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Atypical chemokine receptor 1 (Duffy antigen/chemokine receptor) (Fy glycoprotein) (GpFy) (Glycoprotein D) (Plasmodium vivax receptor) (CD antigen CD234)

 ACKR1_HUMAN             Reviewed;         336 AA.
Q16570; A8YPG5; O75898; Q16300; Q8WWE3; Q9UJP0; Q9UKZ5; Q9UKZ6;
Q9UQE1;
01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
07-JUN-2005, sequence version 3.
27-SEP-2017, entry version 158.
RecName: Full=Atypical chemokine receptor 1;
AltName: Full=Duffy antigen/chemokine receptor;
AltName: Full=Fy glycoprotein;
Short=GpFy;
AltName: Full=Glycoprotein D;
AltName: Full=Plasmodium vivax receptor;
AltName: CD_antigen=CD234;
Name=ACKR1; Synonyms=DARC, FY, GPD;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PARTIAL PROTEIN SEQUENCE, AND
VARIANT ASP-42.
TISSUE=Bone marrow;
PubMed=8248172; DOI=10.1073/pnas.90.22.10793;
Chaudhuri A., Polyakova J., Zbrzezna V., Williams K., Gulati S.,
Pogo A.;
"Cloning of glycoprotein D cDNA, which encodes the major subunit of
the Duffy blood group system and the receptor for the Plasmodium vivax
malaria parasite.";
Proc. Natl. Acad. Sci. U.S.A. 90:10793-10797(1993).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT ASP-42.
TISSUE=Blood;
PubMed=7663520; DOI=10.1038/ng0695-224;
Tournamille C., Colin Y., Cartron J.-P., Le van Kim C.;
"Disruption of a GATA motif in the Duffy gene promoter abolishes
erythroid gene expression in Duffy-negative individuals.";
Nat. Genet. 10:224-228(1995).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
TISSUE=Blood;
PubMed=7833467;
Iwamoto S., Omi T., Kajii E., Ikemoto S.;
"Genomic organization of the glycoprotein D gene: Duffy blood group
Fya/Fyb alloantigen system is associated with a polymorphism at the
44-amino acid residue.";
Blood 85:622-626(1995).
[4]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 2), AND VARIANTS ASP-42;
CYS-89 AND THR-100.
TISSUE=Blood;
PubMed=9731074;
Tournamille C., Le Van Kim C., Gane P., Le Pennec P.Y., Roubinet F.,
Babinet J., Cartron J.-P., Colin Y.;
"Arg89Cys substitution results in very low membrane expression of the
Duffy antigen/receptor for chemokines in Fy(x) individuals.";
Blood 92:2147-2156(1998).
[5]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANTS ASP-42; CYS-89
AND THR-100.
PubMed=9886340; DOI=10.1046/j.1365-2141.1998.01083.x;
Olsson M.L., Smythe J.S., Hansson C., Poole J., Mallinson G.,
Jones J., Avent N.D., Daniels G.;
"The Fy(x) phenotype is associated with a missense mutation in the
Fy(b) allele predicting Arg89Cys in the Duffy glycoprotein.";
Br. J. Haematol. 103:1184-1191(1998).
[6]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT PHE-326.
TISSUE=Peripheral blood;
Doescher A.;
"New polymorphisms in DARC.";
Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases.
[7]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=16710414; DOI=10.1038/nature04727;
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A.,
Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K.,
Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D.,
Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G.,
Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M.,
Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J.,
Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M.,
Loveland J., Lovell J., Lush M.J., Lyne R., Martin S.,
Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S.,
Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C.,
Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z.,
Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E.,
Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A.,
Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R.,
Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V.,
Beck S., Rogers J., Bentley D.R.;
"The DNA sequence and biological annotation of human chromosome 1.";
Nature 441:315-321(2006).
[8]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANT
PHE-326.
TISSUE=Lung;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[9]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-117 (ISOFORMS 1 AND 2).
PubMed=10570183; DOI=10.1073/pnas.96.24.13973;
Zimmerman P.A., Woolley I., Masinde G.L., Miller S.M., McNamara D.T.,
Hazlett F., Mgone C.S., Alpers M.P., Genton B., Boatin B.A.,
Kazura J.W.;
"Emergence of FY*A(null) in a Plasmodium vivax-endemic region of Papua
New Guinea.";
Proc. Natl. Acad. Sci. U.S.A. 96:13973-13977(1999).
[10]
DISULFIDE BONDS, AND GLYCOSYLATION AT ASN-16.
PubMed=12956774; DOI=10.1046/j.1365-2141.2003.04533.x;
Tournamille C., Filipe A., Wasniowska K., Gane P., Lisowska E.,
Cartron J.-P., Colin Y., Le Van Kim C.;
"Structure-function analysis of the extracellular domains of the Duffy
antigen/receptor for chemokines: characterization of antibody and
chemokine binding sites.";
Br. J. Haematol. 122:1014-1023(2003).
[11]
POLYMORPHISM, AND INVOLVEMENT IN RESISTANCE TO MALARIA.
PubMed=17389925; DOI=10.1371/journal.pone.0000336;
Kasehagen L.J., Mueller I., Kiniboro B., Bockarie M.J., Reeder J.C.,
Kazura J.W., Kastens W., McNamara D.T., King C.H., Whalen C.C.,
Zimmerman P.A.;
"Reduced Plasmodium vivax erythrocyte infection in PNG Duffy-negative
heterozygotes.";
PLoS ONE 2:E336-E336(2007).
[12]
REVIEW.
PubMed=20373092; DOI=10.1007/82_2010_19;
Bonecchi R., Savino B., Borroni E.M., Mantovani A., Locati M.;
"Chemokine decoy receptors: structure-function and biological
properties.";
Curr. Top. Microbiol. Immunol. 341:15-36(2010).
[13]
REVIEW.
PubMed=22912641; DOI=10.3389/fimmu.2012.00266;
Novitzky-Basso I., Rot A.;
"Duffy antigen receptor for chemokines and its involvement in
patterning and control of inflammatory chemokines.";
Front. Immunol. 3:266-266(2012).
[14]
REVIEW.
PubMed=22698181; DOI=10.1016/j.imlet.2012.04.004;
Graham G.J., Locati M., Mantovani A., Rot A., Thelen M.;
"The biochemistry and biology of the atypical chemokine receptors.";
Immunol. Lett. 145:30-38(2012).
[15]
REVIEW.
PubMed=23356288; DOI=10.1042/BST20120246;
Cancellieri C., Vacchini A., Locati M., Bonecchi R., Borroni E.M.;
"Atypical chemokine receptors: from silence to sound.";
Biochem. Soc. Trans. 41:231-236(2013).
[16]
VARIANT ASP-42.
TISSUE=Peripheral blood;
PubMed=7705836; DOI=10.1007/BF00208965;
Tournamille C., Le van Kim C., Gane P., Cartron J.-P., Colin Y.;
"Molecular basis and PCR-DNA typing of the Fya/fyb blood group
polymorphism.";
Hum. Genet. 95:407-410(1995).
[17]
VARIANT CYS-89.
PubMed=9746760;
Parasol N., Reid M., Rios M., Castilho L., Harari I., Kosower N.S.;
"A novel mutation in the coding sequence of the FY*B allele of the
Duffy chemokine receptor gene is associated with an altered
erythrocyte phenotype.";
Blood 92:2237-2243(1998).
[18]
INVOLVEMENT IN WBCQ1.
PubMed=18179887; DOI=10.1016/j.ajhg.2007.09.003;
Nalls M.A., Wilson J.G., Patterson N.J., Tandon A., Zmuda J.M.,
Huntsman S., Garcia M., Hu D., Li R., Beamer B.A., Patel K.V.,
Akylbekova E.L., Files J.C., Hardy C.L., Buxbaum S.G., Taylor H.A.,
Reich D., Harris T.B., Ziv E.;
"Admixture mapping of white cell count: genetic locus responsible for
lower white blood cell count in the Health ABC and Jackson Heart
Studies.";
Am. J. Hum. Genet. 82:81-87(2008).
[19]
ERRATUM.
Nalls M.A., Wilson J.G., Patterson N.J., Tandon A., Zmuda J.M.,
Huntsman S., Garcia M., Hu D., Li R., Beamer B.A., Patel K.V.,
Akylbekova E.L., Files J.C., Hardy C.L., Buxbaum S.G., Taylor H.A.,
Reich D., Harris T.B., Ziv E.;
Am. J. Hum. Genet. 82:532-532(2008).
