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BPI fold-containing family A member 1 (Lung-specific protein X) (Nasopharyngeal carcinoma-related protein) (Palate lung and nasal epithelium clone protein) (Secretory protein in upper respiratory tracts) (Short PLUNC1) (SPLUNC1) (Tracheal epithelium-enriched protein) (Von Ebner protein Hl)

 BPIA1_HUMAN             Reviewed;         256 AA.
Q9NP55; A6XMV5; A8K9R3; E1P5M9; Q9NZT0;
18-OCT-2001, integrated into UniProtKB/Swiss-Prot.
01-OCT-2000, sequence version 1.
25-OCT-2017, entry version 141.
RecName: Full=BPI fold-containing family A member 1;
AltName: Full=Lung-specific protein X;
AltName: Full=Nasopharyngeal carcinoma-related protein;
AltName: Full=Palate lung and nasal epithelium clone protein;
AltName: Full=Secretory protein in upper respiratory tracts;
AltName: Full=Short PLUNC1;
Short=SPLUNC1;
AltName: Full=Tracheal epithelium-enriched protein;
AltName: Full=Von Ebner protein Hl;
Flags: Precursor;
Name=BPIFA1; Synonyms=LUNX, NASG, PLUNC, SPLUNC1, SPURT;
ORFNames=UNQ787/PRO1606;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1), AND TISSUE
SPECIFICITY.
PubMed=11018263; DOI=10.1016/S0167-4781(00)00196-2;
Bingle C.D., Bingle L.;
"Characterization of the human plunc gene, a gene product with an
upper airways and nasopharyngeal restricted expression pattern.";
Biochim. Biophys. Acta 1493:363-367(2000).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
He Z.W., Xie L., Xu L.G., Lan K., Liu W., Zhang L., Ren C., Shi J.,
Zhou W., Yao K.;
"Cloning of a novel gene associated with human nasopharyngeal
carcinoma.";
Chin. Sci. Bull. 45:2267-2272(2000).
[3]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY.
TISSUE=Lung;
PubMed=11251963;
DOI=10.1002/1097-0215(200002)9999:9999<::AID-IJC1059>3.0.CO;2-B;
Iwao K., Watanabe T., Fujiwara Y., Takami K., Kodama K.,
Higashiyama M., Yokouchi H., Ozaki K., Monden M., Tanigami A.;
"Isolation of a novel human lung-specific gene, LUNX, a potential
molecular marker for detection of micrometastasis in non-small-cell
lung cancer.";
Int. J. Cancer 91:433-437(2001).
[4]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Zhang B., Yu Y., Li G.;
"Isolation of nasopharynx-specific gene and nasopharyngeal carcinoma
(NPC) susceptibility gene by suppression subtractive hybridization and
cDNA microarray technique.";
Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, AND
INDUCTION BY ATRA.
TISSUE=Tracheobronchial epithelium;
PubMed=12409287; DOI=10.1074/jbc.M210523200;
Di Y.-P., Harper R., Zhao Y., Pahlavan N., Finkbeiner W., Wu R.;
"Molecular cloning and characterization of spurt, a human novel gene
that is retinoic acid-inducible and encodes a secretory protein
specific in upper respiratory tracts.";
J. Biol. Chem. 278:1165-1173(2003).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
PubMed=12975309; DOI=10.1101/gr.1293003;
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S.,
Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J.,
Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J.,
Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A.,
Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H.,
Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D.,
Wood W.I., Godowski P.J., Gray A.M.;
"The secreted protein discovery initiative (SPDI), a large-scale
effort to identify novel human secreted and transmembrane proteins: a
bioinformatics assessment.";
Genome Res. 13:2265-2270(2003).
[7]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Trachea;
PubMed=14702039; DOI=10.1038/ng1285;
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human
cDNAs.";
Nat. Genet. 36:40-45(2004).
[8]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Yu Z., Zheng Z., Tang T., Fu Y.;
"A computer system platform used to predict novel genes.";
Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
[9]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=11780052; DOI=10.1038/414865a;
Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M.,
Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J.,
Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P.,
Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M.,
Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R.,
Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M.,
Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H.,
Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S.,
Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E.,
Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A.,
Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M.,
Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A.,
Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S.,
Rogers J.;
"The DNA sequence and comparative analysis of human chromosome 20.";
Nature 414:865-871(2001).
[10]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
Venter J.C.;
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
[11]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Skeletal muscle;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[12]
PROTEIN SEQUENCE OF 95-152; 157-167 AND 214-232, FUNCTION, AND
SUBCELLULAR LOCATION.
PubMed=11425234;
DOI=10.1002/1522-2683(200105)22:9<1795::AID-ELPS1795>3.0.CO;2-J;
Lindahl M., Stahlbom B., Tagesson C.;
"Identification of a new potential airway irritation marker, palate
lung nasal epithelial clone protein, in human nasal lavage fluid with
two-dimensional electrophoresis and matrix-assisted laser
desorption/ionization-time of flight.";
Electrophoresis 22:1795-1800(2001).
[13]
PROTEIN SEQUENCE OF 95-102; 115-152 AND 157-167, BINDING TO
LIPOPOLYSACCHARIDES, GLYCOSYLATION, AND SUBCELLULAR LOCATION.
PubMed=15158712; DOI=10.1016/j.bbapap.2004.01.001;
Ghafouri B., Kihlstroem E., Tagesson C., Lindahl M.;
"PLUNC in human nasal lavage fluid: multiple isoforms that bind to
lipopolysaccharide.";
Biochim. Biophys. Acta 1699:57-63(2004).
[14]
PROTEIN SEQUENCE OF 110-121, SUBCELLULAR LOCATION, AND TISSUE
SPECIFICITY.
PubMed=12920053; DOI=10.1165/rcmb.2003-0142OC;
Campos M.A., Abreu A.R., Nlend M.C., Cobas M.A., Conner G.E.,
Whitney P.L.;
"Purification and characterization of PLUNC from human
tracheobronchial secretions.";
Am. J. Respir. Cell Mol. Biol. 30:184-192(2004).
[15]
FUNCTION, AND SUBCELLULAR LOCATION.
PubMed=23499554; DOI=10.1016/j.ajpath.2013.01.050;
Liu Y., Bartlett J.A., Di M.E., Bomberger J.M., Chan Y.R., Gakhar L.,
Mallampalli R.K., McCray P.B. Jr., Di Y.P.;
"SPLUNC1/BPIFA1 contributes to pulmonary host defense against
Klebsiella pneumoniae respiratory infection.";
Am. J. Pathol. 182:1519-1531(2013).
[16]
FUNCTION, INTERACTION WITH SCNN1B, SUBCELLULAR LOCATION, AND SUBUNIT.
PubMed=24124190; DOI=10.1152/ajplung.00103.2013;
Hobbs C.A., Blanchard M.G., Alijevic O., Tan C.D., Kellenberger S.,
Bencharit S., Cao R., Kesimer M., Walton W.G., Henderson A.G.,
Redinbo M.R., Stutts M.J., Tarran R.;
"Identification of the SPLUNC1 ENaC-inhibitory domain yields novel
strategies to treat sodium hyperabsorption in cystic fibrosis airway
epithelial cultures.";
Am. J. Physiol. 305:L990-L1001(2013).
[17]
FUNCTION.
PubMed=23132494; DOI=10.1128/IAI.00500-12;
Sayeed S., Nistico L., St Croix C., Di Y.P.;
"Multifunctional role of human SPLUNC1 in Pseudomonas aeruginosa
infection.";
Infect. Immun. 81:285-291(2013).
[18]
X-RAY CRYSTALLOGRAPHY (2.81 ANGSTROMS) OF 19-256, FUNCTION, DISULFIDE
BOND, SUBCELLULAR LOCATION, SUBUNIT, AND IDENTIFICATION BY MASS
SPECTROMETRY.
PubMed=24043776; DOI=10.1073/pnas.1311999110;
Garland A.L., Walton W.G., Coakley R.D., Tan C.D., Gilmore R.C.,
Hobbs C.A., Tripathy A., Clunes L.A., Bencharit S., Stutts M.J.,
Betts L., Redinbo M.R., Tarran R.;
"Molecular basis for pH-dependent mucosal dehydration in cystic
fibrosis airways.";
Proc. Natl. Acad. Sci. U.S.A. 110:15973-15978(2013).
