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Basic helix-loop-helix transcription factor scleraxis

 SCX_MOUSE               Reviewed;         207 AA.
Q64124;
25-NOV-2002, integrated into UniProtKB/Swiss-Prot.
01-NOV-1996, sequence version 1.
25-OCT-2017, entry version 126.
RecName: Full=Basic helix-loop-helix transcription factor scleraxis;
Name=Scx;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=7743923;
Cserjesi P., Brown D., Ligon K.L., Lyons G.E., Copeland N.G.,
Gilbert D.J., Jenkins N.A., Olson E.N.;
"Scleraxis: a basic helix-loop-helix protein that prefigures skeletal
formation during mouse embryogenesis.";
Development 121:1099-1110(1995).
[2]
CHARACTERIZATION.
PubMed=10477299;
Brown D., Wagner D., Li X.-Q., Richardson J.A., Olson E.N.;
"Dual role of the basic helix-loop-helix transcription factor
scleraxis in mesoderm formation and chondrogenesis during mouse
embryogenesis.";
Development 126:4317-4329(1999).
-!- FUNCTION: Plays an early essential role in mesoderm formation, as
well as a later role in formation of somite-derived chondrogenic
lineages.
-!- SUBUNIT: Efficient DNA binding requires dimerization with another
bHLH protein. Dimerizes and binds the E-box consensus sequence
with E12.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-
ProRule:PRU00981}.
-!- TISSUE SPECIFICITY: Expressed in mesenchymal precursors of
cartilage and in connective tissue. Highly expressed in tendons in
the limb, tongue and diaphragm and in cartilage of the bronchi.
-!- DEVELOPMENTAL STAGE: At 6.0-6.5 dpc, expressed throughout the egg
cylinder with highest expression in the epiblast. At 9.5-10.5 dpc,
expressed in the lateral sclerotome and in mesenchymal cells of
the limb buds and body wall. At 11.0 dpc, expressed in a metameric
pattern extending along the length of the embryo. By 11.5 dpc,
expression in the developing vertebrae and invertebral disks is
extended caudally. High expression was seen in precursors of the
ribs and bones of the limbs. Expression in progenitors of the ribs
and the axial and appendicular skeleton becomes down-regulated
when ossification is initiated.
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EMBL; S78079; AAB34266.1; -; mRNA.
CCDS; CCDS27571.1; -.
RefSeq; NP_942588.1; NM_198885.3.
UniGene; Mm.322821; -.
ProteinModelPortal; Q64124; -.
SMR; Q64124; -.
BioGrid; 203115; 1.
STRING; 10090.ENSMUSP00000043668; -.
iPTMnet; Q64124; -.
PhosphoSitePlus; Q64124; -.
PaxDb; Q64124; -.
PRIDE; Q64124; -.
Ensembl; ENSMUST00000043089; ENSMUSP00000043668; ENSMUSG00000034161.
GeneID; 20289; -.
KEGG; mmu:20289; -.
UCSC; uc007wkg.2; mouse.
CTD; 642658; -.
MGI; MGI:102934; Scx.
eggNOG; KOG4029; Eukaryota.
eggNOG; ENOG411227D; LUCA.
GeneTree; ENSGT00760000119097; -.
HOGENOM; HOG000231706; -.
HOVERGEN; HBG036149; -.
InParanoid; Q64124; -.
OMA; GQPCHTT; -.
OrthoDB; EOG091G0RR2; -.
PhylomeDB; Q64124; -.
TreeFam; TF315153; -.
PRO; PR:Q64124; -.
Proteomes; UP000000589; Chromosome 15.
Bgee; ENSMUSG00000034161; -.
CleanEx; MM_SCX; -.
ExpressionAtlas; Q64124; baseline and differential.
GO; GO:0005634; C:nucleus; IDA:UniProtKB.
GO; GO:0005667; C:transcription factor complex; IDA:UniProtKB.
GO; GO:0043425; F:bHLH transcription factor binding; IPI:UniProtKB.
GO; GO:0003677; F:DNA binding; IDA:MGI.
GO; GO:0070888; F:E-box binding; IDA:UniProtKB.
GO; GO:0046982; F:protein heterodimerization activity; IPI:MGI.
GO; GO:0000980; F:RNA polymerase II distal enhancer sequence-specific DNA binding; IDA:NTNU_SB.
