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Apolipoprotein C-II (Apo-CII) (ApoC-II) (Apolipoprotein C2) [Cleaved into: Proapolipoprotein C-II (ProapoC-II)]

 APOC2_MACFA             Reviewed;         101 AA.
P18658;
01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
01-FEB-1996, sequence version 2.
28-MAR-2018, entry version 88.
RecName: Full=Apolipoprotein C-II;
Short=Apo-CII;
Short=ApoC-II;
AltName: Full=Apolipoprotein C2;
Contains:
RecName: Full=Proapolipoprotein C-II;
Short=ProapoC-II;
Flags: Precursor;
Name=APOC2;
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
NCBI_TaxID=9541;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=2481808; DOI=10.1007/BF00225222;
Whitted B.E., Castle C.K., Polites H.G., Melchior G.W., Marotti K.R.;
"Purification, cloning and nucleotide sequence determination of
cynomolgus monkey apolipoprotein C-II: comparison to the human
sequence.";
Mol. Cell. Biochem. 90:69-79(1989).
[2]
PROTEIN SEQUENCE OF 23-49.
PubMed=3105581; DOI=10.1021/bi00379a037;
Herbert P.N., Bausserman L.L., Lynch K.M., Saritelli A.L.,
Kantor M.A., Nicolosi R.J., Shulman R.S.;
"Homologues of the human C and A apolipoproteins in the Macaca
fascicularis (cynomolgus) monkey.";
Biochemistry 26:1457-1463(1987).
-!- FUNCTION: Component of chylomicrons, very low-density lipoproteins
(VLDL), low-density lipoproteins (LDL), and high-density
lipoproteins (HDL) in plasma. Plays an important role in
lipoprotein metabolism as an activator of lipoprotein lipase. Both
proapolipoprotein C-II and apolipoprotein C-II can activate
lipoprotein lipase. {ECO:0000250|UniProtKB:P02655}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P02655}.
-!- PTM: Proapolipoprotein C-II is synthesized as a sialic acid
containing glycoprotein which is subsequently desialylated prior
to its proteolytic processing. {ECO:0000250|UniProtKB:P02655}.
-!- PTM: Proapolipoprotein C-II, the major form found in plasma
undergoes proteolytic cleavage of its N-terminal hexapeptide to
generate apolipoprotein C-II, which occurs as the minor form in
plasma. {ECO:0000250|UniProtKB:P02655}.
-!- SIMILARITY: Belongs to the apolipoprotein C2 family.
{ECO:0000305}.
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EMBL; M86345; AAA36835.1; -; mRNA.
PIR; E26627; E26627.
PIR; I57492; I57492.
RefSeq; NP_001271640.1; NM_001284711.1.
RefSeq; XP_015300138.1; XM_015444652.1.
UniGene; Mfa.8184; -.
ProteinModelPortal; P18658; -.
SMR; P18658; -.
Ensembl; ENSMFAT00000058527; ENSMFAP00000012478; ENSMFAG00000024498.
GeneID; 102116264; -.
KEGG; mcf:102116264; -.
CTD; 344; -.
GeneTree; ENSGT00390000007913; -.
HOVERGEN; HBG050548; -.
KO; K22287; -.
GO; GO:0042627; C:chylomicron; IEA:UniProtKB-KW.
GO; GO:0034363; C:intermediate-density lipoprotein particle; IEA:Ensembl.
GO; GO:0034362; C:low-density lipoprotein particle; IEA:UniProtKB-KW.
GO; GO:0034366; C:spherical high-density lipoprotein particle; IEA:Ensembl.
GO; GO:0034361; C:very-low-density lipoprotein particle; IEA:UniProtKB-KW.
GO; GO:0055102; F:lipase inhibitor activity; IEA:Ensembl.
GO; GO:0008289; F:lipid binding; IEA:Ensembl.
GO; GO:0060230; F:lipoprotein lipase activator activity; IEA:Ensembl.
GO; GO:0016004; F:phospholipase activator activity; IEA:Ensembl.
GO; GO:0043274; F:phospholipase binding; IEA:Ensembl.
GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
GO; GO:0033344; P:cholesterol efflux; IEA:Ensembl.
GO; GO:0034382; P:chylomicron remnant clearance; IEA:Ensembl.
GO; GO:0034384; P:high-density lipoprotein particle clearance; IEA:Ensembl.
GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
GO; GO:0032375; P:negative regulation of cholesterol transport; IEA:Ensembl.
GO; GO:0045833; P:negative regulation of lipid metabolic process; IEA:Ensembl.
GO; GO:0048261; P:negative regulation of receptor-mediated endocytosis; IEA:Ensembl.
GO; GO:0010916; P:negative regulation of very-low-density lipoprotein particle clearance; IEA:Ensembl.
GO; GO:0033700; P:phospholipid efflux; IEA:Ensembl.
GO; GO:0045723; P:positive regulation of fatty acid biosynthetic process; IEA:Ensembl.
GO; GO:0051006; P:positive regulation of lipoprotein lipase activity; IEA:Ensembl.
GO; GO:0010518; P:positive regulation of phospholipase activity; IEA:Ensembl.
GO; GO:0060697; P:positive regulation of phospholipid catabolic process; IEA:Ensembl.
GO; GO:0010898; P:positive regulation of triglyceride catabolic process; IEA:Ensembl.
GO; GO:0070328; P:triglyceride homeostasis; IEA:Ensembl.
InterPro; IPR008019; Apo-CII.
PANTHER; PTHR16566; PTHR16566; 1.
Pfam; PF05355; Apo-CII; 1.
1: Evidence at protein level;
Chylomicron; Direct protein sequencing; Glycoprotein; HDL; LDL;
Lipid degradation; Lipid metabolism; Lipid transport; Secreted;
Sialic acid; Signal; Transport; VLDL.
SIGNAL 1 22 {ECO:0000269|PubMed:3105581}.
CHAIN 23 101 Proapolipoprotein C-II.
/FTId=PRO_0000002025.
CHAIN 29 101 Apolipoprotein C-II.
{ECO:0000250|UniProtKB:P02655}.
/FTId=PRO_0000430840.
REGION 66 74 Lipid binding.
{ECO:0000250|UniProtKB:P02655}.
REGION 78 101 Lipoprotein lipase cofactor.
{ECO:0000250|UniProtKB:P02655}.
CONFLICT 25 25 L -> Q (in Ref. 2; AA sequence).
{ECO:0000305}.
CONFLICT 39 39 R -> Q (in Ref. 2; AA sequence).
{ECO:0000305}.
SEQUENCE 101 AA; 11145 MW; F599316E5073F628 CRC64;
MGTRFLLALC LVLLVLGFEV QGAQLPQQDE PPSPALLSRV QESLSSYWES AKAAAQKLYE
KTYLPAVDEK LRDLYSKSTA AMSTYTGIFT DQVLSVLKGE E


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