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Baseplate wedge protein gp10 (Gene product 10) (gp10)

 BP10_BPT4               Reviewed;         602 AA.
P10928;
01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
01-JUL-1989, sequence version 1.
22-NOV-2017, entry version 97.
RecName: Full=Baseplate wedge protein gp10 {ECO:0000255|HAMAP-Rule:MF_04106, ECO:0000305};
AltName: Full=Gene product 10 {ECO:0000305};
Short=gp10;
Name=10;
Enterobacteria phage T4 (Bacteriophage T4).
Viruses; dsDNA viruses, no RNA stage; Caudovirales; Myoviridae;
Tevenvirinae; T4virus.
NCBI_TaxID=10665;
NCBI_TaxID=562; Escherichia coli.
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=D;
PubMed=2726468; DOI=10.1093/nar/17.8.3303;
Prilipov A.G., Selivanov N.A., Efimov V.P., Marusich E.I.,
Mesyanzhinov V.V.;
"Nucleotide sequences of bacteriophage T4 genes 9, 10 and 11.";
Nucleic Acids Res. 17:3303-3303(1989).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=12626685; DOI=10.1128/MMBR.67.1.86-156.2003;
Miller E.S., Kutter E., Mosig G., Arisaka F., Kunisawa T., Ruger W.;
"Bacteriophage T4 genome.";
Microbiol. Mol. Biol. Rev. 67:86-156(2003).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 535-602.
STRAIN=D;
PubMed=2548819; DOI=10.1089/dna.1.1989.8.287;
Barrett B.K., Berget P.B.;
"Using transposon Tn5 insertions to sequence bacteriophage T4 gene
11.";
DNA 8:287-295(1989).
[4]
SUBCELLULAR LOCATION.
PubMed=2403438;
Watts N.R., Coombs D.H.;
"Structure of the bacteriophage T4 baseplate as determined by chemical
cross-linking.";
J. Virol. 64:143-154(1990).
[5]
REVIEW.
PubMed=14625682; DOI=10.1007/s00018-003-3072-1;
Leiman P.G., Kanamaru S., Mesyanzhinov V.V., Arisaka F.,
Rossmann M.G.;
"Structure and morphogenesis of bacteriophage T4.";
Cell. Mol. Life Sci. 60:2356-2370(2003).
[6]
REVIEW ON FUNCTION.
PubMed=21129200; DOI=10.1186/1743-422X-7-355;
Leiman P.G., Arisaka F., van Raaij M.J., Kostyuchenko V.A.,
Aksyuk A.A., Kanamaru S., Rossmann M.G.;
"Morphogenesis of the T4 tail and tail fibers.";
Virol. J. 7:355-355(2010).
[7]
SUBUNIT.
PubMed=19896486; DOI=10.1016/j.jmb.2009.10.071;
Yap M.L., Mio K., Leiman P.G., Kanamaru S., Arisaka F.;
"The baseplate wedges of bacteriophage T4 spontaneously assemble into
hubless baseplate-like structure in vitro.";
J. Mol. Biol. 395:349-360(2010).
[8]
STRUCTURE BY ELECTRON MICROSCOPY (17.0 ANGSTROMS) OF THE CONTRACTED
TAIL, AND SUBCELLULAR LOCATION.
PubMed=15315755; DOI=10.1016/j.cell.2004.07.022;
Leiman P.G., Chipman P.R., Kostyuchenko V.A., Mesyanzhinov V.V.,
Rossmann M.G.;
"Three-dimensional rearrangement of proteins in the tail of
bacteriophage T4 on infection of its host.";
Cell 118:419-429(2004).
[9]
X-RAY CRYSTALLOGRAPHY (1.2 ANGSTROMS) OF 397-602, AND FUNCTION.
PubMed=16554069; DOI=10.1016/j.jmb.2006.02.058;
Leiman P.G., Shneider M.M., Mesyanzhinov V.V., Rossmann M.G.;
"Evolution of bacteriophage tails: Structure of T4 gene product 10.";
J. Mol. Biol. 358:912-921(2006).
[10]
STRUCTURE BY ELECTRON MICROSCOPY (4.11 ANGSTROMS), SUBUNIT,
SUBCELLULAR LOCATION, FUNCTION, IDENTIFICATION IN THE TAIL FIBER
NETWORK, DISULFIDE BOND, INTERACTION WITH GP7, INTERACTION WITH GP11,
AND INTERACTION WITH GP12.
PubMed=27193680; DOI=10.1038/nature17971;
Taylor N.M., Prokhorov N.S., Guerrero-Ferreira R.C., Shneider M.M.,
Browning C., Goldie K.N., Stahlberg H., Leiman P.G.;
"Structure of the T4 baseplate and its function in triggering sheath
contraction.";
Nature 533:346-352(2016).
-!- FUNCTION: Peripheral baseplate protein that is part of the tail
fiber network. Connects the short tail fibers to the baseplate
(PubMed:16554069). During infection, the baseplate undergoes a
conformational change from a dome-shaped to a star-shaped
structure. At this point, gp10 rotates and acts as a lever that
unfolds the short tail fibers, which then interact with host cell
surface receptors. Involved in the tail assembly.
{ECO:0000269|PubMed:16554069, ECO:0000269|PubMed:27193680,
ECO:0000303|PubMed:21129200}.
-!- SUBUNIT: Homotrimer; disulfide-linked (PubMed:19896486,
PubMed:27193680). Heteromultimer with gp7 (PubMed:19896486,
PubMed:27193680); a gp10 molecule is disulfide-linked to gp7 and
the other two remaining gp10 molecules form a disulfide bond
(PubMed:27193680). The gp10 trimer interacts with gp11 trimer and
with the short tail fiber (STF) composed of the gp12 trimer
(PubMed:27193680). Part of the baseplate macromolecular complex
which consists of gp5, gp5.4, gp27 (central spike complex); gp6,
gp25, gp53 (inner baseplate); gp7, gp8 (intermediate baseplate);
gp9, gp10, gp11, gp12 (peripheral); gp48 and gp54 (proximal region
of the tail tube) (PubMed:27193680). {ECO:0000255|HAMAP-
Rule:MF_04106, ECO:0000269|PubMed:19896486,
ECO:0000269|PubMed:27193680}.
-!- SUBCELLULAR LOCATION: Virion {ECO:0000255|HAMAP-Rule:MF_04106,
ECO:0000269|PubMed:15315755, ECO:0000269|PubMed:2403438,
ECO:0000269|PubMed:27193680}. Note=Present in 18 copies in the
baseplate. {ECO:0000303|PubMed:21129200}.
-!- INDUCTION: Expressed in the late phase of the viral replicative
cycle. {ECO:0000255|HAMAP-Rule:MF_04106}.
-!- SIMILARITY: Belongs to the T4likevirus baseplate wedge protein
gp10 family. {ECO:0000255|HAMAP-Rule:MF_04106}.
-----------------------------------------------------------------------
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EMBL; X14192; CAA32396.1; -; Genomic_DNA.
EMBL; AF158101; AAD42415.1; -; Genomic_DNA.
EMBL; M26253; AAA32493.1; -; Genomic_DNA.
PIR; S04083; GEBPT4.
RefSeq; NP_049768.1; NC_000866.4.
PDB; 2FKK; X-ray; 1.20 A; A=397-602.
PDB; 2FL8; EM; 1.20 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R=1-602.
PDB; 2FL9; EM; 17.00 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R=1-602.
PDB; 5HX2; EM; 3.80 A; G/H/I=1-602.
PDB; 5IV5; EM; 4.11 A; AC/AD/AE/CF/CG/CH/EI/EJ/FA/HB/HC/HD/I/J/K/f/g/h=1-602.
PDB; 5IV7; EM; 6.77 A; AE/AF/AG/CG/DA/DB/FB/FC/FD/I/J/K/Y/Z/a/o/p/q=1-602.
PDBsum; 2FKK; -.
PDBsum; 2FL8; -.
PDBsum; 2FL9; -.
PDBsum; 5HX2; -.
PDBsum; 5IV5; -.
PDBsum; 5IV7; -.
ProteinModelPortal; P10928; -.
SMR; P10928; -.
TCDB; 1.K.1.1.1; the gp27/5 t4-baseplate (t4-bp) family.
