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Aquaporin-1 (AQP-1) (Aquaporin-CHIP) (Water channel protein for red blood cells and kidney proximal tubule)

 AQP1_CANLF              Reviewed;         271 AA.
Q9N2J4;
12-APR-2005, integrated into UniProtKB/Swiss-Prot.
23-JAN-2007, sequence version 3.
10-OCT-2018, entry version 118.
RecName: Full=Aquaporin-1;
Short=AQP-1;
AltName: Full=Aquaporin-CHIP;
AltName: Full=Water channel protein for red blood cells and kidney proximal tubule;
Name=AQP1;
Canis lupus familiaris (Dog) (Canis familiaris).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;
Canis.
NCBI_TaxID=9615;
[1]
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND SUBCELLULAR LOCATION.
STRAIN=Shiba; TISSUE=Kidney;
PubMed=10675514; DOI=10.1016/S0005-2736(99)00218-7;
Higa K., Ochiai H., Fujise H.;
"Molecular cloning and expression of aquaporin 1 (AQP1) in dog kidney
and erythroblasts.";
Biochim. Biophys. Acta 1463:374-382(2000).
-!- FUNCTION: Forms a water-specific channel that provides the plasma
membranes of red cells and kidney proximal tubules with high
permeability to water, thereby permitting water to move in the
direction of an osmotic gradient. {ECO:0000269|PubMed:10675514}.
-!- SUBUNIT: Homotetramer (By similarity). Interacts with EPHB2;
involved in endolymph production in the inner ear. Identified in a
complex with STOM (By similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10675514};
Multi-pass membrane protein {ECO:0000269|PubMed:10675514}.
-!- DOMAIN: Aquaporins contain two tandem repeats each containing
three membrane-spanning domains and a pore-forming loop with the
signature motif Asn-Pro-Ala (NPA).
-!- MISCELLANEOUS: Pharmacologically inhibited by submillimolar
concentrations of mercury. {ECO:0000250}.
-!- SIMILARITY: Belongs to the MIP/aquaporin (TC 1.A.8) family.
{ECO:0000305}.
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EMBL; AB011373; BAA93428.1; -; mRNA.
RefSeq; NP_001003130.1; NM_001003130.1.
UniGene; Cfa.3591; -.
ProteinModelPortal; Q9N2J4; -.
SMR; Q9N2J4; -.
STRING; 9615.ENSCAFP00000004614; -.
PaxDb; Q9N2J4; -.
PRIDE; Q9N2J4; -.
Ensembl; ENSCAFT00000004976; ENSCAFP00000004614; ENSCAFG00000003102.
GeneID; 403732; -.
KEGG; cfa:403732; -.
CTD; 358; -.
eggNOG; KOG0223; Eukaryota.
eggNOG; COG0580; LUCA.
GeneTree; ENSGT00760000119223; -.
HOGENOM; HOG000288286; -.
HOVERGEN; HBG000312; -.
InParanoid; Q9N2J4; -.
KO; K09864; -.
OMA; ELFGTFW; -.
OrthoDB; EOG091G166T; -.
TreeFam; TF312940; -.
Reactome; R-CFA-1237044; Erythrocytes take up carbon dioxide and release oxygen.
Reactome; R-CFA-1247673; Erythrocytes take up oxygen and release carbon dioxide.
Reactome; R-CFA-432040; Vasopressin regulates renal water homeostasis via Aquaporins.
Reactome; R-CFA-432047; Passive transport by Aquaporins.
Proteomes; UP000002254; Chromosome 14.
Bgee; ENSCAFG00000003102; Expressed in 3 organ(s), highest expression level in adult mammalian kidney.
GO; GO:0045177; C:apical part of cell; ISS:UniProtKB.
GO; GO:0016324; C:apical plasma membrane; ISS:UniProtKB.
GO; GO:0030424; C:axon; IEA:Ensembl.
GO; GO:0009925; C:basal plasma membrane; ISS:UniProtKB.
GO; GO:0016323; C:basolateral plasma membrane; ISS:UniProtKB.
GO; GO:0005903; C:brush border; ISS:UniProtKB.
GO; GO:0031526; C:brush border membrane; ISS:UniProtKB.
GO; GO:0005901; C:caveola; IEA:Ensembl.
GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
GO; GO:0031965; C:nuclear membrane; ISS:UniProtKB.
GO; GO:0005634; C:nucleus; ISS:UniProtKB.
GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
GO; GO:0042383; C:sarcolemma; ISS:UniProtKB.
