Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

BH3-interacting domain death agonist (p22 BID) (BID) [Cleaved into: BH3-interacting domain death agonist p15 (p15 BID); BH3-interacting domain death agonist p13 (p13 BID); BH3-interacting domain death agonist p11 (p11 BID)]

 BID_RAT                 Reviewed;         196 AA.
Q9JLT6; Q9JK60;
21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
21-FEB-2006, sequence version 2.
20-JUN-2018, entry version 114.
RecName: Full=BH3-interacting domain death agonist;
AltName: Full=p22 BID;
Short=BID;
Contains:
RecName: Full=BH3-interacting domain death agonist p15;
AltName: Full=p15 BID;
Contains:
RecName: Full=BH3-interacting domain death agonist p13;
AltName: Full=p13 BID;
Contains:
RecName: Full=BH3-interacting domain death agonist p11;
AltName: Full=p11 BID;
Name=Bid;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Sprague-Dawley;
PubMed=12787069; DOI=10.1046/j.1471-4159.2003.01795.x;
Itoh T., Itoh A., Pleasure D.;
"Bcl-2-related protein family gene expression during oligodendroglial
differentiation.";
J. Neurochem. 85:1500-1512(2003).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Sprague-Dawley;
Chen D., Cao G., Chen J.;
"Cloning of rat apoptotic death agonist (BID) and its different
expression in ischemia and normal rat brain.";
Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases.
[3]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-79, AND IDENTIFICATION
BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=22673903; DOI=10.1038/ncomms1871;
Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A.,
Lundby C., Olsen J.V.;
"Quantitative maps of protein phosphorylation sites across 14
different rat organs and tissues.";
Nat. Commun. 3:876-876(2012).
-!- FUNCTION: Induces caspases and apoptosis. Counters the protective
effect of Bcl-2. The major proteolytic product p15 BID allows the
release of cytochrome c (By similarity). {ECO:0000250}.
-!- SUBUNIT: Forms heterodimers either with the pro-apoptotic protein
BAX or the anti-apoptotic protein Bcl-2. p15 BID interacts with
ITCH. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Cytoplasm. Mitochondrion membrane. Note=When
uncleaved, it is predominantly cytoplasmic. p15 BID translocates
to mitochondria as an integral membrane protein. p13 and p22 BID
are associated with the mitochondrial membrane (By similarity).
{ECO:0000250}.
-!- DOMAIN: Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX
for their pro-apoptotic activity and for their interaction with
anti-apoptotic members of the Bcl-2 family.
-!- PTM: TNF-alpha induces a caspase-mediated cleavage of p22 BID into
a major p15 and minor p13 and p11 products. {ECO:0000250}.
-!- PTM: p15 BID is ubiquitinated by ITCH; ubiquitination results in
proteasome-dependent degradation. {ECO:0000250}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; AF259503; AAF71759.1; -; mRNA.
EMBL; AF136282; AAF61422.1; -; mRNA.
RefSeq; NP_073175.1; NM_022684.1.
RefSeq; XP_017448369.1; XM_017592880.1.
UniGene; Rn.31142; -.
ProteinModelPortal; Q9JLT6; -.
SMR; Q9JLT6; -.
ComplexPortal; CPX-2023; BID:BCL-2 complex.
ComplexPortal; CPX-2038; BID:BCL-XL complex.
IntAct; Q9JLT6; 1.
MINT; Q9JLT6; -.
STRING; 10116.ENSRNOP00000016776; -.
iPTMnet; Q9JLT6; -.
PhosphoSitePlus; Q9JLT6; -.
PaxDb; Q9JLT6; -.
PRIDE; Q9JLT6; -.
Ensembl; ENSRNOT00000016776; ENSRNOP00000016776; ENSRNOG00000012439.
GeneID; 64625; -.
KEGG; rno:64625; -.
UCSC; RGD:620160; rat.
CTD; 637; -.
RGD; 620160; Bid.
eggNOG; ENOG410IVZ7; Eukaryota.
eggNOG; ENOG410ZF8F; LUCA.
GeneTree; ENSGT00390000002868; -.
HOGENOM; HOG000010016; -.
HOVERGEN; HBG001703; -.
InParanoid; Q9JLT6; -.
KO; K04726; -.
OMA; RDVFRTT; -.
OrthoDB; EOG091G0LRX; -.
PhylomeDB; Q9JLT6; -.
TreeFam; TF102047; -.
Reactome; R-RNO-111447; Activation of BAD and translocation to mitochondria.
Reactome; R-RNO-111452; Activation and oligomerization of BAK protein.
Reactome; R-RNO-111453; BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members.
Reactome; R-RNO-114294; Activation, translocation and oligomerization of BAX.
Reactome; R-RNO-75108; Activation, myristolyation of BID and translocation to mitochondria.
PRO; PR:Q9JLT6; -.
Proteomes; UP000002494; Chromosome 4.
Bgee; ENSRNOG00000012439; -.
ExpressionAtlas; Q9JLT6; baseline and differential.
Genevisible; Q9JLT6; RN.
GO; GO:0005829; C:cytosol; IDA:RGD.
GO; GO:0032592; C:integral component of mitochondrial membrane; IEA:Ensembl.
GO; GO:0005739; C:mitochondrion; IDA:RGD.
GO; GO:0046982; F:protein heterodimerization activity; IEA:Ensembl.
GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:Ensembl.
GO; GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; IEA:Ensembl.
GO; GO:0007420; P:brain development; IEP:RGD.
GO; GO:0097191; P:extrinsic apoptotic signaling pathway; IEA:Ensembl.
GO; GO:0034349; P:glial cell apoptotic process; IEP:RGD.
GO; GO:0097284; P:hepatocyte apoptotic process; IEA:Ensembl.
GO; GO:0042775; P:mitochondrial ATP synthesis coupled electron transport; IEA:Ensembl.
GO; GO:0097345; P:mitochondrial outer membrane permeabilization; IEA:Ensembl.
GO; GO:1902230; P:negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage; IEA:Ensembl.
GO; GO:2000271; P:positive regulation of fibroblast apoptotic process; IEA:Ensembl.
GO; GO:0010918; P:positive regulation of mitochondrial membrane potential; IEA:Ensembl.
GO; GO:0032464; P:positive regulation of protein homooligomerization; IEA:Ensembl.
GO; GO:0090200; P:positive regulation of release of cytochrome c from mitochondria; IEA:Ensembl.
GO; GO:0051260; P:protein homooligomerization; IEA:Ensembl.
GO; GO:0006626; P:protein targeting to mitochondrion; IEA:Ensembl.
GO; GO:0042127; P:regulation of cell proliferation; IEA:Ensembl.
GO; GO:2000045; P:regulation of G1/S transition of mitotic cell cycle; IEA:Ensembl.
GO; GO:0001836; P:release of cytochrome c from mitochondria; IDA:RGD.
GO; GO:0032355; P:response to estradiol; IEP:RGD.
Gene3D; 1.10.437.10; -; 1.
InterPro; IPR020728; Bcl2_BH3_motif_CS.
InterPro; IPR010479; BID.
InterPro; IPR036834; Blc2-like_sf.
PANTHER; PTHR35447; PTHR35447; 1.
Pfam; PF06393; BID; 1.
PIRSF; PIRSF038018; BID; 1.
SUPFAM; SSF56854; SSF56854; 1.
PROSITE; PS01259; BH3; 1.
1: Evidence at protein level;
Acetylation; Apoptosis; Complete proteome; Cytoplasm; Membrane;
Mitochondrion; Phosphoprotein; Reference proteome; Ubl conjugation.
CHAIN 1 196 BH3-interacting domain death agonist.
/FTId=PRO_0000223369.
CHAIN 61 196 BH3-interacting domain death agonist p15.
{ECO:0000250}.
/FTId=PRO_0000223370.
CHAIN 77 196 BH3-interacting domain death agonist p13.
{ECO:0000250}.
/FTId=PRO_0000223371.
CHAIN 100 196 BH3-interacting domain death agonist p11.
{ECO:0000250}.
/FTId=PRO_0000223372.
MOTIF 87 101 BH3. {ECO:0000250}.
SITE 60 61 Cleavage. {ECO:0000250}.
SITE 76 77 Cleavage. {ECO:0000250}.
SITE 99 100 Cleavage. {ECO:0000250}.
MOD_RES 1 1 N-acetylmethionine.
{ECO:0000250|UniProtKB:P55957}.
MOD_RES 79 79 Phosphoserine.
{ECO:0000244|PubMed:22673903}.
CONFLICT 176 176 V -> A (in Ref. 2; AAF61422).
{ECO:0000305}.
CONFLICT 185 185 S -> F (in Ref. 2; AAF61422).
{ECO:0000305}.
SEQUENCE 196 AA; 22249 MW; C5F6AD2F5D9B52E3 CRC64;
MDSEVSNGSG LGAEHITNLL VFGFLRNNDR DFHQELEVLG QELPVQVYLE GDREDELQTD
GSRASRSFYH GRIEPDSESQ DEVIHNIARH LAQAGDELDH SIQPTLVRQL AAQFMNGSLS
EEDKRNCLAK ALDEVKTSFP RDMENDKAML IMTMLLAKKV ASHAPSLLRD VFRTTVNFIN
QNLFSYVRDL VRNEMD


Related products :

Catalog number Product name Quantity
orb81409 Mouse BH3 Interacting Domain Death Agonist p15 protein Truncated BID Mouse Recombinant also called BH3-interacting domain death agonist p15 produced in E.coli is a single, non-glycosylated polypeptide 2
C106 BH3-Interacting Domain Death Agonist BID lmg
RP17262730002 BH3 Interacting Domain Death Agonist 2 µg
RP17262730010 BH3 Interacting Domain Death Agonist 10 µg
RP17262760001 BH3 Interacting Domain Death Agonist 1 mg
RP17264230002 BH3 Interacting Domain Death Agonist 2 µg
RP17264230010 BH3 Interacting Domain Death Agonist 10 µg
RP17264260001 BH3 Interacting Domain Death Agonist 1 mg
DL-Bid-Ra Rat BH3 Interacting Domain Death Agonist (Bid) ELISA Kit 96T
RP17264330002 BH3 Interacting Domain Death Agonist GST 2 µg
RP17264330010 BH3 Interacting Domain Death Agonist GST 10 µg
RP17264360001 BH3 Interacting Domain Death Agonist GST 1 mg
RP17264430010 BH3 Interacting Domain Death Agonist p15 10 µg
C106 BH3-Interacting Domain Death Agonist BID 500
RP17264460001 BH3 Interacting Domain Death Agonist p15 1 mg
RP17264430002 BH3 Interacting Domain Death Agonist p15 2 µg
PRO-642 Recombinant Mouse BH3 Interacting Domain Death Agonist 2µg
SL0115Ra Rat BH3 interacting domain death agonist,Bid ELISA Kit 96T
DL-Bid-Mu Mouse BH3 Interacting Domain Death Agonist (Bid) ELISA Kit 96T
PRO-642 Recombinant Mouse BH3 Interacting Domain Death Agonist 10µg
PRO-643 Recombinant Mouse BH3 Interacting Domain Death Agonist GST 10µg
pro-627 Recombinant Human BH3 Interacting Domain Death Agonist BID 10
E-EL-R0107 Rat BID (BH3 Interacting Domain Death Agonist) ELISA Kit 96T
E-EL-R0108 Rat BID (BH5 Interacting Domain Death Agonist) ELISA Kit 96T
PRO-627 Recombinant Human BH3 Interacting Domain Death Agonist 2µg


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur