Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Apoptosis regulator Bcl-2

 BCL2_CHICK              Reviewed;         233 AA.
Q00709;
01-APR-1993, integrated into UniProtKB/Swiss-Prot.
01-APR-1993, sequence version 1.
25-OCT-2017, entry version 137.
RecName: Full=Apoptosis regulator Bcl-2;
Name=BCL2; Synonyms=BCL-2;
Gallus gallus (Chicken).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
Phasianidae; Phasianinae; Gallus.
NCBI_TaxID=9031;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=1508712; DOI=10.1093/nar/20.16.4187;
Eguchi Y., Ewert D.L., Tsujimoto Y.;
"Isolation and characterization of the chicken bcl-2 gene: expression
in a variety of tissues including lymphoid and neuronal organs in
adult and embryo.";
Nucleic Acids Res. 20:4187-4192(1992).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=B-cell lymphoma;
PubMed=1511008; DOI=10.1016/0167-4781(92)90064-7;
Cazals-Hatem D.L., Louie D.C., Tanaka S., Reed J.C.;
"Molecular cloning and DNA sequence analysis of cDNA encoding chicken
homologue of the Bcl-2 oncoprotein.";
Biochim. Biophys. Acta 1132:109-113(1992).
-!- FUNCTION: Suppresses apoptosis in a variety of cell systems
including factor-dependent lymphohematopoietic and neural cells.
Regulates cell death by controlling the mitochondrial membrane
permeability. Appears to function in a feedback loop system with
caspases. Inhibits caspase activity either by preventing the
release of cytochrome c from the mitochondria and/or by binding to
the apoptosis-activating factor (APAF-1).
-!- SUBUNIT: Forms homodimers, and heterodimers with BAX, BAD, BAK and
Bcl-X(L). Heterodimerization with BAX requires intact BH1 and BH2
motifs, and is necessary for anti-apoptotic activity (By
similarity). Also interacts with APAF1 and RAF-1 (By similarity).
{ECO:0000250}.
-!- SUBCELLULAR LOCATION: Mitochondrion outer membrane; Single-pass
membrane protein. Nucleus membrane; Single-pass membrane protein.
Endoplasmic reticulum membrane; Single-pass membrane protein.
-!- TISSUE SPECIFICITY: In adult chicken expressed, in thymus, spleen,
kidney, heart, ovary and brain, with the highest levels in the
thymus. In the embryo, highly levels expressed in all tissues with
high levels in the bursa of Fabricius.
-!- DOMAIN: The BH4 motif is required for anti-apoptotic activity and
for interaction with RAF-1. {ECO:0000250}.
-!- SIMILARITY: Belongs to the Bcl-2 family. {ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=CAA78018.1; Type=Frameshift; Positions=63, 82; Evidence={ECO:0000305};
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; D11382; BAA01978.1; -; Genomic_DNA.
EMBL; Z11961; CAA78018.1; ALT_FRAME; mRNA.
PIR; A37332; A37332.
PIR; S24390; S24390.
RefSeq; NP_990670.2; NM_205339.2.
UniGene; Gga.42172; -.
ProteinModelPortal; Q00709; -.
SMR; Q00709; -.
STRING; 9031.ENSGALP00000020984; -.
PaxDb; Q00709; -.
Ensembl; ENSGALT00000021014; ENSGALP00000020984; ENSGALG00000012885.
GeneID; 396282; -.
KEGG; gga:396282; -.
CTD; 596; -.
eggNOG; KOG4728; Eukaryota.
eggNOG; ENOG41123S0; LUCA.
GeneTree; ENSGT00530000062935; -.
HOGENOM; HOG000056452; -.
HOVERGEN; HBG004472; -.
InParanoid; Q00709; -.
KO; K02161; -.
OMA; EWDAGDA; -.
OrthoDB; EOG091G0OCU; -.
PhylomeDB; Q00709; -.
TreeFam; TF315834; -.
