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BLOC-1-related complex subunit 6 (Lysosome-dispersing protein) (Lyspersin)

 BORC6_HUMAN             Reviewed;         357 AA.
Q96GS4; Q53HS4; Q9NXW8;
15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
18-MAY-2010, sequence version 2.
23-MAY-2018, entry version 106.
RecName: Full=BLOC-1-related complex subunit 6 {ECO:0000305};
AltName: Full=Lysosome-dispersing protein {ECO:0000303|PubMed:25898167};
Short=Lyspersin {ECO:0000303|PubMed:25898167};
Name=BORCS6 {ECO:0000312|HGNC:HGNC:25939};
Synonyms=C17orf59 {ECO:0000312|HGNC:HGNC:25939};
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=16625196; DOI=10.1038/nature04689;
Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R.,
Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N.,
Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B.,
Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J.,
Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E.,
Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J.,
Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C.,
Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
"DNA sequence of human chromosome 17 and analysis of rearrangement in
the human lineage.";
Nature 440:1045-1049(2006).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Lung, Ovary, and Skin;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 24-357.
TISSUE=Adipose tissue;
PubMed=14702039; DOI=10.1038/ng1285;
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human
cDNAs.";
Nat. Genet. 36:40-45(2004).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 24-357.
TISSUE=Adipose tissue;
Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y.,
Tanaka A., Yokoyama S.;
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
[5]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-196 AND SER-199, AND
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Cervix carcinoma;
PubMed=18669648; DOI=10.1073/pnas.0805139105;
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
Elledge S.J., Gygi S.P.;
"A quantitative atlas of mitotic phosphorylation.";
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
[6]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Cervix carcinoma;
PubMed=20068231; DOI=10.1126/scisignal.2000475;
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S.,
Mann M.;
"Quantitative phosphoproteomics reveals widespread full
phosphorylation site occupancy during mitosis.";
Sci. Signal. 3:RA3-RA3(2010).
[7]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-168; THR-196 AND
SER-199, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE
ANALYSIS].
TISSUE=Cervix carcinoma, and Erythroleukemia;
PubMed=23186163; DOI=10.1021/pr300630k;
Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
Mohammed S.;
"Toward a comprehensive characterization of a human cancer cell
phosphoproteome.";
J. Proteome Res. 12:260-271(2013).
[8]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-196, AND IDENTIFICATION
BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Liver;
PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D.,
Wang L., Ye M., Zou H.;
"An enzyme assisted RP-RPLC approach for in-depth analysis of human
liver phosphoproteome.";
J. Proteomics 96:253-262(2014).
[9]
FUNCTION, IDENTIFICATION OF THE BORC COMPLEX, AND SUBCELLULAR
LOCATION.
PubMed=25898167; DOI=10.1016/j.devcel.2015.02.011;
Pu J., Schindler C., Jia R., Jarnik M., Backlund P., Bonifacino J.S.;
"BORC, a multisubunit complex that regulates lysosome positioning.";
Dev. Cell 33:176-188(2015).
-!- FUNCTION: As part of the BORC complex may play a role in lysosomes
movement and localization at the cell periphery. Associated with
the cytosolic face of lysosomes, the BORC complex may recruit
ARL8B and couple lysosomes to microtubule plus-end-directed
kinesin motor. {ECO:0000269|PubMed:25898167}.
-!- SUBUNIT: Component of the BLOC-one-related complex (BORC) which is
composed of BLOC1S1, BLOC1S2, BORCS5, BORCS6, BORCS7, BORCS8, KXD1
and SNAPIN. {ECO:0000269|PubMed:25898167}.
-!- INTERACTION:
Q2T9L4:C15orf59; NbExp=4; IntAct=EBI-10193358, EBI-4311436;
Q13561:DCTN2; NbExp=4; IntAct=EBI-10193358, EBI-715074;
Q12929:EPS8; NbExp=3; IntAct=EBI-10193358, EBI-375576;
Q9NQT4:EXOSC5; NbExp=4; IntAct=EBI-10193358, EBI-371876;
Q9H4M3:FBXO44; NbExp=4; IntAct=EBI-10193358, EBI-2322644;
Q9H4M3-2:FBXO44; NbExp=4; IntAct=EBI-10193358, EBI-12104696;
Q9Y2Q5:LAMTOR2; NbExp=4; IntAct=EBI-10193358, EBI-2643704;
P00540:MOS; NbExp=3; IntAct=EBI-10193358, EBI-1757866;
Q9GZM8:NDEL1; NbExp=4; IntAct=EBI-10193358, EBI-928842;
Q149N8:SHPRH; NbExp=3; IntAct=EBI-10193358, EBI-714105;
B2RWP4:TACC2; NbExp=4; IntAct=EBI-10193358, EBI-14211313;
-!- SUBCELLULAR LOCATION: Lysosome membrane
{ECO:0000305|PubMed:25898167}.
