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BPI fold-containing family A member 1 (Palate lung and nasal epithelium clone protein)

 BPIA1_MOUSE             Reviewed;         278 AA.
P97361; Q7TQJ2;
18-OCT-2001, integrated into UniProtKB/Swiss-Prot.
26-APR-2004, sequence version 3.
05-DEC-2018, entry version 127.
RecName: Full=BPI fold-containing family A member 1;
AltName: Full=Palate lung and nasal epithelium clone protein;
Flags: Precursor;
Name=Bpifa1; Synonyms=Plunc, Splunc1;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
STRAIN=ICR; TISSUE=Palate;
PubMed=10224143; DOI=10.1074/jbc.274.19.13698;
Weston W.M., LeClair E.E., Trzyna W., McHugh K.M., Nugent P.,
Lafferty C.M., Ma L., Tuan R.S., Greene R.M.;
"Differential display identification of plunc, a novel gene expressed
in embryonic palate, nasal epithelium, and adult lung.";
J. Biol. Chem. 274:13698-13703(1999).
[2]
ERRATUM.
Weston W.M., LeClair E.E., Trzyna W., McHugh K.M., Nugent P.,
Lafferty C.M., Ma L., Tuan R.S., Greene R.M.;
J. Biol. Chem. 275:8262-8262(2000).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY, AND
DEVELOPMENTAL STAGE.
STRAIN=129/Sv;
PubMed=11396972; DOI=10.1006/bbrc.2001.5024;
LeClair E.E., Nguyen L., Bingle L., MacGowan A., Singleton V.,
Ward S.J., Bingle C.D.;
"Genomic organization of the mouse plunc gene and expression in the
developing airways and thymus.";
Biochem. Biophys. Res. Commun. 284:792-797(2001).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Olfactory epithelium;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5]
FUNCTION, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
PubMed=23499554; DOI=10.1016/j.ajpath.2013.01.050;
Liu Y., Bartlett J.A., Di M.E., Bomberger J.M., Chan Y.R., Gakhar L.,
Mallampalli R.K., McCray P.B. Jr., Di Y.P.;
"SPLUNC1/BPIFA1 contributes to pulmonary host defense against
Klebsiella pneumoniae respiratory infection.";
Am. J. Pathol. 182:1519-1531(2013).
-!- FUNCTION: Plays a role in the innate immune responses of the upper
airways. Reduces the surface tension in secretions from airway
epithelia and inhibits the formation of biofilm by pathogenic
Gram-negative bacteria, such as P.aeruginosa and K.pneumoniae.
Binds bacterial lipopolysaccharide (LPS). Negatively regulates
proteolytic cleavage of SCNN1G, an event that is required for
activation of the epithelial sodium channel (ENaC), and thereby
contributes to airway surface liquid homeostasis and proper
clearance of mucus (By similarity). Plays a role in the airway
inflammatory response after exposure to irritants. May attract
macrophages and neutrophils. May be associated with tumor
progression. {ECO:0000250, ECO:0000269|PubMed:23499554}.
-!- SUBUNIT: Monomer. Interacts (via N-terminus) with SCNN1B, a
subunit of the heterotrimeric epithelial sodium channel (ENaC);
this inhibits proteolytic activation of ENaC (By similarity).
{ECO:0000250}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:23499554}.
Note=Apical side of airway epithelial cells. Detected in airway
surface liquid, nasal mucus and sputum.
-!- TISSUE SPECIFICITY: Detected in airway epithelia (trachea and
lung) and in bronchoalveolar fluid (at protein level). Upper
airways, nasopharyngeal epithelium and thymus. Highest expression
in the trachea and progressive decrease from proximal (bronchial)
to distal (bronchiolar) airways. No expression is detected in the
terminal bronchioles, respiratory bronchioles or lung alveoli.
{ECO:0000269|PubMed:10224143, ECO:0000269|PubMed:11396972,
ECO:0000269|PubMed:23499554}.
-!- DEVELOPMENTAL STAGE: First detected at 14.5 dpc in the
nasopharyngeal epithelium and persists there into adulthood. In
the thymus, weak expression is detected at 16.5 dpc and appears to
be restricted to epithelial cells lining the medullary venules.
This pattern of thymic expression persists until birth and into
early postnatal life but is greatly decreased in the adult thymus.
No expression is detected in the lung until 2 days after birth,
after which expression is detected in cells lining the trachea.
{ECO:0000269|PubMed:11396972}.
-!- SIMILARITY: Belongs to the BPI/LBP/Plunc superfamily. Plunc
family. {ECO:0000305}.
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EMBL; U69172; AAB63256.1; -; mRNA.
EMBL; AF356785; AAK63069.1; -; Genomic_DNA.
EMBL; BC054375; AAH54375.1; -; mRNA.
CCDS; CCDS16925.1; -.
RefSeq; NP_035256.2; NM_011126.3.
UniGene; Mm.268852; -.
PDB; 6BAQ; X-ray; 2.50 A; A/B/C/D/E/F/G/H=38-278.
PDBsum; 6BAQ; -.
ProteinModelPortal; P97361; -.
SMR; P97361; -.
IntAct; P97361; 1.
MINT; P97361; -.
STRING; 10090.ENSMUSP00000028985; -.
PhosphoSitePlus; P97361; -.
MaxQB; P97361; -.
