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Apoptotic protease-activating factor 1 (APAF-1)

 G3WCH3_SARHA            Unreviewed;      1255 AA.
G3WCH3;
16-NOV-2011, integrated into UniProtKB/TrEMBL.
16-NOV-2011, sequence version 1.
20-JUN-2018, entry version 54.
RecName: Full=Apoptotic protease-activating factor 1 {ECO:0000256|PIRNR:PIRNR037646};
Short=APAF-1 {ECO:0000256|PIRNR:PIRNR037646};
Name=APAF1 {ECO:0000313|Ensembl:ENSSHAP00000013128};
Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000013128, ECO:0000313|Proteomes:UP000007648};
[1] {ECO:0000313|Ensembl:ENSSHAP00000013128}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=21709235; DOI=10.1073/pnas.1102838108;
Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E.,
Miller J., Walenz B., Knight J., Qi J., Zhao F., Wang Q.,
Bedoya-Reina O.C., Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A.,
Woodbridge P., Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S.,
Helgen K.M., Lesk A.M., Pringle T.H., Patterson N., Zhang Y.,
Kreiss A., Woods G.M., Jones M.E., Schuster S.C.;
"Genetic diversity and population structure of the endangered
marsupial Sarcophilus harrisii (Tasmanian devil).";
Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
[2] {ECO:0000313|Ensembl:ENSSHAP00000013128}
IDENTIFICATION.
Ensembl;
Submitted (SEP-2011) to UniProtKB.
-!- FUNCTION: Oligomeric Apaf-1 mediates the cytochrome c-dependent
autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the
activation of caspase-3 and apoptosis. This activation requires
ATP. {ECO:0000256|PIRNR:PIRNR037646}.
-!- SUBUNIT: Monomer. Oligomerizes upon binding of cytochrome c and
dATP. {ECO:0000256|PIRNR:PIRNR037646}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|PIRNR:PIRNR037646}.
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EMBL; AEFK01191722; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AEFK01191723; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AEFK01191724; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AEFK01191725; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AEFK01191726; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AEFK01191727; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AEFK01191728; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AEFK01191729; -; NOT_ANNOTATED_CDS; Genomic_DNA.
ProteinModelPortal; G3WCH3; -.
STRING; 9305.ENSSHAP00000013128; -.
Ensembl; ENSSHAT00000013234; ENSSHAP00000013128; ENSSHAG00000011224.
eggNOG; KOG4155; Eukaryota.
eggNOG; KOG4658; Eukaryota.
eggNOG; ENOG410XP3K; LUCA.
GeneTree; ENSGT00920000149054; -.
InParanoid; G3WCH3; -.
OMA; SVNHCRF; -.
OrthoDB; EOG091G036U; -.
TreeFam; TF323866; -.
Proteomes; UP000007648; Unassembled WGS sequence.
GO; GO:0043293; C:apoptosome; IEA:Ensembl.
GO; GO:0005634; C:nucleus; IEA:Ensembl.
GO; GO:0043531; F:ADP binding; IEA:InterPro.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
GO; GO:0008656; F:cysteine-type endopeptidase activator activity involved in apoptotic process; IEA:Ensembl.
GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
GO; GO:0008635; P:activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c; IEA:Ensembl.
GO; GO:0030900; P:forebrain development; IEA:Ensembl.
GO; GO:0070059; P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; IEA:Ensembl.
GO; GO:0001843; P:neural tube closure; IEA:Ensembl.
GO; GO:0051402; P:neuron apoptotic process; IEA:Ensembl.
GO; GO:2001235; P:positive regulation of apoptotic signaling pathway; IEA:Ensembl.
GO; GO:1902510; P:regulation of apoptotic DNA fragmentation; IEA:Ensembl.
CDD; cd08323; CARD_APAF1; 1.
Gene3D; 1.10.10.10; -; 1.
Gene3D; 2.130.10.10; -; 3.
InterPro; IPR017251; Apaf-1.
InterPro; IPR037963; APAF1_CARD_dom.
InterPro; IPR001315; CARD.
InterPro; IPR011029; DEATH-like_dom_sf.
InterPro; IPR020472; G-protein_beta_WD-40_rep.
InterPro; IPR002182; NB-ARC.
InterPro; IPR027417; P-loop_NTPase.
InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
InterPro; IPR001680; WD40_repeat.
InterPro; IPR019775; WD40_repeat_CS.
InterPro; IPR017986; WD40_repeat_dom.
InterPro; IPR036322; WD40_repeat_dom_sf.
InterPro; IPR036388; WH-like_DNA-bd_sf.
Pfam; PF00619; CARD; 1.
Pfam; PF00931; NB-ARC; 1.
Pfam; PF00400; WD40; 8.
PIRSF; PIRSF037646; Apop_pept_activating-1; 1.
PRINTS; PR00320; GPROTEINBRPT.
SMART; SM00320; WD40; 13.
SUPFAM; SSF47986; SSF47986; 1.
SUPFAM; SSF50978; SSF50978; 2.
SUPFAM; SSF52540; SSF52540; 1.
PROSITE; PS50209; CARD; 1.
PROSITE; PS00678; WD_REPEATS_1; 3.
