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Aquaporin-1 (AQP-1) (Aquaporin-CHIP) (Water channel protein CHIP29) (Water channel protein for red blood cells and kidney proximal tubule)

 AQP1_BOVIN              Reviewed;         271 AA.
P47865; Q2HJE2;
01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
23-JAN-2007, sequence version 3.
28-MAR-2018, entry version 141.
RecName: Full=Aquaporin-1;
Short=AQP-1;
AltName: Full=Aquaporin-CHIP;
AltName: Full=Water channel protein CHIP29;
AltName: Full=Water channel protein for red blood cells and kidney proximal tubule;
Name=AQP1;
Bos taurus (Bovine).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Bovinae; Bos.
NCBI_TaxID=9913;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Ocular ciliary epithelium;
PubMed=7526855; DOI=10.1006/bbrc.1994.2539;
Patil R.V., Yang X., Saito I., Coca-Prados M., Wax M.B.;
"Cloning of a novel cDNA homologous to CHIP28 water channel from
ocular ciliary epithelium.";
Biochem. Biophys. Res. Commun. 204:861-866(1994).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Bone marrow;
Joshi S., Recinos A., Jap B.K.;
"Nucleotide sequence of an aquaporin cDNA from bovine bone marrow.";
Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
PubMed=16305752; DOI=10.1186/1471-2164-6-166;
Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
"Characterization of 954 bovine full-CDS cDNA sequences.";
BMC Genomics 6:166-166(2005).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=Hereford; TISSUE=Ascending colon;
NIH - Mammalian Gene Collection (MGC) project;
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
[5]
X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS).
PubMed=10957645; DOI=10.1107/S0907444900008143;
Sui H., Walian P.J., Tang G., Oh A., Jap B.K.;
"Crystallization and preliminary X-ray crystallographic analysis of
water channel AQP1.";
Acta Crystallogr. D 56:1198-1200(2000).
[6]
X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS).
PubMed=11780053; DOI=10.1038/414872a;
Sui H., Han B.-G., Lee J.K., Walian P., Jap B.K.;
"Structural basis of water-specific transport through the AQP1 water
channel.";
Nature 414:872-878(2001).
-!- FUNCTION: Forms a water-specific channel that provides the plasma
membranes of red cells and kidney proximal tubules with high
permeability to water, thereby permitting water to move in the
direction of an osmotic gradient.
-!- SUBUNIT: Homotetramer. Interacts with EPHB2; involved in endolymph
production in the inner ear. Identified in a complex with STOM (By
similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
-!- DOMAIN: Aquaporins contain two tandem repeats each containing
three membrane-spanning domains and a pore-forming loop with the
signature motif Asn-Pro-Ala (NPA).
-!- MISCELLANEOUS: Pharmacologically inhibited by submillimolar
concentrations of mercury.
-!- SIMILARITY: Belongs to the MIP/aquaporin (TC 1.A.8) family.
{ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; S74759; AAB32365.1; -; mRNA.
EMBL; AF028005; AAB84190.1; -; mRNA.
EMBL; BT025412; ABF57368.1; -; mRNA.
EMBL; BC105525; AAI05526.1; -; mRNA.
PIR; JC2348; JC2348.
RefSeq; NP_777127.1; NM_174702.3.
UniGene; Bt.1525; -.
PDB; 1J4N; X-ray; 2.20 A; A=1-271.
PDBsum; 1J4N; -.
ProteinModelPortal; P47865; -.
SMR; P47865; -.
STRING; 9913.ENSBTAP00000000993; -.
PaxDb; P47865; -.
PRIDE; P47865; -.
Ensembl; ENSBTAT00000000993; ENSBTAP00000000993; ENSBTAG00000000745.
GeneID; 282653; -.
KEGG; bta:282653; -.
CTD; 358; -.
eggNOG; KOG0223; Eukaryota.
eggNOG; COG0580; LUCA.
GeneTree; ENSGT00760000119223; -.
HOGENOM; HOG000288286; -.
HOVERGEN; HBG000312; -.
InParanoid; P47865; -.
KO; K09864; -.
OMA; ELFGTFW; -.
OrthoDB; EOG091G166T; -.
TreeFam; TF312940; -.
Reactome; R-BTA-1237044; Erythrocytes take up carbon dioxide and release oxygen.
Reactome; R-BTA-1247673; Erythrocytes take up oxygen and release carbon dioxide.
Reactome; R-BTA-432040; Vasopressin regulates renal water homeostasis via Aquaporins.
Reactome; R-BTA-432047; Passive transport by Aquaporins.
EvolutionaryTrace; P47865; -.
Proteomes; UP000009136; Chromosome 4.
Bgee; ENSBTAG00000000745; -.
GO; GO:0045177; C:apical part of cell; ISS:UniProtKB.
GO; GO:0016324; C:apical plasma membrane; ISS:UniProtKB.
GO; GO:0030424; C:axon; IEA:Ensembl.
GO; GO:0009925; C:basal plasma membrane; ISS:UniProtKB.
GO; GO:0016323; C:basolateral plasma membrane; ISS:UniProtKB.
