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Aurora kinase C (EC 2.7.11.1) (Aurora 3) (Aurora/IPL1-related kinase 3) (ARK-3) (Aurora-related kinase 3) (Aurora/IPL1/Eg2 protein 2) (Serine/threonine-protein kinase 13) (Serine/threonine-protein kinase aurora-C)

 AURKC_HUMAN             Reviewed;         309 AA.
Q9UQB9; O60681; O75442; Q6AZY8; Q6DLZ0; Q9UPK5;
17-JAN-2003, integrated into UniProtKB/Swiss-Prot.
01-MAY-2000, sequence version 1.
18-JUL-2018, entry version 174.
RecName: Full=Aurora kinase C;
EC=2.7.11.1;
AltName: Full=Aurora 3;
AltName: Full=Aurora/IPL1-related kinase 3;
Short=ARK-3;
Short=Aurora-related kinase 3;
AltName: Full=Aurora/IPL1/Eg2 protein 2;
AltName: Full=Serine/threonine-protein kinase 13;
AltName: Full=Serine/threonine-protein kinase aurora-C;
Name=AURKC; Synonyms=AIE2, AIK3, AIRK3, ARK3, STK13;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND SUBCELLULAR LOCATION.
TISSUE=Testis;
PubMed=9809744; DOI=10.1089/dna.1998.17.823;
Tseng T.-C., Chen S.-H., Hsu Y.-P.P., Tang T.K.;
"Protein kinase profile of sperm and eggs: cloning and
characterization of two novel testis-specific protein kinases (AIE1,
AIE2) related to yeast and fly chromosome segregation regulators.";
DNA Cell Biol. 17:823-833(1998).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
TISSUE=Placenta;
PubMed=9799611; DOI=10.1006/geno.1998.5522;
Bernard M., Sanseau P., Henry C., Couturier A., Prigent C.;
"Cloning of STK13, a third human protein kinase related to Drosophila
aurora and budding yeast Ipl1 that maps on chromosome 19q13.3-ter.";
Genomics 53:406-409(1998).
[3]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INDUCTION, AND SUBCELLULAR
LOCATION.
TISSUE=Testis;
PubMed=10066797; DOI=10.1074/jbc.274.11.7334;
Kimura M., Matsuda Y., Yoshioka T., Okano Y.;
"Cell cycle-dependent expression and centrosome localization of a
third human Aurora/Ipl1-related protein kinase, AIK3.";
J. Biol. Chem. 274:7334-7340(1999).
[4]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), TISSUE SPECIFICITY, FUNCTION,
MUTAGENESIS OF THR-198, AND SUBCELLULAR LOCATION.
PubMed=15670791; DOI=10.1016/j.bbrc.2004.12.168;
Yan X., Wu Y., Li Q., Cao L., Liu X., Saiyin H., Yu L.;
"Cloning and characterization of a novel human Aurora C splicing
variant.";
Biochem. Biophys. Res. Commun. 328:353-361(2005).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=15057824; DOI=10.1038/nature02399;
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
Rubin E.M., Lucas S.M.;
"The DNA sequence and biology of human chromosome 19.";
Nature 428:529-535(2004).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[7]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
TISSUE=Brain;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[8]
INDUCTION, FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH INCENP,
AND MUTAGENESIS OF LYS-72.
PubMed=15499654; DOI=10.1002/cm.20039;
Sasai K., Katayama H., Stenoien D.L., Fujii S., Honda R., Kimura M.,
Okano Y., Tatsuka M., Suzuki F., Nigg E.A., Earnshaw W.C.,
Brinkley W.R., Sen S.;
"Aurora-C kinase is a novel chromosomal passenger protein that can
complement Aurora-B kinase function in mitotic cells.";
Cell Motil. Cytoskeleton 59:249-263(2004).
[9]
IDENTIFICATION IN THE CDC COMPLEX, SUBCELLULAR LOCATION, ENZYME
REGULATION, FUNCTION, AND MUTAGENESIS OF LYS-72 AND THR-198.
PubMed=15316025; DOI=10.1074/jbc.M403029200;
Li X., Sakashita G., Matsuzaki H., Sugimoto K., Kimura K., Hanaoka F.,
Taniguchi H., Furukawa K., Urano T.;
"Direct association with inner centromere protein (INCENP) activates
the novel chromosomal passenger protein, Aurora-C.";
J. Biol. Chem. 279:47201-47211(2004).
[10]
IDENTIFICATION IN THE CDC COMPLEX, INTERACTION WITH BIRC5, SUBCELLULAR
LOCATION, FUNCTION, AND MUTAGENESIS OF ASP-166.
PubMed=15938719; DOI=10.1111/j.1365-2443.2005.00863.x;
Yan X., Cao L., Li Q., Wu Y., Zhang H., Saiyin H., Liu X., Zhang X.,
Shi Q., Yu L.;
"Aurora C is directly associated with Survivin and required for
cytokinesis.";
Genes Cells 10:617-626(2005).
[11]
INVOLVEMENT IN SPGF5.
PubMed=17435757; DOI=10.1038/ng2027;
Dieterich K., Soto Rifo R., Faure A.K., Hennebicq S., Ben Amar B.,
Zahi M., Perrin J., Martinez D., Sele B., Jouk P.-S., Ohlmann T.,
Rousseaux S., Lunardi J., Ray P.F.;
"Homozygous mutation of AURKC yields large-headed polyploid
spermatozoa and causes male infertility.";
Nat. Genet. 39:661-665(2007).
[12]
FUNCTION, SUBCELLULAR LOCATION, AND INTERACTION WITH TACC1.
PubMed=21531210; DOI=10.1016/j.bbrc.2011.04.078;
Gabillard J.C., Ulisse S., Baldini E., Sorrenti S., Cremet J.Y.,
Coccaro C., Prigent C., D'Armiento M., Arlot-Bonnemains Y.;
"Aurora-C interacts with and phosphorylates the transforming acidic
coiled-coil 1 protein.";
Biochem. Biophys. Res. Commun. 408:647-653(2011).
[13]
FUNCTION, AND SUBCELLULAR LOCATION.
PubMed=21493633; DOI=10.1093/humrep/der111;
Avo Santos M., van de Werken C., de Vries M., Jahr H., Vromans M.J.,
Laven J.S., Fauser B.C., Kops G.J., Lens S.M., Baart E.B.;
"A role for Aurora C in the chromosomal passenger complex during human
preimplantation embryo development.";
Hum. Reprod. 26:1868-1881(2011).
[14]
INVOLVEMENT IN SPGF5.
PubMed=21733974; DOI=10.1093/molehr/gar050;
Ben Khelifa M., Zouari R., Harbuz R., Halouani L., Arnoult C.,
Lunardi J., Ray P.F.;
"A new AURKC mutation causing macrozoospermia: implications for human
spermatogenesis and clinical diagnosis.";
Mol. Hum. Reprod. 17:762-768(2011).
[15]
INTERACTION WITH BIRC5, SUBUNIT, FUNCTION, AND SUBCELLULAR LOCATION.
PubMed=27332895; DOI=10.1371/journal.pone.0157305;
Sasai K., Katayama H., Hawke D.H., Sen S.;
"Aurora-C interactions with survivin and INCENP reveal shared and
distinct features compared with Aurora-B chromosome passenger protein
complex.";
PLoS ONE 11:E0157305-E0157305(2016).
[16]
VARIANTS [LARGE SCALE ANALYSIS] GLU-52; GLN-148 AND GLN-244.
PubMed=17344846; DOI=10.1038/nature05610;
Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C.,
Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S.,
O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S.,
Bhamra G., Buck G., Choudhury B., Clements J., Cole J., Dicks E.,
Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J.,
Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K.,
Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T.,
West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P.,
Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E.,
DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E.,
Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T.,
Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.;
"Patterns of somatic mutation in human cancer genomes.";
Nature 446:153-158(2007).
-!- FUNCTION: Serine/threonine-protein kinase component of the
chromosomal passenger complex (CPC), a complex that acts as a key
regulator of mitosis. The CPC complex has essential functions at
the centromere in ensuring correct chromosome alignment and
segregation and is required for chromatin-induced microtubule
stabilization and spindle assembly. Plays also a role in meiosis
and more particularly in spermatogenesis. Has redundant cellular
functions with AURKB and can rescue an AURKB knockdown. Like
AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'.
AURKC phosphorylates the CPC complex subunits BIRC5/survivin and
INCENP leading to increased AURKC activity. Phosphorylates TACC1,
another protein involved in cell division, at 'Ser-228'.
