Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

BCL2, apoptosis regulator

 H0WKI0_OTOGA            Unreviewed;       238 AA.
22-FEB-2012, integrated into UniProtKB/TrEMBL.
22-FEB-2012, sequence version 1.
28-FEB-2018, entry version 37.
SubName: Full=BCL2, apoptosis regulator {ECO:0000313|Ensembl:ENSOGAP00000002082};
Name=BCL2 {ECO:0000313|Ensembl:ENSOGAP00000002082};
Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Strepsirrhini;
Lorisiformes; Galagidae; Otolemur.
NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000002082, ECO:0000313|Proteomes:UP000005225};
[1] {ECO:0000313|Ensembl:ENSOGAP00000002082}
The Broad Institute Genome Sequencing Platform;
Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
Walker B.J., Sharpe T., Hall G.;
"Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
[2] {ECO:0000313|Ensembl:ENSOGAP00000002082}
Submitted (JAN-2012) to UniProtKB.
-!- CAUTION: The sequence shown here is derived from an Ensembl
automatic analysis pipeline and should be considered as
preliminary data. {ECO:0000313|Ensembl:ENSOGAP00000002082}.
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
EMBL; AAQR03056574; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AAQR03056575; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AAQR03056576; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AAQR03056577; -; NOT_ANNOTATED_CDS; Genomic_DNA.
RefSeq; XP_003788464.1; XM_003788416.2.
STRING; 30611.ENSOGAP00000002082; -.
Ensembl; ENSOGAT00000002334; ENSOGAP00000002082; ENSOGAG00000002333.
GeneID; 100955447; -.
CTD; 596; -.
eggNOG; KOG4728; Eukaryota.
eggNOG; ENOG41123S0; LUCA.
GeneTree; ENSGT00530000062935; -.
InParanoid; H0WKI0; -.
OrthoDB; EOG091G0OCU; -.
TreeFam; TF315834; -.
Proteomes; UP000005225; Unassembled WGS sequence.
GO; GO:0005829; C:cytosol; IEA:Ensembl.
GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:Ensembl.
GO; GO:0005741; C:mitochondrial outer membrane; IEA:Ensembl.
GO; GO:0043209; C:myelin sheath; IEA:Ensembl.
GO; GO:0031965; C:nuclear membrane; IEA:Ensembl.
GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
GO; GO:0046930; C:pore complex; IEA:Ensembl.
GO; GO:0051434; F:BH3 domain binding; IEA:Ensembl.
GO; GO:0015267; F:channel activity; IEA:Ensembl.
GO; GO:0016248; F:channel inhibitor activity; IEA:Ensembl.
GO; GO:0002020; F:protease binding; IEA:Ensembl.
GO; GO:0046982; F:protein heterodimerization activity; IEA:Ensembl.
GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
GO; GO:0051721; F:protein phosphatase 2A binding; IEA:Ensembl.
GO; GO:0043565; F:sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0008134; F:transcription factor binding; IEA:Ensembl.
GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:Ensembl.
GO; GO:0007015; P:actin filament organization; IEA:Ensembl.
GO; GO:0031103; P:axon regeneration; IEA:Ensembl.
GO; GO:0007409; P:axonogenesis; IEA:Ensembl.
GO; GO:0001782; P:B cell homeostasis; IEA:Ensembl.
GO; GO:0002326; P:B cell lineage commitment; IEA:Ensembl.
GO; GO:0042100; P:B cell proliferation; IEA:Ensembl.
GO; GO:0050853; P:B cell receptor signaling pathway; IEA:Ensembl.
GO; GO:0001662; P:behavioral fear response; IEA:Ensembl.
GO; GO:0001658; P:branching involved in ureteric bud morphogenesis; IEA:Ensembl.
GO; GO:0043375; P:CD8-positive, alpha-beta T cell lineage commitment; IEA:Ensembl.
GO; GO:0007569; P:cell aging; IEA:Ensembl.
GO; GO:0016049; P:cell growth; IEA:Ensembl.
GO; GO:0098609; P:cell-cell adhesion; IEA:Ensembl.
GO; GO:0006974; P:cellular response to DNA damage stimulus; IEA:Ensembl.
