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Apoptotic protease-activating factor 1 (APAF-1)

 G1PBB9_MYOLU            Unreviewed;      1252 AA.
G1PBB9;
19-OCT-2011, integrated into UniProtKB/TrEMBL.
19-OCT-2011, sequence version 1.
20-JUN-2018, entry version 54.
RecName: Full=Apoptotic protease-activating factor 1 {ECO:0000256|PIRNR:PIRNR037646};
Short=APAF-1 {ECO:0000256|PIRNR:PIRNR037646};
Name=APAF1 {ECO:0000313|Ensembl:ENSMLUP00000007636};
Myotis lucifugus (Little brown bat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera;
Vespertilionidae; Myotis.
NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000007636, ECO:0000313|Proteomes:UP000001074};
[1] {ECO:0000313|Ensembl:ENSMLUP00000007636, ECO:0000313|Proteomes:UP000001074}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=21993624; DOI=10.1038/nature10530;
Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
Pedersen J.S., Lander E.S., Kellis M.;
"A high-resolution map of human evolutionary constraint using 29
mammals.";
Nature 478:476-482(2011).
[2] {ECO:0000313|Ensembl:ENSMLUP00000007636}
IDENTIFICATION.
Ensembl;
Submitted (SEP-2011) to UniProtKB.
-!- FUNCTION: Oligomeric Apaf-1 mediates the cytochrome c-dependent
autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the
activation of caspase-3 and apoptosis. This activation requires
ATP. {ECO:0000256|PIRNR:PIRNR037646}.
-!- SUBUNIT: Monomer. Oligomerizes upon binding of cytochrome c and
dATP. {ECO:0000256|PIRNR:PIRNR037646}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|PIRNR:PIRNR037646}.
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EMBL; AAPE02006910; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AAPE02006911; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AAPE02006912; -; NOT_ANNOTATED_CDS; Genomic_DNA.
ProteinModelPortal; G1PBB9; -.
STRING; 59463.ENSMLUP00000007636; -.
Ensembl; ENSMLUT00000008369; ENSMLUP00000007636; ENSMLUG00000008348.
eggNOG; KOG4155; Eukaryota.
eggNOG; KOG4658; Eukaryota.
eggNOG; ENOG410XP3K; LUCA.
GeneTree; ENSGT00920000149054; -.
InParanoid; G1PBB9; -.
OMA; SVNHCRF; -.
OrthoDB; EOG091G036U; -.
TreeFam; TF323866; -.
Proteomes; UP000001074; Unassembled WGS sequence.
GO; GO:0043293; C:apoptosome; IEA:Ensembl.
GO; GO:0005634; C:nucleus; IEA:Ensembl.
GO; GO:0043531; F:ADP binding; IEA:InterPro.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
GO; GO:0008656; F:cysteine-type endopeptidase activator activity involved in apoptotic process; IEA:Ensembl.
GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
GO; GO:0008635; P:activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c; IEA:Ensembl.
GO; GO:0030900; P:forebrain development; IEA:Ensembl.
GO; GO:0070059; P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; IEA:Ensembl.
GO; GO:0001843; P:neural tube closure; IEA:Ensembl.
GO; GO:0051402; P:neuron apoptotic process; IEA:Ensembl.
GO; GO:2001235; P:positive regulation of apoptotic signaling pathway; IEA:Ensembl.
GO; GO:1902510; P:regulation of apoptotic DNA fragmentation; IEA:Ensembl.
CDD; cd08323; CARD_APAF1; 1.
Gene3D; 1.10.10.10; -; 1.
Gene3D; 2.130.10.10; -; 3.
InterPro; IPR017251; Apaf-1.
InterPro; IPR037963; APAF1_CARD_dom.
InterPro; IPR001315; CARD.
InterPro; IPR011029; DEATH-like_dom_sf.
InterPro; IPR020472; G-protein_beta_WD-40_rep.
InterPro; IPR002182; NB-ARC.
InterPro; IPR027417; P-loop_NTPase.
InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
InterPro; IPR001680; WD40_repeat.
InterPro; IPR019775; WD40_repeat_CS.
InterPro; IPR017986; WD40_repeat_dom.
InterPro; IPR036322; WD40_repeat_dom_sf.
InterPro; IPR036388; WH-like_DNA-bd_sf.
Pfam; PF00619; CARD; 1.
Pfam; PF00931; NB-ARC; 1.
Pfam; PF00400; WD40; 9.
PIRSF; PIRSF037646; Apop_pept_activating-1; 1.
PRINTS; PR00320; GPROTEINBRPT.
SMART; SM00320; WD40; 13.
SUPFAM; SSF47986; SSF47986; 1.
SUPFAM; SSF50978; SSF50978; 2.
SUPFAM; SSF52540; SSF52540; 1.
PROSITE; PS50209; CARD; 1.
PROSITE; PS00678; WD_REPEATS_1; 4.
