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Appetite-regulating hormone (Growth hormone secretagogue) (Growth hormone-releasing peptide) (Motilin-related peptide) [Cleaved into: Ghrelin; Obestatin]

 GHRL_CAPHI              Reviewed;         116 AA.
Q6BEG7;
27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
13-SEP-2004, sequence version 1.
05-JUL-2017, entry version 58.
RecName: Full=Appetite-regulating hormone;
AltName: Full=Growth hormone secretagogue;
AltName: Full=Growth hormone-releasing peptide;
AltName: Full=Motilin-related peptide;
Contains:
RecName: Full=Ghrelin;
Contains:
RecName: Full=Obestatin;
Flags: Precursor;
Name=GHRL;
Capra hircus (Goat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Caprinae; Capra.
NCBI_TaxID=9925;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Stomach;
Lin X., Miyazato M., Kaiya H., Ida T., Kangawa K.;
"cDNA cloning of feline and caprine ghrelin.";
Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Ghrelin is the ligand for growth hormone secretagogue
receptor type 1 (GHSR). Induces the release of growth hormone from
the pituitary. Has an appetite-stimulating effect, induces
adiposity and stimulates gastric acid secretion. Involved in
growth regulation (By similarity). {ECO:0000250}.
-!- FUNCTION: Obestatin may be the ligand for GPR39. May have an
appetite-reducing effect resulting in decreased food intake. May
reduce gastric emptying activity and jejunal motility (By
similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Secreted.
-!- PTM: O-octanoylation is essential for ghrelin activity.
{ECO:0000250}.
-!- PTM: Amidation of Leu-97 is essential for obestatin activity.
{ECO:0000250}.
-!- SIMILARITY: Belongs to the motilin family. {ECO:0000305}.
-!- WEB RESOURCE: Name=Protein Spotlight; Note=Gut feelings - Issue 66
of January 2006;
URL="http://web.expasy.org/spotlight/back_issues/066";
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EMBL; AB089200; BAD34669.1; -; mRNA.
RefSeq; XP_017893717.1; XM_018038228.1.
UniGene; Chi.38636; -.
iPTMnet; Q6BEG7; -.
GeneID; 100861189; -.
KEGG; chx:100861189; -.
CTD; 51738; -.
HOVERGEN; HBG018522; -.
KO; K05254; -.
OrthoDB; EOG091G0YG0; -.
GO; GO:0030424; C:axon; ISS:UniProtKB.
GO; GO:0005576; C:extracellular region; ISS:UniProtKB.
GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
GO; GO:0031768; F:ghrelin receptor binding; ISS:UniProtKB.
GO; GO:0016608; F:growth hormone-releasing hormone activity; ISS:UniProtKB.
GO; GO:0005179; F:hormone activity; ISS:UniProtKB.
GO; GO:0030296; F:protein tyrosine kinase activator activity; ISS:UniProtKB.
GO; GO:0008154; P:actin polymerization or depolymerization; ISS:UniProtKB.
GO; GO:0000187; P:activation of MAPK activity; ISS:UniProtKB.
GO; GO:0046697; P:decidualization; ISS:UniProtKB.
GO; GO:0016358; P:dendrite development; ISS:UniProtKB.
GO; GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.
GO; GO:0001937; P:negative regulation of endothelial cell proliferation; ISS:UniProtKB.
GO; GO:0050728; P:negative regulation of inflammatory response; ISS:UniProtKB.
GO; GO:0046676; P:negative regulation of insulin secretion; ISS:UniProtKB.
GO; GO:0032691; P:negative regulation of interleukin-1 beta production; ISS:UniProtKB.
GO; GO:0045409; P:negative regulation of interleukin-6 biosynthetic process; ISS:UniProtKB.
GO; GO:0042536; P:negative regulation of tumor necrosis factor biosynthetic process; ISS:UniProtKB.
GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; ISS:UniProtKB.
GO; GO:0032024; P:positive regulation of insulin secretion; ISS:UniProtKB.
GO; GO:0032097; P:positive regulation of response to food; ISS:UniProtKB.
GO; GO:0051965; P:positive regulation of synapse assembly; ISS:UniProtKB.
GO; GO:0042127; P:regulation of cell proliferation; ISS:UniProtKB.
GO; GO:0032095; P:regulation of response to food; ISS:UniProtKB.
GO; GO:0043627; P:response to estrogen; ISS:UniProtKB.
GO; GO:0009725; P:response to hormone; ISS:UniProtKB.
InterPro; IPR006737; Motilin_assoc.
InterPro; IPR006738; Motilin_ghrelin.
InterPro; IPR005441; Preproghrelin.
PANTHER; PTHR14122; PTHR14122; 1.
Pfam; PF04643; Motilin_assoc; 1.
Pfam; PF04644; Motilin_ghrelin; 1.
PRINTS; PR01624; GHRELIN.
3: Inferred from homology;
Amidation; Hormone; Lipoprotein; Secreted; Signal.
SIGNAL 1 23 {ECO:0000250}.
PEPTIDE 24 50 Ghrelin. {ECO:0000250}.
/FTId=PRO_0000019198.
PROPEP 51 74 Removed in mature form. {ECO:0000250}.
/FTId=PRO_0000019199.
PEPTIDE 75 97 Obestatin. {ECO:0000250}.
/FTId=PRO_0000045136.
PROPEP 98 116 Removed in mature form. {ECO:0000250}.
/FTId=PRO_0000045137.
MOD_RES 97 97 Leucine amide. {ECO:0000250}.
LIPID 26 26 O-octanoyl serine. {ECO:0000250}.
SEQUENCE 116 AA; 12935 MW; CDA67971D72E3303 CRC64;
MPAPRTICSL LLLSMLWMDL AMAGSSFLSP EHQKLQRKEP KKPSGRLKPR ALEGQFDPDV
GSQEEGAEDE LEIRFNAPFN IGIKLSGAQS LQHGQTLGKF LQDILWEEAE ETLADE


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