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Apolipoprotein A-IV (Apo-AIV) (ApoA-IV) (Apolipoprotein A4)

 APOA4_CANLF             Reviewed;         378 AA.
E2RE76;
29-OCT-2014, integrated into UniProtKB/Swiss-Prot.
31-OCT-2012, sequence version 2.
23-MAY-2018, entry version 53.
RecName: Full=Apolipoprotein A-IV {ECO:0000250|UniProtKB:P06727};
Short=Apo-AIV;
Short=ApoA-IV;
AltName: Full=Apolipoprotein A4 {ECO:0000250|UniProtKB:P06727};
Flags: Precursor;
Name=APOA4 {ECO:0000250|UniProtKB:P06727};
Canis lupus familiaris (Dog) (Canis familiaris).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;
Canis.
NCBI_TaxID=9615 {ECO:0000312|EMBL:AAEX03003469};
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Boxer {ECO:0000312|EMBL:AAEX03003469};
PubMed=16341006; DOI=10.1038/nature04338;
Lindblad-Toh K., Wade C.M., Mikkelsen T.S., Karlsson E.K., Jaffe D.B.,
Kamal M., Clamp M., Chang J.L., Kulbokas E.J. III, Zody M.C.,
Mauceli E., Xie X., Breen M., Wayne R.K., Ostrander E.A.,
Ponting C.P., Galibert F., Smith D.R., deJong P.J., Kirkness E.F.,
Alvarez P., Biagi T., Brockman W., Butler J., Chin C.-W., Cook A.,
Cuff J., Daly M.J., DeCaprio D., Gnerre S., Grabherr M., Kellis M.,
Kleber M., Bardeleben C., Goodstadt L., Heger A., Hitte C., Kim L.,
Koepfli K.-P., Parker H.G., Pollinger J.P., Searle S.M.J.,
Sutter N.B., Thomas R., Webber C., Baldwin J., Abebe A.,
Abouelleil A., Aftuck L., Ait-Zahra M., Aldredge T., Allen N., An P.,
Anderson S., Antoine C., Arachchi H., Aslam A., Ayotte L.,
Bachantsang P., Barry A., Bayul T., Benamara M., Berlin A.,
Bessette D., Blitshteyn B., Bloom T., Blye J., Boguslavskiy L.,
Bonnet C., Boukhgalter B., Brown A., Cahill P., Calixte N.,
Camarata J., Cheshatsang Y., Chu J., Citroen M., Collymore A.,
Cooke P., Dawoe T., Daza R., Decktor K., DeGray S., Dhargay N.,
Dooley K., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N.,
Dupes A., Egbiremolen O., Elong R., Falk J., Farina A., Faro S.,
Ferguson D., Ferreira P., Fisher S., FitzGerald M., Foley K.,
Foley C., Franke A., Friedrich D., Gage D., Garber M., Gearin G.,
Giannoukos G., Goode T., Goyette A., Graham J., Grandbois E.,
Gyaltsen K., Hafez N., Hagopian D., Hagos B., Hall J., Healy C.,
Hegarty R., Honan T., Horn A., Houde N., Hughes L., Hunnicutt L.,
Husby M., Jester B., Jones C., Kamat A., Kanga B., Kells C.,
Khazanovich D., Kieu A.C., Kisner P., Kumar M., Lance K., Landers T.,
Lara M., Lee W., Leger J.-P., Lennon N., Leuper L., LeVine S., Liu J.,
Liu X., Lokyitsang Y., Lokyitsang T., Lui A., Macdonald J., Major J.,
Marabella R., Maru K., Matthews C., McDonough S., Mehta T.,
Meldrim J., Melnikov A., Meneus L., Mihalev A., Mihova T., Miller K.,
Mittelman R., Mlenga V., Mulrain L., Munson G., Navidi A., Naylor J.,
Nguyen T., Nguyen N., Nguyen C., Nguyen T., Nicol R., Norbu N.,
Norbu C., Novod N., Nyima T., Olandt P., O'Neill B., O'Neill K.,
Osman S., Oyono L., Patti C., Perrin D., Phunkhang P., Pierre F.,
Priest M., Rachupka A., Raghuraman S., Rameau R., Ray V., Raymond C.,
Rege F., Rise C., Rogers J., Rogov P., Sahalie J., Settipalli S.,
Sharpe T., Shea T., Sheehan M., Sherpa N., Shi J., Shih D., Sloan J.,
Smith C., Sparrow T., Stalker J., Stange-Thomann N., Stavropoulos S.,
Stone C., Stone S., Sykes S., Tchuinga P., Tenzing P., Tesfaye S.,
Thoulutsang D., Thoulutsang Y., Topham K., Topping I., Tsamla T.,
Vassiliev H., Venkataraman V., Vo A., Wangchuk T., Wangdi T.,
Weiand M., Wilkinson J., Wilson A., Yadav S., Yang S., Yang X.,
Young G., Yu Q., Zainoun J., Zembek L., Zimmer A., Lander E.S.;
"Genome sequence, comparative analysis and haplotype structure of the
domestic dog.";
Nature 438:803-819(2005).