GO; GO:0043565; F:sequence-specific DNA binding; IDA:UniProtKB.
GO; GO:0001205; F:transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding; IDA:NTNU_SB.
GO; GO:0030509; P:BMP signaling pathway; IMP:UniProtKB.
GO; GO:0051216; P:cartilage development; NAS:UniProtKB.
GO; GO:0030154; P:cell differentiation; IMP:UniProtKB.
GO; GO:0071773; P:cellular response to BMP stimulus; IEP:UniProtKB.
GO; GO:0071260; P:cellular response to mechanical stimulus; IEP:UniProtKB.
GO; GO:0071560; P:cellular response to transforming growth factor beta stimulus; IEP:UniProtKB.
GO; GO:0002062; P:chondrocyte differentiation; IMP:UniProtKB.
GO; GO:0030199; P:collagen fibril organization; IMP:UniProtKB.
GO; GO:0035993; P:deltoid tuberosity development; IMP:UniProtKB.
GO; GO:0048706; P:embryonic skeletal system development; IEP:UniProtKB.
GO; GO:0001958; P:endochondral ossification; IMP:UniProtKB.
GO; GO:0060325; P:face morphogenesis; IEP:UniProtKB.
GO; GO:0003188; P:heart valve formation; IMP:UniProtKB.
GO; GO:0003179; P:heart valve morphogenesis; IMP:UniProtKB.
GO; GO:0001707; P:mesoderm formation; IMP:UniProtKB.
GO; GO:0043066; P:negative regulation of apoptotic process; IMP:UniProtKB.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IMP:UniProtKB.
GO; GO:0061036; P:positive regulation of cartilage development; IMP:UniProtKB.
GO; GO:0008284; P:positive regulation of cell proliferation; IMP:UniProtKB.
GO; GO:0032967; P:positive regulation of collagen biosynthetic process; IDA:UniProtKB.
GO; GO:2000543; P:positive regulation of gastrulation; IMP:UniProtKB.
GO; GO:0010628; P:positive regulation of gene expression; IDA:UniProtKB.
GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:UniProtKB.
GO; GO:0061035; P:regulation of cartilage development; IMP:UniProtKB.
GO; GO:0061056; P:sclerotome development; IEP:UniProtKB.
GO; GO:0060008; P:Sertoli cell differentiation; ISS:UniProtKB.
GO; GO:0035914; P:skeletal muscle cell differentiation; IMP:MGI.
GO; GO:0035990; P:tendon cell differentiation; IMP:UniProtKB.
GO; GO:0035989; P:tendon development; IMP:UniProtKB.
GO; GO:0035992; P:tendon formation; IMP:UniProtKB.
GO; GO:0001894; P:tissue homeostasis; IMP:UniProtKB.
GO; GO:0006351; P:transcription, DNA-templated; IDA:UniProtKB.
CDD; cd00083; HLH; 1.
Gene3D; 4.10.280.10; -; 1.
InterPro; IPR011598; bHLH_dom.
InterPro; IPR036638; HLH_DNA-bd_sf.
Pfam; PF00010; HLH; 1.
SMART; SM00353; HLH; 1.
SUPFAM; SSF47459; SSF47459; 1.
PROSITE; PS50888; BHLH; 1.
1: Evidence at protein level;
Activator; Complete proteome; Developmental protein; DNA-binding;
Nucleus; Reference proteome; Transcription; Transcription regulation.
CHAIN 1 207 Basic helix-loop-helix transcription
factor scleraxis.
/FTId=PRO_0000127436.
DOMAIN 78 130 bHLH. {ECO:0000255|PROSITE-
ProRule:PRU00981}.
COMPBIAS 161 170 Poly-Pro.
SEQUENCE 207 AA; 22239 MW; 8340052200A85EF9 CRC64;
MSFAMLRSAP PPGRYLYPEV SPLSEDEDRG SESSGSDEKP CRVHAARCGL QGARRRAGGR
RAAGSGPGPG GRPGREPRQR HTANARERDR TNSVNTAFTA LRTLIPTEPA DRKLSKIETL
RLASSYISHL GNVLLVGEAC GDGQPCHSGP AFFHSGRAGS PLPPPPPPPP LARDGGENTQ
PKQICTFCLS NQRKLSKDRD RKTAIRS


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