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Baculoviral IAP repeat-containing protein 5.1-B (Survivin1-B) (Survivin) (XSurvivin1B) (xL_Survivin2) (Su2)

 BI51B_XENLA             Reviewed;         160 AA.
Q4R1J6; Q5HZ94; Q8AXI6;
01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
19-JUL-2005, sequence version 1.
23-MAY-2018, entry version 47.
RecName: Full=Baculoviral IAP repeat-containing protein 5.1-B;
AltName: Full=Survivin1-B {ECO:0000303|PubMed:15853809};
Short=Survivin {ECO:0000312|EMBL:AAN76690.1};
Short=XSurvivin1B {ECO:0000312|EMBL:BAE02678.1};
AltName: Full=xL_Survivin2 {ECO:0000303|PubMed:16759290};
Short=Su2 {ECO:0000303|PubMed:16759290};
Name=birc5.1-b; Synonyms=su2 {ECO:0000303|PubMed:16759290};
Xenopus laevis (African clawed frog).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus;
Xenopus.
NCBI_TaxID=8355;
[1] {ECO:0000305, ECO:0000312|EMBL:AAN76690.1}
NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
TISSUE=Oocyte {ECO:0000269|PubMed:12454937};
PubMed=12454937; DOI=10.1002/dvdy.10194;
Murphy C.R., Sabel J.L., Sandler A.D., Dagle J.M.;
"Survivin mRNA is down-regulated during early Xenopus laevis
embryogenesis.";
Dev. Dyn. 225:597-601(2002).
[2] {ECO:0000305}
NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
TISSUE=Oocyte {ECO:0000269|PubMed:16759290};
PubMed=16759290; DOI=10.1111/j.1432-0436.2006.00073.x;
Du Pasquier D., Phung A.C., Ymlahi-Ouazzani Q., Sinzelle L.,
Ballagny C., Bronchain O., Du Pasquier L., Mazabraud A.;
"Survivin increased vascular development during Xenopus ontogenesis.";
Differentiation 74:244-253(2006).
[3]
NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
TISSUE=Oocyte;
PubMed=15853809; DOI=10.1111/j.1742-4658.2005.04648.x;
Tsuchiya Y., Murai S., Yamashita S.;
"Apoptosis-inhibiting activities of BIR family proteins in Xenopus egg
extracts.";
FEBS J. 272:2237-2250(2005).
[4] {ECO:0000312|EMBL:BAE02678.1}
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Egg {ECO:0000312|EMBL:AAH89127.1};
NIH - Xenopus Gene Collection (XGC) project;
Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases.
[5] {ECO:0000305}
REVIEW.
PubMed=16344111; DOI=10.1016/S0074-7696(05)47002-3;
Wheatley S.P., McNeish I.A.;
"Survivin: a protein with dual roles in mitosis and apoptosis.";
Int. Rev. Cytol. 247:35-88(2005).
-!- FUNCTION: Component of the chromosomal passenger complex (CPC), a
complex that acts as a key regulator of mitosis. The CPC complex
has essential functions at the centromere in ensuring correct
chromosome alignment and segregation and is required for
chromatin-induced microtubule stabilization and spindle assembly.
Stimulates the mitotic kinase activity of aurkb/aurora-B in the
CPC. Does not appear to exhibit anti-apoptotic activity (By
similarity). CPC. Does not appear to exhibit anti-apoptotic
activity. {ECO:0000250, ECO:0000269|PubMed:15853809}.
-!- SUBUNIT: Component of the CPC at least composed of survivin/birc5,
incenp, cdca8/borealin and/or cdca9/dasra-A, and aurkb/aurora-B.
Interacts directly with incenp (via N-terminus), and may weakly
interact with aurkb (via N-terminus) to stabilize the complex.
Interacts with GTP-bound ran in both the S and M phases of the
cell cycle. Also found in a complex with ubiquitin-mediated
signaling proteins including at least usp9x/xFAM, nploc4/npl4 and
ufd1 (By similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O15392}.
Nucleus {ECO:0000250|UniProtKB:O15392}. Chromosome, centromere
{ECO:0000250|UniProtKB:O15392}. Cytoplasm, cytoskeleton, spindle
{ECO:0000250}. Note=Localizes on chromosome arms and inner
centromeres from prophase through metaphase and then transferring
to the spindle midzone and midbody from anaphase through
cytokinesis. {ECO:0000250|UniProtKB:O15392}.
-!- DEVELOPMENTAL STAGE: Expressed maternally. Expressed in the
earliest stages of oocytes, and accumulates during oogenesis. Also
present in early embryos with expression declining rapidly after
the onset of zygotic transcription at the mid-blastula transition
(MBT). Although PubMed:12454937 conclude that, with the exception
of the ovary, expression is absent in adults, PubMed:16759290
suggest that expression is adult-specific and is absent in
embryonic and tadpole stages between gastrulation and
metamorphosis. {ECO:0000269|PubMed:12454937,
ECO:0000269|PubMed:16759290}.
-!- DOMAIN: C-terminus is required for spindle assembly.
{ECO:0000250|UniProtKB:Q8JGN5}.
-!- PTM: Ubiquitination is required for centrosome-targeting.
{ECO:0000250|UniProtKB:O15392}.
-!- SIMILARITY: Belongs to the IAP family. {ECO:0000255}.
-!- SEQUENCE CAUTION:
Sequence=AAH89127.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
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EMBL; AF442492; AAN76690.1; -; mRNA.
EMBL; AB197248; BAE02678.1; -; mRNA.
EMBL; BC089127; AAH89127.1; ALT_INIT; mRNA.
RefSeq; NP_001082350.1; NM_001088881.1.
UniGene; Xl.5519; -.
ProteinModelPortal; Q4R1J6; -.
SMR; Q4R1J6; -.
PRIDE; Q4R1J6; -.
GeneID; 398418; -.
KEGG; xla:398418; -.
CTD; 398418; -.
Xenbase; XB-GENE-5851077; birc5.1.
KO; K08731; -.
GO; GO:0005694; C:chromosome; ISS:UniProtKB.
GO; GO:0032133; C:chromosome passenger complex; ISS:UniProtKB.
GO; GO:0000777; C:condensed chromosome kinetochore; ISS:UniProtKB.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0030496; C:midbody; ISS:UniProtKB.
GO; GO:0005634; C:nucleus; ISS:UniProtKB.
GO; GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0008536; F:Ran GTPase binding; ISS:UniProtKB.
GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.
GO; GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
GO; GO:0006468; P:protein phosphorylation; ISS:UniProtKB.
GO; GO:0051225; P:spindle assembly; ISS:UniProtKB.
CDD; cd00022; BIR; 1.
InterPro; IPR001370; BIR_rpt.
Pfam; PF00653; BIR; 1.
SMART; SM00238; BIR; 1.
PROSITE; PS50143; BIR_REPEAT_2; 1.
2: Evidence at transcript level;
Cell cycle; Cell division; Centromere; Chromosome;
Chromosome partition; Cytoplasm; Cytoskeleton; Metal-binding; Mitosis;
Nucleus; Phosphoprotein; Ubl conjugation; Zinc.
CHAIN 1 160 Baculoviral IAP repeat-containing protein
5.1-B.
/FTId=PRO_0000382462.
REPEAT 13 83 BIR. {ECO:0000255}.
METAL 66 66 Zinc. {ECO:0000250|UniProtKB:O15392,
ECO:0000255|PROSITE-ProRule:PRU00029}.
METAL 69 69 Zinc. {ECO:0000250|UniProtKB:O15392,
ECO:0000255|PROSITE-ProRule:PRU00029}.
METAL 86 86 Zinc. {ECO:0000250|UniProtKB:O15392,
ECO:0000255|PROSITE-ProRule:PRU00029}.
METAL 93 93 Zinc. {ECO:0000250|UniProtKB:O15392,
ECO:0000255|PROSITE-ProRule:PRU00029}.
MOD_RES 43 43 Phosphothreonine; by CDK1. {ECO:0000250}.
CONFLICT 20 20 Missing (in Ref. 2). {ECO:0000305}.
CONFLICT 153 153 Q -> H (in Ref. 1; AAN76690).
{ECO:0000305}.
SEQUENCE 160 AA; 18803 MW; 7A538991C6190F5C CRC64;
MYSAKNRFVQ SVQRLQDFRN MYDYEARLAT FADWPFTENC KCTPENMAKA GFVHCPTENE
PDVACCFFCL KELEGWEPDD DPWNEHSKRS VNCGFLSLTK CVNDLTMEGF LRLEGDRIKS
FYRKFSTVVL QYVEEEMTAA TKRLLEYFSN QHQCSIDLDH


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