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Basic leucine zipper transcriptional factor ATF-like (B-cell-activating transcription factor) (B-ATF)

 BATF_BOVIN              Reviewed;         125 AA.
E1BD44;
28-NOV-2012, integrated into UniProtKB/Swiss-Prot.
02-NOV-2010, sequence version 1.
12-SEP-2018, entry version 49.
RecName: Full=Basic leucine zipper transcriptional factor ATF-like;
AltName: Full=B-cell-activating transcription factor;
Short=B-ATF;
Name=BATF;
Bos taurus (Bovine).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Bovinae; Bos.
NCBI_TaxID=9913;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Hereford;
PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42;
Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C.,
Puiu D., Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S.,
Marcais G., Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.;
"A whole-genome assembly of the domestic cow, Bos taurus.";
Genome Biol. 10:R42.01-R42.10(2009).
-!- FUNCTION: AP-1 family transcription factor that controls the
differentiation of lineage-specific cells in the immune system:
specifically mediates the differentiation of T-helper 17 cells
(Th17), follicular T-helper cells (TfH), CD8(+) dendritic cells
and class-switch recombination (CSR) in B-cells. Acts via the
formation of a heterodimer with JUNB that recognizes and binds DNA
sequence 5'-TGA[CG]TCA-3'. The BATF-JUNB heterodimer also forms a
complex with IRF4 (or IRF8) in immune cells, leading to
recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-
specific regulatory element, followed by cooperative binding of
BATF and IRF4 (or IRF8) and activation of genes. Controls
differentiation of T-helper cells producing interleukin-17 (Th17
cells) by binding to Th17-associated gene promoters: regulates
expression of the transcription factor RORC itself and RORC target
genes such as IL17 (IL17A or IL17B). Also involved in
differentiation of follicular T-helper cells (TfH) by directing
expression of BCL6 and MAF. In B-cells, involved in class-switch
recombination (CSR) by controlling the expression of both AICDA
and of germline transcripts of the intervening heavy-chain region
and constant heavy-chain region (I(H)-C(H)). Following infection,
can participate in CD8(+) dendritic cell differentiation via
interaction with IRF4 and IRF8 to mediate cooperative gene
activation. Regulates effector CD8(+) T-cell differentiation by
regulating expression of SIRT1. Following DNA damage, part of a
differentiation checkpoint that limits self-renewal of
hematopoietic stem cells (HSCs): up-regulated by STAT3, leading to
differentiation of HSCs, thereby restricting self-renewal of HSCs
(By similarity). {ECO:0000250}.
-!- SUBUNIT: Heterodimer; mainly heterodimerizes with JUNB. The BATF-
JUNB heterodimer interacts with IRF4 and IRF8. Interacts (via bZIP
domain) with IRF4 and IRF8; the interaction is direct. Also forms
heterodimers with JUN and JUND. Also Interacts with IFI35 (By
similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-
ProRule:PRU00978}. Cytoplasm {ECO:0000250}. Note=Present in the
nucleus and cytoplasm, but shows increased nuclear translocation
after activation of T-cells. {ECO:0000250}.
-!- PTM: Phosphorylated on serine and threonine residues and at least
one tyrosine residue. Phosphorylation at Ser-43 inhibit DNA
binding activity and transforms it as a negative regulator of AP-1
mediated transcription (By similarity). {ECO:0000250}.
-!- SIMILARITY: Belongs to the bZIP family. {ECO:0000305}.
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EMBL; DAAA02029620; -; NOT_ANNOTATED_CDS; Genomic_DNA.
RefSeq; NP_001193207.1; NM_001206278.1.
UniGene; Bt.9265; -.
SMR; E1BD44; -.
STRING; 9913.ENSBTAP00000035554; -.
PaxDb; E1BD44; -.
PRIDE; E1BD44; -.
Ensembl; ENSBTAT00000035684; ENSBTAP00000035554; ENSBTAG00000025405.
GeneID; 617628; -.
KEGG; bta:617628; -.
CTD; 10538; -.
VGNC; VGNC:26425; BATF.
eggNOG; KOG1414; Eukaryota.
eggNOG; ENOG4111CH5; LUCA.
GeneTree; ENSGT00390000016869; -.
InParanoid; E1BD44; -.
KO; K09034; -.
OMA; DSNDTSY; -.
OrthoDB; EOG091G0YSM; -.
TreeFam; TF332340; -.
Proteomes; UP000009136; Chromosome 10.
Bgee; ENSBTAG00000025405; Expressed in 7 organ(s), highest expression level in spleen.
GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
GO; GO:0005634; C:nucleus; ISS:UniProtKB.
GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:UniProtKB.
GO; GO:0000978; F:RNA polymerase II proximal promoter sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.
GO; GO:0001077; F:transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0006974; P:cellular response to DNA damage stimulus; ISS:UniProtKB.
GO; GO:0001816; P:cytokine production; ISS:UniProtKB.
GO; GO:0042832; P:defense response to protozoan; ISS:UniProtKB.
GO; GO:0030330; P:DNA damage response, signal transduction by p53 class mediator; ISS:UniProtKB.
GO; GO:0060218; P:hematopoietic stem cell differentiation; ISS:UniProtKB.
GO; GO:0045190; P:isotype switching; ISS:UniProtKB.
GO; GO:0002320; P:lymphoid progenitor cell differentiation; ISS:UniProtKB.
GO; GO:0043011; P:myeloid dendritic cell differentiation; ISS:UniProtKB.
GO; GO:0072539; P:T-helper 17 cell differentiation; ISS:UniProtKB.
GO; GO:0072540; P:T-helper 17 cell lineage commitment; ISS:UniProtKB.
GO; GO:0045064; P:T-helper 2 cell differentiation; ISS:UniProtKB.
InterPro; IPR000837; AP-1.
InterPro; IPR029820; BATF.
InterPro; IPR004827; bZIP.
PANTHER; PTHR23351; PTHR23351; 1.
PANTHER; PTHR23351:SF14; PTHR23351:SF14; 1.
Pfam; PF00170; bZIP_1; 1.
PRINTS; PR00042; LEUZIPPRFOS.
SMART; SM00338; BRLZ; 1.
PROSITE; PS50217; BZIP; 1.
PROSITE; PS00036; BZIP_BASIC; 1.
3: Inferred from homology;
Activator; Complete proteome; Cytoplasm; Differentiation; DNA-binding;
Nucleus; Phosphoprotein; Reference proteome; Repressor; Transcription;
Transcription regulation.
CHAIN 1 125 Basic leucine zipper transcriptional
factor ATF-like.
/FTId=PRO_0000420463.
DOMAIN 26 89 bZIP. {ECO:0000255|PROSITE-
ProRule:PRU00978}.
REGION 28 50 Basic motif.
REGION 54 75 Leucine-zipper.
MOD_RES 43 43 Phosphoserine.
{ECO:0000250|UniProtKB:O35284}.
MOD_RES 48 48 Phosphothreonine.
{ECO:0000250|UniProtKB:O35284}.
SEQUENCE 125 AA; 14079 MW; 0BF32190D0B1786B CRC64;
MPHSSDSSDS SFSRSPPPGK QDSSDDVRKV QRREKNRIAA QKSRQRQTQK ADTLHLESED
LEKQNAALRK EIKQLTEEMK YFTSVLSSHE PLCSVLAPGA PSPPEVVYST HAFHQPHVSS
PRFQP


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