GO; GO:0020003; C:symbiont-containing vacuole; IEA:Ensembl.
GO; GO:0008519; F:ammonium transmembrane transporter activity; ISS:UniProtKB.
GO; GO:0035379; F:carbon dioxide transmembrane transporter activity; ISS:UniProtKB.
GO; GO:0046875; F:ephrin receptor binding; IEA:Ensembl.
GO; GO:0015168; F:glycerol transmembrane transporter activity; ISS:UniProtKB.
GO; GO:0005223; F:intracellular cGMP-activated cation channel activity; ISS:UniProtKB.
GO; GO:0030184; F:nitric oxide transmembrane transporter activity; ISS:UniProtKB.
GO; GO:0005267; F:potassium channel activity; ISS:UniProtKB.
GO; GO:0022857; F:transmembrane transporter activity; ISS:UniProtKB.
GO; GO:0015250; F:water channel activity; ISS:UniProtKB.
GO; GO:0005372; F:water transmembrane transporter activity; ISS:UniProtKB.
GO; GO:0072488; P:ammonium transmembrane transport; IBA:GO_Central.
GO; GO:0015696; P:ammonium transport; ISS:UniProtKB.
GO; GO:0048593; P:camera-type eye morphogenesis; IEA:Ensembl.
GO; GO:0035378; P:carbon dioxide transmembrane transport; ISS:UniProtKB.
GO; GO:0015670; P:carbon dioxide transport; ISS:UniProtKB.
GO; GO:0006884; P:cell volume homeostasis; ISS:UniProtKB.
GO; GO:0019725; P:cellular homeostasis; ISS:UniProtKB.
GO; GO:0071474; P:cellular hyperosmotic response; ISS:UniProtKB.
GO; GO:0071320; P:cellular response to cAMP; ISS:UniProtKB.
GO; GO:0071280; P:cellular response to copper ion; ISS:UniProtKB.
GO; GO:0071549; P:cellular response to dexamethasone stimulus; ISS:UniProtKB.
GO; GO:0070301; P:cellular response to hydrogen peroxide; ISS:UniProtKB.
GO; GO:0071456; P:cellular response to hypoxia; ISS:UniProtKB.
GO; GO:0071241; P:cellular response to inorganic substance; ISS:UniProtKB.
GO; GO:0071260; P:cellular response to mechanical stimulus; ISS:UniProtKB.
GO; GO:0071288; P:cellular response to mercury ion; ISS:UniProtKB.
GO; GO:0071300; P:cellular response to retinoic acid; ISS:UniProtKB.
GO; GO:0071472; P:cellular response to salt stress; ISS:UniProtKB.
GO; GO:0034644; P:cellular response to UV; ISS:UniProtKB.
GO; GO:0019934; P:cGMP-mediated signaling; ISS:UniProtKB.
GO; GO:0051458; P:corticotropin secretion; IEA:Ensembl.
GO; GO:0030950; P:establishment or maintenance of actin cytoskeleton polarity; ISS:UniProtKB.
GO; GO:0003094; P:glomerular filtration; IEA:Ensembl.
GO; GO:0015793; P:glycerol transport; ISS:UniProtKB.
GO; GO:0021670; P:lateral ventricle development; ISS:UniProtKB.
GO; GO:0044241; P:lipid digestion; IEA:Ensembl.
GO; GO:0085018; P:maintenance of symbiont-containing vacuole by host; ISS:UniProtKB.
GO; GO:0072220; P:metanephric descending thin limb development; IEA:Ensembl.
GO; GO:0072239; P:metanephric glomerulus vasculature development; IEA:Ensembl.
GO; GO:0072232; P:metanephric proximal convoluted tubule segment 2 development; IEA:Ensembl.
GO; GO:0072230; P:metanephric proximal straight tubule development; IEA:Ensembl.
GO; GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.
GO; GO:0030185; P:nitric oxide transport; ISS:UniProtKB.
GO; GO:0045766; P:positive regulation of angiogenesis; ISS:UniProtKB.
GO; GO:0030335; P:positive regulation of cell migration; IEA:Ensembl.
GO; GO:0048146; P:positive regulation of fibroblast proliferation; ISS:UniProtKB.
GO; GO:0046878; P:positive regulation of saliva secretion; ISS:UniProtKB.
GO; GO:0070295; P:renal water absorption; IEA:Ensembl.
GO; GO:0003097; P:renal water transport; ISS:UniProtKB.
GO; GO:0042493; P:response to drug; ISS:UniProtKB.
