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Apoptotic protease-activating factor 1 (APAF-1)

 F6R504_HORSE            Unreviewed;      1250 AA.
F6R504;
27-JUL-2011, integrated into UniProtKB/TrEMBL.
27-JUL-2011, sequence version 1.
05-DEC-2018, entry version 60.
RecName: Full=Apoptotic protease-activating factor 1 {ECO:0000256|PIRNR:PIRNR037646};
Short=APAF-1 {ECO:0000256|PIRNR:PIRNR037646};
Name=APAF1 {ECO:0000313|Ensembl:ENSECAP00000022364,
ECO:0000313|VGNC:VGNC:15395};
Equus caballus (Horse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000022364, ECO:0000313|Proteomes:UP000002281};
[1] {ECO:0000313|Ensembl:ENSECAP00000022364, ECO:0000313|Proteomes:UP000002281}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000022364,
ECO:0000313|Proteomes:UP000002281};
PubMed=19892987; DOI=10.1126/science.1178158;
Broad Institute Genome Sequencing Platform;
Broad Institute Whole Genome Assembly Team;
Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H.,
Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N.,
Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L.,
Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J.,
Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J.,
Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R.,
Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F.,
Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L.,
Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M.,
White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
"Genome sequence, comparative analysis, and population genetics of the
domestic horse.";
Science 326:865-867(2009).
[2] {ECO:0000313|Ensembl:ENSECAP00000022364}
IDENTIFICATION.
STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000022364};
Ensembl;
Submitted (JUL-2011) to UniProtKB.
-!- FUNCTION: Oligomeric Apaf-1 mediates the cytochrome c-dependent
autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the
activation of caspase-3 and apoptosis. This activation requires
ATP. {ECO:0000256|PIRNR:PIRNR037646}.
-!- SUBUNIT: Monomer. Oligomerizes upon binding of cytochrome c and
dATP. {ECO:0000256|PIRNR:PIRNR037646}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|PIRNR:PIRNR037646}.
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STRING; 9796.ENSECAP00000022364; -.
PaxDb; F6R504; -.
Ensembl; ENSECAT00000026768; ENSECAP00000022364; ENSECAG00000024703.
VGNC; VGNC:15395; APAF1.
eggNOG; KOG4155; Eukaryota.
eggNOG; KOG4658; Eukaryota.
eggNOG; ENOG410XP3K; LUCA.
GeneTree; ENSGT00940000157710; -.
InParanoid; F6R504; -.
OMA; SRIGHKK; -.
OrthoDB; EOG091G036U; -.
TreeFam; TF323866; -.
Proteomes; UP000002281; Chromosome 28.
Bgee; ENSECAG00000024703; Expressed in 3 organ(s), highest expression level in liver.
ExpressionAtlas; F6R504; baseline.
GO; GO:0043293; C:apoptosome; IBA:GO_Central.
GO; GO:0005829; C:cytosol; IBA:GO_Central.
GO; GO:0005634; C:nucleus; IEA:Ensembl.
GO; GO:0043531; F:ADP binding; IEA:InterPro.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
GO; GO:0008656; F:cysteine-type endopeptidase activator activity involved in apoptotic process; IBA:GO_Central.
GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
GO; GO:0008635; P:activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c; IBA:GO_Central.
GO; GO:0030900; P:forebrain development; IEA:Ensembl.
GO; GO:0070059; P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; IEA:Ensembl.
GO; GO:0001843; P:neural tube closure; IEA:Ensembl.
GO; GO:0051402; P:neuron apoptotic process; IEA:Ensembl.
GO; GO:2001235; P:positive regulation of apoptotic signaling pathway; IEA:Ensembl.
GO; GO:1902510; P:regulation of apoptotic DNA fragmentation; IEA:Ensembl.
CDD; cd08323; CARD_APAF1; 1.
Gene3D; 1.10.10.10; -; 1.
Gene3D; 2.130.10.10; -; 2.
InterPro; IPR017251; Apaf-1.
InterPro; IPR037963; APAF1_CARD_dom.
InterPro; IPR001315; CARD.
InterPro; IPR011029; DEATH-like_dom_sf.
InterPro; IPR020472; G-protein_beta_WD-40_rep.
InterPro; IPR002182; NB-ARC.
InterPro; IPR027417; P-loop_NTPase.
InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
InterPro; IPR001680; WD40_repeat.
InterPro; IPR019775; WD40_repeat_CS.
InterPro; IPR017986; WD40_repeat_dom.
InterPro; IPR036322; WD40_repeat_dom_sf.
InterPro; IPR036388; WH-like_DNA-bd_sf.
Pfam; PF00619; CARD; 1.
Pfam; PF00931; NB-ARC; 1.
Pfam; PF00400; WD40; 9.
PIRSF; PIRSF037646; Apop_pept_activating-1; 1.
PRINTS; PR00320; GPROTEINBRPT.
SMART; SM00320; WD40; 13.
SUPFAM; SSF47986; SSF47986; 1.
SUPFAM; SSF50978; SSF50978; 2.
SUPFAM; SSF52540; SSF52540; 1.
PROSITE; PS50209; CARD; 1.
PROSITE; PS00678; WD_REPEATS_1; 3.
PROSITE; PS50082; WD_REPEATS_2; 9.