PaxDb; P97361; -.
PeptideAtlas; P97361; -.
PRIDE; P97361; -.
Ensembl; ENSMUST00000028985; ENSMUSP00000028985; ENSMUSG00000027483.
GeneID; 18843; -.
KEGG; mmu:18843; -.
UCSC; uc008niu.2; mouse.
CTD; 51297; -.
MGI; MGI:1338036; Bpifa1.
eggNOG; ENOG410IWYF; Eukaryota.
eggNOG; ENOG41114MD; LUCA.
GeneTree; ENSGT00940000153099; -.
HOGENOM; HOG000231510; -.
HOVERGEN; HBG045573; -.
InParanoid; P97361; -.
OMA; QGKVCPL; -.
OrthoDB; EOG091G048N; -.
PhylomeDB; P97361; -.
TreeFam; TF337052; -.
Reactome; R-MMU-6803157; Antimicrobial peptides.
PRO; PR:P97361; -.
Proteomes; UP000000589; Chromosome 2.
Bgee; ENSMUSG00000027483; Expressed in 47 organ(s), highest expression level in trachea.
CleanEx; MM_PLUNC; -.
Genevisible; P97361; MM.
GO; GO:0005576; C:extracellular region; ISS:UniProtKB.
GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
GO; GO:0005902; C:microvillus; ISO:MGI.
GO; GO:0008289; F:lipid binding; IEA:InterPro.
GO; GO:0019731; P:antibacterial humoral response; IMP:UniProtKB.
GO; GO:0045087; P:innate immune response; IMP:UniProtKB.
GO; GO:0050891; P:multicellular organismal water homeostasis; ISS:UniProtKB.
GO; GO:1900229; P:negative regulation of single-species biofilm formation in or on host organism; IMP:UniProtKB.
GO; GO:0050828; P:regulation of liquid surface tension; ISS:UniProtKB.
GO; GO:1902305; P:regulation of sodium ion transmembrane transport; ISS:UniProtKB.
InterPro; IPR017943; Bactericidal_perm-incr_a/b_dom.
InterPro; IPR032942; BPI/LBP/Plunc.
InterPro; IPR034307; BPIFA1.
InterPro; IPR017942; Lipid-bd_serum_glycop_N.
PANTHER; PTHR10504; PTHR10504; 1.
PANTHER; PTHR10504:SF70; PTHR10504:SF70; 1.
Pfam; PF01273; LBP_BPI_CETP; 1.
SUPFAM; SSF55394; SSF55394; 1.
1: Evidence at protein level;
3D-structure; Antibiotic; Antimicrobial; Complete proteome;
Disulfide bond; Glycoprotein; Immunity; Innate immunity;
Reference proteome; Repeat; Secreted; Signal.
SIGNAL 1 19 {ECO:0000255}.
CHAIN 20 278 BPI fold-containing family A member 1.
/FTId=PRO_0000017176.
REPEAT 23 28 Repeat 1.
REPEAT 30 36 Repeat 2.
REPEAT 39 44 Repeat 3.
REPEAT 47 52 Repeat 4.
REGION 23 52 4 X 6 AA repeats of G-[LPQ]-[PL]-L-P-L.
CARBOHYD 182 182 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 228 228 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 204 246 {ECO:0000250}.
CONFLICT 226 226 L -> V (in Ref. 1 and 3). {ECO:0000305}.
HELIX 68 71 {ECO:0000244|PDB:6BAQ}.
HELIX 72 86 {ECO:0000244|PDB:6BAQ}.
HELIX 89 94 {ECO:0000244|PDB:6BAQ}.
HELIX 98 103 {ECO:0000244|PDB:6BAQ}.
HELIX 112 120 {ECO:0000244|PDB:6BAQ}.
HELIX 124 128 {ECO:0000244|PDB:6BAQ}.
STRAND 132 140 {ECO:0000244|PDB:6BAQ}.
STRAND 144 147 {ECO:0000244|PDB:6BAQ}.
STRAND 151 167 {ECO:0000244|PDB:6BAQ}.
HELIX 169 171 {ECO:0000244|PDB:6BAQ}.
STRAND 175 191 {ECO:0000244|PDB:6BAQ}.
STRAND 197 206 {ECO:0000244|PDB:6BAQ}.
STRAND 212 215 {ECO:0000244|PDB:6BAQ}.
STRAND 223 226 {ECO:0000244|PDB:6BAQ}.
HELIX 227 254 {ECO:0000244|PDB:6BAQ}.
HELIX 258 269 {ECO:0000244|PDB:6BAQ}.
SEQUENCE 278 AA; 28625 MW; 2540BED994475387 CRC64;
MFLVGSLVVL CGLLAHSTAQ LAGLPLPLGQ GPPLPLNQGP PLPLNQGQLL PLAQGLPLAV
SPALPSNPTD LLAGKFTDAL SGGLLSGGLL GILENIPLLD VIKSGGGNSN GLVGGLLGKL
TSSVPLLNNI LDIKITDPQL LELGLVQSPD GHRLYVTIPL GLTLNVNMPV VGSLLQLAVK
LNITAEVLAV KDNQGRIHLV LGDCTHSPGS LKISLLNGVT PVQSFLDNLT GILTKVLPEL
IQGKVCPLVN GILSGLDVTL VHNIAELLIH GLQFVIKV


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