-!- FUNCTION: Plays a role in the innate immune responses of the upper
airways. Reduces the surface tension in secretions from airway
epithelia and inhibits the formation of biofilm by pathogenic
Gram-negative bacteria, such as P.aeruginosa and K.pneumoniae.
Binds bacterial lipopolysaccharide (LPS). Negatively regulates
proteolytic cleavage of SCNN1G, an event that is required for
activation of the epithelial sodium channel (ENaC), and thereby
contributes to airway surface liquid homeostasis and proper
clearance of mucus. Plays a role in the airway inflammatory
response after exposure to irritants. May attract macrophages and
neutrophils. May be associated with tumor progression.
{ECO:0000269|PubMed:11425234, ECO:0000269|PubMed:23132494,
ECO:0000269|PubMed:23499554, ECO:0000269|PubMed:24043776,
ECO:0000269|PubMed:24124190}.
-!- SUBUNIT: Monomer. Interacts (via N-terminus) with SCNN1B, a
subunit of the heterotrimeric epithelial sodium channel (ENaC);
this inhibits proteolytic activation of ENaC.
{ECO:0000269|PubMed:24043776, ECO:0000269|PubMed:24124190}.
-!- INTERACTION:
Q9NXW9:ALKBH4; NbExp=4; IntAct=EBI-953896, EBI-8637516;
Q9H596:DUSP21; NbExp=4; IntAct=EBI-953896, EBI-7357329;
Q0VD86:INCA1; NbExp=4; IntAct=EBI-953896, EBI-6509505;
P78337:PITX1; NbExp=4; IntAct=EBI-953896, EBI-748265;
O00241-2:SIRPB1; NbExp=4; IntAct=EBI-953896, EBI-10179231;
Q96N21:TEPSIN; NbExp=4; IntAct=EBI-953896, EBI-11139477;
Q92734:TFG; NbExp=4; IntAct=EBI-953896, EBI-357061;
Q9UMX0-2:UBQLN1; NbExp=3; IntAct=EBI-953896, EBI-10173939;
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:11425234,
ECO:0000269|PubMed:12920053, ECO:0000269|PubMed:15158712,
ECO:0000269|PubMed:23499554, ECO:0000269|PubMed:24043776,
ECO:0000269|PubMed:24124190}. Note=Apical side of airway
epithelial cells. Detected in airway surface liquid, nasal mucus
and sputum.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1;
IsoId=Q9NP55-1; Sequence=Displayed;
Name=2;
IsoId=Q9NP55-2; Sequence=VSP_057345;
Note=No experimental confirmation available.;
-!- TISSUE SPECIFICITY: Lung, upper airways and nasopharyngeal
regions, including trachea and nasal epithelium. Specifically
expressed in the secretory ducts and submucosal glands of
tracheobronchial tissues. Highest expression in the trachea and
progressive decrease from proximal (bronchial) to distal
(bronchiolar) airways. Also expressed in lung cancers and some
other types of cancer. {ECO:0000269|PubMed:11018263,
ECO:0000269|PubMed:11251963, ECO:0000269|PubMed:12409287,
ECO:0000269|PubMed:12920053}.
-!- INDUCTION: By all-trans retinoic acid (ATRA).
{ECO:0000269|PubMed:12409287}.
-!- PTM: May be N-glycosylated. {ECO:0000269|PubMed:15158712}.
-!- SIMILARITY: Belongs to the BPI/LBP/Plunc superfamily. Plunc
family. {ECO:0000305}.
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EMBL; AF214562; AAG13653.1; -; Genomic_DNA.
EMBL; AF172993; AAF70860.1; -; mRNA.
EMBL; AF158745; AAF82622.1; -; mRNA.
EMBL; AB024937; BAA93633.1; -; mRNA.
EMBL; AF439448; AAL87636.1; -; mRNA.
EMBL; AF417256; AAO12198.1; -; mRNA.
EMBL; AF417257; AAO12199.1; -; mRNA.
EMBL; AF421369; AAO12200.1; -; Genomic_DNA.
EMBL; AY359020; AAQ89379.1; -; mRNA.
EMBL; AK292778; BAF85467.1; -; mRNA.
EMBL; DQ846869; ABI63356.1; -; mRNA.
EMBL; AL121901; CAC03549.1; -; Genomic_DNA.
