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Baculoviral IAP repeat-containing protein 3 (EC 2.3.2.27) (Apoptosis inhibitor 2) (API2) (Cellular inhibitor of apoptosis 2) (C-IAP2) (IAP homolog C) (Inhibitor of apoptosis protein 1) (hIAP-1) (hIAP1) (RING finger protein 49) (RING-type E3 ubiquitin transferase BIRC3) (TNFR2-TRAF-signaling complex protein 1)

 BIRC3_HUMAN             Reviewed;         604 AA.
Q13489; Q16628; Q9HC27; Q9UP46;
01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
01-NOV-1997, sequence version 2.
22-NOV-2017, entry version 185.
RecName: Full=Baculoviral IAP repeat-containing protein 3;
EC=2.3.2.27 {ECO:0000269|PubMed:21931591, ECO:0000269|PubMed:23453969};
AltName: Full=Apoptosis inhibitor 2;
Short=API2;
AltName: Full=Cellular inhibitor of apoptosis 2;
Short=C-IAP2 {ECO:0000303|PubMed:8548810};
AltName: Full=IAP homolog C;
AltName: Full=Inhibitor of apoptosis protein 1;
Short=hIAP-1;
Short=hIAP1;
AltName: Full=RING finger protein 49;
AltName: Full=RING-type E3 ubiquitin transferase BIRC3 {ECO:0000305};
AltName: Full=TNFR2-TRAF-signaling complex protein 1;
Name=BIRC3; Synonyms=API2, MIHC, RNF49;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=8548810; DOI=10.1016/0092-8674(95)90149-3;
Rothe M., Pan M.-G., Henzel W.J., Ayres T.M., Goeddel D.V.;
"The TNFR2-TRAF signaling complex contains two novel proteins related
to baculoviral inhibitor of apoptosis proteins.";
Cell 83:1243-1252(1995).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Liver;
PubMed=8552191; DOI=10.1038/379349a0;
Liston P., Roy N., Tamai K., Lefebvre C., Baird S., Cherton-Horvat G.,
Farahani R., McLean M., Ikeda J., Mackenzie A., Korneluk R.G.;
"Suppression of apoptosis in mammalian cells by NAIP and a related
family of IAP genes.";
Nature 379:349-353(1996).
[3]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Fetal liver;
PubMed=8643514; DOI=10.1073/pnas.93.10.4974;
Uren A.G., Pakusch M., Hawkins C.J., Puls K.L., Vaux D.L.;
"Cloning and expression of apoptosis inhibitory protein homologs that
function to inhibit apoptosis and/or bind tumor necrosis factor
receptor-associated factors.";
Proc. Natl. Acad. Sci. U.S.A. 93:4974-4978(1996).
[4]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=10233894;
Horrevoets A.J.G., Fontijn R.D., van Zonneveld A.J., de Vries C.J.M.,
ten Cate J.W., Pannekoek H.;
"Vascular endothelial genes that are responsive to tumor necrosis
factor-alpha in vitro are expressed in atherosclerotic lesions,
including inhibitor of apoptosis protein-1, stannin, and two novel
genes.";
Blood 93:3418-3431(1999).
[5]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS ARG-260 AND LYS-401.
NIEHS SNPs program;
Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Lymph;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[7]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 362-441.
PubMed=11066071;
DOI=10.1002/1098-2264(2000)9999:9999<::AID-GCC1036>3.0.CO;2-I;
Baens M., Steyls A., Dierlamm J., De Wolf-Peeters C., Marynen P.;
"Structure of the MLT gene and molecular characterization of the
genomic breakpoint junctions in the t(11;18)(q21;q21) of marginal zone
B-cell lymphomas of MALT type.";
Genes Chromosomes Cancer 29:281-291(2000).
[8]
SUBCELLULAR LOCATION.
PubMed=15665297;
Samuel T., Okada K., Hyer M., Welsh K., Zapata J.M., Reed J.C.;
"cIAP1 Localizes to the nuclear compartment and modulates the cell
cycle.";
Cancer Res. 65:210-218(2005).