-!- FUNCTION: Atypical chemokine receptor that controls chemokine
levels and localization via high-affinity chemokine binding that
is uncoupled from classic ligand-driven signal transduction
cascades, resulting instead in chemokine sequestration,
degradation, or transcytosis. Also known as interceptor
(internalizing receptor) or chemokine-scavenging receptor or
chemokine decoy receptor. Has a promiscuous chemokine-binding
profile, interacting with inflammatory chemokines of both the CXC
and the CC subfamilies but not with homeostatic chemokines. Acts
as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11,
CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES,
MCP-1, TARC and also for the malaria parasites P.vivax and
P.knowlesi. May regulate chemokine bioavailability and,
consequently, leukocyte recruitment through two distinct
mechanisms: when expressed in endothelial cells, it sustains the
abluminal to luminal transcytosis of tissue-derived chemokines and
their subsequent presentation to circulating leukocytes; when
expressed in erythrocytes, serves as blood reservoir of cognate
chemokines but also as a chemokine sink, buffering potential
surges in plasma chemokine levels.
-!- SUBCELLULAR LOCATION: Early endosome. Recycling endosome.
Membrane; Multi-pass membrane protein. Note=Predominantly
localizes to endocytic vesicles, and upon stimulation by the
ligand is internalized via caveolae. Once internalized, the ligand
dissociates from the receptor, and is targeted to degradation
while the receptor is recycled back to the cell membrane.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=2;
IsoId=Q16570-1; Sequence=Displayed;
Name=1;
IsoId=Q16570-2; Sequence=VSP_001323;
-!- TISSUE SPECIFICITY: Found in adult kidney, adult spleen, bone
marrow and fetal liver. In particular, it is expressed along
postcapillary venules throughout the body, except in the adult
liver. Erythroid cells and postcapillary venule endothelium are
the principle tissues expressing duffy. Fy(-A-B) individuals do
not express duffy in the bone marrow, however they do, in
postcapillary venule endothelium.
-!- POLYMORPHISM: DARC is responsible for the Duffy blood group system
(FY) [MIM:110700]. The molecular basis of the Fy(A)=Fy1/Fy(B)=Fy2
blood group antigens is a single variation in position 42; Gly-42
corresponds to Fy(A) and Asp-42 to Fy(B). Individuals that do not
produce the Duffy antigen (FY(A-B-)) are more resistant to
infection by the malarial parasite Plasmodium vivax. This allele
is found predominantly in population of African origin
[MIM:611162].
-!- POLYMORPHISM: Genetic variations in DARC define the white blood
cell count quantitative trait locus 1 (WBCQ1) [MIM:611862].
Peripheral white blood cell count (WBC) is a common clinical
measurement, used to determine evidence of acute infammation or
infection. Peripheral WBC is the sum of several cell types
including neutrophils and lymphocytes, which are the most common
types of WBC, as well as less common cell types such as
eosinophils, basophils, and monocytes. Elevated WBC has been
associated with risk of coronary heart disease, cancer, and all-
cause mortality. White blood cell levels have widespread clinical
applications including assessment of patients undergoing
chemotherapy and evaluation of infection.
-!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
Atypical chemokine receptor subfamily. {ECO:0000305}.
-!- WEB RESOURCE: Name=dbRBC/BGMUT; Note=Blood group antigen gene
mutation database;
URL="https://www.ncbi.nlm.nih.gov/gv/mhc/xslcgi.cgi?cmd=bgmut/systems_info&system=duffy";
-!- WEB RESOURCE: Name=Wikipedia; Note=Duffy antigen entry;
URL="https://en.wikipedia.org/wiki/Duffy_antigen";
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EMBL; U01839; AAC50055.1; -; mRNA.
EMBL; X85785; CAA59770.1; -; Genomic_DNA.
EMBL; S76830; AAB33239.1; -; Genomic_DNA.
EMBL; AF055992; AAC72301.1; -; Genomic_DNA.
EMBL; AF030521; AAD20435.1; -; mRNA.
EMBL; AM887935; CAP12644.1; -; Genomic_DNA.
EMBL; AL035403; CAB56228.1; -; Genomic_DNA.
EMBL; BC017817; AAH17817.1; -; mRNA.
EMBL; AF100634; AAF02415.1; -; Genomic_DNA.
