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Apolipoprotein E (Apo-E)

 APOE_CHLSB              Reviewed;         317 AA.
A0A0D9S1R0;
11-MAY-2016, integrated into UniProtKB/Swiss-Prot.
27-MAY-2015, sequence version 1.
27-SEP-2017, entry version 21.
RecName: Full=Apolipoprotein E;
Short=Apo-E;
Flags: Precursor;
Name=APOE;
Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Cercopithecidae; Cercopithecinae; Chlorocebus.
NCBI_TaxID=60711;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Warren W., Wilson R.K.;
Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
[2]
IDENTIFICATION.
Puppione D.L.;
Unpublished observations (MAR-2016).
-!- FUNCTION: Mediates the binding, internalization, and catabolism of
lipoprotein particles. It can serve as a ligand for the LDL (apo
B/E) receptor and for the specific apo-E receptor (chylomicron
remnant) of hepatic tissues. {ECO:0000250|UniProtKB:P02649}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P02649}.
-!- PTM: Phosphorylated by FAM20C in the extracellular medium.
{ECO:0000250|UniProtKB:P02649}.
-!- SIMILARITY: Belongs to the apolipoprotein A1/A4/E family.
{ECO:0000305}.
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EMBL; AQIB01135960; -; NOT_ANNOTATED_CDS; Genomic_DNA.
RefSeq; XP_007995346.1; XM_007997155.1.
RefSeq; XP_007995347.1; XM_007997156.1.
SMR; A0A0D9S1R0; -.
Ensembl; ENSCSAT00000001277; ENSCSAP00000014799; ENSCSAG00000003246.
GeneID; 103234841; -.
KEGG; csab:103234841; -.
CTD; 348; -.
GeneTree; ENSGT00730000111315; -.
KO; K04524; -.
OMA; MGSRTRD; -.
Proteomes; UP000029965; Chromosome 6.
GO; GO:0106003; C:amyloid-beta complex; IEA:Ensembl.
GO; GO:0072562; C:blood microparticle; IEA:Ensembl.
GO; GO:0042627; C:chylomicron; IEA:UniProtKB-KW.
GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
GO; GO:0031012; C:extracellular matrix; IEA:Ensembl.
GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
GO; GO:0034364; C:high-density lipoprotein particle; IEA:UniProtKB-KW.
GO; GO:0034363; C:intermediate-density lipoprotein particle; IEA:Ensembl.
GO; GO:0034362; C:low-density lipoprotein particle; IEA:Ensembl.
GO; GO:0005634; C:nucleus; IEA:Ensembl.
GO; GO:0005886; C:plasma membrane; IEA:GOC.
GO; GO:0034361; C:very-low-density lipoprotein particle; IEA:UniProtKB-KW.
GO; GO:0001540; F:amyloid-beta binding; IEA:Ensembl.
GO; GO:0016209; F:antioxidant activity; IEA:Ensembl.
GO; GO:0017127; F:cholesterol transporter activity; IEA:Ensembl.
GO; GO:0008201; F:heparin binding; IEA:UniProtKB-KW.
GO; GO:0071813; F:lipoprotein particle binding; IEA:Ensembl.
GO; GO:0050750; F:low-density lipoprotein particle receptor binding; IEA:Ensembl.
GO; GO:0046911; F:metal chelating activity; IEA:Ensembl.
GO; GO:0060228; F:phosphatidylcholine-sterol O-acyltransferase activator activity; IEA:Ensembl.
GO; GO:0005543; F:phospholipid binding; IEA:Ensembl.
GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
GO; GO:0048156; F:tau protein binding; IEA:Ensembl.
GO; GO:0070326; F:very-low-density lipoprotein particle receptor binding; IEA:Ensembl.
GO; GO:0097113; P:AMPA glutamate receptor clustering; IEA:Ensembl.
GO; GO:0042982; P:amyloid precursor protein metabolic process; IEA:Ensembl.
GO; GO:0048844; P:artery morphogenesis; IEA:Ensembl.
GO; GO:0006874; P:cellular calcium ion homeostasis; IEA:Ensembl.
GO; GO:0019934; P:cGMP-mediated signaling; IEA:Ensembl.
GO; GO:0006707; P:cholesterol catabolic process; IEA:Ensembl.
GO; GO:0033344; P:cholesterol efflux; IEA:Ensembl.
GO; GO:0042632; P:cholesterol homeostasis; IEA:Ensembl.
GO; GO:0034382; P:chylomicron remnant clearance; IEA:Ensembl.
GO; GO:0055089; P:fatty acid homeostasis; IEA:Ensembl.
GO; GO:0007186; P:G-protein coupled receptor signaling pathway; IEA:Ensembl.
GO; GO:0034380; P:high-density lipoprotein particle assembly; IEA:Ensembl.
GO; GO:0034384; P:high-density lipoprotein particle clearance; IEA:Ensembl.
GO; GO:0034375; P:high-density lipoprotein particle remodeling; IEA:Ensembl.
GO; GO:0010877; P:lipid transport involved in lipid storage; IEA:Ensembl.
GO; GO:0042158; P:lipoprotein biosynthetic process; IEA:Ensembl.
GO; GO:0042159; P:lipoprotein catabolic process; IEA:Ensembl.
GO; GO:0035641; P:locomotory exploration behavior; IEA:Ensembl.
GO; GO:0015909; P:long-chain fatty acid transport; IEA:Ensembl.
GO; GO:0007616; P:long-term memory; IEA:Ensembl.
GO; GO:0034374; P:low-density lipoprotein particle remodeling; IEA:Ensembl.
GO; GO:0051651; P:maintenance of location in cell; IEA:Ensembl.
GO; GO:1902430; P:negative regulation of amyloid-beta formation; IEA:Ensembl.
GO; GO:0043537; P:negative regulation of blood vessel endothelial cell migration; IEA:Ensembl.
GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IEA:Ensembl.
GO; GO:0045541; P:negative regulation of cholesterol biosynthetic process; IEA:Ensembl.
GO; GO:0001937; P:negative regulation of endothelial cell proliferation; IEA:Ensembl.
GO; GO:0050728; P:negative regulation of inflammatory response; IEA:Ensembl.
GO; GO:1900272; P:negative regulation of long-term synaptic potentiation; IEA:Ensembl.
GO; GO:0043407; P:negative regulation of MAP kinase activity; IEA:Ensembl.
GO; GO:1901215; P:negative regulation of neuron death; IEA:Ensembl.
GO; GO:0010977; P:negative regulation of neuron projection development; IEA:Ensembl.
GO; GO:0010544; P:negative regulation of platelet activation; IEA:Ensembl.
GO; GO:1901630; P:negative regulation of presynaptic membrane organization; IEA:Ensembl.
GO; GO:0090209; P:negative regulation of triglyceride metabolic process; IEA:Ensembl.
GO; GO:0007263; P:nitric oxide mediated signal transduction; IEA:Ensembl.
GO; GO:0097114; P:NMDA glutamate receptor clustering; IEA:Ensembl.
GO; GO:0033700; P:phospholipid efflux; IEA:Ensembl.
GO; GO:0044794; P:positive regulation by host of viral process; IEA:Ensembl.
GO; GO:0030828; P:positive regulation of cGMP biosynthetic process; IEA:Ensembl.
GO; GO:0010875; P:positive regulation of cholesterol efflux; IEA:Ensembl.
GO; GO:0010873; P:positive regulation of cholesterol esterification; IEA:Ensembl.
GO; GO:0060999; P:positive regulation of dendritic spine development; IEA:Ensembl.
GO; GO:1902952; P:positive regulation of dendritic spine maintenance; IEA:Ensembl.
GO; GO:0045807; P:positive regulation of endocytosis; IEA:Ensembl.
GO; GO:1905855; P:positive regulation of heparan sulfate binding; IEA:Ensembl.
GO; GO:1905860; P:positive regulation of heparan sulfate proteoglycan binding; IEA:Ensembl.
GO; GO:0046889; P:positive regulation of lipid biosynthetic process; IEA:Ensembl.
GO; GO:1903002; P:positive regulation of lipid transport across blood brain barrier; IEA:Ensembl.
GO; GO:0032805; P:positive regulation of low-density lipoprotein particle receptor catabolic process; IEA:Ensembl.
GO; GO:0051044; P:positive regulation of membrane protein ectodomain proteolysis; IEA:Ensembl.
GO; GO:0051000; P:positive regulation of nitric-oxide synthase activity; IEA:Ensembl.
