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Autophagy-related protein 31 (CIK1 suppressor protein 1) (Protein CIS1)

 ATG31_YEAST             Reviewed;         196 AA.
Q12421; D6VS08; Q03939;
20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
01-NOV-1996, sequence version 1.
27-SEP-2017, entry version 112.
RecName: Full=Autophagy-related protein 31;
AltName: Full=CIK1 suppressor protein 1;
AltName: Full=Protein CIS1;
Name=ATG31; Synonyms=CIS1; OrderedLocusNames=YDR022C;
ORFNames=PZD196, YD9335.08c;
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
NCBI_TaxID=559292;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=8896275;
DOI=10.1002/(SICI)1097-0061(199609)12:10B<1085::AID-YEA9>3.3.CO;2-S;
Eide L.G., Sander C., Prydz H.;
"Sequencing and analysis of a 35.4 kb region on the right arm of
chromosome IV from Saccharomyces cerevisiae reveal 23 open reading
frames.";
Yeast 12:1085-1090(1996).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 204508 / S288c;
PubMed=9169867;
Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G.,
Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C.,
Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F.,
Delaveau T., del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M.,
Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T.,
Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C.,
Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S.,
Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N.,
Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M.,
Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L.,
Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M.,
Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S.,
Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M.,
Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S.,
Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K.,
Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D.,
Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C.,
Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T.,
Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E.,
Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W.,
Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K.,
Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S.,
Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A.,
Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R.,
Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S.,
Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M.,
Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y.,
Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M.,
Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E.,
Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R.,
Waterston R., Albermann K., Hani J., Heumann K., Kleine K.,
Mewes H.-W., Zollner A., Zaccaria P.;
"The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.";
Nature 387:75-78(1997).
[3]
GENOME REANNOTATION.
STRAIN=ATCC 204508 / S288c;
PubMed=24374639; DOI=10.1534/g3.113.008995;
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M.,
Cherry J.M.;
"The reference genome sequence of Saccharomyces cerevisiae: Then and
now.";
G3 (Bethesda) 4:389-398(2014).
[4]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ATCC 204508 / S288c;
PubMed=17322287; DOI=10.1101/gr.6037607;
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A.,
Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F.,
Williamson J., Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G.,
Kolodner R.D., LaBaer J.;
"Approaching a complete repository of sequence-verified protein-
encoding clones for Saccharomyces cerevisiae.";
Genome Res. 17:536-543(2007).
[5]
FUNCTION.
PubMed=9348527; DOI=10.1091/mbc.8.10.1829;
Manning B.D., Padmanabha R., Snyder M.;
"The Rho-GEF Rom2p localizes to sites of polarized cell growth and
participates in cytoskeletal functions in Saccharomyces cerevisiae.";
Mol. Biol. Cell 8:1829-1844(1997).
[6]
SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
PubMed=14562095; DOI=10.1038/nature02026;
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
Weissman J.S., O'Shea E.K.;
"Global analysis of protein localization in budding yeast.";
Nature 425:686-691(2003).
[7]
LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
PubMed=14562106; DOI=10.1038/nature02046;
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A.,
Dephoure N., O'Shea E.K., Weissman J.S.;
"Global analysis of protein expression in yeast.";
Nature 425:737-741(2003).
[8]
FUNCTION, SUBCELLULAR LOCATION, AND INTERACTION WITH ATG17.
PubMed=17362880; DOI=10.1016/j.bbrc.2007.02.150;
Kabeya Y., Kawamata T., Suzuki K., Ohsumi Y.;
"Cis1/Atg31 is required for autophagosome formation in Saccharomyces
cerevisiae.";
Biochem. Biophys. Res. Commun. 356:405-410(2007).
[9]
FUNCTION, SUBCELLULAR LOCATION, AND INTERACTION WITH ATG1.
PubMed=18287526; DOI=10.1091/mbc.E07-10-1048;
Kawamata T., Kamada Y., Kabeya Y., Sekito T., Ohsumi Y.;
"Organization of the pre-autophagosomal structure responsible for
autophagosome formation.";
Mol. Biol. Cell 19:2039-2050(2008).
[10]
INTERACTION WITH ATG17 AND ATG29.
PubMed=19337029; DOI=10.4161/auto.5.5.8382;
Cao Y., Nair U., Yasumura-Yorimitsu K., Klionsky D.J.;
"A multiple ATG gene knockout strain for yeast two-hybrid analysis.";
Autophagy 5:699-705(2009).
[11]
IDENTIFICATION IN THE ATG17-ATG29-ATG31 COMPLEX, INTERACTION WITH THE
ATG1-ATG13 COMPLEX, AND PHOSPHORYLATION.
PubMed=19755117; DOI=10.1016/j.bbrc.2009.09.034;
Kabeya Y., Noda N.N., Fujioka Y., Suzuki K., Inagaki F., Ohsumi Y.;
"Characterization of the Atg17-Atg29-Atg31 complex specifically
required for starvation-induced autophagy in Saccharomyces
cerevisiae.";
Biochem. Biophys. Res. Commun. 389:612-615(2009).
[12]
FUNCTION.
PubMed=19793921; DOI=10.1091/mbc.E09-03-0225;
Kanki T., Wang K., Baba M., Bartholomew C.R., Lynch-Day M.A., Du Z.,
Geng J., Mao K., Yang Z., Yen W.L., Klionsky D.J.;
"A genomic screen for yeast mutants defective in selective
mitochondria autophagy.";
Mol. Biol. Cell 20:4730-4738(2009).
-!- FUNCTION: Plays a role in starvation-induced autophagy. Involved
in mitophagy. Functions with ATG17 and ATG29 at the
preautophagosomal structure (PAS) in order to form normal
autophagosomes under starvation conditions. May be involved in
microtubule function, such as chromosome segregation and
karyogamy. {ECO:0000269|PubMed:17362880,
ECO:0000269|PubMed:18287526, ECO:0000269|PubMed:19793921,
ECO:0000269|PubMed:9348527}.
-!- SUBUNIT: Forms a stable complex with ATG17 and ATG29. Interacts
directly with ATG29. The ATG17-ATG29-ATG31 complex interacts with
the ATG1-ATG13 complex. Note=The interaction with the ATG1-ATG13
complex is induced by starvation. {ECO:0000269|PubMed:17362880,
ECO:0000269|PubMed:18287526, ECO:0000269|PubMed:19337029,
ECO:0000269|PubMed:19755117}.
-!- INTERACTION:
Q06410:ATG17; NbExp=7; IntAct=EBI-34768, EBI-30856;
-!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000305}.
Preautophagosomal structure.
-!- PTM: Phosphorylated. {ECO:0000269|PubMed:19755117}.
-!- MISCELLANEOUS: Present with 486 molecules/cell in log phase SD
medium. {ECO:0000269|PubMed:14562106}.
-----------------------------------------------------------------------
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EMBL; X95966; CAA65214.1; -; Genomic_DNA.
EMBL; Z74318; CAA98843.1; -; Genomic_DNA.
EMBL; Z49770; CAA89847.1; -; Genomic_DNA.
EMBL; AY557645; AAS55971.1; -; Genomic_DNA.
EMBL; BK006938; DAA11868.1; -; Genomic_DNA.
PIR; S63429; S63429.
RefSeq; NP_010305.1; NM_001180330.1.
ProteinModelPortal; Q12421; -.
BioGrid; 32072; 59.
DIP; DIP-2667N; -.
IntAct; Q12421; 15.
MINT; MINT-536673; -.
STRING; 4932.YDR022C; -.
iPTMnet; Q12421; -.
MaxQB; Q12421; -.
PRIDE; Q12421; -.
EnsemblFungi; YDR022C; YDR022C; YDR022C.
GeneID; 851585; -.
KEGG; sce:YDR022C; -.
EuPathDB; FungiDB:YDR022C; -.
SGD; S000002429; ATG31.
HOGENOM; HOG000001031; -.
InParanoid; Q12421; -.
KO; K21144; -.
OMA; AMFPTNI; -.
OrthoDB; EOG092C4ON6; -.
BioCyc; YEAST:G3O-29639-MONOMER; -.
PRO; PR:Q12421; -.
Proteomes; UP000002311; Chromosome IV.
GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
GO; GO:0000407; C:pre-autophagosomal structure; IDA:SGD.
GO; GO:0006914; P:autophagy; IMP:SGD.
GO; GO:0000422; P:autophagy of mitochondrion; IMP:SGD.
GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.
GO; GO:0000741; P:karyogamy; IEA:UniProtKB-KW.
GO; GO:0044805; P:late nucleophagy; IMP:SGD.
GO; GO:0034727; P:piecemeal microautophagy of nucleus; IMP:SGD.
GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
InterPro; IPR018621; Atg31.
Pfam; PF09795; Atg31; 1.
1: Evidence at protein level;
Autophagy; Chromosome partition; Complete proteome; Cytoplasm;
Cytoskeleton; Karyogamy; Microtubule; Phosphoprotein;
Protein transport; Reference proteome; Transport.
CHAIN 1 196 Autophagy-related protein 31.
/FTId=PRO_0000076210.
SEQUENCE 196 AA; 22191 MW; CC2396854F29D250 CRC64;
MNVTVTVYDK NVKYRLEENI KNNKGPSNDD QPAYNNESKS TDGSDYAMFP TNIKYIFEDN
NDELVDSSDA ALTAGIDKVG DELENVIIVQ LDESGSLEDI TLISDQYELL SHRTNSLSLE
ENQMRTLSSH GDDKSNDEEE ELSVDSDRFR VDSDIELDVI SQFCDLSPFL RDLSLNDLIK
LYVTQNEQLQ MLSNSV


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