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Apolipoprotein A-IV

 F1N3Q7_BOVIN            Unreviewed;       380 AA.
F1N3Q7;
03-MAY-2011, integrated into UniProtKB/TrEMBL.
03-MAY-2011, sequence version 1.
23-MAY-2018, entry version 59.
SubName: Full=Apolipoprotein A-IV {ECO:0000313|EMBL:DAA22387.1, ECO:0000313|Ensembl:ENSBTAP00000026345};
Name=APOA4 {ECO:0000313|EMBL:DAA22387.1,
ECO:0000313|Ensembl:ENSBTAP00000026345, ECO:0000313|VGNC:VGNC:26024};
ORFNames=BOS_14370 {ECO:0000313|EMBL:DAA22387.1};
Bos taurus (Bovine).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Bovinae; Bos.
NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000026345, ECO:0000313|Proteomes:UP000009136};
[1] {ECO:0000313|EMBL:DAA22387.1, ECO:0000313|Ensembl:ENSBTAP00000026345, ECO:0000313|Proteomes:UP000009136}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000026345,
ECO:0000313|Proteomes:UP000009136};
PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42;
Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C.,
Puiu D., Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S.,
Marcais G., Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.;
"A whole-genome assembly of the domestic cow, Bos taurus.";
Genome Biol. 10:R42.01-R42.10(2009).
[2] {ECO:0000313|Ensembl:ENSBTAP00000026345}
IDENTIFICATION.
STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000026345};
Ensembl;
Submitted (MAR-2016) to UniProtKB.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00412673}.
-!- SIMILARITY: Belongs to the apolipoprotein A1/A4/E family.
{ECO:0000256|SAAS:SAAS00598075}.
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EMBL; DAAA02040389; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; GJ062397; DAA22387.1; -; Genomic_DNA.
RefSeq; XP_005215912.1; XM_005215855.3.
RefSeq; XP_010810673.1; XM_010812371.2.
RefSeq; XP_015330105.1; XM_015474619.1.
UniGene; Bt.15890; -.
PRIDE; F1N3Q7; -.
Ensembl; ENSBTAT00000026345; ENSBTAP00000026345; ENSBTAG00000019770.
GeneID; 537301; -.
CTD; 337; -.
VGNC; VGNC:26024; APOA4.
eggNOG; ENOG410IKU1; Eukaryota.
eggNOG; ENOG41119VI; LUCA.
GeneTree; ENSGT00530000063081; -.
OMA; RTQVNTQ; -.
OrthoDB; EOG091G0IA5; -.
TreeFam; TF334458; -.
Reactome; R-BTA-8963888; Chylomicron assembly.
Reactome; R-BTA-8963901; Chylomicron remodeling.
Reactome; R-BTA-975634; Retinoid metabolism and transport.
Proteomes; UP000009136; Chromosome 15.
Bgee; ENSBTAG00000019770; -.
GO; GO:0009986; C:cell surface; IEA:Ensembl.
GO; GO:0042627; C:chylomicron; IEA:Ensembl.
GO; GO:0034364; C:high-density lipoprotein particle; IEA:Ensembl.
GO; GO:0034361; C:very-low-density lipoprotein particle; IEA:Ensembl.
GO; GO:0016209; F:antioxidant activity; IEA:Ensembl.
GO; GO:0017127; F:cholesterol transporter activity; IEA:Ensembl.
GO; GO:0005507; F:copper ion binding; IEA:Ensembl.
GO; GO:0031210; F:phosphatidylcholine binding; IEA:Ensembl.
GO; GO:0060228; F:phosphatidylcholine-sterol O-acyltransferase activator activity; IEA:Ensembl.
GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
GO; GO:0033344; P:cholesterol efflux; IEA:Ensembl.
GO; GO:0042632; P:cholesterol homeostasis; IEA:Ensembl.
GO; GO:0008203; P:cholesterol metabolic process; IEA:Ensembl.