GO; GO:0033363; P:secretory granule organization; IEA:Ensembl.
GO; GO:0019233; P:sensory perception of pain; IEA:Ensembl.
GO; GO:0035377; P:transepithelial water transport; ISS:UniProtKB.
GO; GO:0006833; P:water transport; ISS:UniProtKB.
GO; GO:0042060; P:wound healing; IEA:Ensembl.
CDD; cd00333; MIP; 1.
Gene3D; 1.20.1080.10; -; 1.
InterPro; IPR023271; Aquaporin-like.
InterPro; IPR023274; Aquaporin_1.
InterPro; IPR034294; Aquaporin_transptr.
InterPro; IPR000425; MIP.
InterPro; IPR022357; MIP_CS.
PANTHER; PTHR19139; PTHR19139; 1.
Pfam; PF00230; MIP; 1.
PRINTS; PR02013; AQUAPORIN1.
PRINTS; PR00783; MINTRINSICP.
SUPFAM; SSF81338; SSF81338; 1.
TIGRFAMs; TIGR00861; MIP; 1.
PROSITE; PS00221; MIP; 1.
2: Evidence at transcript level;
Cell membrane; Complete proteome; Glycoprotein; Membrane;
Phosphoprotein; Reference proteome; Repeat; Transmembrane;
Transmembrane helix; Transport.
CHAIN 1 271 Aquaporin-1.
/FTId=PRO_0000063919.
TOPO_DOM 1 9 Cytoplasmic. {ECO:0000250}.
TRANSMEM 10 34 Helical; Name=Helix 1. {ECO:0000250}.
TOPO_DOM 35 50 Extracellular. {ECO:0000250}.
TRANSMEM 51 68 Helical; Name=Helix 2. {ECO:0000250}.
TOPO_DOM 69 73 Cytoplasmic. {ECO:0000250}.
INTRAMEM 74 78
INTRAMEM 79 88 Helical; Name=Helix B. {ECO:0000250}.
TOPO_DOM 89 92 Cytoplasmic. {ECO:0000250}.
TRANSMEM 93 117 Helical; Name=Helix 3. {ECO:0000250}.
TOPO_DOM 118 142 Extracellular. {ECO:0000250}.
TRANSMEM 143 158 Helical; Name=Helix 4. {ECO:0000250}.
TOPO_DOM 159 169 Cytoplasmic. {ECO:0000250}.
TRANSMEM 170 187 Helical; Name=Helix 5. {ECO:0000250}.
TOPO_DOM 188 189 Extracellular. {ECO:0000250}.
INTRAMEM 190 193
INTRAMEM 194 204 Helical; Name=Helix E. {ECO:0000250}.
TOPO_DOM 205 215 Extracellular. {ECO:0000250}.
TRANSMEM 216 230 Helical; Name=Helix 6. {ECO:0000250}.
TOPO_DOM 231 271 Cytoplasmic. {ECO:0000250}.
MOTIF 78 80 NPA 1.
MOTIF 194 196 NPA 2.
COMPBIAS 161 164 Poly-Arg.
SITE 58 58 Substrate discrimination. {ECO:0000250}.
SITE 182 182 Substrate discrimination. {ECO:0000250}.
SITE 191 191 Hg(2+)-sensitive residue. {ECO:0000250}.
SITE 197 197 Substrate discrimination. {ECO:0000250}.
MOD_RES 249 249 Phosphoserine.
{ECO:0000250|UniProtKB:Q02013}.
MOD_RES 255 255 Phosphotyrosine.
{ECO:0000250|UniProtKB:Q02013}.
MOD_RES 264 264 Phosphoserine.
{ECO:0000250|UniProtKB:Q02013}.
CARBOHYD 42 42 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
SEQUENCE 271 AA; 28799 MW; 36027BB358A99C52 CRC64;
MASEFKKKLF WRAVVAEFLA MILFVFISIG SALGFNYPVR NNQTAGAAQD NVKVSLAFGL
SIATLAQSVG HISGAHLNPA VTLGLLLSCQ ISILRAVMYI IAQCVGAIVA TAILSGITSS
LPDNSLGRNE LAPGVNSGQG LGIEIIGTLQ LVLCVLATTD RRRRDLGGSG PLAIGLSVAL
GHLLAIDYTG CGINPARSFG SSVITHNFKD HWIFWVGPFI GGALAVLIYD FILAPRSSDL
TDRVKVWTSG QVEEYELDGD DINSRVEMKP K


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