-!- SIMILARITY: Belongs to the BORCS6 family. {ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=AAH09261.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Sequence=AAH18880.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Sequence=AAH70272.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Sequence=BAA90889.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Sequence=BAD96226.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
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EMBL; AC129492; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BC009261; AAH09261.1; ALT_INIT; mRNA.
EMBL; BC018880; AAH18880.1; ALT_INIT; mRNA.
EMBL; BC070272; AAH70272.1; ALT_INIT; mRNA.
EMBL; AK000021; BAA90889.1; ALT_INIT; mRNA.
EMBL; AK222506; BAD96226.1; ALT_INIT; mRNA.
CCDS; CCDS11133.2; -.
RefSeq; NP_060092.2; NM_017622.2.
UniGene; Hs.129563; -.
ProteinModelPortal; Q96GS4; -.
BioGrid; 120149; 57.
DIP; DIP-29465N; -.
IntAct; Q96GS4; 36.
STRING; 9606.ENSP00000373669; -.
iPTMnet; Q96GS4; -.
PhosphoSitePlus; Q96GS4; -.
BioMuta; C17orf59; -.
DMDM; 296434462; -.
EPD; Q96GS4; -.
MaxQB; Q96GS4; -.
PaxDb; Q96GS4; -.
PeptideAtlas; Q96GS4; -.
PRIDE; Q96GS4; -.
Ensembl; ENST00000389017; ENSP00000373669; ENSG00000196544.
GeneID; 54785; -.
KEGG; hsa:54785; -.
UCSC; uc010vut.3; human.
CTD; 54785; -.
EuPathDB; HostDB:ENSG00000196544.7; -.
GeneCards; BORCS6; -.
H-InvDB; HIX0039063; -.
H-InvDB; HIX0202400; -.
HGNC; HGNC:25939; BORCS6.
HPA; HPA045415; -.
HPA; HPA060791; -.
MIM; 616599; gene.
neXtProt; NX_Q96GS4; -.
OpenTargets; ENSG00000196544; -.
PharmGKB; PA142672242; -.
eggNOG; KOG4514; Eukaryota.
eggNOG; ENOG4111TSS; LUCA.
GeneTree; ENSGT00490000043453; -.
HOGENOM; HOG000111935; -.
HOVERGEN; HBG060339; -.
InParanoid; Q96GS4; -.
KO; K20820; -.
OMA; GGANRHP; -.
OrthoDB; EOG091G0NP7; -.
PhylomeDB; Q96GS4; -.
GenomeRNAi; 54785; -.
PRO; PR:Q96GS4; -.
Proteomes; UP000005640; Chromosome 17.
Bgee; ENSG00000196544; -.
CleanEx; HS_C17orf59; -.
Genevisible; Q96GS4; HS.
GO; GO:0099078; C:BORC complex; IDA:UniProtKB.
GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
GO; GO:0032418; P:lysosome localization; IMP:UniProtKB.
InterPro; IPR019314; BORCS6.
Pfam; PF10157; BORCS6; 1.
1: Evidence at protein level;
Complete proteome; Lysosome; Membrane; Phosphoprotein;
Reference proteome.
CHAIN 1 357 BLOC-1-related complex subunit 6.
/FTId=PRO_0000286827.
COMPBIAS 231 258 Pro-rich.
MOD_RES 168 168 Phosphoserine.
{ECO:0000244|PubMed:23186163}.
MOD_RES 196 196 Phosphothreonine.
{ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:23186163,
ECO:0000244|PubMed:24275569}.
MOD_RES 199 199 Phosphoserine.
{ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:23186163}.
CONFLICT 202 202 E -> K (in Ref. 3; BAA90889).
{ECO:0000305}.
CONFLICT 336 336 Q -> R (in Ref. 3; BAA90889 and 4;
BAD96226). {ECO:0000305}.
SEQUENCE 357 AA; 37226 MW; BBA89770528FA9E9 CRC64;
MESSRGRPGP ETDLLAVAEH QALVFGGGPG RTSSEPPAGL RVSGEEETEN VGGANRHPRT
SPKTSSCGVV HRPEREALEN EPGPQGTLSG AGSRRGAPGA EHEPSLSSRH KNPAPPEGKP
SSGRDCRRGG PGGGMDVEQQ EEEDNDEEAA AGSRAGRSFS SRLQDSRSLD GLSEACGGAG
SSGSAESGAG GGRRATISSP LELEGTVSRH GDLTHFVANN LQLKIRLSGA PPPPPSAPAR
PCPAPAPTPT PAIPPIDPEV LRDLERLSRE LGGRVDRLLR GLGGAVQELT ALSVGCIQTY
RDAVDSLGEA VDMSIKGMYT LLARCEELER ALQPVQGLAR QVRDIRRTLE VLEALCK


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