Reactome; R-GGA-111453; BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members.
Reactome; R-GGA-844455; The NLRP1 inflammasome.
PRO; PR:Q00709; -.
Proteomes; UP000000539; Chromosome 2.
Bgee; ENSGALG00000012885; -.
GO; GO:0005829; C:cytosol; IEA:Ensembl.
GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO; GO:0005741; C:mitochondrial outer membrane; ISS:UniProtKB.
GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
GO; GO:0043209; C:myelin sheath; IEA:Ensembl.
GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
GO; GO:0046930; C:pore complex; IEA:Ensembl.
GO; GO:0051434; F:BH3 domain binding; IEA:Ensembl.
GO; GO:0015267; F:channel activity; IEA:Ensembl.
GO; GO:0016248; F:channel inhibitor activity; IEA:Ensembl.
GO; GO:0002020; F:protease binding; IEA:Ensembl.
GO; GO:0046982; F:protein heterodimerization activity; IBA:GO_Central.
GO; GO:0042803; F:protein homodimerization activity; IBA:GO_Central.
GO; GO:0051721; F:protein phosphatase 2A binding; IEA:Ensembl.
GO; GO:0043565; F:sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0008134; F:transcription factor binding; IEA:Ensembl.
GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:Ensembl.
GO; GO:0007015; P:actin filament organization; IEA:Ensembl.
GO; GO:0031103; P:axon regeneration; IEA:Ensembl.
GO; GO:0007409; P:axonogenesis; IEA:Ensembl.
GO; GO:0001782; P:B cell homeostasis; IEA:Ensembl.
GO; GO:0002326; P:B cell lineage commitment; IEA:Ensembl.
GO; GO:0042100; P:B cell proliferation; IEA:Ensembl.
GO; GO:0050853; P:B cell receptor signaling pathway; IEA:Ensembl.
GO; GO:0001662; P:behavioral fear response; IEA:Ensembl.
GO; GO:0001658; P:branching involved in ureteric bud morphogenesis; IEA:Ensembl.
GO; GO:0043375; P:CD8-positive, alpha-beta T cell lineage commitment; IEA:Ensembl.
GO; GO:0007569; P:cell aging; IEA:Ensembl.
GO; GO:0016049; P:cell growth; IEA:Ensembl.
GO; GO:0098609; P:cell-cell adhesion; IEA:Ensembl.
GO; GO:0042149; P:cellular response to glucose starvation; IEA:Ensembl.
GO; GO:0071456; P:cellular response to hypoxia; IEA:Ensembl.
GO; GO:0071310; P:cellular response to organic substance; IEA:Ensembl.
GO; GO:0021747; P:cochlear nucleus development; IEA:Ensembl.
GO; GO:0051607; P:defense response to virus; IEA:Ensembl.
GO; GO:0048546; P:digestive tract morphogenesis; IEA:Ensembl.
GO; GO:0043583; P:ear development; IEA:Ensembl.
GO; GO:0032469; P:endoplasmic reticulum calcium ion homeostasis; IEA:Ensembl.
GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IBA:GO_Central.
GO; GO:0008625; P:extrinsic apoptotic signaling pathway via death domain receptors; IEA:Ensembl.
GO; GO:0048041; P:focal adhesion assembly; IEA:Ensembl.
GO; GO:0022612; P:gland morphogenesis; IEA:Ensembl.
GO; GO:0032835; P:glomerulus development; IEA:Ensembl.
GO; GO:0048873; P:homeostasis of number of cells within a tissue; IEA:Ensembl.
GO; GO:0008630; P:intrinsic apoptotic signaling pathway in response to DNA damage; IBA:GO_Central.
GO; GO:0070059; P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; IEA:Ensembl.
GO; GO:0008631; P:intrinsic apoptotic signaling pathway in response to oxidative stress; IEA:Ensembl.
GO; GO:0070306; P:lens fiber cell differentiation; TAS:AgBase.