GO; GO:0042744; P:hydrogen peroxide catabolic process; IEA:Ensembl.
GO; GO:0002227; P:innate immune response in mucosa; IEA:Ensembl.
GO; GO:0007159; P:leukocyte cell-cell adhesion; IEA:Ensembl.
GO; GO:0016042; P:lipid catabolic process; IEA:Ensembl.
GO; GO:0042157; P:lipoprotein metabolic process; IEA:InterPro.
GO; GO:0034445; P:negative regulation of plasma lipoprotein oxidation; IEA:Ensembl.
GO; GO:0046470; P:phosphatidylcholine metabolic process; IEA:Ensembl.
GO; GO:0033700; P:phospholipid efflux; IEA:Ensembl.
GO; GO:0010873; P:positive regulation of cholesterol esterification; IEA:Ensembl.
GO; GO:0045723; P:positive regulation of fatty acid biosynthetic process; IEA:Ensembl.
GO; GO:0051006; P:positive regulation of lipoprotein lipase activity; IEA:Ensembl.
GO; GO:0010898; P:positive regulation of triglyceride catabolic process; IEA:Ensembl.
GO; GO:0065005; P:protein-lipid complex assembly; IEA:Ensembl.
GO; GO:0030300; P:regulation of intestinal cholesterol absorption; IEA:Ensembl.
GO; GO:0019430; P:removal of superoxide radicals; IEA:Ensembl.
GO; GO:0006982; P:response to lipid hydroperoxide; IEA:Ensembl.
GO; GO:0035634; P:response to stilbenoid; IEA:Ensembl.
GO; GO:0043691; P:reverse cholesterol transport; IEA:Ensembl.
GO; GO:0034372; P:very-low-density lipoprotein particle remodeling; IEA:Ensembl.
InterPro; IPR000074; ApoA_E.
Pfam; PF01442; Apolipoprotein; 2.
3: Inferred from homology;
Coiled coil {ECO:0000256|SAM:Coils};
Complete proteome {ECO:0000313|Proteomes:UP000009136};
Lipid transport {ECO:0000256|SAAS:SAAS00491985};
Lipoprotein {ECO:0000313|EMBL:DAA22387.1};
Reference proteome {ECO:0000313|Proteomes:UP000009136};
Secreted {ECO:0000256|SAAS:SAAS00491987};
Signal {ECO:0000256|SAM:SignalP};
Transport {ECO:0000256|SAAS:SAAS00491985}.
SIGNAL 1 20 {ECO:0000256|SAM:SignalP}.
CHAIN 21 380 {ECO:0000256|SAM:SignalP}.
/FTId=PRO_5014089110.
COILED 88 112 {ECO:0000256|SAM:Coils}.
COILED 246 266 {ECO:0000256|SAM:Coils}.
COILED 282 302 {ECO:0000256|SAM:Coils}.
SEQUENCE 380 AA; 42990 MW; 9D3F49D2A70BE77C CRC64;
MFLKAVVLSL ALVAVTGAEA EVNADQVATV IWDYFSQLGN NAKKAVEHIQ KSELTQQLNT
LFQDKLGEVS TYTDDLQKKL VPFATELHER LTKDSEKLKE EIRKELEDLR ARLLPHATEV
SQKIGDNVRE LQQRLGPYAE ELRTQVDTQA QQLRRQLTPY AERMEKVMRQ NLDQLQASLA
PYAEELQATV NQRVEELKGR LTPYADQLQT KIEENVEELR RSLAPYAQDV QGKLNHQLEG
LAFQMKKHAE ELKAKISAKA EELRQGLVPL VNSVHGSQLG NAEDLQKSLA ELSSRLDQQV
EDFRRTVGPY GETFNKAMVQ QLDTLRQKLG PLAGDVEDHL SFLEKDLRDK VSSFFNTLKE
KESQAPALPA QEEMPVPLGG


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