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BTB/POZ domain-containing protein DOT3 (Protein DEFECTIVELY ORGANIZED TRIBUTARIES 3)

 DOT3_ARATH              Reviewed;         607 AA.
Q9LFU0;
28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
01-OCT-2000, sequence version 1.
25-APR-2018, entry version 92.
RecName: Full=BTB/POZ domain-containing protein DOT3;
AltName: Full=Protein DEFECTIVELY ORGANIZED TRIBUTARIES 3 {ECO:0000303|PubMed:18643975};
Name=DOT3 {ECO:0000303|PubMed:18643975}; OrderedLocusNames=At5g10250;
ORFNames=F18D22.20;
Arabidopsis thaliana (Mouse-ear cress).
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae;
Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae;
Arabidopsis.
NCBI_TaxID=3702;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=cv. Columbia;
PubMed=11130714; DOI=10.1038/35048507;
Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K.,
Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S.,
Nakazaki N., Naruo K., Okumura S., Shinpo S., Takeuchi C., Wada T.,
Watanabe A., Yamada M., Yasuda M., Sato S., de la Bastide M.,
Huang E., Spiegel L., Gnoj L., O'Shaughnessy A., Preston R.,
Habermann K., Murray J., Johnson D., Rohlfing T., Nelson J.,
Stoneking T., Pepin K., Spieth J., Sekhon M., Armstrong J., Becker M.,
Belter E., Cordum H., Cordes M., Courtney L., Courtney W., Dante M.,
Du H., Edwards J., Fryman J., Haakensen B., Lamar E., Latreille P.,
Leonard S., Meyer R., Mulvaney E., Ozersky P., Riley A., Strowmatt C.,
Wagner-McPherson C., Wollam A., Yoakum M., Bell M., Dedhia N.,
Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D., Baker J.,
Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S.,
Langham S.-A., McCullagh B., Robben J., Grymonprez B., Zimmermann W.,
Ramsperger U., Wedler H., Balke K., Wedler E., Peters S.,
van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R.,
Weitzenegger T., Bothe G., Rose M., Hauf J., Berneiser S., Hempel S.,
Feldpausch M., Lamberth S., Villarroel R., Gielen J., Ardiles W.,
Bents O., Lemcke K., Kolesov G., Mayer K.F.X., Rudd S., Schoof H.,
Schueller C., Zaccaria P., Mewes H.-W., Bevan M., Fransz P.F.;
"Sequence and analysis of chromosome 5 of the plant Arabidopsis
thaliana.";
Nature 408:823-826(2000).
[2]
GENOME REANNOTATION.
STRAIN=cv. Columbia;
PubMed=27862469; DOI=10.1111/tpj.13415;
Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
Town C.D.;
"Araport11: a complete reannotation of the Arabidopsis thaliana
reference genome.";
Plant J. 89:789-804(2017).
[3]
DOMAIN BTB.
PubMed=15749712; DOI=10.1074/jbc.M413247200;
Gingerich D.J., Gagne J.M., Salter D.W., Hellmann H., Estelle M.,
Ma L., Vierstra R.D.;
"Cullins 3a and 3b assemble with members of the broad
complex/tramtrack/bric-a-brac (BTB) protein family to form essential
ubiquitin-protein ligases (E3s) in Arabidopsis.";
J. Biol. Chem. 280:18810-18821(2005).
[4]
FUNCTION, TISSUE SPECIFICITY, AND DISRUPTION PHENOTYPE.
PubMed=18643975; DOI=10.1111/j.1365-313X.2008.03595.x;
Petricka J.J., Clay N.K., Nelson T.M.;
"Vein patterning screens and the defectively organized tributaries
mutants in Arabidopsis thaliana.";
Plant J. 56:251-263(2008).
-!- FUNCTION: May act as a substrate-specific adapter of an E3
ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates
the ubiquitination and subsequent proteasomal degradation of
target proteins (By similarity). Involved in leaf vasculature
patterning (PubMed:18643975). {ECO:0000250,
ECO:0000269|PubMed:18643975}.
-!- PATHWAY: Protein modification; protein ubiquitination.
-!- TISSUE SPECIFICITY: Expressed in emerging leaf primordia.
{ECO:0000269|PubMed:18643975}.
-!- DOMAIN: The BTB/POZ domain mediates the interaction with some
component of ubiquitin ligase complexes.
{ECO:0000269|PubMed:15749712}.
-!- DISRUPTION PHENOTYPE: Defects in shoot and primary root growth and
aberrant parallel venation pattern in juvenile leaves.