PROSITE; PS50294; WD_REPEATS_REGION; 1.
4: Predicted;
Apoptosis {ECO:0000256|PIRNR:PIRNR037646};
ATP-binding {ECO:0000256|PIRNR:PIRNR037646,
ECO:0000256|PIRSR:PIRSR037646-50};
Complete proteome {ECO:0000313|Proteomes:UP000002281};
Cytoplasm {ECO:0000256|PIRNR:PIRNR037646};
Nucleotide-binding {ECO:0000256|PIRNR:PIRNR037646,
ECO:0000256|PIRSR:PIRSR037646-50};
Reference proteome {ECO:0000313|Proteomes:UP000002281};
WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
DOMAIN 2 91 CARD. {ECO:0000259|PROSITE:PS50209}.
DOMAIN 612 1250 WD_REPEATS_REGION.
{ECO:0000259|PROSITE:PS50294}.
REPEAT 612 653 WD. {ECO:0000256|PROSITE-
ProRule:PRU00221}.
REPEAT 654 695 WD. {ECO:0000256|PROSITE-
ProRule:PRU00221}.
REPEAT 696 739 WD. {ECO:0000256|PROSITE-
ProRule:PRU00221}.
REPEAT 740 781 WD. {ECO:0000256|PROSITE-
ProRule:PRU00221}.
REPEAT 879 911 WD. {ECO:0000256|PROSITE-
ProRule:PRU00221}.
REPEAT 1000 1041 WD. {ECO:0000256|PROSITE-
ProRule:PRU00221}.
REPEAT 1041 1081 WD. {ECO:0000256|PROSITE-
ProRule:PRU00221}.
REPEAT 1082 1116 WD. {ECO:0000256|PROSITE-
ProRule:PRU00221}.
REPEAT 1124 1165 WD. {ECO:0000256|PROSITE-
ProRule:PRU00221}.
NP_BIND 155 162 ATP. {ECO:0000256|PIRSR:PIRSR037646-50}.
BINDING 266 266 ATP. {ECO:0000256|PIRSR:PIRSR037646-50}.
SEQUENCE 1250 AA; 141898 MW; 771E957666B1BC92 CRC64;
RMDAKARNCL LQHREALEKD IKTSYIMDYM ISDGVLTVSE EEKVKNEPTR QQKAAMLIKM
ILKKDNYCYI SFYKALLQEG YKDLAALLHG GIPVLSSSNG KDSLVGVTSY VKTVLCEGGV
PQRPVVFVTR KKLVHAIRQK LLKLDGEPGW VTIYGMAGCG KSVLAAEAVR DHTLLEGCFP
GGVHWLSVGK QDKSGLLMKL QNLCTRLDQD ESFSQRLPLN IEEAKDRLRI LMLRKHPRSL
LILDDVWDPW VLKAFDNQCQ ILLTTRDRSV TDSVMGPKYV IPVESGLGKE KGLEILSLFV
NMKKADLPEQ AHSIIKECKG SPLVVSLIGA LLRDFPNRWE YYLRQLQNKQ FKRIRKCSSY
DYEALDEAMS ISVEMLREDI KDYYTDLSIL QKDVKVPTKV LCILWDMETE EVEDILQEFV
NKSLLFCDRN GKSFRYYLHD LQVDFLTEKN RSQLQDLHRK IITQFQRHHR LHTLSPDQED
CMYWYNFLAY HMASANMHKE LCALMFSLDW IKAKTELVGP AHLIHEFVEY RHILDEKDCS
VCENFQEFLS LNGHLLGRQP FPNIVQLGLC EPETSEVYQQ AKLQAKQEVD NGMLYLEWIN
KKNIKNLSRL VVRPHTDAVY HACFSGDGQR IASCGADKTL QVFKAETGEK LLEIKAHEDE
VLCCAFSTDD RFIATCSVDK KVKIWNSMTG ELVHTYDEHS EQVNCCHFTN NSHHLLLATG
SSDSFLKLWD LNEKDCRNTM FGHTNSVNHC RFSPDDKLLA SCSADGSLKL WDVKSANERK
SINVKQFFIS SEEPQEDMEV IVKCCSWSSD GARIMVAAKN KIFLVDVHTC GLLAEIHTGH
HSTIQYCDFS PSNHLAVVAL SQYCVELWNM DSCLKVADCR GHLSWVHSVM FSPDGSSFLT
SSDDETIRLW ETKKVCKNSG IVLKQEIDVL FQENEVMILA VDNMRRLQLI NGKTGQIDYL
TEAQVSSCCL SPHLQYVALG GEDGAIKILE LLNNRIFQSK IGHKSAVRHV QFTTDGKTLI
SSSDDSVIQV WNWQSEEYVF LQAHQEAVKD FRLLRNSRLL SWSFDGTVKV WNIITGRIEK
DFVCHQDTVL SCDISPDATK FSSTSADKTA KIWSFELLSP LHELRGHKGC VRCSVFSGDS
TLLATGDDNG EIRIWSVSNG ELLHLCAPIS VEEGAATHGG WVTDLCFSPD SKMLVSAEGS
LKWWNAVTGE SAQTFYTNGT NLKKIHVSPD FKTYVTVDNL GILYILQVLE


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