GO; GO:0005903; C:brush border; ISS:UniProtKB.
GO; GO:0031526; C:brush border membrane; ISS:UniProtKB.
GO; GO:0005901; C:caveola; IEA:Ensembl.
GO; GO:0032127; C:dense core granule membrane; IDA:MGI.
GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
GO; GO:0031965; C:nuclear membrane; ISS:UniProtKB.
GO; GO:0005634; C:nucleus; ISS:UniProtKB.
GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
GO; GO:0042383; C:sarcolemma; ISS:UniProtKB.
GO; GO:0020003; C:symbiont-containing vacuole; IEA:Ensembl.
GO; GO:0008519; F:ammonium transmembrane transporter activity; ISS:UniProtKB.
GO; GO:0035379; F:carbon dioxide transmembrane transporter activity; ISS:UniProtKB.
GO; GO:0046875; F:ephrin receptor binding; IEA:Ensembl.
GO; GO:0015168; F:glycerol transmembrane transporter activity; ISS:UniProtKB.
GO; GO:0005223; F:intracellular cGMP activated cation channel activity; ISS:UniProtKB.
GO; GO:0030184; F:nitric oxide transmembrane transporter activity; ISS:UniProtKB.
GO; GO:0005267; F:potassium channel activity; ISS:UniProtKB.
GO; GO:0022857; F:transmembrane transporter activity; ISS:UniProtKB.
GO; GO:0015250; F:water channel activity; ISS:UniProtKB.
GO; GO:0005372; F:water transmembrane transporter activity; ISS:UniProtKB.
GO; GO:0072488; P:ammonium transmembrane transport; IBA:GO_Central.
GO; GO:0015696; P:ammonium transport; ISS:UniProtKB.
GO; GO:0048593; P:camera-type eye morphogenesis; IEA:Ensembl.
GO; GO:0035378; P:carbon dioxide transmembrane transport; ISS:UniProtKB.
GO; GO:0015670; P:carbon dioxide transport; ISS:UniProtKB.
GO; GO:0006884; P:cell volume homeostasis; ISS:UniProtKB.
GO; GO:0019725; P:cellular homeostasis; ISS:UniProtKB.
GO; GO:0071474; P:cellular hyperosmotic response; ISS:UniProtKB.
GO; GO:0071320; P:cellular response to cAMP; ISS:UniProtKB.
GO; GO:0071280; P:cellular response to copper ion; ISS:UniProtKB.
GO; GO:0071549; P:cellular response to dexamethasone stimulus; ISS:UniProtKB.
GO; GO:0070301; P:cellular response to hydrogen peroxide; ISS:UniProtKB.
GO; GO:0071456; P:cellular response to hypoxia; ISS:UniProtKB.
GO; GO:0071241; P:cellular response to inorganic substance; ISS:UniProtKB.
GO; GO:0071260; P:cellular response to mechanical stimulus; ISS:UniProtKB.
GO; GO:0071288; P:cellular response to mercury ion; ISS:UniProtKB.
GO; GO:0071300; P:cellular response to retinoic acid; ISS:UniProtKB.
GO; GO:0071472; P:cellular response to salt stress; ISS:UniProtKB.
GO; GO:0034644; P:cellular response to UV; ISS:UniProtKB.
GO; GO:0006182; P:cGMP biosynthetic process; ISS:UniProtKB.
GO; GO:0051458; P:corticotropin secretion; IEA:Ensembl.
GO; GO:0030950; P:establishment or maintenance of actin cytoskeleton polarity; ISS:UniProtKB.
GO; GO:0003094; P:glomerular filtration; IEA:Ensembl.
GO; GO:0015793; P:glycerol transport; ISS:UniProtKB.
GO; GO:0021670; P:lateral ventricle development; ISS:UniProtKB.
GO; GO:0044241; P:lipid digestion; IEA:Ensembl.
GO; GO:0085018; P:maintenance of symbiont-containing vacuole by host; ISS:UniProtKB.
GO; GO:0072220; P:metanephric descending thin limb development; IEA:Ensembl.
GO; GO:0072239; P:metanephric glomerulus vasculature development; IEA:Ensembl.
GO; GO:0072232; P:metanephric proximal convoluted tubule segment 2 development; IEA:Ensembl.
GO; GO:0072230; P:metanephric proximal straight tubule development; IEA:Ensembl.
GO; GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.
GO; GO:0030185; P:nitric oxide transport; ISS:UniProtKB.
GO; GO:0045766; P:positive regulation of angiogenesis; ISS:UniProtKB.
GO; GO:0030335; P:positive regulation of cell migration; IEA:Ensembl.
GO; GO:0048146; P:positive regulation of fibroblast proliferation; ISS:UniProtKB.
GO; GO:0046878; P:positive regulation of saliva secretion; ISS:UniProtKB.
GO; GO:0070295; P:renal water absorption; IEA:Ensembl.
GO; GO:0003097; P:renal water transport; ISS:UniProtKB.
GO; GO:0042493; P:response to drug; ISS:UniProtKB.
