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Aurora kinase (EC 2.7.11.1) (ApAurora)

 AURK_PATPE              Reviewed;         407 AA.
D7UQM5;
25-JAN-2012, integrated into UniProtKB/Swiss-Prot.
05-OCT-2010, sequence version 1.
22-NOV-2017, entry version 31.
RecName: Full=Aurora kinase {ECO:0000312|EMBL:BAJ10384.1};
EC=2.7.11.1 {ECO:0000250|UniProtKB:O14965};
AltName: Full=ApAurora {ECO:0000303|PubMed:21048162};
Name=aur {ECO:0000312|EMBL:BAJ10384.1};
Patiria pectinifera (Starfish) (Asterina pectinifera).
Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Asterozoa;
Asteroidea; Valvatacea; Valvatida; Asterinidae; Patiria.
NCBI_TaxID=7594;
[1] {ECO:0000305, ECO:0000312|EMBL:BAJ10384.1}
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, ENZYME REGULATION, SUBCELLULAR
LOCATION, DEVELOPMENTAL STAGE, AND MUTAGENESIS OF ASP-290.
TISSUE=Oocyte {ECO:0000269|PubMed:21048162};
PubMed=21048162; DOI=10.1242/jcs.076315;
Abe Y., Okumura E., Hosoya T., Hirota T., Kishimoto T.;
"A single starfish Aurora kinase performs the combined functions of
Aurora-A and Aurora-B in human cells.";
J. Cell Sci. 123:3978-3988(2010).
-!- FUNCTION: Serine/threonine protein kinase that contributes to the
regulation of cell cycle progression. Involved in meiotic
apparatus formation and polar body extrusion. Contributes to Plk1
activation and phosphorylation of histone H3 at 'Ser-10' during
meiosis I. Required for accurate progression of early embryonic M
phase. Involved in chromosome alignment and cleavage furrow
formation during early embryonic cycles. May be involved in
mitotic spindle formation and cytokinesis.
{ECO:0000269|PubMed:21048162}.
-!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
{ECO:0000250|UniProtKB:O14965}.
-!- ENZYME REGULATION: Cdc2 activity is required for activation.
{ECO:0000269|PubMed:21048162}.
-!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle
{ECO:0000269|PubMed:21048162}. Midbody
{ECO:0000269|PubMed:21048162}. Cytoplasm, cytoskeleton,
microtubule organizing center, centrosome
{ECO:0000269|PubMed:21048162}. Nucleus
{ECO:0000269|PubMed:21048162}. Chromosome
{ECO:0000269|PubMed:21048162}. Chromosome, centromere
{ECO:0000269|PubMed:21048162}. Note=Localized to cytoplasm in
immature oocytes. After 1-methyladenine-induced oocyte maturation
during meiosis I, becomes localized initially to the chromosomes,
then to both chromosomes and the meiotic spindle, and subsequently
relocates from the chromosomes to the midzone at anaphase onset.
{ECO:0000269|PubMed:21048162}.
-!- DEVELOPMENTAL STAGE: Expressed in immature oocytes. Expressed at
constant levels during meiosis and early embryonic cycles (at
protein level). {ECO:0000269|PubMed:21048162}.
-!- SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr
protein kinase family. {ECO:0000255|PROSITE-ProRule:PRU00159}.
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EMBL; AB530259; BAJ10384.1; -; mRNA.
ProteinModelPortal; D7UQM5; -.
SMR; D7UQM5; -.
GO; GO:0005813; C:centrosome; ISS:UniProtKB.
GO; GO:0000775; C:chromosome, centromeric region; IEA:UniProtKB-SubCell.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
GO; GO:0030496; C:midbody; IEA:UniProtKB-SubCell.
GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO; GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
GO; GO:0007275; P:multicellular organism development; IEA:UniProtKB-KW.
InterPro; IPR030616; Aur.
InterPro; IPR011009; Kinase-like_dom_sf.
InterPro; IPR000719; Prot_kinase_dom.
InterPro; IPR017441; Protein_kinase_ATP_BS.
InterPro; IPR008271; Ser/Thr_kinase_AS.
PANTHER; PTHR24350; PTHR24350; 1.
Pfam; PF00069; Pkinase; 1.
SMART; SM00220; S_TKc; 1.
SUPFAM; SSF56112; SSF56112; 1.
PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
1: Evidence at protein level;
ATP-binding; Cell cycle; Cell division; Centromere; Chromosome;
Cytoplasm; Cytoskeleton; Developmental protein; Kinase; Meiosis;
Mitosis; Nucleotide-binding; Nucleus; Serine/threonine-protein kinase;
Transferase.
CHAIN 1 407 Aurora kinase.
/FTId=PRO_0000415403.
DOMAIN 147 399 Protein kinase. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
NP_BIND 224 227 ATP. {ECO:0000250|UniProtKB:O14965,
ECO:0000255|PROSITE-ProRule:PRU00159}.
ACT_SITE 272 272 Proton acceptor.
{ECO:0000250|UniProtKB:O14965,
ECO:0000255|PROSITE-ProRule:PRU00159,
ECO:0000255|PROSITE-ProRule:PRU10027}.
BINDING 157 157 ATP; via amide nitrogen.
{ECO:0000250|UniProtKB:O14965,
ECO:0000255|PROSITE-ProRule:PRU00159}.
BINDING 176 176 ATP. {ECO:0000250|UniProtKB:O14965,
ECO:0000255|PROSITE-ProRule:PRU00159}.
BINDING 290 290 ATP. {ECO:0000250|UniProtKB:O14965,
ECO:0000255|PROSITE-ProRule:PRU00159}.
MUTAGEN 290 290 D->A: Loss of kinase activity.
{ECO:0000269|PubMed:21048162}.
SEQUENCE 407 AA; 45947 MW; 1A9DC847213E7216 CRC64;
MTPTGPSHHS MAPKRVLPAA SQSNMYGNIR SASTTSTTAS TSSQALRLLQ NAKTSKNADN
RIAHAERQGP PSAHPAAMQK PAARVAPSNE NRPDPAARQH QHQQQLQQQK ATGHDRVLKE
SQAGNSTTTT MTSTQSKEAN KWSLANFDIG RPLGKGKFGN VYLAREKKSK FIVALKVLFK
SQLQKAKVEH QLRREIEIQS HLRHDHILRL YGYFYDDTRV YLILEYAARG ELYKEMQAQK
AGHFDEDRSA VYIYQLAKAL LYCHEKKVIH RDIKPENLLL DLKGDLKIAD FGWSVHAPSS
RRATLCGTLD YLPPEMIEGK THDEKVDLWS LGVLCYEFLV GKPPFESQGN TETYRKITKV
EFTFPKHVSE GARDLICKLL KHNPSHRLSL EGVIAHAWIQ EKISQRS


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Catalog number Product name Quantity
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