EMBL; AF100634; AAF02416.1; -; Genomic_DNA.
CCDS; CCDS1183.1; -. [Q16570-1]
CCDS; CCDS44252.1; -. [Q16570-2]
PIR; I52608; I52608.
RefSeq; NP_001116423.1; NM_001122951.2. [Q16570-2]
RefSeq; NP_002027.2; NM_002036.3. [Q16570-1]
UniGene; Hs.153381; -.
PDB; 4NUU; X-ray; 1.95 A; C=16-43.
PDB; 4NUV; X-ray; 2.60 A; C/D=14-43.
PDBsum; 4NUU; -.
PDBsum; 4NUV; -.
ProteinModelPortal; Q16570; -.
SMR; Q16570; -.
BioGrid; 108808; 2.
DIP; DIP-3783N; -.
STRING; 9606.ENSP00000357103; -.
ChEMBL; CHEMBL2321626; -.
PhosphoSitePlus; Q16570; -.
BioMuta; DARC; -.
DMDM; 67476970; -.
PaxDb; Q16570; -.
PeptideAtlas; Q16570; -.
PRIDE; Q16570; -.
DNASU; 2532; -.
Ensembl; ENST00000368121; ENSP00000357103; ENSG00000213088. [Q16570-2]
Ensembl; ENST00000368122; ENSP00000357104; ENSG00000213088. [Q16570-1]
Ensembl; ENST00000537147; ENSP00000441985; ENSG00000213088. [Q16570-1]
GeneID; 2532; -.
KEGG; hsa:2532; -.
CTD; 2532; -.
DisGeNET; 2532; -.
EuPathDB; HostDB:ENSG00000213088.9; -.
GeneCards; ACKR1; -.
HGNC; HGNC:4035; ACKR1.
HPA; HPA016421; -.
HPA; HPA017672; -.
MalaCards; ACKR1; -.
MIM; 110700; phenotype.
MIM; 611162; phenotype.
MIM; 611862; phenotype.
MIM; 613665; gene.
neXtProt; NX_Q16570; -.
OpenTargets; ENSG00000213088; -.
PharmGKB; PA28451; -.
eggNOG; ENOG410IHK3; Eukaryota.
eggNOG; ENOG41119V5; LUCA.
GeneTree; ENSGT00390000006372; -.
HOVERGEN; HBG051419; -.
InParanoid; Q16570; -.
KO; K06574; -.
OMA; HCVATPL; -.
PhylomeDB; Q16570; -.
TreeFam; TF105419; -.
Reactome; R-HSA-375276; Peptide ligand-binding receptors.
GeneWiki; Duffy_antigen_system; -.
GenomeRNAi; 2532; -.
PRO; PR:Q16570; -.
Proteomes; UP000005640; Chromosome 1.
Bgee; ENSG00000213088; -.
CleanEx; HS_DARC; -.
ExpressionAtlas; Q16570; baseline and differential.
Genevisible; Q16570; HS.
GO; GO:0005769; C:early endosome; IEA:UniProtKB-SubCell.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005886; C:plasma membrane; TAS:Reactome.
GO; GO:0055037; C:recycling endosome; IEA:UniProtKB-SubCell.
GO; GO:0019957; F:C-C chemokine binding; IPI:BHF-UCL.
GO; GO:0004930; F:G-protein coupled receptor activity; IEA:UniProtKB-KW.
GO; GO:0004872; F:receptor activity; TAS:ProtInc.
GO; GO:0004888; F:transmembrane signaling receptor activity; TAS:ProtInc.
GO; GO:0070098; P:chemokine-mediated signaling pathway; IEA:InterPro.
GO; GO:0006952; P:defense response; NAS:UniProtKB.
GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
GO; GO:0032642; P:regulation of chemokine production; IBA:GO_Central.
CDD; cd15010; 7tmA_ACKR1_DARC; 1.
InterPro; IPR005384; Duffy_chemokine_rcpt.
PANTHER; PTHR14181; PTHR14181; 1.
PRINTS; PR01559; DUFFYANTIGEN.
1: Evidence at protein level;
3D-structure; Alternative splicing; Blood group antigen;
Complete proteome; Direct protein sequencing; Disulfide bond;
Endosome; G-protein coupled receptor; Glycoprotein; Membrane;
Polymorphism; Receptor; Reference proteome; Transducer; Transmembrane;
Transmembrane helix.
