Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

BRISC and BRCA1-A complex member 1 (Mediator of RAP80 interactions and targeting subunit of 40 kDa) (New component of the BRCA1-A complex)

 BABA1_DANRE             Reviewed;         370 AA.
Q6AXK4;
05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
05-MAY-2009, sequence version 2.
12-SEP-2018, entry version 87.
RecName: Full=BRISC and BRCA1-A complex member 1;
AltName: Full=Mediator of RAP80 interactions and targeting subunit of 40 kDa;
AltName: Full=New component of the BRCA1-A complex;
Name=babam1; Synonyms=merit40, nba1; ORFNames=Zgc:100909;
Danio rerio (Zebrafish) (Brachydanio rerio).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
Cyprinidae; Danio.
NCBI_TaxID=7955;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Embryo;
NIH - Zebrafish Gene Collection (ZGC) project;
Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Component of the BRCA1-A complex, a complex that
specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A
and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1
heterodimer to sites of DNA damage at double-strand breaks (DSBs).
The BRCA1-A complex also possesses deubiquitinase activity that
specifically removes 'Lys-63'-linked ubiquitin on histones H2A and
H2AX. In the BRCA1-A complex, it is required for the complex
integrity and its localization at DSBs. Component of the BRISC
complex, a multiprotein complex that specifically cleaves 'Lys-
63'-linked ubiquitin in various substrates. In these 2 complexes,
it is probably required to maintain the stability of babam2 and
help the 'Lys-63'-linked deubiquitinase activity mediated by
brcc3/brcc36 component. The BRISC complex is required for normal
mitotic spindle assembly and microtubule attachment to
kinetochores via its role in deubiquitinating numa1. Plays a role
in interferon signaling via its role in the deubiquitination of
the interferon receptor ifnar1; deubiquitination increases ifnar1
activity by enhancing its stability and cell surface expression.
Down-regulates the response to bacterial lipopolysaccharide (LPS)
via its role in ifnar1 deubiquitination.
{ECO:0000250|UniProtKB:Q9NWV8}.
-!- SUBUNIT: Component of the ARISC complex, at least composed of
uimc1/rap80, abraxas1, brcc3/brcc36, babam2 and babam1/nba1.
Component of the BRCA1-A complex, at least composed of brca1,
bard1, uimc1/rap80, abraxas1, brcc3/brcc36, babam2 and
babam1/nba1. In the BRCA1-A complex, interacts directly with
abraxas1 and babam2. Component of the BRISC complex, at least
composed of abraxas2, brcc3/brcc36, babam2 and babam1/nba1.
{ECO:0000250|UniProtKB:Q9NWV8}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9NWV8}.
Nucleus {ECO:0000250|UniProtKB:Q9NWV8}. Note=Localizes at sites of
DNA damage at double-strand breaks (DSBs).
{ECO:0000250|UniProtKB:Q9NWV8}.
-!- DOMAIN: The VWFA-like region is similar to the VWFA domain. Its
presence reveals similarities between the structure of the 19S
proteasome and the BRCA1-A complexes.
{ECO:0000250|UniProtKB:Q9NWV8}.
-!- SIMILARITY: Belongs to the BABAM1 family. {ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=AAH79500.1; Type=Frameshift; Positions=289; Evidence={ECO:0000305};
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; BC079500; AAH79500.1; ALT_FRAME; mRNA.
RefSeq; NP_001003752.2; NM_001003752.2.
RefSeq; XP_017213706.1; XM_017358217.1.
UniGene; Dr.78771; -.
STRING; 7955.ENSDARP00000015195; -.
PaxDb; Q6AXK4; -.
PRIDE; Q6AXK4; -.
Ensembl; ENSDART00000008980; ENSDARP00000015195; ENSDARG00000077526.
Ensembl; ENSDART00000122262; ENSDARP00000108272; ENSDARG00000077526.
GeneID; 445296; -.
KEGG; dre:445296; -.
CTD; 29086; -.
ZFIN; ZDB-GENE-040808-6; babam1.
eggNOG; ENOG410IF7E; Eukaryota.
eggNOG; ENOG4111NFW; LUCA.
GeneTree; ENSGT00390000016934; -.
InParanoid; Q6AXK4; -.
KO; K20776; -.
OMA; RPFQSHA; -.
PhylomeDB; Q6AXK4; -.
TreeFam; TF329070; -.
Reactome; R-DRE-5689901; Metalloprotease DUBs.
Reactome; R-DRE-5693565; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks.
Reactome; R-DRE-5693607; Processing of DNA double-strand break ends.
Reactome; R-DRE-69473; G2/M DNA damage checkpoint.
PRO; PR:Q6AXK4; -.
Proteomes; UP000000437; Chromosome 11.
Bgee; ENSDARG00000077526; Expressed in 17 organ(s), highest expression level in testis.
ExpressionAtlas; Q6AXK4; baseline.
GO; GO:0070531; C:BRCA1-A complex; ISS:UniProtKB.
GO; GO:0070552; C:BRISC complex; ISS:UniProtKB.
GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO; GO:0005634; C:nucleus; ISS:UniProtKB.
GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
GO; GO:0006302; P:double-strand break repair; ISS:UniProtKB.
GO; GO:0045739; P:positive regulation of DNA repair; ISS:UniProtKB.
GO; GO:0070536; P:protein K63-linked deubiquitination; ISS:UniProtKB.
GO; GO:0010212; P:response to ionizing radiation; ISS:UniProtKB.
GO; GO:0072425; P:signal transduction involved in G2 DNA damage checkpoint; ISS:UniProtKB.
InterPro; IPR026126; BABAM1.
InterPro; IPR036465; vWFA_dom_sf.
PANTHER; PTHR15660; PTHR15660; 1.
SUPFAM; SSF53300; SSF53300; 1.
2: Evidence at transcript level;
Cell cycle; Cell division; Chromatin regulator; Complete proteome;
Cytoplasm; DNA damage; DNA repair; Mitosis; Nucleus;
Reference proteome; Ubl conjugation pathway.
CHAIN 1 370 BRISC and BRCA1-A complex member 1.
/FTId=PRO_0000373929.
REGION 137 340 VWFA-like.
SEQUENCE 370 AA; 40901 MW; D178C0E8FDA733CF CRC64;
METTEPGQAD GEERMMDLRP RTRSNPEGAE DRRSSTGSLN SSLPSAPQPA VGSRVEGEGE
AASSDSPPVS ATAIAATASV PVAAVGNTTT TNTASLPAMS PAVKERPKPS QPTMPTQIPP
SAELHLRAPR VNCPEKVIIC LDLSEEMSLQ KLESINGSKT NALNISQKMI EMFVRTKHKI
DKRHEFALVV VNDDAMWLSG FTSDPRELCS CLYDLETNVC ESFNLEDLFN VILQKIELPQ
MENIQTIPPP FVVRTLLVFS RHAGMLQFNP SDAVKKMLQS PYFFFDVVFL HNGTEEQTED
TSWKDVYASF CELDTKGMCY RFEVSLCGPA IELHNCMAKL LCHPLQRPFQ SHASYSLLED
EDTLENEATV