GeneID; 1258808; -.
KEGG; vg:1258808; -.
OrthoDB; VOG0900004J; -.
EvolutionaryTrace; P10928; -.
Proteomes; UP000009087; Genome.
GO; GO:0019012; C:virion; IDA:CACAO.
GO; GO:0098025; C:virus tail, baseplate; IDA:UniProtKB.
GO; GO:0019076; P:viral release from host cell; IEA:InterPro.
GO; GO:0098003; P:viral tail assembly; IEA:UniProtKB-KW.
HAMAP; MF_04106; BP10_T4; 1.
InterPro; IPR008987; Baseplate_struct_prot_Gp9/10.
InterPro; IPR034695; BP10_T4.
InterPro; IPR036240; Gp9-like_sf.
Pfam; PF07880; T4_gp9_10; 1.
SUPFAM; SSF50017; SSF50017; 1.
1: Evidence at protein level;
3D-structure; Complete proteome; Disulfide bond; Late protein;
Reference proteome; Viral baseplate protein;
Viral release from host cell; Viral tail assembly; Viral tail protein;
Virion.
CHAIN 1 602 Baseplate wedge protein gp10.
/FTId=PRO_0000165000.
DISULFID 555 555 Interchain (with C-187 in GP7);
alternate. {ECO:0000269|PubMed:27193680}.
DISULFID 555 555 Interchain; alternate.
{ECO:0000255|HAMAP-Rule:MF_04106,
ECO:0000269|PubMed:27193680}.
STRAND 414 416 {ECO:0000244|PDB:2FKK}.
STRAND 420 423 {ECO:0000244|PDB:2FKK}.
STRAND 425 427 {ECO:0000244|PDB:2FKK}.
STRAND 432 435 {ECO:0000244|PDB:2FKK}.
STRAND 439 441 {ECO:0000244|PDB:2FKK}.
HELIX 446 453 {ECO:0000244|PDB:2FKK}.
STRAND 459 464 {ECO:0000244|PDB:2FKK}.
HELIX 470 473 {ECO:0000244|PDB:2FKK}.
STRAND 477 480 {ECO:0000244|PDB:2FKK}.
TURN 497 499 {ECO:0000244|PDB:2FKK}.
STRAND 500 506 {ECO:0000244|PDB:2FKK}.
STRAND 512 516 {ECO:0000244|PDB:2FKK}.
STRAND 523 525 {ECO:0000244|PDB:2FKK}.
HELIX 529 531 {ECO:0000244|PDB:2FKK}.
STRAND 596 602 {ECO:0000244|PDB:2FKK}.
SEQUENCE 602 AA; 66232 MW; 1159B8C7EBB8EF54 CRC64;
MKQNINIGNV VDDGTGDYLR KGGIKINENF DELYYELGDG DVPYSAGAWK TYNASSGQTL
TAEWGKSYAI NTSSGRVTIN LPKGTVNDYN KVIRARDVFA TWNVNPVTLV AASGDTIKGS
AVPVEINVRF SDLELVYCAP GRWEYVKNKQ IDKITSSDIS NVARKEFLVE VQGQTDFLDV
FRGTSYNVNN IRVKHRGNEL YYGDVFSENS DFGSPGENEG ELVPLDGFNI RLRQPCNIGD
TVQIETFMDG VSQWRSSYTR RQIRLLDSKL TSKTSLEGSI YVTDLSTMKS IPFSAFGLIP
GEPINPNSLE VRFNGILQEL AGTVGMPLFH CVGADSDDEV ECSVLGGTWE QSHTDYSVET
DENGIPEILH FDSVFEHGDI INITWFNNDL GTLLTKDEII DETDNLYVSQ GPGVDISGDV
NLTDFDKIGW PNVEAVQSYQ RAFNAVSNIF DTIYPIGTIY ENAVNPNNPV TYMGFGSWKL
FGQGKVLVGW NEDISDPNFA LNNNDLDSGG NPSHTAGGTG GSTSVTLENA NLPATETDEE
VLIVDENGSV IVGGCQYDPD ESGPIYTKYR EAKASTNSTH TPPTSITNIQ PYITVYRWIR
IA


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