{ECO:0000269|PubMed:15316025, ECO:0000269|PubMed:15499654,
ECO:0000269|PubMed:15670791, ECO:0000269|PubMed:15938719,
ECO:0000269|PubMed:21493633, ECO:0000269|PubMed:21531210,
ECO:0000269|PubMed:27332895}.
-!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
-!- ENZYME REGULATION: Okadaic acid, an inhibitor of protein
phosphatase 1 (PP1), protein phosphatase 2A (PP2A) and protein
phosphatase 5 (PP5), increases AURKC activity. AURKC is also
stabilized through its interaction with INCENP, which acts also as
an activator. {ECO:0000269|PubMed:15316025}.
-!- SUBUNIT: Component of the chromosomal passenger complex (CPC)
composed of at least BIRC5/survivin, CDCA8/borealin, INCENP, AURKB
or AURKC; predominantly independent AURKB- and AURKC-containing
complexes exist; in the complex interacts directly with
BIRC5/survivin and INCENP. Interacts with TACC1.
{ECO:0000269|PubMed:15316025, ECO:0000269|PubMed:15499654,
ECO:0000269|PubMed:15938719, ECO:0000269|PubMed:21531210,
ECO:0000269|PubMed:27332895}.
-!- INTERACTION:
O15392:BIRC5; NbExp=10; IntAct=EBI-3926851, EBI-518823;
Q9NQS7:INCENP; NbExp=16; IntAct=EBI-3926851, EBI-307907;
-!- SUBCELLULAR LOCATION: Nucleus. Chromosome. Chromosome, centromere
{ECO:0000269|PubMed:27332895}. Cytoplasm, cytoskeleton, spindle
{ECO:0000269|PubMed:15938719}. Note=Distributes in the condensed
chromosomes during prophase to metaphase. After entering anaphase,
there is a dissociation from separated chromosomes and a
redistribution to midzone microtubules, and finally remains in the
midbody during cytokinesis. {ECO:0000269|PubMed:21531210}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=3;
Name=1;
IsoId=Q9UQB9-1; Sequence=Displayed;
Name=2;
IsoId=Q9UQB9-2; Sequence=VSP_004872;
Name=3; Synonyms=Aurora C-SV;
IsoId=Q9UQB9-3; Sequence=VSP_041095;
-!- TISSUE SPECIFICITY: Isoform 1 and isoform 2 are expressed in
testis. Elevated expression levels were seen only in a subset of
cancer cell lines such as Hep-G2, Huh-7 and HeLa. Expression is
maximum at M phase. {ECO:0000269|PubMed:15670791}.
-!- INDUCTION: Expression is cell cycle-regulated, with an increase
during G2 and M phases. {ECO:0000269|PubMed:10066797,
ECO:0000269|PubMed:15499654}.
-!- DISEASE: Spermatogenic failure 5 (SPGF5) [MIM:243060]: An
infertility disorder caused by spermatogenesis defects. Semen from
affected men show close to 100% morphologically abnormal
multiflagellar spermatozoa with low motility, oversized irregular
heads, and abnormal midpiece and acrosome.
{ECO:0000269|PubMed:17435757, ECO:0000269|PubMed:21733974}.
Note=The disease is caused by mutations affecting the gene
represented in this entry.
-!- SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr
protein kinase family. Aurora subfamily. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
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EMBL; AF054621; AAC25955.1; -; mRNA.
EMBL; AF059681; AAC77369.1; -; mRNA.
EMBL; AB017332; BAA76292.1; -; mRNA.
EMBL; AY661554; AAT64422.1; -; mRNA.
EMBL; AC005261; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; CH471135; EAW72485.1; -; Genomic_DNA.
EMBL; BC075064; AAH75064.2; -; mRNA.
CCDS; CCDS33128.1; -. [Q9UQB9-1]
CCDS; CCDS46205.1; -. [Q9UQB9-3]
CCDS; CCDS46206.1; -. [Q9UQB9-2]
RefSeq; NP_001015878.1; NM_001015878.1. [Q9UQB9-1]
RefSeq; NP_001015879.1; NM_001015879.1. [Q9UQB9-3]
RefSeq; NP_003151.2; NM_003160.2. [Q9UQB9-2]
UniGene; Hs.98338; -.