GO; GO:0002320; P:lymphoid progenitor cell differentiation; IEA:Ensembl.
GO; GO:0008584; P:male gonad development; IEA:Ensembl.
GO; GO:0006582; P:melanin metabolic process; IEA:Ensembl.
GO; GO:0030318; P:melanocyte differentiation; IEA:Ensembl.
GO; GO:0014031; P:mesenchymal cell development; IEA:Ensembl.
GO; GO:0001656; P:metanephros development; IEA:Ensembl.
GO; GO:2000811; P:negative regulation of anoikis; IEA:Ensembl.
GO; GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.
GO; GO:0010507; P:negative regulation of autophagy; IEA:Ensembl.
GO; GO:0010523; P:negative regulation of calcium ion transport into cytosol; IEA:Ensembl.
GO; GO:0030308; P:negative regulation of cell growth; IEA:Ensembl.
GO; GO:0030336; P:negative regulation of cell migration; IEA:Ensembl.
GO; GO:0032848; P:negative regulation of cellular pH reduction; ISS:UniProtKB.
GO; GO:2001240; P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
GO; GO:2000134; P:negative regulation of G1/S transition of mitotic cell cycle; IEA:Ensembl.
GO; GO:2001243; P:negative regulation of intrinsic apoptotic signaling pathway; IBA:GO_Central.
GO; GO:0033033; P:negative regulation of myeloid cell apoptotic process; IEA:Ensembl.
GO; GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Ensembl.
GO; GO:0030279; P:negative regulation of ossification; IEA:Ensembl.
GO; GO:0033689; P:negative regulation of osteoblast proliferation; IEA:Ensembl.
GO; GO:2000378; P:negative regulation of reactive oxygen species metabolic process; IEA:Ensembl.
GO; GO:0046671; P:negative regulation of retinal cell programmed cell death; IEA:Ensembl.
GO; GO:0051402; P:neuron apoptotic process; IEA:Ensembl.
GO; GO:0048599; P:oocyte development; IEA:Ensembl.
GO; GO:0035265; P:organ growth; IEA:Ensembl.
GO; GO:0001503; P:ossification; IEA:Ensembl.
GO; GO:0001541; P:ovarian follicle development; IEA:Ensembl.
GO; GO:0018105; P:peptidyl-serine phosphorylation; IEA:Ensembl.
GO; GO:0018107; P:peptidyl-threonine phosphorylation; IEA:Ensembl.
GO; GO:0048753; P:pigment granule organization; IEA:Ensembl.
GO; GO:0030890; P:positive regulation of B cell proliferation; IEA:Ensembl.
GO; GO:0043085; P:positive regulation of catalytic activity; IEA:Ensembl.
GO; GO:0030307; P:positive regulation of cell growth; IEA:Ensembl.
GO; GO:0045636; P:positive regulation of melanocyte differentiation; IEA:Ensembl.
GO; GO:0040018; P:positive regulation of multicellular organism growth; IEA:Ensembl.
GO; GO:0014042; P:positive regulation of neuron maturation; IEA:Ensembl.
GO; GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IEA:Ensembl.
GO; GO:0048743; P:positive regulation of skeletal muscle fiber development; IEA:Ensembl.
GO; GO:0014911; P:positive regulation of smooth muscle cell migration; IEA:Ensembl.
GO; GO:0009791; P:post-embryonic development; IEA:Ensembl.
GO; GO:0006470; P:protein dephosphorylation; IEA:Ensembl.
GO; GO:0000209; P:protein polyubiquitination; IEA:Ensembl.
GO; GO:0072593; P:reactive oxygen species metabolic process; IEA:Ensembl.
GO; GO:0001952; P:regulation of cell-matrix adhesion; IEA:Ensembl.
GO; GO:0010468; P:regulation of gene expression; IEA:Ensembl.
GO; GO:0010559; P:regulation of glycoprotein biosynthetic process; IEA:Ensembl.