EMBL; CH471077; EAW76327.1; -; Genomic_DNA.
EMBL; CH471077; EAW76328.1; -; Genomic_DNA.
EMBL; CH471077; EAW76329.1; -; Genomic_DNA.
EMBL; BC012549; AAH12549.1; -; mRNA.
CCDS; CCDS13217.1; -. [Q9NP55-1]
RefSeq; NP_001230122.1; NM_001243193.1. [Q9NP55-1]
RefSeq; NP_057667.1; NM_016583.3. [Q9NP55-1]
RefSeq; NP_570913.1; NM_130852.2. [Q9NP55-1]
UniGene; Hs.211092; -.
PDB; 4KEG; X-ray; 2.50 A; A=43-256.
PDB; 4KGH; X-ray; 2.81 A; A/B=19-256.
PDB; 4KGO; X-ray; 3.19 A; A/B=19-256.
PDB; 4N4X; X-ray; 2.50 A; A=43-256.
PDB; 5I7J; X-ray; 2.54 A; A/B=19-256.
PDB; 5I7K; X-ray; 2.55 A; A/B=19-256.
PDB; 5I7L; X-ray; 2.60 A; A/B=19-256.
PDBsum; 4KEG; -.
PDBsum; 4KGH; -.
PDBsum; 4KGO; -.
PDBsum; 4N4X; -.
PDBsum; 5I7J; -.
PDBsum; 5I7K; -.
PDBsum; 5I7L; -.
ProteinModelPortal; Q9NP55; -.
SMR; Q9NP55; -.
BioGrid; 119448; 14.
IntAct; Q9NP55; 49.
MINT; MINT-2873129; -.
STRING; 9606.ENSP00000346251; -.
iPTMnet; Q9NP55; -.
PhosphoSitePlus; Q9NP55; -.
BioMuta; BPIFA1; -.
DMDM; 17380173; -.
PaxDb; Q9NP55; -.
PeptideAtlas; Q9NP55; -.
PRIDE; Q9NP55; -.
DNASU; 51297; -.
Ensembl; ENST00000354297; ENSP00000346251; ENSG00000198183. [Q9NP55-1]
Ensembl; ENST00000375413; ENSP00000364562; ENSG00000198183. [Q9NP55-1]
Ensembl; ENST00000375422; ENSP00000364571; ENSG00000198183. [Q9NP55-1]
Ensembl; ENST00000618484; ENSP00000482297; ENSG00000198183. [Q9NP55-2]
GeneID; 51297; -.
KEGG; hsa:51297; -.
UCSC; uc002wyt.5; human. [Q9NP55-1]
CTD; 51297; -.
DisGeNET; 51297; -.
EuPathDB; HostDB:ENSG00000198183.11; -.
GeneCards; BPIFA1; -.
HGNC; HGNC:15749; BPIFA1.
HPA; CAB025669; -.
MIM; 607412; gene.
neXtProt; NX_Q9NP55; -.
OpenTargets; ENSG00000198183; -.
PharmGKB; PA33423; -.
eggNOG; ENOG410IWYF; Eukaryota.
eggNOG; ENOG41114MD; LUCA.
GeneTree; ENSGT00840000129898; -.
HOGENOM; HOG000231510; -.
HOVERGEN; HBG045573; -.
InParanoid; Q9NP55; -.
OMA; QGKVCPL; -.
OrthoDB; EOG091G048N; -.
PhylomeDB; Q9NP55; -.
TreeFam; TF337052; -.
Reactome; R-HSA-6803157; Antimicrobial peptides.
ChiTaRS; BPIFA1; human.
GeneWiki; Plunc; -.
GenomeRNAi; 51297; -.
PRO; PR:Q9NP55; -.
Proteomes; UP000005640; Chromosome 20.
Bgee; ENSG00000198183; -.
CleanEx; HS_PLUNC; -.
Genevisible; Q9NP55; HS.
GO; GO:0005576; C:extracellular region; IDA:UniProtKB.
GO; GO:0005615; C:extracellular space; IDA:UniProtKB.
GO; GO:0008289; F:lipid binding; IEA:InterPro.
GO; GO:0019731; P:antibacterial humoral response; IDA:UniProtKB.
GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; IEP:UniProtKB.
