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BH3-interacting domain death agonist (p22 BID) (BID) [Cleaved into: BH3-interacting domain death agonist p15 (p15 BID); BH3-interacting domain death agonist p13 (p13 BID); BH3-interacting domain death agonist p11 (p11 BID)]

 BID_RAT                 Reviewed;         196 AA.
Q9JLT6; Q9JK60;
21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
21-FEB-2006, sequence version 2.
16-JAN-2019, entry version 119.
RecName: Full=BH3-interacting domain death agonist;
AltName: Full=p22 BID;
Short=BID;
Contains:
RecName: Full=BH3-interacting domain death agonist p15;
AltName: Full=p15 BID;
Contains:
RecName: Full=BH3-interacting domain death agonist p13;
AltName: Full=p13 BID;
Contains:
RecName: Full=BH3-interacting domain death agonist p11;
AltName: Full=p11 BID;
Name=Bid;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Sprague-Dawley;
PubMed=12787069; DOI=10.1046/j.1471-4159.2003.01795.x;
Itoh T., Itoh A., Pleasure D.;
"Bcl-2-related protein family gene expression during oligodendroglial
differentiation.";
J. Neurochem. 85:1500-1512(2003).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Sprague-Dawley;
Chen D., Cao G., Chen J.;
"Cloning of rat apoptotic death agonist (BID) and its different
expression in ischemia and normal rat brain.";
Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases.
[3]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-79, AND IDENTIFICATION
BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=22673903; DOI=10.1038/ncomms1871;
Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A.,
Lundby C., Olsen J.V.;
"Quantitative maps of protein phosphorylation sites across 14
different rat organs and tissues.";
Nat. Commun. 3:876-876(2012).
-!- FUNCTION: Induces caspases and apoptosis. Counters the protective
effect of Bcl-2. The major proteolytic product p15 BID allows the
release of cytochrome c (By similarity).
{ECO:0000250|UniProtKB:P70444}.
-!- SUBUNIT: Forms heterodimers either with the pro-apoptotic protein
BAX or the anti-apoptotic protein Bcl-2. p15 BID interacts with
ITCH. Interacts with PLEKHN1. {ECO:0000250|UniProtKB:P55957,
ECO:0000250|UniProtKB:P70444}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P70444}.
Mitochondrion membrane {ECO:0000250|UniProtKB:P70444}.
Mitochondrion outer membrane {ECO:0000250|UniProtKB:P55957}.
Note=When uncleaved, it is predominantly cytoplasmic (By
similarity). {ECO:0000250|UniProtKB:P70444}.
-!- SUBCELLULAR LOCATION: BH3-interacting domain death agonist p15:
Mitochondrion membrane {ECO:0000250|UniProtKB:P70444}.
Note=Translocates to mitochondria as an integral membrane protein.
{ECO:0000250|UniProtKB:P70444}.
-!- SUBCELLULAR LOCATION: BH3-interacting domain death agonist p13:
Mitochondrion membrane {ECO:0000250|UniProtKB:P70444}.
Note=Associated with the mitochondrial membrane.
{ECO:0000250|UniProtKB:P70444}.
-!- DOMAIN: Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX
for their pro-apoptotic activity and for their interaction with
anti-apoptotic members of the Bcl-2 family.
-!- PTM: TNF-alpha induces a caspase-mediated cleavage of p22 BID into
a major p15 and minor p13 and p11 products.
{ECO:0000250|UniProtKB:P70444}.
-!- PTM: p15 BID is ubiquitinated by ITCH; ubiquitination results in
proteasome-dependent degradation. {ECO:0000250|UniProtKB:P70444}.
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EMBL; AF259503; AAF71759.1; -; mRNA.
EMBL; AF136282; AAF61422.1; -; mRNA.
RefSeq; NP_073175.1; NM_022684.1.
RefSeq; XP_017448369.1; XM_017592880.1.
UniGene; Rn.31142; -.
ProteinModelPortal; Q9JLT6; -.
SMR; Q9JLT6; -.
ComplexPortal; CPX-2023; BID:BCL-2 complex.
ComplexPortal; CPX-2038; BID:BCL-XL complex.
IntAct; Q9JLT6; 1.
MINT; Q9JLT6; -.
STRING; 10116.ENSRNOP00000016776; -.
iPTMnet; Q9JLT6; -.
PhosphoSitePlus; Q9JLT6; -.
jPOST; Q9JLT6; -.
PaxDb; Q9JLT6; -.
PRIDE; Q9JLT6; -.
Ensembl; ENSRNOT00000016776; ENSRNOP00000016776; ENSRNOG00000012439.
GeneID; 64625; -.
KEGG; rno:64625; -.
UCSC; RGD:620160; rat.
CTD; 637; -.
RGD; 620160; Bid.
eggNOG; ENOG410IVZ7; Eukaryota.
eggNOG; ENOG410ZF8F; LUCA.
GeneTree; ENSGT00390000002868; -.
HOGENOM; HOG000010016; -.
HOVERGEN; HBG001703; -.
InParanoid; Q9JLT6; -.
KO; K04726; -.
OMA; FRTTVNF; -.
OrthoDB; 1218538at2759; -.
PhylomeDB; Q9JLT6; -.
TreeFam; TF102047; -.
Reactome; R-RNO-111447; Activation of BAD and translocation to mitochondria.
Reactome; R-RNO-111452; Activation and oligomerization of BAK protein.
Reactome; R-RNO-111453; BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members.
Reactome; R-RNO-114294; Activation, translocation and oligomerization of BAX.
Reactome; R-RNO-75108; Activation, myristolyation of BID and translocation to mitochondria.
PRO; PR:Q9JLT6; -.
Proteomes; UP000002494; Chromosome 4.
Bgee; ENSRNOG00000012439; Expressed in 10 organ(s), highest expression level in spleen.
ExpressionAtlas; Q9JLT6; baseline and differential.
Genevisible; Q9JLT6; RN.
GO; GO:0005829; C:cytosol; IDA:RGD.
GO; GO:0032592; C:integral component of mitochondrial membrane; IEA:Ensembl.
GO; GO:0005741; C:mitochondrial outer membrane; ISS:UniProtKB.
GO; GO:0005739; C:mitochondrion; IDA:RGD.
GO; GO:0046982; F:protein heterodimerization activity; IEA:Ensembl.
GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:Ensembl.
GO; GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; IBA:GO_Central.
GO; GO:0008637; P:apoptotic mitochondrial changes; IBA:GO_Central.
GO; GO:0007420; P:brain development; IEP:RGD.
GO; GO:0097191; P:extrinsic apoptotic signaling pathway; IEA:Ensembl.
GO; GO:0034349; P:glial cell apoptotic process; IEP:RGD.
GO; GO:0097284; P:hepatocyte apoptotic process; IEA:Ensembl.
GO; GO:0042775; P:mitochondrial ATP synthesis coupled electron transport; IEA:Ensembl.
GO; GO:0097345; P:mitochondrial outer membrane permeabilization; IEA:Ensembl.
GO; GO:1902230; P:negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage; IEA:Ensembl.
GO; GO:0034263; P:positive regulation of autophagy in response to ER overload; IMP:RGD.
GO; GO:2001238; P:positive regulation of extrinsic apoptotic signaling pathway; IBA:GO_Central.
GO; GO:2000271; P:positive regulation of fibroblast apoptotic process; IEA:Ensembl.
GO; GO:2001244; P:positive regulation of intrinsic apoptotic signaling pathway; IBA:GO_Central.
GO; GO:0010918; P:positive regulation of mitochondrial membrane potential; IEA:Ensembl.
GO; GO:0032464; P:positive regulation of protein homooligomerization; IEA:Ensembl.
GO; GO:0090200; P:positive regulation of release of cytochrome c from mitochondria; IBA:GO_Central.
GO; GO:0051260; P:protein homooligomerization; IEA:Ensembl.
GO; GO:0006626; P:protein targeting to mitochondrion; IEA:Ensembl.
GO; GO:0042127; P:regulation of cell proliferation; IEA:Ensembl.
GO; GO:2000045; P:regulation of G1/S transition of mitotic cell cycle; IEA:Ensembl.
GO; GO:0001836; P:release of cytochrome c from mitochondria; IDA:RGD.
GO; GO:0032355; P:response to estradiol; IEP:RGD.
GO; GO:0002931; P:response to ischemia; IEP:RGD.
Gene3D; 1.10.437.10; -; 1.
InterPro; IPR020728; Bcl2_BH3_motif_CS.
InterPro; IPR010479; BID.
InterPro; IPR036834; Blc2-like_sf.
PANTHER; PTHR35447; PTHR35447; 1.
Pfam; PF06393; BID; 1.
PIRSF; PIRSF038018; BID; 1.
SUPFAM; SSF56854; SSF56854; 1.
PROSITE; PS01259; BH3; 1.
1: Evidence at protein level;
Acetylation; Apoptosis; Complete proteome; Cytoplasm; Membrane;
Mitochondrion; Mitochondrion outer membrane; Phosphoprotein;
Reference proteome; Ubl conjugation.
CHAIN 1 196 BH3-interacting domain death agonist.
/FTId=PRO_0000223369.
CHAIN 61 196 BH3-interacting domain death agonist p15.
{ECO:0000250|UniProtKB:P70444}.
/FTId=PRO_0000223370.
CHAIN 77 196 BH3-interacting domain death agonist p13.
{ECO:0000250|UniProtKB:P70444}.
/FTId=PRO_0000223371.
CHAIN 100 196 BH3-interacting domain death agonist p11.
{ECO:0000250|UniProtKB:P70444}.
/FTId=PRO_0000223372.
MOTIF 87 101 BH3. {ECO:0000250|UniProtKB:P70444}.
SITE 60 61 Cleavage. {ECO:0000250|UniProtKB:P70444}.
SITE 76 77 Cleavage. {ECO:0000250|UniProtKB:P70444}.
SITE 99 100 Cleavage. {ECO:0000250|UniProtKB:P70444}.
MOD_RES 1 1 N-acetylmethionine.
{ECO:0000250|UniProtKB:P55957}.
MOD_RES 79 79 Phosphoserine.
{ECO:0000244|PubMed:22673903}.
CONFLICT 176 176 V -> A (in Ref. 2; AAF61422).
{ECO:0000305}.
CONFLICT 185 185 S -> F (in Ref. 2; AAF61422).
{ECO:0000305}.
SEQUENCE 196 AA; 22249 MW; C5F6AD2F5D9B52E3 CRC64;
MDSEVSNGSG LGAEHITNLL VFGFLRNNDR DFHQELEVLG QELPVQVYLE GDREDELQTD
GSRASRSFYH GRIEPDSESQ DEVIHNIARH LAQAGDELDH SIQPTLVRQL AAQFMNGSLS
EEDKRNCLAK ALDEVKTSFP RDMENDKAML IMTMLLAKKV ASHAPSLLRD VFRTTVNFIN
QNLFSYVRDL VRNEMD


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