.
OMA; AYFEKTQ; -.
Proteomes; UP000029965; Chromosome 20.
GO; GO:0042627; C:chylomicron; IEA:Ensembl.
GO; GO:0034366; C:spherical high-density lipoprotein particle; IEA:Ensembl.
GO; GO:0034361; C:very-low-density lipoprotein particle; IEA:Ensembl.
GO; GO:0034190; F:apolipoprotein receptor binding; IEA:Ensembl.
GO; GO:0015485; F:cholesterol binding; IEA:Ensembl.
GO; GO:0017127; F:cholesterol transporter activity; IEA:Ensembl.
GO; GO:0031072; F:heat shock protein binding; IEA:Ensembl.
GO; GO:0008035; F:high-density lipoprotein particle binding; IEA:Ensembl.
GO; GO:0070653; F:high-density lipoprotein particle receptor binding; IEA:Ensembl.
GO; GO:0055102; F:lipase inhibitor activity; IEA:Ensembl.
GO; GO:0031210; F:phosphatidylcholine binding; IEA:Ensembl.
GO; GO:0060228; F:phosphatidylcholine-sterol O-acyltransferase activator activity; IEA:Ensembl.
GO; GO:0046982; F:protein heterodimerization activity; IEA:Ensembl.
GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
GO; GO:0033344; P:cholesterol efflux; IEA:Ensembl.
GO; GO:0042632; P:cholesterol homeostasis; IEA:Ensembl.
GO; GO:0008203; P:cholesterol metabolic process; IEA:Ensembl.
GO; GO:0046340; P:diacylglycerol catabolic process; IEA:Ensembl.
GO; GO:0034380; P:high-density lipoprotein particle assembly; IEA:Ensembl.
GO; GO:0034384; P:high-density lipoprotein particle clearance; IEA:Ensembl.
GO; GO:0034375; P:high-density lipoprotein particle remodeling; IEA:Ensembl.
GO; GO:0042157; P:lipoprotein metabolic process; IEA:Ensembl.
GO; GO:0034374; P:low-density lipoprotein particle remodeling; IEA:Ensembl.
GO; GO:0060621; P:negative regulation of cholesterol import; IEA:Ensembl.
GO; GO:0060695; P:negative regulation of cholesterol transporter activity; IEA:Ensembl.
GO; GO:0002740; P:negative regulation of cytokine secretion involved in immune response; IEA:Ensembl.
GO; GO:0060192; P:negative regulation of lipase activity; IEA:Ensembl.
GO; GO:0050995; P:negative regulation of lipid catabolic process; IEA:Ensembl.
GO; GO:0010903; P:negative regulation of very-low-density lipoprotein particle remodeling; IEA:Ensembl.
GO; GO:0018206; P:peptidyl-methionine modification; IEA:Ensembl.
GO; GO:0006656; P:phosphatidylcholine biosynthetic process; IEA:Ensembl.
GO; GO:0009395; P:phospholipid catabolic process; IEA:Ensembl.
GO; GO:0033700; P:phospholipid efflux; IEA:Ensembl.
GO; GO:0010873; P:positive regulation of cholesterol esterification; IEA:Ensembl.
GO; GO:0045416; P:positive regulation of interleukin-8 biosynthetic process; IEA:Ensembl.
GO; GO:0050996; P:positive regulation of lipid catabolic process; IEA:Ensembl.
GO; GO:0018158; P:protein oxidation; IEA:Ensembl.
GO; GO:0030300; P:regulation of intestinal cholesterol absorption; IEA:Ensembl.
GO; GO:0031647; P:regulation of protein stability; IEA:Ensembl.
GO; GO:0009749; P:response to glucose; IEA:Ensembl.
GO; GO:0043691; P:reverse cholesterol transport; IEA:Ensembl.
GO; GO:0034370; P:triglyceride-rich lipoprotein particle remodeling; IEA:Ensembl.
InterPro; IPR006801; ApoA-II.
InterPro; IPR036172; ApoA-II_sf.
PANTHER; PTHR11027; PTHR11027; 1.
Pfam; PF04711; ApoA-II; 1.
ProDom; PD010397; ApoA-II; 1.
SUPFAM; SSF82936; SSF82936; 1.
3: Inferred from homology;
Cleavage on pair of basic residues; Complete proteome; HDL;
Lipid transport; Oxidation; Phosphoprotein; Reference proteome;
Secreted; Signal; Transport.
SIGNAL 1 18 {ECO:0000255}.
CHAIN 19 100 Proapolipoprotein A-II.
{ECO:0000250|UniProtKB:P18656}.
/FTId=PRO_0000441382.
CHAIN 24 100 Apolipoprotein A-II.
{ECO:0000250|UniProtKB:P02652}.
/FTId=PRO_0000441383.
CHAIN 24 99 Truncated apolipoprotein A-II.
{ECO:0000250|UniProtKB:P02652}.
/FTId=PRO_0000441384.
MOD_RES 49 49 Methionine sulfoxide.
{ECO:0000250|UniProtKB:P02652}.
MOD_RES 54 54 Phosphoserine.
{ECO:0000250|UniProtKB:P02652}.
MOD_RES 68 68 Phosphoserine.
{ECO:0000250|UniProtKB:P02652}.
SEQUENCE 100 AA; 11200 MW; 1DA9C545AD177AA7 CRC64;
MKLLAATVLL LTVCSLEGAL VRRQAEEPSV ESLVSQYFQT VTDYGKDLME KVKSPELQAQ
AKAYFEKSKE QLTPLVKKAG TDLVNFLSYF VELRTQPATQ


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