GO; GO:0019730; P:antimicrobial humoral response; TAS:Reactome.
GO; GO:0051607; P:defense response to virus; IEP:UniProtKB.
GO; GO:0002395; P:immune response in nasopharyngeal-associated lymphoid tissue; IEP:UniProtKB.
GO; GO:0045087; P:innate immune response; IDA:UniProtKB.
GO; GO:0050891; P:multicellular organismal water homeostasis; IDA:UniProtKB.
GO; GO:1900229; P:negative regulation of single-species biofilm formation in or on host organism; IMP:UniProtKB.
GO; GO:0050828; P:regulation of liquid surface tension; IDA:UniProtKB.
GO; GO:1902305; P:regulation of sodium ion transmembrane transport; IDA:UniProtKB.
InterPro; IPR017943; Bactericidal_perm-incr_a/b_dom.
InterPro; IPR032942; BPI/LBP/Plunc.
InterPro; IPR034307; BPIFA1.
InterPro; IPR017942; Lipid-bd_serum_glycop_N.
PANTHER; PTHR10504; PTHR10504; 1.
PANTHER; PTHR10504:SF70; PTHR10504:SF70; 1.
Pfam; PF01273; LBP_BPI_CETP; 1.
SUPFAM; SSF55394; SSF55394; 1.
1: Evidence at protein level;
3D-structure; Alternative splicing; Antibiotic; Antimicrobial;
Complete proteome; Direct protein sequencing; Disulfide bond;
Glycoprotein; Immunity; Innate immunity; Reference proteome; Secreted;
Signal.
SIGNAL 1 19 {ECO:0000255}.
CHAIN 20 256 BPI fold-containing family A member 1.
/FTId=PRO_0000017175.
DISULFID 180 224 {ECO:0000269|PubMed:24043776}.
VAR_SEQ 16 29 Missing (in isoform 2).
{ECO:0000303|Ref.8}.
/FTId=VSP_057345.
CONFLICT 220 220 Q -> K (in Ref. 1; AAF70860).
{ECO:0000305}.
HELIX 46 60 {ECO:0000244|PDB:4KEG}.
HELIX 63 68 {ECO:0000244|PDB:4KEG}.
HELIX 73 75 {ECO:0000244|PDB:5I7J}.
HELIX 92 96 {ECO:0000244|PDB:5I7J}.
STRAND 99 101 {ECO:0000244|PDB:5I7L}.
STRAND 108 114 {ECO:0000244|PDB:4KEG}.
STRAND 118 121 {ECO:0000244|PDB:4KEG}.
STRAND 124 127 {ECO:0000244|PDB:4KGO}.
STRAND 128 139 {ECO:0000244|PDB:4KEG}.
TURN 144 146 {ECO:0000244|PDB:5I7J}.
STRAND 151 166 {ECO:0000244|PDB:4KEG}.
STRAND 168 170 {ECO:0000244|PDB:4KEG}.
STRAND 172 176 {ECO:0000244|PDB:4KEG}.
TURN 183 185 {ECO:0000244|PDB:4N4X}.
STRAND 187 190 {ECO:0000244|PDB:4KEG}.
STRAND 193 196 {ECO:0000244|PDB:5I7J}.
HELIX 200 202 {ECO:0000244|PDB:5I7L}.
HELIX 205 231 {ECO:0000244|PDB:4KEG}.
HELIX 235 246 {ECO:0000244|PDB:4KEG}.
TURN 247 249 {ECO:0000244|PDB:5I7J}.
SEQUENCE 256 AA; 26713 MW; EDF152FBC35315BC CRC64;
MFQTGGLIVF YGLLAQTMAQ FGGLPVPLDQ TLPLNVNPAL PLSPTGLAGS LTNALSNGLL
SGGLLGILEN LPLLDILKPG GGTSGGLLGG LLGKVTSVIP GLNNIIDIKV TDPQLLELGL
VQSPDGHRLY VTIPLGIKLQ VNTPLVGASL LRLAVKLDIT AEILAVRDKQ ERIHLVLGDC
THSPGSLQIS LLDGLGPLPI QGLLDSLTGI LNKVLPELVQ GNVCPLVNEV LRGLDITLVH
DIVNMLIHGL QFVIKV


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