ProteinModelPortal; Q9UQB9; -.
SMR; Q9UQB9; -.
BioGrid; 112671; 26.
IntAct; Q9UQB9; 9.
STRING; 9606.ENSP00000302898; -.
BindingDB; Q9UQB9; -.
ChEMBL; CHEMBL3935; -.
GuidetoPHARMACOLOGY; 1938; -.
iPTMnet; Q9UQB9; -.
PhosphoSitePlus; Q9UQB9; -.
BioMuta; AURKC; -.
DMDM; 27805738; -.
EPD; Q9UQB9; -.
PaxDb; Q9UQB9; -.
PeptideAtlas; Q9UQB9; -.
PRIDE; Q9UQB9; -.
ProteomicsDB; 85538; -.
ProteomicsDB; 85539; -. [Q9UQB9-2]
ProteomicsDB; 85540; -. [Q9UQB9-3]
DNASU; 6795; -.
Ensembl; ENST00000302804; ENSP00000302898; ENSG00000105146. [Q9UQB9-1]
Ensembl; ENST00000415300; ENSP00000407162; ENSG00000105146. [Q9UQB9-3]
Ensembl; ENST00000598785; ENSP00000471830; ENSG00000105146. [Q9UQB9-2]
GeneID; 6795; -.
KEGG; hsa:6795; -.
UCSC; uc002qoc.4; human. [Q9UQB9-1]
CTD; 6795; -.
DisGeNET; 6795; -.
EuPathDB; HostDB:ENSG00000105146.12; -.
GeneCards; AURKC; -.
HGNC; HGNC:11391; AURKC.
HPA; HPA034859; -.
MalaCards; AURKC; -.
MIM; 243060; phenotype.
MIM; 603495; gene.
neXtProt; NX_Q9UQB9; -.
OpenTargets; ENSG00000105146; -.
Orphanet; 137893; Male infertility due to large-headed multiflagellar polyploid spermatozoa.
PharmGKB; PA36200; -.
eggNOG; KOG0580; Eukaryota.
eggNOG; ENOG410XNRB; LUCA.
GeneTree; ENSGT00910000144066; -.
HOGENOM; HOG000233016; -.
HOVERGEN; HBG108519; -.
InParanoid; Q9UQB9; -.
KO; K11480; -.
OMA; WVQAHSR; -.
OrthoDB; EOG091G0EU2; -.
PhylomeDB; Q9UQB9; -.
TreeFam; TF105331; -.
SignaLink; Q9UQB9; -.
SIGNOR; Q9UQB9; -.
GeneWiki; AURKC; -.
GenomeRNAi; 6795; -.
PRO; PR:Q9UQB9; -.
Proteomes; UP000005640; Chromosome 19.
Bgee; ENSG00000105146; -.
CleanEx; HS_AURKC; -.
ExpressionAtlas; Q9UQB9; baseline and differential.
Genevisible; Q9UQB9; HS.
GO; GO:0032133; C:chromosome passenger complex; TAS:UniProtKB.
GO; GO:0000793; C:condensed chromosome; IDA:UniProtKB.
GO; GO:0000780; C:condensed nuclear chromosome, centromeric region; IBA:GO_Central.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
GO; GO:0030496; C:midbody; IDA:UniProtKB.
GO; GO:0005819; C:spindle; TAS:UniProtKB.
GO; GO:0005876; C:spindle microtubule; IBA:GO_Central.
GO; GO:0051233; C:spindle midzone; IDA:UniProtKB.
GO; GO:0031616; C:spindle pole centrosome; IBA:GO_Central.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0035174; F:histone serine kinase activity; IBA:GO_Central.
GO; GO:0004672; F:protein kinase activity; IDA:UniProtKB.
GO; GO:0004712; F:protein serine/threonine/tyrosine kinase activity; TAS:UniProtKB.
GO; GO:0008608; P:attachment of spindle microtubules to kinetochore; TAS:UniProtKB.
GO; GO:0000910; P:cytokinesis; IEA:InterPro.
GO; GO:0016570; P:histone modification; TAS:UniProtKB.
GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
GO; GO:0051256; P:mitotic spindle midzone assembly; TAS:UniProtKB.
GO; GO:0048599; P:oocyte development; IEA:InterPro.
GO; GO:0032467; P:positive regulation of cytokinesis; TAS:UniProtKB.
GO; GO:0006468; P:protein phosphorylation; IDA:UniProtKB.
GO; GO:0007283; P:spermatogenesis; IEA:InterPro.
InterPro; IPR030616; Aur.
InterPro; IPR030613; AURKC.
InterPro; IPR011009; Kinase-like_dom_sf.
InterPro; IPR000719; Prot_kinase_dom.
InterPro; IPR017441; Protein_kinase_ATP_BS.
InterPro; IPR008271; Ser/Thr_kinase_AS.
PANTHER; PTHR24350; PTHR24350; 1.
PANTHER; PTHR24350:SF3; PTHR24350:SF3; 1.
Pfam; PF00069; Pkinase; 1.
SMART; SM00220; S_TKc; 1.
SUPFAM; SSF56112; SSF56112; 1.
PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
1: Evidence at protein level;
Alternative splicing; ATP-binding; Cell cycle; Cell division;
Centromere; Chromosome; Complete proteome; Cytoplasm; Cytoskeleton;
Kinase; Meiosis; Mitosis; Nucleotide-binding; Nucleus; Phosphoprotein;
Polymorphism; Reference proteome; Serine/threonine-protein kinase;
Transferase.
CHAIN 1 309 Aurora kinase C.
/FTId=PRO_0000085660.
DOMAIN 43 293 Protein kinase. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
NP_BIND 49 57 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
REGION 292 309 Interaction with BIRC5.
{ECO:0000269|PubMed:27332895}.
ACT_SITE 166 166 Proton acceptor. {ECO:0000255|PROSITE-
ProRule:PRU00159, ECO:0000255|PROSITE-
ProRule:PRU10027}.
BINDING 72 72 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
MOD_RES 198 198 Phosphothreonine; by PKA.
{ECO:0000250|UniProtKB:O88445}.
VAR_SEQ 1 34 Missing (in isoform 2).
{ECO:0000303|PubMed:15489334,
ECO:0000303|PubMed:9799611}.
/FTId=VSP_004872.
VAR_SEQ 1 20 MSSPRAVVQLGKAQPAGEEL -> M (in isoform 3).
{ECO:0000303|PubMed:15670791}.
/FTId=VSP_041095.
VARIANT 52 52 G -> E (in a lung adenocarcinoma sample;
somatic mutation).
{ECO:0000269|PubMed:17344846}.
/FTId=VAR_040385.
VARIANT 148 148 E -> Q (in a lung squamous cell carcinoma
sample; somatic mutation).
{ECO:0000269|PubMed:17344846}.
/FTId=VAR_040386.
VARIANT 244 244 H -> Q (in a lung adenocarcinoma sample;
somatic mutation).
{ECO:0000269|PubMed:17344846}.
/FTId=VAR_040387.
MUTAGEN 72 72 K->R: Impairs kinase activity.
{ECO:0000269|PubMed:15316025,
ECO:0000269|PubMed:15499654}.
MUTAGEN 166 166 D->Y: Impairs kinase activity, and keeps
AURKC with the chromosomes until the end
of mitosis.
{ECO:0000269|PubMed:15938719}.
MUTAGEN 198 198 T->A: Impairs kinase activity.
{ECO:0000269|PubMed:15316025,
ECO:0000269|PubMed:15670791}.
CONFLICT 109 109 Y -> H (in Ref. 1; AAC25955).
{ECO:0000305}.
CONFLICT 150 150 L -> V (in Ref. 2; AAC77369).
{ECO:0000305}.
CONFLICT 193 195 SLR -> LPE (in Ref. 2; AAC77369).
{ECO:0000305}.
SEQUENCE 309 AA; 35591 MW; 41B7DFCA91704201 CRC64;
MSSPRAVVQL GKAQPAGEEL ATANQTAQQP SSPAMRRLTV DDFEIGRPLG KGKFGNVYLA
RLKESHFIVA LKVLFKSQIE KEGLEHQLRR EIEIQAHLQH PNILRLYNYF HDARRVYLIL
EYAPRGELYK ELQKSEKLDE QRTATIIEEL ADALTYCHDK KVIHRDIKPE NLLLGFRGEV
KIADFGWSVH TPSLRRKTMC GTLDYLPPEM IEGRTYDEKV DLWCIGVLCY ELLVGYPPFE
SASHSETYRR ILKVDVRFPL SMPLGARDLI SRLLRYQPLE RLPLAQILKH PWVQAHSRRV
LPPCAQMAS


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18-272-196949 Aurora A - Rabbit polyclonal to Aurora A; EC 2.7.11.1; Aurora kinase A; Aurora-A; Serine_threonine kinase 15; Aurora_IPL1-related kinase 1; Aurora-related kinase 1; hARK1; Breast-tumor-amplified kinas 0.05 mg
18-272-195864 Aurora A - Rabbit polyclonal to Aurora A; EC 2.7.11.1; Aurora kinase A; Aurora-A; Serine_threonine kinase 15; Aurora_IPL1-related kinase 1; Aurora-related kinase 1; hARK1; Breast-tumor-amplified kinas 0.05 mg
18-783-76670 RABBIT ANTI HUMAN AURORA-A KINASE - STK6; EC 2.7.11.1; Aurora kinase A; Aurora-A; ratAurA Polyclonal 0.05 mg
MA-20115 Mouse Monoclonal Anti-Human aurora kinase B, AIK2 or aurora-B (AURKB) 100 ul
EIAAB31334 Bos taurus,Bovine,PKN,PKN1,PRK1,PRKCL1,Protein kinase C-like 1,Protein kinase C-like PKN,Protein kinase PKN-alpha,Protein-kinase C-related kinase 1,Serine_threonine-protein kinase N1,Serine-threonine
EIAAB31332 Mouse,Mus musculus,Pkn,Pkn1,Prk1,Prkcl1,Protein kinase C-like 1,Protein kinase C-like PKN,Protein-kinase C-related kinase 1,Serine_threonine-protein kinase N1,Serine-threonine protein kinase N
32-114 AURKB (aurora kinase B, AIK2 or aurora-B), with 344-amino acid protein(about 39kDa),localizes to microtubules near kinetochores, specifically to the specialized microtubules called K-fibers. AURKB is 0.1 mL
MA-20115 Mouse Monoclonal Anti-Human aurora kinase B, AIK2 or aurora-B (AURKB) Species Reactivity: Human 100 ul Product tipe: Antibodies
orb60146 PHA-739358 PHA-739358(Danusertib) is a pyrrolo-pyrazole and small molecule Aurora kinases and Bcr-Abl kinase inhibitor with IC50 of 13, 79, and 61 nM for Aurora A, B, and C, respectively. For research 5 mg
orb60267 JNJ-7706621 A Dual Inhibitor of Cyclin-Dependent Kinases and Aurora Kinases. In vitro kinase IC50 CDK1_Cyclin B(0.009 umol_L), Aurora-A(0.011 umol_L). For research use only. 1 mg
48-815 Aurora-Related Kinase 1 Antibody 0.05 mL
orb60430 Aurora A Inhibitor I Aurora A Inhibitor I is a selective Aurora A inhibitor (Aurora A IC50 at 0.0034 10 mg
20-321-175192 AURORA-A KINASE (CROSS REACTIVE WITH MOUSE) - MONOCLONAL ANTIBODY TO HUMAN AURORA-A KINASE (CROSS REACTIVE WITH MOUSE) Monoclonal 0.1 mg
40002 Aurora Kinase B Human Protein 10
40004 Aurora Kinase A Human Protein 10
80R-1199 Aurora Kinase B protein (His tag), Conjugated Proteins 100 ug
pka-355 Recombinant Human Aurora Kinase B PROTEIN KINASES 1mg
80R-1165 Aurora kinase A protein (His tag), Conjugated Proteins 50 ug
pka-350 Recombinant Human Aurora Kinase A PROTEIN KINASES 1mg
pka-355 Recombinant Human Aurora Kinase B PROTEIN KINASES 2
pka-350 Recombinant Human Aurora Kinase A PROTEIN KINASES 2
orb80774 Human Aurora Kinase A protein Proteins 2
pka-355 Recombinant Human Aurora Kinase B PROTEIN KINASES 10
pka-350 Recombinant Human Aurora Kinase A PROTEIN KINASES 10
orb80775 Human Aurora Kinase B protein Proteins 2


 

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