CHAIN 1 336 Atypical chemokine receptor 1.
/FTId=PRO_0000152585.
TOPO_DOM 1 63 Extracellular. {ECO:0000255}.
TRANSMEM 64 84 Helical; Name=1. {ECO:0000255}.
TOPO_DOM 85 95 Cytoplasmic. {ECO:0000255}.
TRANSMEM 96 116 Helical; Name=2. {ECO:0000255}.
TOPO_DOM 117 129 Extracellular. {ECO:0000255}.
TRANSMEM 130 153 Helical; Name=3. {ECO:0000255}.
TOPO_DOM 154 166 Cytoplasmic. {ECO:0000255}.
TRANSMEM 167 187 Helical; Name=4. {ECO:0000255}.
TOPO_DOM 188 207 Extracellular. {ECO:0000255}.
TRANSMEM 208 228 Helical; Name=5. {ECO:0000255}.
TOPO_DOM 229 244 Cytoplasmic. {ECO:0000255}.
TRANSMEM 245 265 Helical; Name=6. {ECO:0000255}.
TOPO_DOM 266 287 Extracellular. {ECO:0000255}.
TRANSMEM 288 308 Helical; Name=7. {ECO:0000255}.
TOPO_DOM 309 336 Cytoplasmic. {ECO:0000255}.
CARBOHYD 16 16 N-linked (GlcNAc...) asparagine.
{ECO:0000269|PubMed:12956774}.
CARBOHYD 33 33 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 51 276 {ECO:0000269|PubMed:12956774}.
DISULFID 129 195 {ECO:0000269|PubMed:12956774}.
VAR_SEQ 1 7 MGNCLHR -> MASSGYVLQ (in isoform 1).
{ECO:0000303|PubMed:8248172,
ECO:0000303|PubMed:9886340}.
/FTId=VSP_001323.
VARIANT 42 42 G -> D (antigen Fy(b); dbSNP:rs12075).
{ECO:0000269|PubMed:7663520,
ECO:0000269|PubMed:7705836,
ECO:0000269|PubMed:8248172,
ECO:0000269|PubMed:9731074,
ECO:0000269|PubMed:9886340}.
/FTId=VAR_003480.
VARIANT 89 89 R -> C (antigen Fy(x); dbSNP:rs34599082).
{ECO:0000269|PubMed:9731074,
ECO:0000269|PubMed:9746760,
ECO:0000269|PubMed:9886340}.
/FTId=VAR_015068.
VARIANT 100 100 A -> T (in dbSNP:rs13962).
{ECO:0000269|PubMed:9731074,
ECO:0000269|PubMed:9886340}.
/FTId=VAR_015069.
VARIANT 203 203 L -> Q (in dbSNP:rs3027020).
/FTId=VAR_044116.
VARIANT 326 326 S -> F (in dbSNP:rs17851570).
{ECO:0000269|PubMed:15489334,
ECO:0000269|Ref.6}.
/FTId=VAR_044117.
HELIX 22 28 {ECO:0000244|PDB:4NUU}.