[2]
IDENTIFICATION.
Puppione D.L.;
Unpublished observations (AUG-2014).
-!- FUNCTION: May have a role in chylomicrons and VLDL secretion and
catabolism. Required for efficient activation of lipoprotein
lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major
component of HDL and chylomicrons. {ECO:0000250|UniProtKB:P06727}.
-!- SUBUNIT: Homodimer. {ECO:0000250|UniProtKB:P06727}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P06727}.
-!- DOMAIN: Nine of the thirteen 22-amino acid tandem repeats (each
22-mer is actually a tandem array of two, A and B, related 11-
mers) occurring in this sequence are predicted to be highly alpha-
helical, and many of these helices are amphipathic. They may
therefore serve as lipid-binding domains with lecithin:cholesterol
acyltransferase (LCAT) activating abilities.
{ECO:0000250|UniProtKB:P06727}.
-!- SIMILARITY: Belongs to the apolipoprotein A1/A4/E family.
{ECO:0000305}.
-----------------------------------------------------------------------
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-----------------------------------------------------------------------
EMBL; AAEX03003469; -; NOT_ANNOTATED_CDS; Genomic_DNA.
SMR; E2RE76; -.
STRING; 9615.ENSCAFP00000019615; -.
PaxDb; E2RE76; -.
PRIDE; E2RE76; -.
Ensembl; ENSCAFT00000021121; ENSCAFP00000019615; ENSCAFG00000013306.
VGNC; VGNC:53263; APOA4.
eggNOG; ENOG410IKU1; Eukaryota.
eggNOG; ENOG41119VI; LUCA.
GeneTree; ENSGT00530000063081; -.
InParanoid; E2RE76; -.
OMA; RTQVNTQ; -.
OrthoDB; EOG091G0IA5; -.
TreeFam; TF334458; -.
Reactome; R-CFA-8963888; Chylomicron assembly.
Reactome; R-CFA-8963901; Chylomicron remodeling.
Reactome; R-CFA-975634; Retinoid metabolism and transport.
Proteomes; UP000002254; Chromosome 5.
Bgee; ENSCAFG00000013306; -.
GO; GO:0072562; C:blood microparticle; IBA:GO_Central.
GO; GO:0009986; C:cell surface; IEA:Ensembl.
GO; GO:0042627; C:chylomicron; IBA:GO_Central.
GO; GO:0034364; C:high-density lipoprotein particle; IBA:GO_Central.
GO; GO:0034361; C:very-low-density lipoprotein particle; IEA:Ensembl.
GO; GO:0016209; F:antioxidant activity; IEA:Ensembl.
GO; GO:0015485; F:cholesterol binding; IBA:GO_Central.
GO; GO:0017127; F:cholesterol transporter activity; IBA:GO_Central.
GO; GO:0005507; F:copper ion binding; IEA:Ensembl.
GO; GO:0031210; F:phosphatidylcholine binding; IBA:GO_Central.
GO; GO:0060228; F:phosphatidylcholine-sterol O-acyltransferase activator activity; IBA:GO_Central.
GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
GO; GO:0006695; P:cholesterol biosynthetic process; IBA:GO_Central.
GO; GO:0033344; P:cholesterol efflux; IBA:GO_Central.
GO; GO:0042632; P:cholesterol homeostasis; IBA:GO_Central.
GO; GO:0034380; P:high-density lipoprotein particle assembly; IBA:GO_Central.
GO; GO:0042744; P:hydrogen peroxide catabolic process; IEA:Ensembl.
GO; GO:0002227; P:innate immune response in mucosa; IEA:Ensembl.
GO; GO:0007159; P:leukocyte cell-cell adhesion; IEA:Ensembl.
GO; GO:0042157; P:lipoprotein metabolic process; IBA:GO_Central.
GO; GO:0034445; P:negative regulation of plasma lipoprotein oxidation; IEA:Ensembl.
GO; GO:0031102; P:neuron projection regeneration; IBA:GO_Central.
GO; GO:0046470; P:phosphatidylcholine metabolic process; IBA:GO_Central.
GO; GO:0033700; P:phospholipid efflux; IBA:GO_Central.
GO; GO:0010873; P:positive regulation of cholesterol esterification; IBA:GO_Central.
GO; GO:0045723; P:positive regulation of fatty acid biosynthetic process; IBA:GO_Central.
GO; GO:0051006; P:positive regulation of lipoprotein lipase activity; IBA:GO_Central.
GO; GO:0010898; P:positive regulation of triglyceride catabolic process; IBA:GO_Central.
GO; GO:0030300; P:regulation of intestinal cholesterol absorption; IBA:GO_Central.
GO; GO:0019430; P:removal of superoxide radicals; IEA:Ensembl.
GO; GO:0006982; P:response to lipid hydroperoxide; IEA:Ensembl.
GO; GO:0043691; P:reverse cholesterol transport; IBA:GO_Central.
GO; GO:0019433; P:triglyceride catabolic process; IBA:GO_Central.
GO; GO:0070328; P:triglyceride homeostasis; IBA:GO_Central.
GO; GO:0034372; P:very-low-density lipoprotein particle remodeling; IBA:GO_Central.
InterPro; IPR000074; ApoA_E.
Pfam; PF01442; Apolipoprotein; 3.
3: Inferred from homology;
Chylomicron; Complete proteome; HDL; Lipid transport;
Reference proteome; Repeat; Secreted; Signal; Transport.
SIGNAL 1 20 {ECO:0000255}.
CHAIN 21 378 Apolipoprotein A-IV.
/FTId=PRO_0000430569.
REPEAT 33 54 1.
REPEAT 60 81 2.
REPEAT 82 98 3.
REPEAT 110 130 4.
REPEAT 131 152 5.
REPEAT 153 174 6.
REPEAT 175 196 7.
REPEAT 197 218 8.
REPEAT 219 240 9.
REPEAT 241 262 10.
REPEAT 263 280 11.
REPEAT 281 302 12.
REPEAT 303 324 13.
REGION 33 324 13 X 22 AA approximate tandem repeats.
SEQUENCE 378 AA; 42536 MW; 8471FBC9E8F8ED41 CRC64;
MFLKAVVLTL SLVAITGARA EVSADQVATV VWDYFSQLSN NAKEAVEHLQ QSELTQQLKS
VTKGHISALR VIEKGRERNS WEHSRRVGPC EIMGRQVGIF GQPLRVATLP NCDLPVNSVP
PNTHLSQAVG PYAEELRTQV NTHAEQLRNQ LTSHAQRMQS ALRQNVDDLH SSLTPFADEL
KAKIDQNVEE LKGHLTPYTD ELKVKIDQNV EELRRSLAPY AQDVQEKLNH QLEGLAFQMK
KNAEELKAKI SANAEELRQR LAPVAEDVRG KLKDNTAGLH KSLAELSSRL DQQVEEFRRN
VGPYGETFNK ALLQQVEELR QKLGPYAGDM EDHLSFLEKD LRDKVNSFFS TLQEKESQDT
PVALPKQEQE QSAVPLES


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