GO; GO:0046902; P:regulation of mitochondrial membrane permeability; ISS:HGNC.
GO; GO:0051881; P:regulation of mitochondrial membrane potential; ISS:HGNC.
GO; GO:0006808; P:regulation of nitrogen utilization; IEA:Ensembl.
GO; GO:0043497; P:regulation of protein heterodimerization activity; IEA:Ensembl.
GO; GO:0043496; P:regulation of protein homodimerization activity; IEA:Ensembl.
GO; GO:0032880; P:regulation of protein localization; IEA:Ensembl.
GO; GO:0031647; P:regulation of protein stability; IEA:Ensembl.
GO; GO:0022898; P:regulation of transmembrane transporter activity; IEA:Ensembl.
GO; GO:0045069; P:regulation of viral genome replication; IEA:Ensembl.
GO; GO:0001836; P:release of cytochrome c from mitochondria; ISS:HGNC.
GO; GO:0003014; P:renal system process; IEA:Ensembl.
GO; GO:0034097; P:response to cytokine; IEA:Ensembl.
GO; GO:0042493; P:response to drug; IEA:Ensembl.
GO; GO:0010332; P:response to gamma radiation; IEA:Ensembl.
GO; GO:0051384; P:response to glucocorticoid; IEA:Ensembl.
GO; GO:0042542; P:response to hydrogen peroxide; IEA:Ensembl.
GO; GO:0010039; P:response to iron ion; IEA:Ensembl.
GO; GO:0002931; P:response to ischemia; IEA:Ensembl.
GO; GO:0035094; P:response to nicotine; IEA:Ensembl.
GO; GO:0009636; P:response to toxic substance; IEA:Ensembl.
GO; GO:0010224; P:response to UV-B; IEA:Ensembl.
GO; GO:0048536; P:spleen development; IEA:Ensembl.
GO; GO:0033077; P:T cell differentiation in thymus; IEA:Ensembl.
GO; GO:0043029; P:T cell homeostasis; IEA:Ensembl.
GO; GO:0048538; P:thymus development; IEA:Ensembl.
Gene3D; 1.10.437.10; -; 1.
InterPro; IPR013278; Apop_reg_Bcl2.
InterPro; IPR002475; Bcl2-like.
InterPro; IPR004725; Bcl2/BclX.
InterPro; IPR020717; Bcl2_BH1_motif_CS.
InterPro; IPR020726; Bcl2_BH2_motif_CS.
InterPro; IPR020728; Bcl2_BH3_motif_CS.
InterPro; IPR003093; Bcl2_BH4.
InterPro; IPR020731; Bcl2_BH4_motif_CS.
InterPro; IPR036834; Blc2-like_sf.
InterPro; IPR026298; Blc2_fam.
PANTHER; PTHR11256; PTHR11256; 1.
PANTHER; PTHR11256:SF11; PTHR11256:SF11; 1.
Pfam; PF00452; Bcl-2; 1.
Pfam; PF02180; BH4; 1.
PRINTS; PR01863; APOPREGBCL2.
PRINTS; PR01862; BCL2FAMILY.
SMART; SM00265; BH4; 1.
SUPFAM; SSF56854; SSF56854; 1.
TIGRFAMs; TIGR00865; bcl-2; 1.
PROSITE; PS50062; BCL2_FAMILY; 1.
PROSITE; PS01080; BH1; 1.
PROSITE; PS01258; BH2; 1.
PROSITE; PS01259; BH3; 1.
PROSITE; PS01260; BH4_1; 1.
PROSITE; PS50063; BH4_2; 1.
2: Evidence at transcript level;
Apoptosis; Complete proteome; Endoplasmic reticulum; Membrane;
Mitochondrion; Mitochondrion outer membrane; Nucleus;
Reference proteome; Transmembrane; Transmembrane helix.
CHAIN 1 233 Apoptosis regulator Bcl-2.
/FTId=PRO_0000143051.
