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BPI fold-containing family A member 1 (Lung and nasal epithelium carcinoma-associated protein) (Palate lung and nasal epithelium clone protein)

 BPIA1_PIG               Reviewed;         249 AA.
Q5XW65; Q5XW64;
05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
23-NOV-2004, sequence version 1.
25-OCT-2017, entry version 59.
RecName: Full=BPI fold-containing family A member 1;
AltName: Full=Lung and nasal epithelium carcinoma-associated protein;
AltName: Full=Palate lung and nasal epithelium clone protein;
Flags: Precursor;
Name=BPIFA1; Synonyms=PLUNC, SPLUNC1;
Sus scrofa (Pig).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;
Sus.
NCBI_TaxID=9823;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], AND TISSUE SPECIFICITY.
TISSUE=Lung;
PubMed=15777615; DOI=10.1016/j.bbaexp.2005.01.005;
Larsen K., Madsen L.B., Bendixen C.;
"Porcine SPLUNC1: molecular cloning, characterization and expression
analysis.";
Biochim. Biophys. Acta 1727:220-226(2005).
-!- FUNCTION: Plays a role in the innate immune responses of the upper
airways. Reduces the surface tension in secretions from airway
epithelia and inhibits the formation of biofilm by pathogenic
Gram-negative bacteria, such as P.aeruginosa and K.pneumoniae.
Binds bacterial lipopolysaccharide (LPS). Negatively regulates
proteolytic cleavage of SCNN1G, an event that is required for
activation of the epithelial sodium channel (ENaC), and thereby
contributes to airway surface liquid homeostasis and proper
clearance of mucus. Plays a role in the airway inflammatory
response after exposure to irritants. May attract macrophages and
neutrophils. May be associated with tumor progression (By
similarity). {ECO:0000250}.
-!- SUBUNIT: Monomer. Interacts (via N-terminus) with SCNN1B, a
subunit of the heterotrimeric epithelial sodium channel (ENaC);
this inhibits proteolytic activation of ENaC (By similarity).
{ECO:0000250}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Note=Apical side of
airway epithelial cells. Detected in airway surface liquid, nasal
mucus and sputum (By similarity). {ECO:0000250}.
-!- TISSUE SPECIFICITY: Expressed in lung and trachea.
{ECO:0000269|PubMed:15777615}.
-!- MISCELLANEOUS: Binds lipopolysaccharides. {ECO:0000250}.
-!- SIMILARITY: Belongs to the BPI/LBP/Plunc superfamily. Plunc
family. {ECO:0000305}.
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EMBL; AY733063; AAU43633.1; -; mRNA.
EMBL; AY733064; AAU43634.1; -; Genomic_DNA.
RefSeq; NP_001005727.1; NM_001005727.1.
UniGene; Ssc.26445; -.
ProteinModelPortal; Q5XW65; -.
SMR; Q5XW65; -.
PaxDb; Q5XW65; -.
PRIDE; Q5XW65; -.
GeneID; 449524; -.
KEGG; ssc:449524; -.
CTD; 51297; -.
eggNOG; ENOG410IWYF; Eukaryota.
eggNOG; ENOG41114MD; LUCA.
HOGENOM; HOG000231510; -.
HOVERGEN; HBG045573; -.
InParanoid; Q5XW65; -.
Proteomes; UP000008227; Unplaced.
GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
GO; GO:0008289; F:lipid binding; IEA:InterPro.
GO; GO:0019731; P:antibacterial humoral response; ISS:UniProtKB.
GO; GO:0045087; P:innate immune response; ISS:UniProtKB.
GO; GO:0050891; P:multicellular organismal water homeostasis; ISS:UniProtKB.
GO; GO:1900229; P:negative regulation of single-species biofilm formation in or on host organism; ISS:UniProtKB.
GO; GO:0050828; P:regulation of liquid surface tension; ISS:UniProtKB.
GO; GO:1902305; P:regulation of sodium ion transmembrane transport; ISS:UniProtKB.
InterPro; IPR017943; Bactericidal_perm-incr_a/b_dom.
InterPro; IPR032942; BPI/LBP/Plunc.
InterPro; IPR034307; BPIFA1.
InterPro; IPR017942; Lipid-bd_serum_glycop_N.
PANTHER; PTHR10504; PTHR10504; 1.
PANTHER; PTHR10504:SF70; PTHR10504:SF70; 1.
Pfam; PF01273; LBP_BPI_CETP; 1.
SUPFAM; SSF55394; SSF55394; 1.
2: Evidence at transcript level;
Antibiotic; Antimicrobial; Complete proteome; Disulfide bond;
Glycoprotein; Immunity; Innate immunity; Reference proteome; Secreted;
Signal.
SIGNAL 1 15 {ECO:0000255}.
CHAIN 16 249 BPI fold-containing family A member 1.
/FTId=PRO_0000017177.
COMPBIAS 13 211 Leu-rich.
CARBOHYD 151 151 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 173 217 {ECO:0000250}.
SEQUENCE 249 AA; 25829 MW; 5E3085F1994ACF06 CRC64;
MFQVAGLIVF CGLLAQTTAL LEALPLGKAL PLALDQSPTD LVGSLTSTLS NGLLSEGVLG
ILGNLPLLDI LKAGGNTPSG LLGGLLGKLS STIPLLNDIV DLQITDPQLL ELGLVQSPDG
HRLYVTIPLS LVLNVKTSVV GSLLKLAVKL NITVELLAVK DEQGKSHLVL GDCTHSPGSL
KISLLDGLGP LVPQDLLDSI TGVLDNVLPG LVQGEVCPLV NEVLSHLDVT LVHSIVDALI
QGQEFVIKV


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