{ECO:0000269|PubMed:18643975}.
-!- SIMILARITY: Belongs to the NPH3 family. {ECO:0000255|PROSITE-
ProRule:PRU00982}.
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EMBL; AL360334; CAB96681.1; -; Genomic_DNA.
EMBL; CP002688; AED91513.1; -; Genomic_DNA.
PIR; T50813; T50813.
RefSeq; NP_196587.1; NM_121063.2.
UniGene; At.54800; -.
ProteinModelPortal; Q9LFU0; -.
STRING; 3702.AT5G10250.1; -.
PaxDb; Q9LFU0; -.
EnsemblPlants; AT5G10250.1; AT5G10250.1; AT5G10250.
GeneID; 830889; -.
Gramene; AT5G10250.1; AT5G10250.1; AT5G10250.
KEGG; ath:AT5G10250; -.
Araport; AT5G10250; -.
TAIR; locus:2145387; AT5G10250.
eggNOG; ENOG410IK41; Eukaryota.
eggNOG; ENOG41113GE; LUCA.
HOGENOM; HOG000239180; -.
InParanoid; Q9LFU0; -.
OMA; KCGYIGR; -.
OrthoDB; EOG0936051O; -.
PhylomeDB; Q9LFU0; -.
UniPathway; UPA00143; -.
PRO; PR:Q9LFU0; -.
Proteomes; UP000006548; Chromosome 5.
ExpressionAtlas; Q9LFU0; baseline and differential.
Genevisible; Q9LFU0; AT.
GO; GO:0010588; P:cotyledon vascular tissue pattern formation; IMP:TAIR.
GO; GO:0010305; P:leaf vascular tissue pattern formation; IMP:TAIR.
GO; GO:0010087; P:phloem or xylem histogenesis; IMP:TAIR.
GO; GO:0080022; P:primary root development; IMP:TAIR.
GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
GO; GO:0048367; P:shoot system development; IMP:TAIR.
InterPro; IPR000210; BTB/POZ_dom.
InterPro; IPR027356; NPH3_dom.
InterPro; IPR011333; SKP1/BTB/POZ_sf.
Pfam; PF03000; NPH3; 1.
SUPFAM; SSF54695; SSF54695; 1.
PROSITE; PS50097; BTB; 1.
PROSITE; PS51649; NPH3; 1.
2: Evidence at transcript level;
Coiled coil; Complete proteome; Phosphoprotein; Reference proteome;
Ubl conjugation pathway.
CHAIN 1 607 BTB/POZ domain-containing protein DOT3.
/FTId=PRO_0000409562.
DOMAIN 52 121 BTB. {ECO:0000255|PROSITE-
ProRule:PRU00037}.
DOMAIN 211 487 NPH3. {ECO:0000255|PROSITE-
ProRule:PRU00982}.
COILED 511 563 {ECO:0000255}.
MOD_RES 428 428 Phosphotyrosine.
{ECO:0000250|UniProtKB:Q9FMF5}.
SEQUENCE 607 AA; 69973 MW; E5B70AF834C684DD CRC64;
MNSVSAAERL KSFGDAGPVC NKSIIFPSRV VTLANSFEKK DRSWYVKSQI PTDLSIQVND
ITFKAHKFPL ISKCGYISSI ELKPSTSENG YHLKLENFPG GADTFETILK FCYNLPLDLN
PLNVAPLRCA SEYLYMTEEF EAGNLISKTE AFITFVVLAS WRDTLTVLRS CTNLSPWAEN
LQIVRRCCDL LAWKACNDNN IPEDVVDRNE RCLYNDIATL DIDHFMRVIT TMKARRAKPQ
ITGKIIMKYA DNFLPVINDD LEGIKGYGLG KNELQFSVNR GRMEESNSLG CQEHKETIES
LVSVLPPQSG AVSCHFLLRM LKTSIVYSAS PALISDLEKR VGMALEDANV CDLLIPNFKN
EEQQERVRIF EFFLMHEQQQ VLGKPSISKL LDNYLAEIAK DPYLPITKFQ VLAEMLPENA
WKCHDGLYRA IDMFLKTHPS LSDHDRRRLC KTMNCEKLSL DACLHAAQND RLPLRTIVQI
NTQVLFSEQV KMRMMMQDKL PEKEEENSGG REDKRMSRDN EIIKTLKEEL ENVKKKMSEL
QSDYNELQQE YERLSSKQKS SHNWGLRWQK VKKSFQTKRE DEETRERTRR RSSTGQRTSF
RRRMSMS


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