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BPI fold-containing family B member 6 (Bactericidal/permeability-increasing protein-like 3)

 BPIB6_HUMAN             Reviewed;         453 AA.
Q8NFQ5;
29-AUG-2003, integrated into UniProtKB/Swiss-Prot.
01-OCT-2002, sequence version 1.
07-NOV-2018, entry version 124.
RecName: Full=BPI fold-containing family B member 6;
AltName: Full=Bactericidal/permeability-increasing protein-like 3;
Flags: Precursor;
Name=BPIFB6; Synonyms=BPIL3;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Tonsil;
PubMed=12185532; DOI=10.1007/s00251-002-0467-3;
Mulero J.J., Boyle B.J., Bradley S., Bright J.M., Nelken S.T.,
Ho T.T., Mize N.K., Childs J.D., Ballinger D.G., Ford J.E., Rupp F.;
"Three new human members of the lipid transfer/lipopolysaccharide
binding protein family (LT/LBP).";
Immunogenetics 54:293-300(2002).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=11780052; DOI=10.1038/414865a;
Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M.,
Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J.,
Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P.,
Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M.,
Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R.,
Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M.,
Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H.,
Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S.,
Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E.,
Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A.,
Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M.,
Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A.,
Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S.,
Rogers J.;
"The DNA sequence and comparative analysis of human chromosome 20.";
Nature 414:865-871(2001).
[3]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Leukemic T-cell;
PubMed=19690332; DOI=10.1126/scisignal.2000007;
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
Rodionov V., Han D.K.;
"Quantitative phosphoproteomic analysis of T cell receptor signaling
reveals system-wide modulation of protein-protein interactions.";
Sci. Signal. 2:RA46-RA46(2009).
[4]
VARIANT HIS-296.
PubMed=21076407; DOI=10.1038/ng.712;
Vissers L.E., de Ligt J., Gilissen C., Janssen I., Steehouwer M.,
de Vries P., van Lier B., Arts P., Wieskamp N., del Rosario M.,
van Bon B.W., Hoischen A., de Vries B.B., Brunner H.G., Veltman J.A.;
"A de novo paradigm for mental retardation.";
Nat. Genet. 42:1109-1112(2010).
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
-!- TISSUE SPECIFICITY: Detected at very low levels in normal tonsils,
and at higher levels in hypertrophic tonsils.
-!- SIMILARITY: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP
family. {ECO:0000305}.
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EMBL; AF465767; AAM73985.1; -; mRNA.
EMBL; AL121756; -; NOT_ANNOTATED_CDS; Genomic_DNA.
CCDS; CCDS13211.1; -.
RefSeq; NP_777557.1; NM_174897.2.
UniGene; Hs.375090; -.
ProteinModelPortal; Q8NFQ5; -.
SMR; Q8NFQ5; -.
iPTMnet; Q8NFQ5; -.
PhosphoSitePlus; Q8NFQ5; -.
BioMuta; BPIFB6; -.
DMDM; 34395537; -.
PaxDb; Q8NFQ5; -.
PeptideAtlas; Q8NFQ5; -.
PRIDE; Q8NFQ5; -.
ProteomicsDB; 73335; -.
DNASU; 128859; -.
Ensembl; ENST00000349552; ENSP00000344929; ENSG00000167104.
GeneID; 128859; -.
KEGG; hsa:128859; -.
UCSC; uc010zuc.2; human.
CTD; 128859; -.
EuPathDB; HostDB:ENSG00000167104.11; -.
GeneCards; BPIFB6; -.
HGNC; HGNC:16504; BPIFB6.
HPA; HPA043057; -.
MIM; 614110; gene.
neXtProt; NX_Q8NFQ5; -.
PharmGKB; PA25406; -.
eggNOG; KOG4160; Eukaryota.
eggNOG; ENOG410Z88E; LUCA.
GeneTree; ENSGT00730000110772; -.
HOGENOM; HOG000231740; -.
HOVERGEN; HBG095916; -.
InParanoid; Q8NFQ5; -.
OMA; FMGGNME; -.
OrthoDB; EOG091G048N; -.
PhylomeDB; Q8NFQ5; -.
TreeFam; TF315617; -.
Reactome; R-HSA-6803157; Antimicrobial peptides.
GenomeRNAi; 128859; -.
PRO; PR:Q8NFQ5; -.
Proteomes; UP000005640; Chromosome 20.
Bgee; ENSG00000167104; Expressed in 7 organ(s), highest expression level in minor salivary gland.
CleanEx; HS_BPIL3; -.
ExpressionAtlas; Q8NFQ5; baseline and differential.
Genevisible; Q8NFQ5; HS.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0008289; F:lipid binding; IEA:InterPro.
InterPro; IPR017943; Bactericidal_perm-incr_a/b_dom.
InterPro; IPR032942; BPI/LBP/Plunc.
InterPro; IPR032948; BPIFB6.
InterPro; IPR001124; Lipid-bd_serum_glycop_C.
InterPro; IPR017942; Lipid-bd_serum_glycop_N.
PANTHER; PTHR10504; PTHR10504; 1.
PANTHER; PTHR10504:SF71; PTHR10504:SF71; 1.
Pfam; PF01273; LBP_BPI_CETP; 1.
Pfam; PF02886; LBP_BPI_CETP_C; 1.
SMART; SM00329; BPI2; 1.
SUPFAM; SSF55394; SSF55394; 2.
1: Evidence at protein level;
Complete proteome; Disulfide bond; Glycoprotein; Polymorphism;
Reference proteome; Secreted; Signal.
SIGNAL 1 18 {ECO:0000255}.
CHAIN 19 453 BPI fold-containing family B member 6.
/FTId=PRO_0000017168.
CARBOHYD 114 114 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 190 190 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 137 174 {ECO:0000250}.
VARIANT 16 16 T -> M (in dbSNP:rs17301126).
/FTId=VAR_033632.
VARIANT 97 97 V -> I (in dbSNP:rs2070317).
/FTId=VAR_024518.
VARIANT 149 149 P -> T (in dbSNP:rs11907355).
/FTId=VAR_033633.
VARIANT 296 296 R -> H (de novo variant found in a
patient with mental retardation;
dbSNP:rs79809934).
{ECO:0000269|PubMed:21076407}.
/FTId=VAR_065088.
VARIANT 347 347 S -> G (in dbSNP:rs4911287).
/FTId=VAR_033634.
SEQUENCE 453 AA; 49717 MW; 19379CA22A41CE5C CRC64;
MLRILCLALC SLLTGTRADP GALLRLGMDI MNQVQSAMDE SHILEKMAAE AGKKQPGMKP
IKGITNLKVK DVQLPVITLN FVPGVGIFQC VSTGMTVTGK SFMGGNMEII VALNITATNR
LLRDEETGLP VFKSEGCEVI LVNVKTNLPS NMLPKMVNKF LDSTLHKVLP GLMCPAIDAV
LVYVNRKWTN LSDPMPVGQM GTVKYVLMSA PATTASYIQL DFSPVVQQQK GKTIKLADAG
EALTFPEGYA KGSSQLLLPA TFLSAELALL QKSFHVNIQD TMIGELPPQT TKTLARFIPE
VAVAYPKSKP LTTQIKIKKP PKVTMKTGKS LLHLHSTLEM FAARWRSKAP MSLFLLEVHF
NLKVQYSVHE NQLQMATSLD RLLSLSRKSS SIGNFNEREL TGFITSYLEE AYIPVVNDVL
QVGLPLPDFL AMNYNLAELD IVENALMLDL KLG


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