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BRCA1 (Fragment)

 A9CDC9_SORAR            Unreviewed;       262 AA.
A9CDC9;
15-JAN-2008, integrated into UniProtKB/TrEMBL.
15-JAN-2008, sequence version 1.
25-OCT-2017, entry version 37.
SubName: Full=BRCA1 {ECO:0000313|EMBL:ABG22208.1};
Flags: Fragment;
Name=BRCA1 {ECO:0000313|EMBL:ABG22208.1};
Sorex araneus (Eurasian common shrew) (European shrew).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Insectivora; Soricidae; Soricinae;
Sorex.
NCBI_TaxID=42254 {ECO:0000313|EMBL:ABG22208.1};
[1] {ECO:0000313|EMBL:ABG22208.1}
NUCLEOTIDE SEQUENCE.
STRAIN=1 {ECO:0000313|EMBL:ABG22208.1};
PubMed=17267241; DOI=10.1016/j.ympev.2006.12.002;
Dubey S., Salamin N., Ohdachi S.D., Barriere P., Vogel P.;
"Molecular phylogenetics of shrews (Mammalia: Soricidae) reveal timing
of transcontinental colonizations.";
Mol. Phylogenet. Evol. 44:126-137(2007).
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EMBL; DQ630237; ABG22208.1; -; Genomic_DNA.
OrthoDB; EOG091G0670; -.
GO; GO:0070531; C:BRCA1-A complex; IEA:Ensembl.
GO; GO:0031436; C:BRCA1-BARD1 complex; IEA:Ensembl.
GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
GO; GO:0030529; C:intracellular ribonucleoprotein complex; IEA:Ensembl.
GO; GO:0000800; C:lateral element; IEA:Ensembl.
GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
GO; GO:0003684; F:damaged DNA binding; IEA:Ensembl.
GO; GO:0003723; F:RNA binding; IEA:Ensembl.
GO; GO:0070063; F:RNA polymerase binding; IEA:Ensembl.
GO; GO:0001105; F:RNA polymerase II transcription coactivator activity; IEA:Ensembl.
GO; GO:0044212; F:transcription regulatory region DNA binding; IEA:Ensembl.
GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:Ensembl.
GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:Ensembl.
GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
GO; GO:0071681; P:cellular response to indole-3-methanol; IEA:Ensembl.
GO; GO:0071356; P:cellular response to tumor necrosis factor; IEA:Ensembl.
GO; GO:0007098; P:centrosome cycle; IEA:Ensembl.
GO; GO:0043009; P:chordate embryonic development; IEA:Ensembl.
GO; GO:0007059; P:chromosome segregation; IEA:Ensembl.
GO; GO:0009048; P:dosage compensation by inactivation of X chromosome; IEA:Ensembl.
GO; GO:0000724; P:double-strand break repair via homologous recombination; IEA:Ensembl.
GO; GO:0031572; P:G2 DNA damage checkpoint; IEA:Ensembl.
GO; GO:0008630; P:intrinsic apoptotic signaling pathway in response to DNA damage; IEA:Ensembl.
GO; GO:0044818; P:mitotic G2/M transition checkpoint; IEA:Ensembl.
GO; GO:1902042; P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; IEA:Ensembl.
GO; GO:0045717; P:negative regulation of fatty acid biosynthetic process; IEA:Ensembl.
GO; GO:0035067; P:negative regulation of histone acetylation; IEA:Ensembl.
GO; GO:0051572; P:negative regulation of histone H3-K4 methylation; IEA:Ensembl.
GO; GO:0051573; P:negative regulation of histone H3-K9 methylation; IEA:Ensembl.
GO; GO:0033147; P:negative regulation of intracellular estrogen receptor signaling pathway; IEA:Ensembl.
GO; GO:2000378; P:negative regulation of reactive oxygen species metabolic process; IEA:Ensembl.
GO; GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl.
GO; GO:0071158; P:positive regulation of cell cycle arrest; IEA:Ensembl.
GO; GO:0045739; P:positive regulation of DNA repair; IEA:Ensembl.
GO; GO:0051571; P:positive regulation of histone H3-K4 methylation; IEA:Ensembl.
GO; GO:2000617; P:positive regulation of histone H3-K9 acetylation; IEA:Ensembl.
GO; GO:0051574; P:positive regulation of histone H3-K9 methylation; IEA:Ensembl.
GO; GO:2000620; P:positive regulation of histone H4-K16 acetylation; IEA:Ensembl.
GO; GO:0070512; P:positive regulation of histone H4-K20 methylation; IEA:Ensembl.
GO; GO:0031398; P:positive regulation of protein ubiquitination; IEA:Ensembl.
GO; GO:0010575; P:positive regulation of vascular endothelial growth factor production; IEA:Ensembl.
GO; GO:0006301; P:postreplication repair; IEA:Ensembl.
GO; GO:0051865; P:protein autoubiquitination; IEA:Ensembl.
GO; GO:0085020; P:protein K6-linked ubiquitination; IEA:Ensembl.
GO; GO:0044030; P:regulation of DNA methylation; IEA:Ensembl.
GO; GO:0006349; P:regulation of gene expression by genetic imprinting; IEA:Ensembl.
GO; GO:0043627; P:response to estrogen; IEA:Ensembl.
GO; GO:0010212; P:response to ionizing radiation; IEA:Ensembl.
InterPro; IPR011364; BRCA1.
InterPro; IPR031099; BRCA1-associated.
InterPro; IPR025994; BRCA1_serine_dom.
PANTHER; PTHR13763; PTHR13763; 1.
PANTHER; PTHR13763:SF0; PTHR13763:SF0; 1.
Pfam; PF12820; BRCT_assoc; 1.
4: Predicted;
DOMAIN 38 192 BRCT_assoc. {ECO:0000259|Pfam:PF12820}.
NON_TER 1 1 {ECO:0000313|EMBL:ABG22208.1}.
NON_TER 262 262 {ECO:0000313|EMBL:ABG22208.1}.
SEQUENCE 262 AA; 29403 MW; 727D82875F2CC960 CRC64;
KSKQPSLAKS QQNRWTESKE KYDRQTSSAE KKVDLSADPL SGRKQPNKQE LPCSGSSRDS
QEMTWITQNS SIQKVNDWFS RSDDVLSSDD FHDAGLESNT EVAEIIEISS TADEFSGSSE
QIDLTASESR RTLSKPVESN IEDKIFGKTY RRKTSFPNLN RITEDVILGS SILEPHIAPE
QPFTNKLKRK RSMTSSLCPE DFIKKGDLAV VQKTPEKVIE KSDQTDQNGQ VMNITTNGES
ETKIDYAQKG KNTNPTESSE KE


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