GO; GO:0042149; P:cellular response to glucose starvation; IEA:Ensembl.
GO; GO:0071456; P:cellular response to hypoxia; IEA:Ensembl.
GO; GO:0071310; P:cellular response to organic substance; IEA:Ensembl.
GO; GO:0021747; P:cochlear nucleus development; IEA:Ensembl.
GO; GO:0051607; P:defense response to virus; IEA:Ensembl.
GO; GO:0048546; P:digestive tract morphogenesis; IEA:Ensembl.
GO; GO:0043583; P:ear development; IEA:Ensembl.
GO; GO:0032469; P:endoplasmic reticulum calcium ion homeostasis; IEA:Ensembl.
GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
GO; GO:0008625; P:extrinsic apoptotic signaling pathway via death domain receptors; IEA:Ensembl.
GO; GO:0048041; P:focal adhesion assembly; IEA:Ensembl.
GO; GO:0022612; P:gland morphogenesis; IEA:Ensembl.
GO; GO:0032835; P:glomerulus development; IEA:Ensembl.
GO; GO:0031069; P:hair follicle morphogenesis; IEA:Ensembl.
GO; GO:0048873; P:homeostasis of number of cells within a tissue; IEA:Ensembl.
GO; GO:0070059; P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; IEA:Ensembl.
GO; GO:0008631; P:intrinsic apoptotic signaling pathway in response to oxidative stress; IEA:Ensembl.
GO; GO:0002320; P:lymphoid progenitor cell differentiation; IEA:Ensembl.
GO; GO:0008584; P:male gonad development; IEA:Ensembl.
GO; GO:0006582; P:melanin metabolic process; IEA:Ensembl.
GO; GO:0030318; P:melanocyte differentiation; IEA:Ensembl.
GO; GO:0014031; P:mesenchymal cell development; IEA:Ensembl.
GO; GO:0001656; P:metanephros development; IEA:Ensembl.
GO; GO:2000811; P:negative regulation of anoikis; IEA:Ensembl.
GO; GO:0010507; P:negative regulation of autophagy; IEA:Ensembl.
GO; GO:0010523; P:negative regulation of calcium ion transport into cytosol; IEA:Ensembl.
GO; GO:0030308; P:negative regulation of cell growth; IEA:Ensembl.
GO; GO:0030336; P:negative regulation of cell migration; IEA:Ensembl.
GO; GO:0032848; P:negative regulation of cellular pH reduction; IEA:Ensembl.
GO; GO:2001240; P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
GO; GO:2000134; P:negative regulation of G1/S transition of mitotic cell cycle; IEA:Ensembl.
GO; GO:2001243; P:negative regulation of intrinsic apoptotic signaling pathway; IEA:Ensembl.
GO; GO:0033033; P:negative regulation of myeloid cell apoptotic process; IEA:Ensembl.
GO; GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Ensembl.
GO; GO:0030279; P:negative regulation of ossification; IEA:Ensembl.
GO; GO:0033689; P:negative regulation of osteoblast proliferation; IEA:Ensembl.
GO; GO:2000378; P:negative regulation of reactive oxygen species metabolic process; IEA:Ensembl.
GO; GO:0046671; P:negative regulation of retinal cell programmed cell death; IEA:Ensembl.
GO; GO:0051402; P:neuron apoptotic process; IEA:Ensembl.
GO; GO:0048599; P:oocyte development; IEA:Ensembl.
GO; GO:0035265; P:organ growth; IEA:Ensembl.
GO; GO:0001503; P:ossification; IEA:Ensembl.
GO; GO:0001541; P:ovarian follicle development; IEA:Ensembl.
GO; GO:0018105; P:peptidyl-serine phosphorylation; IEA:Ensembl.
GO; GO:0018107; P:peptidyl-threonine phosphorylation; IEA:Ensembl.
GO; GO:0048753; P:pigment granule organization; IEA:Ensembl.
GO; GO:0030890; P:positive regulation of B cell proliferation; IEA:Ensembl.
GO; GO:0043085; P:positive regulation of catalytic activity; IEA:Ensembl.
GO; GO:0030307; P:positive regulation of cell growth; IEA:Ensembl.
GO; GO:0045636; P:positive regulation of melanocyte differentiation; IEA:Ensembl.