TRANSMEM 208 228 Helical. {ECO:0000255}.
MOTIF 10 30 BH4.
MOTIF 87 101 BH3.
MOTIF 130 149 BH1.
MOTIF 181 196 BH2.
CONFLICT 121 121 H -> T (in Ref. 2; CAA78018).
{ECO:0000305}.
CONFLICT 139 139 G -> V (in Ref. 2; CAA78018).
{ECO:0000305}.
SEQUENCE 233 AA; 25687 MW; 5252555ACB6E4C3D CRC64;
MAHPGRRGYD NREIVLKYIH YKLSQRGYDW AAGEDRPPVP PAPAPAAAPA AVAAAGASSH
HRPEPPGSAA ASEVPPAEGL RPAPPGVHLA LRQAGDEFSR RYQRDFAQMS GQLHLTPFTA
HGRFVAVVEE LFRDGVNWGR IVAFFEFGGV MCVESVNREM SPLVDNIATW MTEYLNRHLH
NWIQDNGGWD AFVELYGNSM RPLFDFSWIS LKTILSLVLV GACITLGAYL GHK


Related products :

Catalog number Product name Quantity
EIAAB29959 Mouse,Mus musculus,Par4,Par-4,Pawr,PRKC apoptosis WT1 regulator protein,Prostate apoptosis response 4 protein
EIAAB29958 Homo sapiens,Human,PAR4,Par-4,PAWR,PRKC apoptosis WT1 regulator protein,Prostate apoptosis response 4 protein
18-003-42147 PRKC apoptosis WT1 regulator protein - Prostate apoptosis response 4 protein; Par-4 Polyclonal 0.05 mg Aff Pur
18-003-42272 PRKC apoptosis WT1 regulator protein - Prostate apoptosis response 4 protein; Par-4 Polyclonal 0.1 mg Protein A
EIAAB29960 Par4,Par-4,Pawr,PRKC apoptosis WT1 regulator protein,Prostate apoptosis response 4 protein,Rat,Rattus norvegicus,Transcriptional repressor Par-4-like protein PAWR
2227 A novel regulator of apoptosis 0.5 mg
CF02 Apoptosis Regulator BAX BAX 500
2227 A novel regulator of apoptosis 0.1 mg
CF02 Apoptosis Regulator BAX BAX lmg
EIAAB05873 CARP1,CARP-1,CCAR1,Cell cycle and apoptosis regulatory protein 1,Cell division cycle and apoptosis regulator protein 1,Death inducer with SAP domain,DIS,Homo sapiens,Human
EIAAB05874 Carp1,CARP-1,Ccar1,Cell cycle and apoptosis regulatory protein 1,Cell division cycle and apoptosis regulator protein 1,Mouse,Mus musculus
ER512 Apoptosis regulator BAX Elisa Kit 96T
18-661-15192 Apoptosis regulator Bcl-2 - N_A Polyclonal 0.1 mg
CSB-EL002573RA Rat Apoptosis regulator BAX(BAX) ELISA kit 96T
EM584 Apoptosis regulator BAX Elisa Kit 96T
3152 (CT) Regulator of mitochondrion apoptosis 0.5 mg
3145 (IN) Regulator of mitochondrion apoptosis 0.5 mg
3147 Regulator of mitochondrion apoptosis 0.5 mg
3151 (CT) Regulator of mitochondrion apoptosis 0.5 mg
3149 (NT) Regulator of mitochondrion apoptosis 0.5 mg
EM454 Apoptosis regulator Bcl-2 Elisa Kit 96T
3145 (IN) Regulator of mitochondrion apoptosis 0.1 mg
3152 (CT) Regulator of mitochondrion apoptosis 0.1 mg
18-003-42867 Apoptosis regulator Bcl-2 - N_A Polyclonal 0.05 mg Aff Pur
CF02 Human Apoptosis Regulator BAX BAX l0


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur