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BMP/retinoic acid-inducible neural-specific protein 1 (Deleted in bladder cancer protein 1 homolog)

 BRNP1_MOUSE             Reviewed;         760 AA.
Q920P3; Q80ZL2; Q812F0; Q8C1C9; Q920P4; Q9QXL0;
24-JAN-2006, integrated into UniProtKB/Swiss-Prot.
01-DEC-2001, sequence version 1.
28-FEB-2018, entry version 103.
RecName: Full=BMP/retinoic acid-inducible neural-specific protein 1;
AltName: Full=Deleted in bladder cancer protein 1 homolog;
Flags: Precursor;
Name=Brinp1; Synonyms=Brinp, Dbc1, Dbccr1, Fam5a;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1), TISSUE
SPECIFICITY, AND DEVELOPMENTAL STAGE.
TISSUE=Brain, and Embryonic stem cell;
PubMed=15193423; DOI=10.1016/j.molbrainres.2004.04.001;
Kawano H., Nakatani T., Mori T., Ueno S., Fukaya M., Abe A.,
Kobayashi M., Toda F., Watanabe M., Matsuoka I.;
"Identification and characterization of novel developmentally
regulated neural-specific proteins, BRINP family.";
Brain Res. Mol. Brain Res. 125:60-75(2004).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
STRAIN=C57BL/6J; TISSUE=Brain;
Ochal L.K., Sowden M.P., Messing E.M., Wheeless L.L., Reeder J.E.;
"Mouse DBCCR1 cDNA.";
Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
STRAIN=C57BL/6J; TISSUE=Brain, and Corpora quadrigemina;
PubMed=16141072; DOI=10.1126/science.1112014;
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=C57BL/6J;
PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
Lindblad-Toh K., Eichler E.E., Ponting C.P.;
"Lineage-specific biology revealed by a finished genome assembly of
the mouse.";
PLoS Biol. 7:E1000112-E1000112(2009).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
STRAIN=C57BL/6J; TISSUE=Brain, and Eye;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[6]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Brain;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and
expression.";
Cell 143:1174-1189(2010).
[7]
FUNCTION, INDUCTION, AND TISSUE SPECIFICITY.
PubMed=20025061; DOI=10.1002/jnr.22315;
Terashima M., Kobayashi M., Motomiya M., Inoue N., Yoshida T.,
Okano H., Iwasaki N., Minami A., Matsuoka I.;
"Analysis of the expression and function of BRINP family genes during
neuronal differentiation in mouse embryonic stem cell-derived neural
stem cells.";
J. Neurosci. Res. 88:1387-1393(2010).
-!- FUNCTION: Inhibits cell proliferation by negative regulation of
the G1/S transition. Mediates cell death which is not of the
classical apoptotic type and regulates expression of components of
the plasminogen pathway. {ECO:0000269|PubMed:20025061}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1;
IsoId=Q920P3-1; Sequence=Displayed;
Name=2;
IsoId=Q920P3-2; Sequence=VSP_017024, VSP_017025;
Note=No experimental confirmation available.;
-!- TISSUE SPECIFICITY: Expressed in brain. Weakly expressed in
embryonic stem (ES) cells and in ES-derived neural stem cells
(NSCs). {ECO:0000269|PubMed:15193423,
ECO:0000269|PubMed:20025061}.
-!- DEVELOPMENTAL STAGE: Expressed from 9.5 dpc.
{ECO:0000269|PubMed:15193423}.
-!- INDUCTION: Up-regulated upon differentiation into neuronal cells
in the presence of retinoic acid and BDNF. Up-regulated upon
differentiation into astroglial cells.
{ECO:0000269|PubMed:20025061}.
-!- SIMILARITY: Belongs to the BRINP family. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; AB060587; BAB70600.1; -; Genomic_DNA.
EMBL; AB060589; BAB70601.1; -; mRNA.
EMBL; AB088118; BAC55204.1; -; Genomic_DNA.
EMBL; AF202896; AAF17579.1; -; mRNA.
EMBL; AK028321; BAC25879.1; -; mRNA.
EMBL; AK045420; BAC32355.1; -; mRNA.
EMBL; BX088573; CAI26033.1; -; Genomic_DNA.
EMBL; BX649413; CAI26033.1; JOINED; Genomic_DNA.
EMBL; BX649413; CAI24368.1; -; Genomic_DNA.
EMBL; BX088573; CAI24368.1; JOINED; Genomic_DNA.
EMBL; BC048789; AAH48789.1; -; mRNA.
EMBL; BC079630; AAH79630.1; -; mRNA.
CCDS; CCDS18272.1; -. [Q920P3-1]
RefSeq; NP_064351.2; NM_019967.2. [Q920P3-1]
UniGene; Mm.248788; -.
ProteinModelPortal; Q920P3; -.
BioGrid; 208138; 2.
IntAct; Q920P3; 1.
STRING; 10090.ENSMUSP00000030036; -.
PhosphoSitePlus; Q920P3; -.
PaxDb; Q920P3; -.
PeptideAtlas; Q920P3; -.
PRIDE; Q920P3; -.
Ensembl; ENSMUST00000030036; ENSMUSP00000030036; ENSMUSG00000028351. [Q920P3-1]
GeneID; 56710; -.
KEGG; mmu:56710; -.
UCSC; uc008thw.1; mouse. [Q920P3-1]
UCSC; uc008thx.1; mouse. [Q920P3-2]
CTD; 1620; -.
MGI; MGI:1928478; Brinp1.
eggNOG; ENOG410IF4X; Eukaryota.
eggNOG; ENOG410XQ74; LUCA.
GeneTree; ENSGT00390000008571; -.
HOGENOM; HOG000049122; -.
HOVERGEN; HBG081412; -.
InParanoid; Q920P3; -.
OMA; PNHQMPR; -.
OrthoDB; EOG091G02AS; -.
PhylomeDB; Q920P3; -.
TreeFam; TF331600; -.
ChiTaRS; Brinp1; mouse.
PRO; PR:Q920P3; -.
Proteomes; UP000000589; Chromosome 4.
Bgee; ENSMUSG00000028351; -.
CleanEx; MM_DBC1; -.
Genevisible; Q920P3; MM.
GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO; GO:0030425; C:dendrite; IBA:GO_Central.
GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
GO; GO:0043025; C:neuronal cell body; IBA:GO_Central.
GO; GO:0001662; P:behavioral fear response; IMP:MGI.
GO; GO:0007050; P:cell cycle arrest; IEA:UniProtKB-KW.
GO; GO:0008219; P:cell death; ISS:UniProtKB.
GO; GO:0071300; P:cellular response to retinoic acid; IDA:UniProtKB.
GO; GO:0035640; P:exploration behavior; IMP:MGI.
GO; GO:0042711; P:maternal behavior; IMP:MGI.
GO; GO:0045786; P:negative regulation of cell cycle; ISS:UniProtKB.
GO; GO:0045930; P:negative regulation of mitotic cell cycle; IDA:UniProtKB.
GO; GO:0050768; P:negative regulation of neurogenesis; IMP:MGI.
GO; GO:0045666; P:positive regulation of neuron differentiation; IDA:UniProtKB.
GO; GO:0007614; P:short-term memory; IMP:MGI.
GO; GO:0035176; P:social behavior; IMP:MGI.
GO; GO:0071625; P:vocalization behavior; IMP:MGI.
InterPro; IPR033237; BRINP.
InterPro; IPR020864; MACPF.
PANTHER; PTHR15564; PTHR15564; 1.
Pfam; PF01823; MACPF; 1.
SMART; SM00457; MACPF; 1.
1: Evidence at protein level;
Alternative splicing; Cell cycle; Complete proteome; Cytoplasm;
Glycoprotein; Growth arrest; Reference proteome; Signal.
SIGNAL 1 16 {ECO:0000255}.
CHAIN 17 760 BMP/retinoic acid-inducible neural-
specific protein 1.
/FTId=PRO_0000045767.
DOMAIN 68 251 MACPF.
CARBOHYD 156 156 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 433 433 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 443 443 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 553 553 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 599 599 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 630 630 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 676 676 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
VAR_SEQ 308 320 DEFKSFMKRLPSN -> GTQTTTVNASGQT (in
isoform 2).
{ECO:0000303|PubMed:15489334}.
/FTId=VSP_017024.
VAR_SEQ 321 760 Missing (in isoform 2).
{ECO:0000303|PubMed:15489334}.
/FTId=VSP_017025.
CONFLICT 62 62 R -> Q (in Ref. 3; BAC25879).
{ECO:0000305}.
CONFLICT 157 158 AT -> VP (in Ref. 2; AAF17579).
{ECO:0000305}.
CONFLICT 550 551 QM -> FQR (in Ref. 2; AAF17579).
{ECO:0000305}.
CONFLICT 608 608 W -> V (in Ref. 2; AAF17579).
{ECO:0000305}.
SEQUENCE 760 AA; 88641 MW; 746E954368F1E49A CRC64;
MNWRFVELLY FLFVWGRISV QPSRQEPAGT DQHVSKEFDW LISDRGPFHH SRSYLSFVER
HRQGFTTRYK IYREFARWKV RNTAIERRDL VRHPVPLMPE FQRSIRLLGR RPTTQQFIDT
IIKKYGTHLL ISATLGGEEA LTMYMDKSRL DRKSGNATQS VEALHQLASS YFVDRDGTMR
RLHEIQISTG AIKVTETRTG PLGCNSYDNL DSVSSVLLQS TESKLHLQGL QIIFPQYLQE
KFVQSALSYI MCNGEGEYVC QNSQCRCQCA EEFPQCNCPI TDIQIMEFTL ANMAKAWTEA
YKDLENSDEF KSFMKRLPSN HFLTIGSIHQ HWGNDWDLQS RYKLLQSATE AQRQKIQRTA
RKLFGLSVRC RHNPNHQLPR ERTIQQWLAR VQSLLYCNEN GFWGTFLESQ RSCVCHGSTT
LCQRPIPCII GGNNSCAMCS LANISLCGSC NKGYKLYRGR CEPQNVDSER SEQFISFETD
LDFQDLELKY LLQKMDSRLY VHTTFISNEI RLDTFFDPRW RKRMSLTLKS NKNRMDFIHM
VIGMSMRICQ MRNSSLDPMF FVYVNPFSGS HSEGWNMPFG EFGYPRWEKI RLQNSQCYNW
TLLLGNRWKT FFETVHIYLR SRTRLPTLRN ETGQGPVDLS DPSKRQFYIK ISDVQVFGYS
LRFNADLLRS AVQQVNQSYT QGGQFYSSSS VMLLMLDIRD RINRLAPPVA PGKPQLDLFS
CMLKHRLKLT NSEIIRVNHA LDLYNTEILK QSDQMTAKLC


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