GO; GO:0040018; P:positive regulation of multicellular organism growth; IEA:Ensembl.
GO; GO:0014042; P:positive regulation of neuron maturation; IEA:Ensembl.
GO; GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IEA:Ensembl.
GO; GO:0048743; P:positive regulation of skeletal muscle fiber development; IEA:Ensembl.
GO; GO:0014911; P:positive regulation of smooth muscle cell migration; IEA:Ensembl.
GO; GO:0009791; P:post-embryonic development; IEA:Ensembl.
GO; GO:0006470; P:protein dephosphorylation; IEA:Ensembl.
GO; GO:0000209; P:protein polyubiquitination; IEA:Ensembl.
GO; GO:0072593; P:reactive oxygen species metabolic process; IEA:Ensembl.
GO; GO:0001952; P:regulation of cell-matrix adhesion; IEA:Ensembl.
GO; GO:0010468; P:regulation of gene expression; IEA:Ensembl.
GO; GO:0010559; P:regulation of glycoprotein biosynthetic process; IEA:Ensembl.
GO; GO:0046902; P:regulation of mitochondrial membrane permeability; IEA:Ensembl.
GO; GO:0051881; P:regulation of mitochondrial membrane potential; IEA:Ensembl.
GO; GO:0006808; P:regulation of nitrogen utilization; IEA:Ensembl.
GO; GO:0043497; P:regulation of protein heterodimerization activity; IEA:Ensembl.
GO; GO:0043496; P:regulation of protein homodimerization activity; IEA:Ensembl.
GO; GO:0032880; P:regulation of protein localization; IEA:Ensembl.
GO; GO:0031647; P:regulation of protein stability; IEA:Ensembl.
GO; GO:0022898; P:regulation of transmembrane transporter activity; IEA:Ensembl.
GO; GO:0045069; P:regulation of viral genome replication; IEA:Ensembl.
GO; GO:0001836; P:release of cytochrome c from mitochondria; IEA:Ensembl.
GO; GO:0003014; P:renal system process; IEA:Ensembl.
GO; GO:0034097; P:response to cytokine; IEA:Ensembl.
GO; GO:0010332; P:response to gamma radiation; IEA:Ensembl.
GO; GO:0051384; P:response to glucocorticoid; IEA:Ensembl.
GO; GO:0042542; P:response to hydrogen peroxide; IEA:Ensembl.
GO; GO:0010039; P:response to iron ion; IEA:Ensembl.
GO; GO:0002931; P:response to ischemia; IEA:Ensembl.
GO; GO:0035094; P:response to nicotine; IEA:Ensembl.
GO; GO:0010224; P:response to UV-B; IEA:Ensembl.
GO; GO:0048536; P:spleen development; IEA:Ensembl.
GO; GO:0033077; P:T cell differentiation in thymus; IEA:Ensembl.
GO; GO:0043029; P:T cell homeostasis; IEA:Ensembl.
GO; GO:0048538; P:thymus development; IEA:Ensembl.
Gene3D; 1.10.437.10; -; 1.
InterPro; IPR013278; Apop_reg_Bcl2.
InterPro; IPR002475; Bcl2-like.
InterPro; IPR004725; Bcl2/BclX.
InterPro; IPR020717; Bcl2_BH1_motif_CS.
InterPro; IPR020726; Bcl2_BH2_motif_CS.
InterPro; IPR020728; Bcl2_BH3_motif_CS.
InterPro; IPR003093; Bcl2_BH4.
InterPro; IPR020731; Bcl2_BH4_motif_CS.
InterPro; IPR036834; Blc2-like_sf.
InterPro; IPR026298; Blc2_fam.
PANTHER; PTHR11256; PTHR11256; 1.
PANTHER; PTHR11256:SF11; PTHR11256:SF11; 1.
Pfam; PF00452; Bcl-2; 1.
Pfam; PF02180; BH4; 1.
SMART; SM00265; BH4; 1.
SUPFAM; SSF56854; SSF56854; 1.
TIGRFAMs; TIGR00865; bcl-2; 1.
PROSITE; PS01080; BH1; 1.
PROSITE; PS01258; BH2; 1.
PROSITE; PS01259; BH3; 1.
PROSITE; PS01260; BH4_1; 1.
PROSITE; PS50063; BH4_2; 1.
4: Predicted;
Apoptosis {ECO:0000256|PROSITE-ProRule:PRU00025};
Complete proteome {ECO:0000313|Proteomes:UP000005225};
Membrane {ECO:0000256|SAM:Phobius};
Reference proteome {ECO:0000313|Proteomes:UP000005225};
Transmembrane {ECO:0000256|SAM:Phobius};
Transmembrane helix {ECO:0000256|SAM:Phobius}.
TRANSMEM 214 235 Helical. {ECO:0000256|SAM:Phobius}.
DOMAIN 11 30 BH4_2. {ECO:0000259|PROSITE:PS50063}.
MOTIF 11 30 BH4. {ECO:0000256|PROSITE-
SEQUENCE 238 AA; 26177 MW; 3C0B42451EADA3CF CRC64;

Related products :

Catalog number Product name Quantity
CSB-EL002611CH Chicken Apoptosis regulator Bcl-2(BCL2) ELISA kit 96T
CSB-EL002611BO Bovine Apoptosis regulator Bcl-2(BCL2) ELISA kit 96T
E0778m ELISA kit Apoptosis regulator Bcl-2,Bcl2,Bcl-2,Mouse,Mus musculus 96T
E0778r ELISA kit Apoptosis regulator Bcl-2,Bcl2,Bcl-2,Rat,Rattus norvegicus 96T
CSB-EL002611CH Chicken Apoptosis regulator Bcl-2(BCL2) ELISA kit SpeciesChicken 96T
E0778m ELISA Apoptosis regulator Bcl-2,Bcl2,Bcl-2,Mouse,Mus musculus 96T
E0778b ELISA Apoptosis regulator Bcl-2,BCL2,Bos taurus,Bovine 96T
E0778b ELISA kit Apoptosis regulator Bcl-2,BCL2,Bos taurus,Bovine 96T
U0778b CLIA Apoptosis regulator Bcl-2,BCL2,Bos taurus,Bovine 96T
U0778r CLIA Apoptosis regulator Bcl-2,Bcl2,Bcl-2,Rat,Rattus norvegicus 96T
E0778r ELISA Apoptosis regulator Bcl-2,Bcl2,Bcl-2,Rat,Rattus norvegicus 96T
CSB-EL002611BO Bovine Apoptosis regulator Bcl-2(BCL2) ELISA kit SpeciesBovine 96T
U0778m CLIA Apoptosis regulator Bcl-2,Bcl2,Bcl-2,Mouse,Mus musculus 96T
E0778b ELISA Kit FOR Apoptosis regulator Bcl-2; organism: Bovine; gene name: BCL2 96T
U0778h CLIA Apoptosis regulator Bcl-2,BCL2,Homo sapiens,Human 96T
E0778h ELISA kit Apoptosis regulator Bcl-2,BCL2,Homo sapiens,Human 96T
E0778h ELISA Apoptosis regulator Bcl-2,BCL2,Homo sapiens,Human 96T
E1343h ELISA kit Apoptosis regulator BAX,BAX,BCL2L4,Bcl2-L-4,Bcl-2-like protein 4,Homo sapiens,Human 96T
GWB-47C732 Apoptosis Regulator Bcl-2 (BCL2) Rabbit anti-Human Polyclonal (Ser70) Antibody
U1343h CLIA Apoptosis regulator BAX,BAX,BCL2L4,Bcl2-L-4,Bcl-2-like protein 4,Homo sapiens,Human 96T
GWB-E2C8B2 Apoptosis Regulator Bcl-2 (BCL2) Rabbit anti-Human Polyclonal (Thr56) Antibody
E1343h ELISA Apoptosis regulator BAX,BAX,BCL2L4,Bcl2-L-4,Bcl-2-like protein 4,Homo sapiens,Human 96T
U0778c CLIA Apoptosis regulator Bcl-2,BCL2,BCL-2,Chicken,Gallus gallus 96T
E0778c ELISA kit Apoptosis regulator Bcl-2,BCL2,BCL-2,Chicken,Gallus gallus 96T
E0778c ELISA Apoptosis regulator Bcl-2,BCL2,BCL-2,Chicken,Gallus gallus 96T


GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur

Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur



9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017


france@gentaur.com | Gentaur

Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123

GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U

spain@gentaur.com | Gentaur

ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636

GENTAUR Poland Sp. z o.o.

ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556


Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur