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BPI fold-containing family C protein (Bactericidal/permeability-increasing protein-like 2) (BPI-like 2)

 BPIFC_HUMAN             Reviewed;         507 AA.
Q8NFQ6; A2RRF1;
29-AUG-2003, integrated into UniProtKB/Swiss-Prot.
01-OCT-2002, sequence version 1.
31-JAN-2018, entry version 114.
RecName: Full=BPI fold-containing family C protein;
AltName: Full=Bactericidal/permeability-increasing protein-like 2;
Short=BPI-like 2;
Flags: Precursor;
Name=BPIFC; Synonyms=BPIL2;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
TISSUE=Fetal skin;
PubMed=12185532; DOI=10.1007/s00251-002-0467-3;
Mulero J.J., Boyle B.J., Bradley S., Bright J.M., Nelken S.T.,
Ho T.T., Mize N.K., Childs J.D., Ballinger D.G., Ford J.E., Rupp F.;
"Three new human members of the lipid transfer/lipopolysaccharide
binding protein family (LT/LBP).";
Immunogenetics 54:293-300(2002).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=10591208; DOI=10.1038/990031;
Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M.,
Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K.,
Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P.,
Bird C.P., Blakey S.E., Bridgeman A.M., Buck D., Burgess J.,
Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G.,
Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R.,
Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E.,
Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G.,
Evans K.L., Fey J.M., Fleming K., French L., Garner A.A.,
Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C.,
Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S.,
Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A.,
Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M.,
Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T.,
Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J.,
Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T.,
Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T.,
Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L.,
Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M.,
Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L.,
Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L.,
Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N.,
Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J.,
Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S.,
Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T.,
Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I.,
Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H.,
Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L.,
Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z.,
Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P.,
Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S.,
Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J.,
Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T.,
Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J.,
Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R.,
Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S.,
Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E.,
Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P.,
Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E.,
O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X.,
Khan A.S., Lane L., Tilahun Y., Wright H.;
"The DNA sequence of human chromosome 22.";
Nature 402:489-495(1999).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1;
IsoId=Q8NFQ6-1; Sequence=Displayed;
Name=2;
IsoId=Q8NFQ6-2; Sequence=VSP_056033, VSP_056034;
Note=No experimental confirmation available.;
-!- TISSUE SPECIFICITY: Detected in the basal layer of the epidermis
from inflammatory skin from psoriasis patients, but not in normal
skin.
-!- SIMILARITY: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP
family. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; AF465766; AAM73984.1; -; mRNA.
EMBL; AL021937; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BC131582; AAI31583.1; -; mRNA.
CCDS; CCDS13906.1; -. [Q8NFQ6-1]
RefSeq; NP_777592.1; NM_174932.2. [Q8NFQ6-1]
RefSeq; XP_011528390.1; XM_011530088.2. [Q8NFQ6-1]
RefSeq; XP_011528391.1; XM_011530089.1. [Q8NFQ6-1]
RefSeq; XP_011528392.1; XM_011530090.1. [Q8NFQ6-1]
UniGene; Hs.372939; -.
UniGene; Hs.736771; -.
ProteinModelPortal; Q8NFQ6; -.
SMR; Q8NFQ6; -.
iPTMnet; Q8NFQ6; -.
PhosphoSitePlus; Q8NFQ6; -.
BioMuta; BPIFC; -.
DMDM; 34395538; -.
PaxDb; Q8NFQ6; -.
PeptideAtlas; Q8NFQ6; -.
PRIDE; Q8NFQ6; -.
Ensembl; ENST00000300399; ENSP00000300399; ENSG00000184459. [Q8NFQ6-1]
Ensembl; ENST00000397452; ENSP00000380594; ENSG00000184459. [Q8NFQ6-1]
Ensembl; ENST00000534972; ENSP00000439123; ENSG00000184459. [Q8NFQ6-2]
GeneID; 254240; -.
KEGG; hsa:254240; -.
UCSC; uc003amn.2; human. [Q8NFQ6-1]
CTD; 254240; -.
DisGeNET; 254240; -.
EuPathDB; HostDB:ENSG00000184459.8; -.
GeneCards; BPIFC; -.
HGNC; HGNC:16503; BPIFC.
HPA; HPA037665; -.
HPA; HPA043306; -.
MIM; 614109; gene.
neXtProt; NX_Q8NFQ6; -.
OpenTargets; ENSG00000184459; -.
PharmGKB; PA25405; -.
eggNOG; KOG4160; Eukaryota.
eggNOG; ENOG410Z88E; LUCA.
GeneTree; ENSGT00730000110583; -.
HOGENOM; HOG000236259; -.
HOVERGEN; HBG105709; -.
InParanoid; Q8NFQ6; -.
OMA; FAEPMEK; -.
OrthoDB; EOG091G069B; -.
PhylomeDB; Q8NFQ6; -.
TreeFam; TF315617; -.
GenomeRNAi; 254240; -.
PRO; PR:Q8NFQ6; -.
Proteomes; UP000005640; Chromosome 22.
Bgee; ENSG00000184459; -.
CleanEx; HS_BPIL2; -.
ExpressionAtlas; Q8NFQ6; baseline and differential.
Genevisible; Q8NFQ6; HS.
GO; GO:0005615; C:extracellular space; IEA:InterPro.
GO; GO:0001530; F:lipopolysaccharide binding; NAS:UniProtKB.
GO; GO:0005543; F:phospholipid binding; NAS:UniProtKB.
InterPro; IPR017943; Bactericidal_perm-incr_a/b_dom.
InterPro; IPR030675; BPI/LBP.
InterPro; IPR032942; BPI/LBP/Plunc.
InterPro; IPR032950; BPIFC.
InterPro; IPR001124; Lipid-bd_serum_glycop_C.
InterPro; IPR017954; Lipid-bd_serum_glycop_CS.
InterPro; IPR017942; Lipid-bd_serum_glycop_N.
PANTHER; PTHR10504; PTHR10504; 1.
PANTHER; PTHR10504:SF17; PTHR10504:SF17; 1.
Pfam; PF01273; LBP_BPI_CETP; 1.
Pfam; PF02886; LBP_BPI_CETP_C; 1.
PIRSF; PIRSF002417; Lipid_binding_protein; 1.
SMART; SM00328; BPI1; 1.
SMART; SM00329; BPI2; 1.
SUPFAM; SSF55394; SSF55394; 2.
PROSITE; PS00400; LBP_BPI_CETP; 1.
2: Evidence at transcript level;
Alternative splicing; Complete proteome; Disulfide bond; Glycoprotein;
Polymorphism; Reference proteome; Secreted; Signal.
SIGNAL 1 23 {ECO:0000255}.
CHAIN 24 507 BPI fold-containing family C protein.
/FTId=PRO_0000017166.
CARBOHYD 79 79 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 92 92 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 113 113 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 213 213 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 225 225 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 257 257 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 301 301 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 355 355 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 372 372 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 415 415 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 161 200 {ECO:0000250}.
VAR_SEQ 1 186 Missing (in isoform 2).
{ECO:0000303|PubMed:15489334}.
/FTId=VSP_056033.
VAR_SEQ 327 383 Missing (in isoform 2).
{ECO:0000303|PubMed:15489334}.
/FTId=VSP_056034.
VARIANT 269 269 V -> A (in dbSNP:rs2076051).
/FTId=VAR_024516.
VARIANT 302 302 V -> L (in dbSNP:rs5994570).
/FTId=VAR_033631.
VARIANT 451 451 S -> P (in dbSNP:rs5998478).
/FTId=VAR_024517.
VARIANT 479 479 E -> A (in dbSNP:rs35856742).
/FTId=VAR_049741.
SEQUENCE 507 AA; 56469 MW; CA5285C625AC06E2 CRC64;
MCTKTIPVLW GCFLLWNLYV SSSQTIYPGI KARITQRALD YGVQAGMKMI EQMLKEKKLP
DLSGSESLEF LKVDYVNYNF SNIKISAFSF PNTSLAFVPG VGIKALTNHG TANISTDWGF
ESPLFQDTGG ADLFLSGVYF TGIIILTRND FGHPTLKLQD CYAQLSHAHV SFSGELSVLY
NSFAEPMEKP ILKNLNEMLC PIIASEVKAL NANLSTLEVL TKIDNYTLLD YSLISSPEIT
ENYLDLNLKG VFYPLENLTD PPFSPVPFVL PERSNSMLYI GIAEYFFKSA SFAHFTAGVF
NVTLSTEEIS NHFVQNSQGL GNVLSRIAEI YILSQPFMVR IMATEPPIIN LQPGNFTLDI
PASIMMLTQP KNSTVETIVS MDFVASTSVG LVILGQRLVC SLSLNRFRLA LPESNRSNIE
VLRFENILSS ILHFGVLPLA NAKLQQGFPL SNPHKFLFVN SDIEVLEGFL LISTDLKYET
SSKQQPSFHV WEGLNLISRQ WRGKSAP


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