GO; GO:1902995; P:positive regulation of phospholipid efflux; IEA:Ensembl.
GO; GO:1901628; P:positive regulation of postsynaptic membrane organization; IEA:Ensembl.
GO; GO:0017038; P:protein import; IEA:Ensembl.
GO; GO:0006898; P:receptor-mediated endocytosis; IEA:Ensembl.
GO; GO:1905906; P:regulation of amyloid fibril formation; IEA:Ensembl.
GO; GO:1900221; P:regulation of amyloid-beta clearance; IEA:Ensembl.
GO; GO:2000822; P:regulation of behavioral fear response; IEA:Ensembl.
GO; GO:0032489; P:regulation of Cdc42 protein signal transduction; IEA:Ensembl.
GO; GO:1905890; P:regulation of cellular response to very-low-density lipoprotein particle stimulus; IEA:Ensembl.
GO; GO:0010468; P:regulation of gene expression; IEA:Ensembl.
GO; GO:0032462; P:regulation of protein homooligomerization; IEA:Ensembl.
GO; GO:0061771; P:response to caloric restriction; IEA:Ensembl.
GO; GO:0002021; P:response to dietary excess; IEA:Ensembl.
GO; GO:0006979; P:response to oxidative stress; IEA:Ensembl.
GO; GO:0043691; P:reverse cholesterol transport; IEA:Ensembl.
GO; GO:0070328; P:triglyceride homeostasis; IEA:Ensembl.
GO; GO:0006641; P:triglyceride metabolic process; IEA:Ensembl.
GO; GO:0042311; P:vasodilation; IEA:Ensembl.
GO; GO:0034447; P:very-low-density lipoprotein particle clearance; IEA:Ensembl.
GO; GO:0034372; P:very-low-density lipoprotein particle remodeling; IEA:Ensembl.
GO; GO:0019068; P:virion assembly; IEA:Ensembl.
InterPro; IPR000074; ApoA_E.
Pfam; PF01442; Apolipoprotein; 1.
3: Inferred from homology;
Chylomicron; Complete proteome; Glycoprotein; HDL; Heparin-binding;
Lipid transport; Oxidation; Phosphoprotein; Reference proteome;
Repeat; Secreted; Signal; Transport; VLDL.
SIGNAL 1 18 {ECO:0000255}.
CHAIN 19 317 Apolipoprotein E.
/FTId=PRO_5002346112.
REPEAT 80 101 1.
REPEAT 102 123 2.
REPEAT 124 145 3.
REPEAT 146 167 4.
REPEAT 168 189 5.
REPEAT 190 211 6.
REPEAT 212 233 7.
REPEAT 234 255 8.
REGION 80 255 8 X 22 AA approximate tandem repeats.
REGION 158 168 LDL receptor binding.
{ECO:0000250|UniProtKB:P02649}.
REGION 162 165 Heparin-binding.
{ECO:0000250|UniProtKB:P02649}.
REGION 229 236 Heparin-binding.
{ECO:0000250|UniProtKB:P02649}.
MOD_RES 143 143 Methionine sulfoxide.
{ECO:0000250|UniProtKB:P08226}.
MOD_RES 147 147 Phosphoserine.
{ECO:0000250|UniProtKB:P02649}.
CARBOHYD 212 212 O-linked (GalNAc...) threonine.
{ECO:0000250|UniProtKB:P02649}.
SEQUENCE 317 AA; 36020 MW; 86958EAF4F7F1610 CRC64;
MKVLWAALLV TFLAGCQAKV EQPVEPETEP ELRPQTEWQS GQPWELALGR FWDYLRWVQT
LSEQVQEELL SPQVTQELTT LMDETMKELK AYKSELEEQL SPVAEETRAR LSKELQAAQA
RLGADMEDVR SRLVQYRSEV QAMLGQSTEE LRARLASHLR KLRKRLLRDA DDLQKRLAVY
QAGAREGAER GVSAIRERLG PLVEQGRVRA ATVGSLASQP LQERAQALGE RLRARMEEMG
SRTRDRLDEV KEQVAEVRAK LEEQAQQISL QAEAFQARLK SWFEPLVEDM QRQWAGLVEK
VQAAVGASTA PVPSDNH


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