SEQUENCE 336 AA; 35553 MW; C3F2A3E71D972E2D CRC64;
MGNCLHRAEL SPSTENSSQL DFEDVWNSSY GVNDSFPDGD YGANLEAAAP CHSCNLLDDS
ALPFFILTSV LGILASSTVL FMLFRPLFRW QLCPGWPVLA QLAVGSALFS IVVPVLAPGL
GSTRSSALCS LGYCVWYGSA FAQALLLGCH ASLGHRLGAG QVPGLTLGLT VGIWGVAALL
TLPVTLASGA SGGLCTLIYS TELKALQATH TVACLAIFVL LPLGLFGAKG LKKALGMGPG
PWMNILWAWF IFWWPHGVVL GLDFLVRSKL LLLSTCLAQQ ALDLLLNLAE ALAILHCVAT
PLLLALFCHQ ATRTLLPSLP LPEGWSSHLD TLGSKS


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15-288-21049 C-C chemokine receptor type 6 - C-C CKR-6; CC-CKR-6; CCR-6; LARC receptor; GPR-CY4; GPRCY4; Chemokine receptor-like 3; CKR-L3; DRY6; G-protein coupled receptor 29; CD196 antigen Polyclonal 0.1 mg
15-288-21049 C-C chemokine receptor type 6 - C-C CKR-6; CC-CKR-6; CCR-6; LARC receptor; GPR-CY4; GPRCY4; Chemokine receptor-like 3; CKR-L3; DRY6; G-protein coupled receptor 29; CD196 antigen Polyclonal 0.05 mg
18-461-10471 C-C chemokine receptor type 6 - C-C CKR-6; CC-CKR-6; CCR-6; LARC receptor; GPR-CY4; GPRCY4; Chemokine receptor-like 3; CKR-L3; DRY6; G-protein coupled receptor 29; CD196 antigen Polyclonal 0.05 ml
18-461-10474 C-C chemokine receptor type 6 - C-C CKR-6; CC-CKR-6; CCR-6; LARC receptor; GPR-CY4; GPRCY4; Chemokine receptor-like 3; CKR-L3; DRY6; G-protein coupled receptor 29; CD196 antigen Polyclonal 0.05 ml
ACKR1_HUMAN Human ELISA Kit FOR Duffy antigen per chemokine receptor 96T
E0863Rb Bovine ELISA Kit FOR Duffy antigen per chemokine receptor 96T
EIAAB06213 C-C chemokine receptor-like 2,Ccr11,Ccrl2,Chemokine receptor CCR11,G-protein coupled beta chemokine receptor,Lccr,L-CCR,Lipopolysacharide-inducible C-C chemokine receptor,Mouse,Mus musculus
DUFFY_MOUSE ELISA Kit FOR Duffy antigen per chemokine receptor; organism: Mouse; gene name: Darc 96T
DUFFY_BOVIN ELISA Kit FOR Duffy antigen per chemokine receptor; organism: Bovine; gene name: DARC 96T
EIAAB06214 C-C chemokine receptor-like 2,CCR11,CCR6,CCRL2,Chemokine receptor CCR11,Chemokine receptor X,CKRX,CRAM,HCR,Homo sapiens,Human,Putative MCP-1 chemokine receptor
18-272-196971 Chemokine Receptor D6 - Goat polyclonal to Chemokine Receptor D6; Chemokine-binding protein D6; C-C chemokine receptor D6; Chemokine receptor CCR-9; Chemokine receptor CCR-10 Polyclonal 0.1 mg
EIAAB05877 C-C chemokine receptor D6,CCBP2,CCR10,Chemokine receptor CCR-10,Chemokine receptor CCR-9,Chemokine-binding protein 2,Chemokine-binding protein D6,CMKBR9,Homo sapiens,Human
E0670r ELISA kit Cd44,CD44 antigen,ECMR-III,Extracellular matrix receptor III,GP90 lymphocyte homing_adhesion receptor,Hermes antigen,HUTCH-I,Hyaluronate receptor,PGP-1,PGP-I,Phagocytic glycoprotein 1,Phago 96T
18-461-10328 C-C chemokine receptor-like 2 - Putative MCP-1 chemokine receptor; Chemokine receptor CCR11; Chemokine receptor X Polyclonal 0.05 ml
18-461-10329 C-C chemokine receptor-like 2 - Putative MCP-1 chemokine receptor; Chemokine receptor CCR11; Chemokine receptor X Polyclonal 0.05 ml
E0018h ELISA kit CCXCR1,Chemokine XC receptor 1,GPR5,G-protein coupled receptor 5,Homo sapiens,Human,Lymphotactin receptor,XC chemokine receptor 1,XCR1 96T
U0018h CLIA CCXCR1,Chemokine XC receptor 1,GPR5,G-protein coupled receptor 5,Homo sapiens,Human,Lymphotactin receptor,XC chemokine receptor 1,XCR1 96T
E0018h ELISA CCXCR1,Chemokine XC receptor 1,GPR5,G-protein coupled receptor 5,Homo sapiens,Human,Lymphotactin receptor,XC chemokine receptor 1,XCR1 96T
EIAAB25056 CD200 cell surface glycoprotein receptor,Cd200r1,Cell surface glycoprotein CD200 receptor 1,Cell surface glycoprotein OX2 receptor 1,Mox2r,OX102 antigen,Ox2r,Rat,Rattus norvegicus


 

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