[9]
REVIEW ON FUNCTION.
PubMed=18414036; DOI=10.4161/cc.7.8.5783;
Dubrez-Daloz L., Dupoux A., Cartier J.;
"IAPs: more than just inhibitors of apoptosis proteins.";
Cell Cycle 7:1036-1046(2008).
[10]
REVIEW ON FUNCTION.
PubMed=20888210; DOI=10.1016/j.ceb.2010.08.025;
Lopez J., Meier P.;
"To fight or die - inhibitor of apoptosis proteins at the crossroad of
innate immunity and death.";
Curr. Opin. Cell Biol. 22:872-881(2010).
[11]
REVIEW ON FUNCTION.
PubMed=20651737; DOI=10.1038/nrc2889;
Gyrd-Hansen M., Meier P.;
"IAPs: from caspase inhibitors to modulators of NF-kappaB,
inflammation and cancer.";
Nat. Rev. Cancer 10:561-574(2010).
[12]
REVIEW ON FUNCTION.
PubMed=21447281;
Damgaard R.B., Gyrd-Hansen M.;
"Inhibitor of apoptosis (IAP) proteins in regulation of inflammation
and innate immunity.";
Discov. Med. 11:221-231(2011).
[13]
ENZYME REGULATION, AND INTERACTION WITH USP19.
PubMed=21849505; DOI=10.1074/jbc.M111.282020;
Mei Y., Hahn A.A., Hu S., Yang X.;
"The USP19 deubiquitinase regulates the stability of c-IAP1 and c-
IAP2.";
J. Biol. Chem. 286:35380-35387(2011).
[14]
FUNCTION IN THE UBIQUITINATION OF RIPK1; RIPK2; RIPK3 AND RIPK4,
INTERACTION WITH RIPK1; RIPK2; RIPK3 AND RIPK4, AND CATALYTIC
ACTIVITY.
PubMed=21931591; DOI=10.1371/journal.pone.0022356;
Bertrand M.J., Lippens S., Staes A., Gilbert B., Roelandt R.,
De Medts J., Gevaert K., Declercq W., Vandenabeele P.;
"cIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin
chains to receptor interacting proteins kinases 1 to 4 (RIP1-4).";
PLoS ONE 6:E22356-E22356(2011).
[15]
REVIEW ON FUNCTION.
PubMed=22095281; DOI=10.1038/cdd.2011.163;
Darding M., Meier P.;
"IAPs: guardians of RIPK1.";
Cell Death Differ. 19:58-66(2012).
[16]
FUNCTION IN IKBKE UBIQUITINATION, AND CATALYTIC ACTIVITY.
PubMed=23453969; DOI=10.1016/j.celrep.2013.01.031;
Zhou A.Y., Shen R.R., Kim E., Lock Y.J., Xu M., Chen Z.J., Hahn W.C.;
"IKKepsilon-mediated tumorigenesis requires K63-linked
polyubiquitination by a cIAP1/cIAP2/TRAF2 E3 ubiquitin ligase
complex.";
Cell Rep. 3:724-733(2013).
-!- FUNCTION: Multi-functional protein which regulates not only
caspases and apoptosis, but also modulates inflammatory signaling
and immunity, mitogenic kinase signaling and cell proliferation,
as well as cell invasion and metastasis. Acts as an E3 ubiquitin-
protein ligase regulating NF-kappa-B signaling and regulates both
canonical and non-canonical NF-kappa-B signaling by acting in
opposite directions: acts as a positive regulator of the canonical
pathway and suppresses constitutive activation of non-canonical
NF-kappa-B signaling. The target proteins for its E3 ubiquitin-
protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4,
CASP3, CASP7, CASP8, IKBKE, TRAF1, and BCL10. Acts as an important
regulator of innate immune signaling via regulation of Toll-like
receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like
receptors (RLRs), collectively referred to as pattern recognition
receptors (PRRs). Protects cells from spontaneous formation of the
ripoptosome, a large multi-protein complex that has the capability
to kill cancer cells in a caspase-dependent and caspase-
independent manner. Suppresses ripoptosome formation by
ubiquitinating RIPK1 and CASP8. {ECO:0000269|PubMed:21931591,
ECO:0000269|PubMed:23453969}.