PROSITE; PS50082; WD_REPEATS_2; 9.
PROSITE; PS50294; WD_REPEATS_REGION; 1.
4: Predicted;
Apoptosis {ECO:0000256|PIRNR:PIRNR037646};
ATP-binding {ECO:0000256|PIRNR:PIRNR037646};
Coiled coil {ECO:0000256|SAM:Coils};
Complete proteome {ECO:0000313|Proteomes:UP000007648};
Cytoplasm {ECO:0000256|PIRNR:PIRNR037646};
Nucleotide-binding {ECO:0000256|PIRNR:PIRNR037646};
Reference proteome {ECO:0000313|Proteomes:UP000007648};
WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
DOMAIN 2 91 CARD. {ECO:0000259|PROSITE:PS50209}.
DOMAIN 611 1170 WD_REPEATS_REGION.
{ECO:0000259|PROSITE:PS50294}.
REPEAT 611 652 WD. {ECO:0000256|PROSITE-
ProRule:PRU00221}.
REPEAT 653 694 WD. {ECO:0000256|PROSITE-
ProRule:PRU00221}.
REPEAT 695 738 WD. {ECO:0000256|PROSITE-
ProRule:PRU00221}.
REPEAT 739 768 WD. {ECO:0000256|PROSITE-
ProRule:PRU00221}.
REPEAT 881 913 WD. {ECO:0000256|PROSITE-
ProRule:PRU00221}.
REPEAT 1005 1046 WD. {ECO:0000256|PROSITE-
ProRule:PRU00221}.
REPEAT 1046 1086 WD. {ECO:0000256|PROSITE-
ProRule:PRU00221}.
REPEAT 1087 1128 WD. {ECO:0000256|PROSITE-
ProRule:PRU00221}.
REPEAT 1129 1170 WD. {ECO:0000256|PROSITE-
ProRule:PRU00221}.
COILED 372 392 {ECO:0000256|SAM:Coils}.
SEQUENCE 1255 AA; 143628 MW; 74358AF8E059C148 CRC64;
RMDAKAWNCL LQHKEALERD IKTSYLMDHM ISDRALSLSE EEKIRDQPTQ KKRAAMLIRV
LLEKDNNSYI SFYNALLHEG YKDLAFLLQD GIPLSSHNGK DSADGVTSYV KTVLCEGGVP
QRPVVFVTRK KLVKSIQEKL YKLDGEPGWV TVYGMAGCGK SVLAAEAVRD HSLLQTCFPG
GVHWVSIGKQ DKSGLLMKLQ NLCTRLDQDG AFSQRLPLNL EEAKDRLHFL MLRKCPRSLL
ILDDIWDSWV LKAFDNHHQI LLTSRDKSVT DSVMGPKYVV PVESGLRKEK GLEILSLFVN
MKKTDLPEQA HSIVRECKGS PLVVSLIGAL LRDFPNRWGY YLRQLQNKQF KRIRKSSSYD
YEALDEAMSI SVERLNEALQ KYYKDLSILQ KDVRVPTKVL CILWDMETEE VEDILQEFIN
KSLLFYDRNG KSFHYYLHDL QVDFLMEKNR DQLQELHKKV VTQFQRYYKV HSLASDQEDS
MYWYNFLVYH MANANMRQEL CDLLFSLDWI KAKTELVGPA HLIHEFMQYS HLLDKKDCTI
RENFQEFLSL NGHLLGRQPF PNIVQLGLCE PETSEIYRQA KLRAKQEVDK GRLYLEWINK
KNIKKLSRLV VRPHTDAVYH ACFSEDGQRI ASCGADKTLQ VLKAETGERL LEIEAHEDDV
LCCAFSKDDR FIATCSVDKK VKIWNSRTGD LVHTYDEHTE QVNCCHFTNM EHHLLLATGS
NDYFLKLWDL NKKECRNTLF GHANSVNHCR FSPDDKYLVS CSADGTLKKS KLWDVRSANE
WSSIDVRQHF LNSDGRQEDV EVMVKCCSWS SDGMRVMAAA ANRLLVFDVH SRNLVGQIHT
GYSSTIRYCD FFPKSHLAVV ALSHYCVELW NMDTGIKVAD CRGHLSWVHC VAFSPDGSSF
LTASDDETIR LWETKKVCKN SAVMLKQEVD VVFREDEVMI LAIDNVRRLQ LINGKTGHTD
YLTEAQKSRI SCCCLSPDLR YVALGEEDGS VKILELPNGR EFRSRMGHEK AVRRVQFTSD
GRTLISSSDD STVQVWNWHS EEFVFLKAHQ EPVKDFRLLQ NSQLLTWSFD GTVKVWNILT
GKVEKDFVCH QGTVLSCDIS PDATKFSSAS ADKTAKIWSF ESHSPLHELR GHEGCVRCSV
FSGDSALLAT GDDNGEIRIW NVSTGQRLHS CVPVTVEKGE TAFVGWVTDL RFSPDSRTLV
SAGAYLKWWN VDTGESLQTF YTNGTNLKTI HVSPSFKTYV TVDNLGILYV LQALE


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