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Aurora kinase C (EC 2.7.11.1) (Aurora 3) (Aurora/IPL1-related kinase 3) (ARK-3) (Aurora-related kinase 3) (Aurora/IPL1/Eg2 protein 1) (Serine/threonine-protein kinase 13) (Serine/threonine-protein kinase aurora-C)

 AURKC_MOUSE             Reviewed;         282 AA.
O88445; Q9JLC2;
17-JAN-2003, integrated into UniProtKB/Swiss-Prot.
01-NOV-1998, sequence version 1.
22-NOV-2017, entry version 133.
RecName: Full=Aurora kinase C;
EC=2.7.11.1;
AltName: Full=Aurora 3;
AltName: Full=Aurora/IPL1-related kinase 3;
Short=ARK-3;
Short=Aurora-related kinase 3;
AltName: Full=Aurora/IPL1/Eg2 protein 1;
AltName: Full=Serine/threonine-protein kinase 13;
AltName: Full=Serine/threonine-protein kinase aurora-C;
Name=Aurkc; Synonyms=Aie1, Aik3, Airk3, Ark3, Stk13;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=BALB/cJ;
PubMed=9809744; DOI=10.1089/dna.1998.17.823;
Tseng T.-C., Chen S.-H., Hsu Y.-P.P., Tang T.K.;
"Protein kinase profile of sperm and eggs: cloning and
characterization of two novel testis-specific protein kinases (AIE1,
AIE2) related to yeast and fly chromosome segregation regulators.";
DNA Cell Biol. 17:823-833(1998).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=129;
PubMed=11098217; DOI=10.1089/10445490050199063;
Hu H.M., Chuang C.K., Lee M.J., Tseng T.C., Tang T.K.;
"Genomic organization, expression, and chromosome localization of a
third aurora-related kinase gene, Aie1.";
DNA Cell Biol. 19:679-688(2000).
[3]
FUNCTION, MUTAGENESIS OF THR-171 AND THR-175, AND PHOSPHORYLATION AT
THR-171 BY PKA.
PubMed=11879579; DOI=10.1089/10445490252810302;
Chen S.H., Tang T.K.;
"Mutational analysis of the phosphorylation sites of the Aie1 (Aurora-
C) kinase in vitro.";
DNA Cell Biol. 21:41-46(2002).
[4]
FUNCTION.
PubMed=21613325; DOI=10.1242/dev.066381;
Fernandez-Miranda G., Trakala M., Martin J., Escobar B., Gonzalez A.,
Ghyselinck N.B., Ortega S., Canamero M., de Castro I.P., Malumbres M.;
"Genetic disruption of aurora B uncovers an essential role for aurora
C during early mammalian development.";
Development 138:2661-2672(2011).
-!- FUNCTION: Serine/threonine-protein kinase component of the
chromosomal passenger complex (CPC), a complex that acts as a key
regulator of mitosis. The CPC complex has essential functions at
the centromere in ensuring correct chromosome alignment and
segregation and is required for chromatin-induced microtubule
stabilization and spindle assembly. Plays also a role in meiosis
and more particularly in spermatogenesis. Has redundant cellular
functions with AURKB and can rescue an AURKB knockdown. Like
AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'.
AURKC phosphorylates the CPC complex subunits BIRC5/survivin and
INCENP leading to increased AURKC activity. Phosphorylates TACC1,
another protein involved in cell division, at 'Ser-228'.
{ECO:0000269|PubMed:11879579, ECO:0000269|PubMed:21613325}.
-!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
-!- ENZYME REGULATION: Okadaic acid, an inhibitor of protein
phosphatase 1 (PP1), protein phosphatase 2A (PP2A) and protein
phosphatase 5 (PP5), increases AURKC activity. AURKC is also
stabilized through its interaction with INCENP, which acts also as
an activator (By similarity). {ECO:0000250|UniProtKB:Q9UQB9}.
-!- SUBUNIT: Component of the chromosomal passenger complex (CPC)
composed of at least BIRC5/survivin, CDCA8/borealin, INCENP, AURKB
or AURKC; predominantly independent AURKB- and AURKC-containing
complexes exist; in the complex interacts directly with
BIRC5/survivin and INCENP. Interacts with TACC1.
{ECO:0000250|UniProtKB:Q9UQB9}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome
{ECO:0000250}. Chromosome, centromere
{ECO:0000250|UniProtKB:Q9UQB9}. Cytoplasm, cytoskeleton, spindle
{ECO:0000250|UniProtKB:Q9UQB9}. Note=Distributes in the condensed
chromosomes during prophase to metaphase. After entering anaphase,
there is a dissociation from separated chromosomes and a
redistribution to midzone microtubules, and finally remains in the
midbody during cytokinesis (By similarity).
{ECO:0000250|UniProtKB:Q9UQB9}.
-!- TISSUE SPECIFICITY: Expressed only in testis.
-!- DEVELOPMENTAL STAGE: Expressed on day 14 dpc in prepubertal
testis, expression reached its plateau on day 21 dpc and remained
at a high level in adult.
-!- SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr
protein kinase family. Aurora subfamily. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
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EMBL; AF054620; AAC25954.1; -; mRNA.
EMBL; AF195272; AAF25838.1; -; Genomic_DNA.
UniGene; Mm.261572; -.
ProteinModelPortal; O88445; -.
SMR; O88445; -.
STRING; 10090.ENSMUSP00000083426; -.
iPTMnet; O88445; -.
PhosphoSitePlus; O88445; -.
PaxDb; O88445; -.
PRIDE; O88445; -.
MGI; MGI:1321119; Aurkc.
eggNOG; KOG0580; Eukaryota.
eggNOG; ENOG410XNRB; LUCA.
HOVERGEN; HBG108519; -.
InParanoid; O88445; -.
PRO; PR:O88445; -.
Proteomes; UP000000589; Unplaced.
CleanEx; MM_AURKC; -.
GO; GO:0005694; C:chromosome; IDA:MGI.
GO; GO:0032133; C:chromosome passenger complex; IBA:GO_Central.
GO; GO:0000775; C:chromosome, centromeric region; IDA:MGI.
GO; GO:0000793; C:condensed chromosome; ISS:UniProtKB.
GO; GO:0000780; C:condensed nuclear chromosome, centromeric region; IBA:GO_Central.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
GO; GO:1990385; C:meiotic spindle midzone; IDA:MGI.
GO; GO:0030496; C:midbody; ISS:UniProtKB.
GO; GO:0005876; C:spindle microtubule; IBA:GO_Central.
GO; GO:0051233; C:spindle midzone; ISS:UniProtKB.
GO; GO:0031616; C:spindle pole centrosome; IBA:GO_Central.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0035174; F:histone serine kinase activity; IBA:GO_Central.
GO; GO:0004672; F:protein kinase activity; IDA:MGI.
GO; GO:0004712; F:protein serine/threonine/tyrosine kinase activity; IBA:GO_Central.
GO; GO:0000910; P:cytokinesis; IEA:InterPro.
GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
GO; GO:0007052; P:mitotic spindle organization; IBA:GO_Central.
GO; GO:0048599; P:oocyte development; IEA:InterPro.
GO; GO:0046777; P:protein autophosphorylation; IDA:MGI.
GO; GO:0006468; P:protein phosphorylation; ISS:UniProtKB.
GO; GO:0032465; P:regulation of cytokinesis; IBA:GO_Central.
GO; GO:0007283; P:spermatogenesis; IEA:InterPro.
GO; GO:0051255; P:spindle midzone assembly; IEA:InterPro.
InterPro; IPR030616; Aur.
InterPro; IPR030613; AURKC.
InterPro; IPR011009; Kinase-like_dom_sf.
InterPro; IPR000719; Prot_kinase_dom.
InterPro; IPR017441; Protein_kinase_ATP_BS.
InterPro; IPR008271; Ser/Thr_kinase_AS.
PANTHER; PTHR24350; PTHR24350; 1.
PANTHER; PTHR24350:SF3; PTHR24350:SF3; 1.
Pfam; PF00069; Pkinase; 1.
SMART; SM00220; S_TKc; 1.
SUPFAM; SSF56112; SSF56112; 1.
PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
1: Evidence at protein level;
ATP-binding; Cell cycle; Cell division; Centromere; Chromosome;
Complete proteome; Cytoplasm; Cytoskeleton; Kinase; Meiosis; Mitosis;
Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome;
Serine/threonine-protein kinase; Transferase.
CHAIN 1 282 Aurora kinase C.
/FTId=PRO_0000085661.
DOMAIN 16 266 Protein kinase. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
NP_BIND 22 30 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
ACT_SITE 139 139 Proton acceptor. {ECO:0000255|PROSITE-
ProRule:PRU00159, ECO:0000255|PROSITE-
ProRule:PRU10027}.
BINDING 45 45 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
MOD_RES 171 171 Phosphothreonine; by PKA.
{ECO:0000269|PubMed:11879579}.
MUTAGEN 171 171 T->A: Impairs kinase activity, when
associated with A-175.
{ECO:0000269|PubMed:11879579}.
MUTAGEN 175 175 T->A: Impairs kinase activity, when
associated with A-171.
{ECO:0000269|PubMed:11879579}.
CONFLICT 74 74 R -> P (in Ref. 2; AAF25838).
{ECO:0000305}.
SEQUENCE 282 AA; 32907 MW; 7CB8AEC4984B7883 CRC64;
MEPSTSTRKH FTINDFEIGR PLGRGKFGRV YLARLKENHF IVALKVLFKS EIEKEGLEHQ
LRREVEIQAH LQHRNILRLY NYFYDDTRIY LILEYAPGGE LYKELQRHQK LDQQRTATII
QELSDALTYC HEKKVIHRDI KPENLLLGLN GEVKISDFGW SVHTPSLRRK TMCGTLDYLP
PEMIAQKPYN EMVDLWCIGV LCYELLVGKP PFESSTSSET YRRIRQVDFK FPSSVPAGAQ
DLISKLLRYH PSERLSLAQV LKHPWVREHS RRVLPPCVHG AS


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