PROSITE; PS50082; WD_REPEATS_2; 9.
PROSITE; PS50294; WD_REPEATS_REGION; 1.
4: Predicted;
Apoptosis {ECO:0000256|PIRNR:PIRNR037646};
ATP-binding {ECO:0000256|PIRNR:PIRNR037646};
Complete proteome {ECO:0000313|Proteomes:UP000001074};
Cytoplasm {ECO:0000256|PIRNR:PIRNR037646};
Nucleotide-binding {ECO:0000256|PIRNR:PIRNR037646};
Reference proteome {ECO:0000313|Proteomes:UP000001074};
WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
DOMAIN 3 92 CARD. {ECO:0000259|PROSITE:PS50209}.
DOMAIN 614 1216 WD_REPEATS_REGION.
{ECO:0000259|PROSITE:PS50294}.
REPEAT 614 655 WD. {ECO:0000256|PROSITE-
ProRule:PRU00221}.
REPEAT 656 697 WD. {ECO:0000256|PROSITE-
ProRule:PRU00221}.
REPEAT 698 741 WD. {ECO:0000256|PROSITE-
ProRule:PRU00221}.
REPEAT 742 783 WD. {ECO:0000256|PROSITE-
ProRule:PRU00221}.
REPEAT 881 913 WD. {ECO:0000256|PROSITE-
ProRule:PRU00221}.
REPEAT 1002 1043 WD. {ECO:0000256|PROSITE-
ProRule:PRU00221}.
REPEAT 1043 1083 WD. {ECO:0000256|PROSITE-
ProRule:PRU00221}.
REPEAT 1084 1118 WD. {ECO:0000256|PROSITE-
ProRule:PRU00221}.
REPEAT 1126 1167 WD. {ECO:0000256|PROSITE-
ProRule:PRU00221}.
SEQUENCE 1252 AA; 142150 MW; 0B56571381AF8942 CRC64;
GRMDAKARNC LLQHREALEK DIKTPYIMDH MISDGVLTPS EEEKVKNEPT QQHRAAMLIK
MILKKDNDSY ISFYNALLHE GYKDLAVLLH SGLPVISSSN GKDSVGGITS YVRTVLCEGG
VPQRPVVFVT RKKLVNAIQQ KLFKLHGEPG WVTVYGMAGC GKTVLAAEAV RDHDLLESCF
PGGVHWVSVG KQDKSGLLMK LQNLCTRLDQ DESFSQRLPL NIEEAKDRLR ILMLRKHPRS
LLILDDVWDP WVLKAFDNQC QILLTTRDKS VTDSVMGPKY VVSVESGLGK EKGLEILSLF
VNMKKADLPE EAHSIIKECK GSPLVVSLIG ALLRDFPKRW EYYLRQLQNK QFKRIRKSSS
YDYEALDEAM SISVDMLRED IKSYYTDLSI FQKDVKVPTK VLCVLWDMET EEVEDILQEF
VNKSLLFCDR NGKSFCYYLH DLQVDFLTEQ NRSQLQDLHK KIITQFQRHH QLHALSPDQE
DCMYWYNFLA YHMASANMHK KELCALMFSL DWIKAKTELV GPAHLIHEFV EYRDILDEKD
YAVCENFQEF LSLNGHLLGR QPFPSIVQLG LCEPETSEVY QQAKLQAKQE VDNGVLYLEW
INKKNIKNLS RLVVRPHTDA VYHACFSEDG HRIASCGADK TLQVFKAETG EKLLEIKGHE
DEVLCCAFST DDKFIATCSV DKKVKIWNSV TGQLVQSYDE HSEQVNCCHF THSRHHLLLA
TGSSDCFLKL WDLDQKECRN TMFGHTNSVN HCRFSPDDKF LASCSADGTL KLWDVKSANE
RKSINVKQFF LSSEEPQEDI EVIVKCCSWS SDGSKIMVAA KNKIFLLDID TSGLLTEIHI
GHNSTIRYCD FSPHNHLAVV ALSQYCVELW NVDSCLKVAD CRGHLSWVHC VMFSPDGSSF
LTSSDDQTIR LWETKKVCEN SAIVLKQEID VVFQENEVMV LAVDNIRRLQ LINGKTGQID
YLTEAQISCC CLSPHLQYVA FGGHDGTIKI LELLNNRLFQ SRNGHKNTVR HIQFTADGKT
LISSSDDSTI QVWNWQSEEY FFLQAHQETV KDFRLLKNSR LLSWSFDGTV KVWNITTGRI
EKDFVCHQDT VLSCDVSSDA TKFSSTSADN TAKIWSFELL SPLHELKGHK GCVRCSAFSV
DSTLLATGDD NGEIRIWNVS SGVLLHLCAP VSVEEGAATH GGWVTDLCFS PDSKMLVSAG
GYLKWWNVIT GESSQTFYTN GTNLMKIHVS PDFKTYVTVD NLGILYILQT LE


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