GO; GO:0033363; P:secretory granule organization; IEA:Ensembl.
GO; GO:0019233; P:sensory perception of pain; IEA:Ensembl.
GO; GO:0035377; P:transepithelial water transport; ISS:UniProtKB.
GO; GO:0006833; P:water transport; ISS:UniProtKB.
GO; GO:0042060; P:wound healing; IEA:Ensembl.
CDD; cd00333; MIP; 1.
Gene3D; 1.20.1080.10; -; 1.
InterPro; IPR023271; Aquaporin-like.
InterPro; IPR023274; Aquaporin_1.
InterPro; IPR034294; Aquaporin_transptr.
InterPro; IPR000425; MIP.
InterPro; IPR022357; MIP_CS.
PANTHER; PTHR19139; PTHR19139; 1.
Pfam; PF00230; MIP; 1.
PRINTS; PR02013; AQUAPORIN1.
PRINTS; PR00783; MINTRINSICP.
SUPFAM; SSF81338; SSF81338; 1.
TIGRFAMs; TIGR00861; MIP; 1.
PROSITE; PS00221; MIP; 1.
1: Evidence at protein level;
3D-structure; Cell membrane; Complete proteome; Glycoprotein;
Membrane; Phosphoprotein; Reference proteome; Repeat; Transmembrane;
Transmembrane helix; Transport.
CHAIN 1 271 Aquaporin-1.
/FTId=PRO_0000063918.
TOPO_DOM 1 9 Cytoplasmic.
TRANSMEM 10 34 Helical; Name=Helix 1.
TOPO_DOM 35 50 Extracellular.
TRANSMEM 51 68 Helical; Name=Helix 2.
TOPO_DOM 69 73 Cytoplasmic.
INTRAMEM 74 78
INTRAMEM 79 88 Helical; Name=Helix B.
TOPO_DOM 89 92 Cytoplasmic.
TRANSMEM 93 117 Helical; Name=Helix 3.
TOPO_DOM 118 142 Extracellular.
TRANSMEM 143 158 Helical; Name=Helix 4.
TOPO_DOM 159 169 Cytoplasmic.
TRANSMEM 170 187 Helical; Name=Helix 5.
TOPO_DOM 188 189 Extracellular.
INTRAMEM 190 193
INTRAMEM 194 204 Helical; Name=Helix E.
TOPO_DOM 205 215 Extracellular.
TRANSMEM 216 230 Helical; Name=Helix 6.
TOPO_DOM 231 271 Cytoplasmic.
MOTIF 78 80 NPA 1.
MOTIF 194 196 NPA 2.
COMPBIAS 161 164 Poly-Arg.
SITE 58 58 Substrate discrimination.
SITE 182 182 Substrate discrimination.
SITE 191 191 Hg(2+)-sensitive residue.
SITE 197 197 Substrate discrimination.
MOD_RES 249 249 Phosphoserine.
{ECO:0000250|UniProtKB:Q02013}.
MOD_RES 255 255 Phosphotyrosine.
{ECO:0000250|UniProtKB:Q02013}.
MOD_RES 264 264 Phosphoserine.
{ECO:0000250|UniProtKB:Q02013}.
CARBOHYD 42 42 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
HELIX 6 33 {ECO:0000244|PDB:1J4N}.
HELIX 34 36 {ECO:0000244|PDB:1J4N}.
HELIX 51 73 {ECO:0000244|PDB:1J4N}.
HELIX 79 87 {ECO:0000244|PDB:1J4N}.
HELIX 93 117 {ECO:0000244|PDB:1J4N}.
TURN 118 120 {ECO:0000244|PDB:1J4N}.
HELIX 139 141 {ECO:0000244|PDB:1J4N}.
HELIX 142 158 {ECO:0000244|PDB:1J4N}.
HELIX 170 189 {ECO:0000244|PDB:1J4N}.
HELIX 195 204 {ECO:0000244|PDB:1J4N}.
TURN 209 212 {ECO:0000244|PDB:1J4N}.
HELIX 213 230 {ECO:0000244|PDB:1J4N}.
TURN 231 233 {ECO:0000244|PDB:1J4N}.
HELIX 240 244 {ECO:0000244|PDB:1J4N}.
HELIX 245 247 {ECO:0000244|PDB:1J4N}.
SEQUENCE 271 AA; 28800 MW; 3A1C9A2071CDA5E4 CRC64;
MASEFKKKLF WRAVVAEFLA MILFIFISIG SALGFHYPIK SNQTTGAVQD NVKVSLAFGL
SIATLAQSVG HISGAHLNPA VTLGLLLSCQ ISVLRAIMYI IAQCVGAIVA TAILSGITSS
LPDNSLGLNA LAPGVNSGQG LGIEIIGTLQ LVLCVLATTD RRRRDLGGSG PLAIGFSVAL
GHLLAIDYTG CGINPARSFG SSVITHNFQD HWIFWVGPFI GAALAVLIYD FILAPRSSDL
TDRVKVWTSG QVEEYDLDAD DINSRVEMKP K


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