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Baseplate protein gp46 (Gene product 46) (gp46) (Gene product V) (gpV)

 BP46_BPMU               Reviewed;         145 AA.
Q9T1V3;
01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
01-MAY-2000, sequence version 1.
20-JUN-2018, entry version 54.
RecName: Full=Baseplate protein gp46;
AltName: Full=Gene product 46;
Short=gp46;
AltName: Full=Gene product V;
Short=gpV;
OrderedLocusNames=Mup46;
Escherichia phage Mu (Bacteriophage Mu).
Viruses; dsDNA viruses, no RNA stage; Caudovirales; Myoviridae;
Muvirus.
NCBI_TaxID=10677;
NCBI_TaxID=543; Enterobacteriaceae.
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=11922669; DOI=10.1006/jmbi.2002.5437;
Morgan G.J., Hatfull G.F., Casjens S., Hendrix R.W.;
"Bacteriophage Mu genome sequence: analysis and comparison with Mu-
like prophages in Haemophilus, Neisseria and Deinococcus.";
J. Mol. Biol. 317:337-359(2002).
[2]
DISRUPTION PHENOTYPE.
PubMed=3904174; DOI=10.1016/0042-6822(85)90388-5;
Grundy F.J., Howe M.M.;
"Morphogenetic structures present in lysates of amber mutants of
bacteriophage Mu.";
Virology 143:485-504(1985).
[3]
INDUCTION.
PubMed=8293968;
Chiang L.W., Howe M.M.;
"Mutational analysis of a C-dependent late promoter of bacteriophage
Mu.";
Genetics 135:619-629(1993).
[4]
REVIEW.
PubMed=22297511; DOI=10.1007/978-1-4614-0980-9_5;
Leiman P.G., Shneider M.M.;
"Contractile tail machines of bacteriophages.";
Adv. Exp. Med. Biol. 726:93-114(2012).
[5]
SUBUNIT, AND SUBCELLULAR LOCATION.
PubMed=27555589; DOI=10.1073/pnas.1607966113;
Buettner C.R., Wu Y., Maxwell K.L., Davidson A.R.;
"Baseplate assembly of phage Mu: Defining the conserved core
components of contractile-tailed phages and related bacterial
systems.";
Proc. Natl. Acad. Sci. U.S.A. 113:10174-10179(2016).
-!- FUNCTION: Component of the baseplate. Probable connector between
the central and peripheral parts of the baseplate. Probably
involved in tail assembly.
-!- SUBUNIT: Part of a complex composed of three DNA circularization
protein N, three baseplate hub protein gp44 and three sub-complex
wedge (made of two copies of each baseplate protein gp46, gp47 and
gp48) that forms the baseplate. {ECO:0000269|PubMed:27555589}.
-!- SUBCELLULAR LOCATION: Virion {ECO:0000269|PubMed:27555589}. Host
cytoplasm {ECO:0000305}. Note=Baseplate protein.
{ECO:0000269|PubMed:27555589}.
-!- INDUCTION: Expressed in the late phase of the viral replicative
cycle. Expression of late genes is activated by the viral late
transcription activator C. {ECO:0000269|PubMed:8293968}.
-!- DISRUPTION PHENOTYPE: No tail is synthesized.
{ECO:0000269|PubMed:3904174}.
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EMBL; AF083977; AAF01124.1; -; Genomic_DNA.
RefSeq; NP_050650.1; NC_000929.1.
GeneID; 2636291; -.
KEGG; vg:2636291; -.
OrthoDB; VOG090000ZJ; -.
Proteomes; UP000002611; Genome.
GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0098025; C:virus tail, baseplate; IEA:UniProtKB-KW.
GO; GO:0098003; P:viral tail assembly; IEA:UniProtKB-KW.
InterPro; IPR010877; Phage_Mu_Gp46.
Pfam; PF07409; GP46; 1.
1: Evidence at protein level;
Complete proteome; Host cytoplasm; Late protein; Reference proteome;
Viral baseplate protein; Viral release from host cell;
Viral tail assembly; Viral tail protein; Virion.
CHAIN 1 145 Baseplate protein gp46.
/FTId=PRO_0000077840.
SEQUENCE 145 AA; 16323 MW; 3B65E0D1113E28B7 CRC64;
MTDLAIIWTN GRGDIAQDGI DMLTDDSLTT DVTISLFTDR RALDSDTLPD GSDDRRGWWG
DSYRDRPIGS RLWLLSREKA TPDTLERARG YAEEALEWLK TAGRVSAINV RAEQLHQGWL
YLYIALTLPD GSVIPYEFKA AFNGV


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