-!- CATALYTIC ACTIVITY: S-ubiquitinyl-[E2 ubiquitin-conjugating
enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-
conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor
protein]-L-lysine. {ECO:0000269|PubMed:21931591,
ECO:0000269|PubMed:23453969}.
-!- ENZYME REGULATION: USP19 regulates the stability of BIRC3/c-IAP2
by preventing its ubiquitination. {ECO:0000269|PubMed:21849505}.
-!- SUBUNIT: Interacts with DIABLO/SMAC and with PRSS25; these
interactions inhibit apoptotic suppressor activity. The BIR motifs
region interacts with TNF receptor associated factors 1 and 2
(TRAF1 and TRAF2) to form a heteromeric complex, which is then
recruited to the tumor necrosis factor receptor 2 (TNFR2).
Interaction with TRAF2 is required for ubiquitination of IKBKE,
degradation of NFKBIA and activation of NF-kappa-B. Interacts with
RIP1, RIP2, RIP3, RIP4 and USP19. {ECO:0000269|PubMed:21849505,
ECO:0000269|PubMed:21931591}.
-!- INTERACTION:
P55211:CASP9; NbExp=2; IntAct=EBI-517709, EBI-516799;
Q13546:RIPK1; NbExp=3; IntAct=EBI-517709, EBI-358507;
O43353:RIPK2; NbExp=3; IntAct=EBI-517709, EBI-358522;
Q9Y572:RIPK3; NbExp=3; IntAct=EBI-517709, EBI-298250;
P57078:RIPK4; NbExp=3; IntAct=EBI-517709, EBI-4422308;
Q13077:TRAF1; NbExp=2; IntAct=EBI-517709, EBI-359224;
Q12933:TRAF2; NbExp=7; IntAct=EBI-517709, EBI-355744;
P62837:UBE2D2; NbExp=2; IntAct=EBI-517709, EBI-347677;
P61088:UBE2N; NbExp=2; IntAct=EBI-517709, EBI-1052908;
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15665297}.
Nucleus {ECO:0000269|PubMed:15665297}.
-!- TISSUE SPECIFICITY: Highly expressed in fetal lung, and kidney. In
the adult, expression is mainly seen in lymphoid tissues,
including spleen, thymus and peripheral blood lymphocytes.
-!- PTM: Auto-ubiquitinated and degraded by the proteasome in
apoptotic cells.
-!- DISEASE: Note=A chromosomal aberration involving BIRC3 is
recurrent in low-grade mucosa-associated lymphoid tissue (MALT
lymphoma). Translocation t(11;18)(q21;q21) with MALT1. This
translocation is found in approximately 50% of cytogenetically
abnormal low-grade MALT lymphoma.
-!- SIMILARITY: Belongs to the IAP family. {ECO:0000305}.
-!- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology
and Haematology;
URL="http://atlasgeneticsoncology.org/Genes/BIRC3ID239.html";
-!- WEB RESOURCE: Name=NIEHS-SNPs;
URL="http://egp.gs.washington.edu/data/birc3/";
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EMBL; L49432; AAC41943.1; -; mRNA.
EMBL; U45878; AAC50371.1; -; mRNA.
EMBL; U37546; AAC50507.1; -; mRNA.
EMBL; AF070674; AAC83232.1; -; mRNA.
EMBL; AY764389; AAU88144.1; -; Genomic_DNA.
EMBL; BC037420; AAH37420.1; -; mRNA.
EMBL; AF178945; AAG09369.1; -; Genomic_DNA.
CCDS; CCDS8315.1; -.
PIR; S68449; S68449.
RefSeq; NP_001156.1; NM_001165.4.
RefSeq; NP_892007.1; NM_182962.2.
RefSeq; XP_016873132.1; XM_017017643.1.
UniGene; Hs.127799; -.
PDB; 2UVL; X-ray; 1.91 A; A/B=244-337.
PDB; 3EB5; X-ray; 2.00 A; A=536-604.
PDB; 3EB6; X-ray; 3.40 A; A=536-604.
PDB; 3M0A; X-ray; 2.61 A; D=26-99.
PDB; 3M0D; X-ray; 2.80 A; D=26-99.
PDBsum; 2UVL; -.
PDBsum; 3EB5; -.
PDBsum; 3EB6; -.
PDBsum; 3M0A; -.
PDBsum; 3M0D; -.
ProteinModelPortal; Q13489; -.
SMR; Q13489; -.
BioGrid; 106827; 79.
CORUM; Q13489; -.
DIP; DIP-33720N; -.
IntAct; Q13489; 40.
MINT; MINT-216139; -.
STRING; 9606.ENSP00000263464; -.
BindingDB; Q13489; -.
ChEMBL; CHEMBL5335; -.
GuidetoPHARMACOLOGY; 2792; -.
MEROPS; I32.007; -.
iPTMnet; Q13489; -.
PhosphoSitePlus; Q13489; -.
BioMuta; BIRC3; -.
DMDM; 2497236; -.
EPD; Q13489; -.
MaxQB; Q13489; -.
PaxDb; Q13489; -.
PeptideAtlas; Q13489; -.
PRIDE; Q13489; -.
Ensembl; ENST00000263464; ENSP00000263464; ENSG00000023445.
Ensembl; ENST00000532808; ENSP00000432907; ENSG00000023445.
Ensembl; ENST00000615299; ENSP00000481903; ENSG00000023445.
GeneID; 330; -.
KEGG; hsa:330; -.
UCSC; uc001pgx.5; human.
CTD; 330; -.
DisGeNET; 330; -.
EuPathDB; HostDB:ENSG00000023445.13; -.
GeneCards; BIRC3; -.
HGNC; HGNC:591; BIRC3.
HPA; HPA002317; -.
MalaCards; BIRC3; -.
MIM; 601721; gene.
neXtProt; NX_Q13489; -.
OpenTargets; ENSG00000023445; -.
Orphanet; 52417; MALT lymphoma.
PharmGKB; PA25360; -.
eggNOG; KOG1101; Eukaryota.
eggNOG; ENOG410YPNM; LUCA.
GeneTree; ENSGT00500000044782; -.
HOGENOM; HOG000232059; -.
HOVERGEN; HBG004848; -.
InParanoid; Q13489; -.
KO; K16060; -.
OMA; CAMNTEK; -.
OrthoDB; EOG091G0CXH; -.
PhylomeDB; Q13489; -.
TreeFam; TF105356; -.
Reactome; R-HSA-168638; NOD1/2 Signaling Pathway.
Reactome; R-HSA-168927; TICAM1, RIP1-mediated IKK complex recruitment.
Reactome; R-HSA-5213460; RIPK1-mediated regulated necrosis.
Reactome; R-HSA-5357905; Regulation of TNFR1 signaling.
Reactome; R-HSA-5357956; TNFR1-induced NFkappaB signaling pathway.
Reactome; R-HSA-5668541; TNFR2 non-canonical NF-kB pathway.
Reactome; R-HSA-5675482; Regulation of necroptotic cell death.
Reactome; R-HSA-5676594; TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway.
Reactome; R-HSA-5689880; Ub-specific processing proteases.
Reactome; R-HSA-937041; IKK complex recruitment mediated by RIP1.
SignaLink; Q13489; -.
SIGNOR; Q13489; -.
ChiTaRS; BIRC3; human.
EvolutionaryTrace; Q13489; -.
GeneWiki; Baculoviral_IAP_repeat-containing_protein_3; -.
GenomeRNAi; 330; -.
PMAP-CutDB; Q13489; -.
PRO; PR:Q13489; -.
Proteomes; UP000005640; Chromosome 11.
Bgee; ENSG00000023445; -.
CleanEx; HS_BIRC3; -.
ExpressionAtlas; Q13489; baseline and differential.
Genevisible; Q13489; HS.
GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO; GO:0005829; C:cytosol; IDA:HPA.
GO; GO:0045121; C:membrane raft; IEA:Ensembl.
GO; GO:0005654; C:nucleoplasm; IDA:HPA.
GO; GO:0005634; C:nucleus; IDA:UniProtKB.
GO; GO:0043234; C:protein complex; IEA:Ensembl.
GO; GO:0043027; F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process; IBA:GO_Central.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0016740; F:transferase activity; EXP:Reactome.
GO; GO:0004842; F:ubiquitin-protein transferase activity; IDA:UniProtKB.
GO; GO:0007166; P:cell surface receptor signaling pathway; TAS:ProtInc.
GO; GO:0007249; P:I-kappaB kinase/NF-kappaB signaling; TAS:Reactome.
GO; GO:1990001; P:inhibition of cysteine-type endopeptidase activity involved in apoptotic process; IBA:GO_Central.
GO; GO:0043066; P:negative regulation of apoptotic process; TAS:ProtInc.
GO; GO:0060546; P:negative regulation of necroptotic process; IBA:GO_Central.
GO; GO:0038061; P:NIK/NF-kappaB signaling; TAS:UniProtKB.
GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; TAS:UniProtKB.
GO; GO:0031398; P:positive regulation of protein ubiquitination; IDA:UniProtKB.
GO; GO:0016579; P:protein deubiquitination; TAS:Reactome.
GO; GO:0051291; P:protein heterooligomerization; IEA:Ensembl.
GO; GO:0042981; P:regulation of apoptotic process; IMP:UniProtKB.
GO; GO:2000116; P:regulation of cysteine-type endopeptidase activity; TAS:UniProtKB.
GO; GO:0050727; P:regulation of inflammatory response; TAS:UniProtKB.
GO; GO:0045088; P:regulation of innate immune response; TAS:UniProtKB.
GO; GO:0060544; P:regulation of necroptotic process; IMP:UniProtKB.
GO; GO:0070424; P:regulation of nucleotide-binding oligomerization domain containing signaling pathway; TAS:UniProtKB.
GO; GO:0039535; P:regulation of RIG-I signaling pathway; TAS:UniProtKB.
GO; GO:0034121; P:regulation of toll-like receptor signaling pathway; TAS:UniProtKB.
GO; GO:0010803; P:regulation of tumor necrosis factor-mediated signaling pathway; TAS:Reactome.
GO; GO:0007283; P:spermatogenesis; IEA:Ensembl.
GO; GO:0035666; P:TRIF-dependent toll-like receptor signaling pathway; TAS:Reactome.
GO; GO:0033209; P:tumor necrosis factor-mediated signaling pathway; TAS:Reactome.
CDD; cd00022; BIR; 3.
Gene3D; 3.30.40.10; -; 1.
InterPro; IPR001370; BIR_rpt.
InterPro; IPR001315; CARD.
InterPro; IPR011029; DEATH-like_dom_sf.
InterPro; IPR001841; Znf_RING.
InterPro; IPR013083; Znf_RING/FYVE/PHD.
Pfam; PF00653; BIR; 3.
Pfam; PF00619; CARD; 1.
SMART; SM00238; BIR; 3.
SMART; SM00114; CARD; 1.
SMART; SM00184; RING; 1.
SUPFAM; SSF47986; SSF47986; 1.
PROSITE; PS01282; BIR_REPEAT_1; 3.
PROSITE; PS50143; BIR_REPEAT_2; 3.
PROSITE; PS50209; CARD; 1.
PROSITE; PS50089; ZF_RING_2; 1.
1: Evidence at protein level;
3D-structure; Apoptosis; Chromosomal rearrangement; Complete proteome;
Cytoplasm; Metal-binding; Nucleus; Polymorphism; Reference proteome;
Repeat; Transferase; Ubl conjugation; Ubl conjugation pathway; Zinc;
Zinc-finger.
CHAIN 1 604 Baculoviral IAP repeat-containing protein
3.
/FTId=PRO_0000122349.
REPEAT 29 96 BIR 1.
REPEAT 169 235 BIR 2.
REPEAT 255 322 BIR 3.
DOMAIN 439 529 CARD. {ECO:0000255|PROSITE-
ProRule:PRU00046}.
ZN_FING 557 592 RING-type. {ECO:0000255|PROSITE-
ProRule:PRU00175}.
METAL 292 292 Zinc. {ECO:0000255|PROSITE-
ProRule:PRU00029}.
METAL 295 295 Zinc. {ECO:0000255|PROSITE-
ProRule:PRU00029}.
METAL 312 312 Zinc. {ECO:0000255|PROSITE-
ProRule:PRU00029}.
METAL 319 319 Zinc. {ECO:0000255|PROSITE-
ProRule:PRU00029}.
SITE 442 443 Breakpoint for translocation to form
BIRC3-MALT1.
VARIANT 260 260 K -> R (in dbSNP:rs2276113).
{ECO:0000269|Ref.5}.
/FTId=VAR_021069.
VARIANT 386 386 V -> M (in dbSNP:rs12222256).
/FTId=VAR_049536.
VARIANT 401 401 R -> K (in dbSNP:rs17881197).
{ECO:0000269|Ref.5}.
/FTId=VAR_021070.
CONFLICT 18 18 N -> Y (in Ref. 4; AAC83232).
{ECO:0000305}.
CONFLICT 119 119 N -> H (in Ref. 2; AAC50371).
{ECO:0000305}.
CONFLICT 153 153 D -> E (in Ref. 2; AAC50371).
{ECO:0000305}.
CONFLICT 163 163 H -> P (in Ref. 2; AAC50371).
{ECO:0000305}.
CONFLICT 165 165 A -> P (in Ref. 2; AAC50371).
{ECO:0000305}.
CONFLICT 191 191 K -> R (in Ref. 2; AAC50371).
{ECO:0000305}.
CONFLICT 364 364 F -> L (in Ref. 2; AAC50371).
{ECO:0000305}.
CONFLICT 552 552 Q -> P (in Ref. 2; AAC50371).
{ECO:0000305}.
HELIX 28 34 {ECO:0000244|PDB:3M0A}.
HELIX 35 38 {ECO:0000244|PDB:3M0A}.
HELIX 47 52 {ECO:0000244|PDB:3M0A}.
STRAND 55 57 {ECO:0000244|PDB:3M0A}.
STRAND 64 66 {ECO:0000244|PDB:3M0A}.
TURN 67 69 {ECO:0000244|PDB:3M0A}.
HELIX 82 89 {ECO:0000244|PDB:3M0A}.
TURN 94 97 {ECO:0000244|PDB:3M0A}.
HELIX 250 252 {ECO:0000244|PDB:2UVL}.
HELIX 255 260 {ECO:0000244|PDB:2UVL}.
HELIX 261 264 {ECO:0000244|PDB:2UVL}.
HELIX 273 278 {ECO:0000244|PDB:2UVL}.
STRAND 281 285 {ECO:0000244|PDB:2UVL}.
TURN 286 288 {ECO:0000244|PDB:2UVL}.
STRAND 289 292 {ECO:0000244|PDB:2UVL}.
TURN 293 295 {ECO:0000244|PDB:2UVL}.
STRAND 298 301 {ECO:0000244|PDB:2UVL}.
HELIX 308 315 {ECO:0000244|PDB:2UVL}.
HELIX 320 334 {ECO:0000244|PDB:2UVL}.
HELIX 544 555 {ECO:0000244|PDB:3EB5}.
TURN 558 560 {ECO:0000244|PDB:3EB5}.
STRAND 561 564 {ECO:0000244|PDB:3EB5}.
STRAND 567 570 {ECO:0000244|PDB:3EB5}.
STRAND 575 577 {ECO:0000244|PDB:3EB5}.
TURN 579 581 {ECO:0000244|PDB:3EB5}.
HELIX 582 584 {ECO:0000244|PDB:3EB5}.
STRAND 589 591 {ECO:0000244|PDB:3EB5}.
STRAND 597 600 {ECO:0000244|PDB:3EB5}.
SEQUENCE 604 AA; 68372 MW; 8581A00BA9AAB4A7 CRC64;
MNIVENSIFL SNLMKSANTF ELKYDLSCEL YRMSTYSTFP AGVPVSERSL ARAGFYYTGV
NDKVKCFCCG LMLDNWKRGD SPTEKHKKLY PSCRFVQSLN SVNNLEATSQ PTFPSSVTNS
THSLLPGTEN SGYFRGSYSN SPSNPVNSRA NQDFSALMRS SYHCAMNNEN ARLLTFQTWP
LTFLSPTDLA KAGFYYIGPG DRVACFACGG KLSNWEPKDN AMSEHLRHFP KCPFIENQLQ
DTSRYTVSNL SMQTHAARFK TFFNWPSSVL VNPEQLASAG FYYVGNSDDV KCFCCDGGLR
CWESGDDPWV QHAKWFPRCE YLIRIKGQEF IRQVQASYPH LLEQLLSTSD SPGDENAESS
IIHFEPGEDH SEDAIMMNTP VINAAVEMGF SRSLVKQTVQ RKILATGENY RLVNDLVLDL
LNAEDEIREE ERERATEEKE SNDLLLIRKN RMALFQHLTC VIPILDSLLT AGIINEQEHD
VIKQKTQTSL QARELIDTIL VKGNIAATVF RNSLQEAEAV LYEHLFVQQD IKYIPTEDVS
DLPVEEQLRR LQEERTCKVC MDKEVSIVFI PCGHLVVCKD CAPSLRKCPI CRSTIKGTVR
TFLS


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Catalog number Product name Quantity
18-272-197117 cIAP2 - Rabbit polyclonal to cIAP2; Inhibitor of apoptosis protein 1; HIAP1; HIAP-1; C-IAP2; TNFR2-TRAF-signaling complex protein 1; IAP homolog C; Apoptosis inhibitor 2; API2; RING finger protein 49 0.05 mg
18-661-15190 Baculoviral IAP repeat-containing protein 2 - Inhibitor of apoptosis protein 2; HIAP2; HIAP-2; C-IAP1; TNFR2-TRAF signaling complex protein 2; IAP homolog B Polyclonal 0.1 mg
18-272-197083 cIAP1 - Rabbit polyclonal to cIAP1; Inhibitor of apoptosis protein 2; HIAP2; HIAP-2; C-IAP1; TNFR2-TRAF-signaling complex protein 2; IAP homolog B; RING finger protein 48 Polyclonal 0.05 mg
18-661-15126 Baculoviral IAP repeat-containing protein 7 - Kidney inhibitor of apoptosis protein; KIAP; Melanoma inhibitor of apoptosis protein; ML-IAP; Livin Polyclonal 0.1 mg
EIAAB46501 API3,Baculoviral IAP repeat-containing protein 4,BIRC4,E3 ubiquitin-protein ligase XIAP,hIAP3,hIAP-3,hILP,Homo sapiens,Human,IAP3,IAP-3,IAP-like protein,ILP,Inhibitor of apoptosis protein 3,XIAP,X-lin
18-661-15131 Baculoviral IAP repeat-containing protein 8 - Inhibitor of apoptosis-like protein 2; IAP-like protein 2; ILP-2; Testis-specific inhibitor of apoptosis Polyclonal 0.1 mg
U2045m CLIA kit Api4,Apoptosis inhibitor 4,Apoptosis inhibitor survivin,Baculoviral IAP repeat-containing protein 5,Birc5,Iap4,Mouse,Mus musculus,TIAP 96T
U2045h CLIA API4,Apoptosis inhibitor 4,Apoptosis inhibitor survivin,Baculoviral IAP repeat-containing protein 5,BIRC5,Homo sapiens,Human,IAP4 96T
E2045m ELISA kit Api4,Apoptosis inhibitor 4,Apoptosis inhibitor survivin,Baculoviral IAP repeat-containing protein 5,Birc5,Iap4,Mouse,Mus musculus,TIAP 96T
U2045h CLIA kit API4,Apoptosis inhibitor 4,Apoptosis inhibitor survivin,Baculoviral IAP repeat-containing protein 5,BIRC5,Homo sapiens,Human,IAP4 96T
E2045h ELISA API4,Apoptosis inhibitor 4,Apoptosis inhibitor survivin,Baculoviral IAP repeat-containing protein 5,BIRC5,Homo sapiens,Human,IAP4 96T
E2045m ELISA Api4,Apoptosis inhibitor 4,Apoptosis inhibitor survivin,Baculoviral IAP repeat-containing protein 5,Birc5,Iap4,Mouse,Mus musculus,TIAP 96T
E2045h ELISA kit API4,Apoptosis inhibitor 4,Apoptosis inhibitor survivin,Baculoviral IAP repeat-containing protein 5,BIRC5,Homo sapiens,Human,IAP4 96T
U2045m CLIA Api4,Apoptosis inhibitor 4,Apoptosis inhibitor survivin,Baculoviral IAP repeat-containing protein 5,Birc5,Iap4,Mouse,Mus musculus,TIAP 96T
18-661-15083 Baculoviral IAP repeat-containing protein 5 - Apoptosis inhibitor survivin; Apoptosis inhibitor 4 Polyclonal 0.1 mg
18-661-15082 Baculoviral IAP repeat-containing protein 5 - Apoptosis inhibitor survivin; Apoptosis inhibitor 4 Polyclonal 0.1 mg
18-661-15084 Baculoviral IAP repeat-containing protein 5 - Apoptosis inhibitor survivin; Apoptosis inhibitor 4 Polyclonal 0.1 mg
20-272-190690 Livin - Mouse monoclonal [88C570] to Livin; Kidney inhibitor of apoptosis protein; KIAP; Melanoma inhibitor of apoptosis protein; ML-IAP; Livin; RING finger protein 50 Monoclonal 0.05 mg
18-661-15191 Baculoviral IAP repeat-containing protein 4 - Inhibitor of apoptosis protein 3; X-linked inhibitor of apoptosis protein; X-linked IAP; IAP-like protein; HILP Polyclonal 0.1 mg
EIAAB46500 Api3,Baculoviral IAP repeat-containing protein 4,Birc4,E3 ubiquitin-protein ligase XIAP,IAP homolog A,IAP-3,Inhibitor of apoptosis protein 3,Rat,Rattus norvegicus,rIAP3,rIAP-3,Xiap,X-linked IAP,X-link
EIAAB46499 Aipa,Api3,Baculoviral IAP repeat-containing protein 4,Birc4,E3 ubiquitin-protein ligase XIAP,IAP homolog A,IAP-3,Inhibitor of apoptosis protein 3,mIAP3,mIAP-3,Miha,Mouse,Mus musculus,Xiap,X-linked IAP
U2045p CLIA Apoptosis inhibitor survivin,Baculoviral IAP repeat-containing protein 5,BIRC5,Pig,Sus scrofa 96T
U2045p CLIA kit Apoptosis inhibitor survivin,Baculoviral IAP repeat-containing protein 5,BIRC5,Pig,Sus scrofa 96T
E2045p ELISA kit Apoptosis inhibitor survivin,Baculoviral IAP repeat-containing protein 5,BIRC5,Pig,Sus scrofa 96T
E2045p ELISA Apoptosis inhibitor survivin,Baculoviral IAP repeat-containing protein 5,BIRC5,Pig,Sus scrofa 96T


 

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