Related products :

Catalog number Product name Quantity
BABA1_RAT Rat ELISA Kit FOR BRISC and BRCA1-A complex member 1 96T
E14300m Human ELISA Kit FOR BRISC and BRCA1-A complex member 1 96T
CSB-EL003477HU Human BRISC and BRCA1-A complex member 1(C19orf62) ELISA kit 96T
CSB-EL003477HU Human BRISC and BRCA1-A complex member 1(C19orf62) ELISA kit SpeciesHuman 96T
BABA1_HUMAN ELISA Kit FOR BRISC and BRCA1-A complex member 1; organism: Human; gene name: BABAM1 96T
BABA1_BOVIN ELISA Kit FOR BRISC and BRCA1-A complex member 1; organism: Bovine; gene name: BABAM1 96T
CSB-EL025608RA Rat BRCA1-A complex subunit RAP80(UIMC1) ELISA kit 96T
EIAAB45306 BRCA1-A complex subunit RAP80,Pig,RAP80,Receptor-associated protein 80,Sus scrofa,Ubiquitin interaction motif-containing protein 1,UIMC1
EIAAB45308 BRCA1-A complex subunit RAP80,Rap80,Rat,Rattus norvegicus,Receptor-associated protein 80,Ubiquitin interaction motif-containing protein 1,Uimc1
CSB-EL025608MO Mouse BRCA1-A complex subunit RAP80(UIMC1) ELISA kit 96T
CSB-EL025608PI Pig BRCA1-A complex subunit RAP80(UIMC1) ELISA kit SpeciesPig 96T
CSB-EL025608HU Human BRCA1-A complex subunit RAP80(UIMC1) ELISA kit 96T
CSB-EL025608RA Rat BRCA1-A complex subunit RAP80(UIMC1) ELISA kit SpeciesRat 96T
EIAAB45305 BRCA1-A complex subunit RAP80,Mouse,Mus musculus,Rap80,Receptor-associated protein 80,Rip110,Rxrip110,Ubiquitin interaction motif-containing protein 1,Uimc1
CSB-EL025608HU Human BRCA1-A complex subunit RAP80(UIMC1) ELISA kit SpeciesHuman 96T
CSB-EL025608MO Mouse BRCA1-A complex subunit RAP80(UIMC1) ELISA kit SpeciesMouse 96T
UIMC1_HUMAN ELISA Kit FOR BRCA1-A complex subunit RAP80; organism: Human; gene name: UIMC1 96T
EIAAB45307 BRCA1-A complex subunit RAP80,Homo sapiens,Human,RAP80,Receptor-associated protein 80,Retinoid X receptor-interacting protein 110,RXRIP110,Ubiquitin interaction motif-containing protein 1,UIMC1
28-735 MED21 belongs to the Mediator complex subunit 21 family. It is the component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent ge 0.05 mg
E4222h Human New Component Of The BRCA1 A Complex 1 ELISA 96T
CSB-EL002808RA Rat BRCA1-A complex subunit BRE(BRE) ELISA kit 96T
CSB-EL002808HU Human BRCA1-A complex subunit BRE(BRE) ELISA kit 96T
BRE_CHICK Chicken ELISA Kit FOR BRCA1-A complex subunit BRE 96T
E1357m Rat ELISA Kit FOR BRCA1-A complex subunit Abraxas 96T
AE54129BO Bovine BRCA1-A complex subunit BRE (BRE) ELISA Kit 48T


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur