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Basic salivary proline-rich protein 2 (Salivary proline-rich protein) (Con1 glycoprotein) [Cleaved into: Basic proline-rich peptide IB-1; Basic proline-rich peptide P-E (IB-9); Basic proline-rich peptide IB-7; Basic proline-rich peptide IB-8c (Basic peptide P-F); Basic proline-rich peptide IB-4]

 PRB2_HUMAN              Reviewed;         416 AA.
P02812; O00599; P02811; P04281;
21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
23-OCT-2007, sequence version 3.
05-DEC-2018, entry version 131.
RecName: Full=Basic salivary proline-rich protein 2;
Short=Salivary proline-rich protein;
AltName: Full=Con1 glycoprotein;
Contains:
RecName: Full=Basic proline-rich peptide IB-1;
Contains:
RecName: Full=Basic proline-rich peptide P-E;
AltName: Full=IB-9;
Contains:
RecName: Full=Basic proline-rich peptide IB-7;
Contains:
RecName: Full=Basic proline-rich peptide IB-8c;
AltName: Full=Basic peptide P-F;
Contains:
RecName: Full=Basic proline-rich peptide IB-4;
Flags: Precursor;
Name=PRB2;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT PRO-274.
PubMed=16541075; DOI=10.1038/nature04569;
Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M.,
Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B.,
Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D.,
Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z.,
Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z.,
Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H.,
Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H.,
Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V.,
Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J.,
Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A.,
Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M.,
Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E.,
Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M.,
Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R.,
Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J.,
Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C.,
Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M.,
Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M.,
Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P.,
Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L.,
Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E.,
Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C.,
Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F.,
Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M.,
Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S.,
Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M.,
Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D.,
Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I.,
Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T.,
Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S.,
Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D.,
Kucherlapati R., Weinstock G., Gibbs R.A.;
"The finished DNA sequence of human chromosome 12.";
Nature 440:346-351(2006).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-156.
PubMed=17974005; DOI=10.1186/1471-2164-8-399;
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H.,
Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K.,
Ottenwaelder B., Poustka A., Wiemann S., Schupp I.;
"The full-ORF clone resource of the German cDNA consortium.";
BMC Genomics 8:399-399(2007).
[3]
PROTEIN SEQUENCE OF 17-112, PYROGLUTAMATE FORMATION AT GLN-17, AND
PHOSPHORYLATION AT SER-24.
TISSUE=Saliva;
PubMed=3521730; DOI=10.1021/bi00357a013;
Kauffman D., Hofmann T., Bennick A., Keller P.;
"Basic proline-rich proteins from human parotid saliva: complete
covalent structures of proteins IB-1 and IB-6.";
Biochemistry 25:2387-2392(1986).
[4]
PROTEIN SEQUENCE OF 52-112.
TISSUE=Saliva;
PubMed=6924859; DOI=10.1021/bi00268a036;
Kauffman D., Wong R., Bennick A., Keller P.;
"Basic proline-rich proteins from human parotid saliva: complete
covalent structure of protein IB-9 and partial structure of protein
IB-6, members of a polymorphic pair.";
Biochemistry 21:6558-6562(1982).
[5]
PROTEIN SEQUENCE OF 52-112.
TISSUE=Saliva;
PubMed=7118863; DOI=10.1093/oxfordjournals.jbchem.a133900;
Isemura S., Saitoh E., Sanada K.;
"Fractionation and characterization of basic proline-rich peptides of
human parotid saliva and the amino acid sequence of proline-rich
peptide P-E.";
J. Biochem. 91:2067-2075(1982).
[6]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-416, PROTEIN SEQUENCE OF
175-235, GLYCOSYLATION, AND VARIANT CON1- PRO-274.
PubMed=8554050;
Azen E.A., Amberger E., Fisher S., Prakobphol A., Niece R.L.;
"PRB1, PRB2, and PRB4 coded polymorphisms among human salivary
concanavalin-A binding, II-1, and Po proline-rich proteins.";
Am. J. Hum. Genet. 58:143-153(1996).
[7]
PROTEIN SEQUENCE OF 113-171; 299-359 AND 361-416.
TISSUE=Saliva;
PubMed=1849422; DOI=10.1021/bi00228a001;
Kauffman D.L., Bennick A., Blum M., Keller P.J.;
"Basic proline-rich proteins from human parotid saliva: relationships
of the covalent structures of ten proteins from a single individual.";
Biochemistry 30:3351-3356(1991).
[8]
NUCLEOTIDE SEQUENCE [MRNA] OF 166-416.
PubMed=2993301;
Maeda N., Kim H.-S., Azen E.A., Smithies O.;
"Differential RNA splicing and post-translational cleavages in the
human salivary proline-rich protein gene system.";
J. Biol. Chem. 260:11123-11130(1985).
[9]
PROTEIN SEQUENCE OF 299-359.
TISSUE=Saliva;
PubMed=6874669; DOI=10.1093/jb/93.3.883;
Saitoh E., Isemura S., Sanada K.;
"Complete amino acid sequence of a basic proline-rich peptide, P-F,
from human parotid saliva.";
J. Biochem. 93:883-888(1983).
[10]
POLYMORPHISM.
PubMed=2851479;
Lyons K.M., Stein J.H., Smithies O.;
"Length polymorphisms in human proline-rich protein genes generated by
intragenic unequal crossing over.";
Genetics 120:267-278(1988).
[11]
PROTEOLYTIC PROCESSING, AND IDENTIFICATION BY MASS SPECTROMETRY.
PubMed=18463091; DOI=10.1074/jbc.M708282200;
Helmerhorst E.J., Sun X., Salih E., Oppenheim F.G.;
"Identification of Lys-Pro-Gln as a novel cleavage site specificity of
saliva-associated proteases.";
J. Biol. Chem. 283:19957-19966(2008).
[12]
GLYCOSYLATION AT ASN-230; SER-232 AND ASN-272, PHOSPHORYLATION AT
SER-52, PYROGLUTAMATE FORMATION AT GLN-17, AND IDENTIFICATION BY MASS
SPECTROMETRY.
PubMed=20879038; DOI=10.1002/pmic.201000261;
Vitorino R., Alves R., Barros A., Caseiro A., Ferreira R., Lobo M.C.,
Bastos A., Duarte J., Carvalho D., Santos L.L., Amado F.L.;
"Finding new posttranslational modifications in salivary proline-rich
proteins.";
Proteomics 10:3732-3742(2010).
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
-!- PTM: N- and O-glycosylated. In head and neck cancer patients, O-
glycosylated with glucosylgalactosyl carbohydrate moiety. This
modification would require prior hydroxylation on the lysine
residue. {ECO:0000269|PubMed:20879038,
ECO:0000269|PubMed:8554050}.
-!- PTM: Proteolytically cleaved at the tripeptide Xaa-Pro-Gln, where
Xaa in the P(3) position is mostly lysine. The endoprotease may be
of microbial origin. {ECO:0000269|PubMed:18463091}.
-!- PTM: Pyroglutamate formation occurs on terminal Gln residues of
cleaved peptides. Pyroglutamate formation found on at least Gln-
398 and Gln-400. {ECO:0000269|PubMed:18463091}.
-!- POLYMORPHISM: The number of repeats is polymorphic and varies
among different alleles (PubMed:2851479).
{ECO:0000269|PubMed:2851479}.
-!- MISCELLANEOUS: Peptides IB-9 and P-E are the same peptide.
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EMBL; AC078950; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BX484538; -; NOT_ANNOTATED_CDS; mRNA.
EMBL; S80905; AAB50686.1; -; Genomic_DNA.
EMBL; K03208; AAA60189.1; -; mRNA.
CCDS; CCDS41757.2; -.
PIR; B40750; PIHUB6.
PIR; E25372; PIHUPF.
UniGene; Hs.654486; -.
IntAct; P02812; 2.
STRING; 9606.ENSP00000374013; -.
iPTMnet; P02812; -.
PhosphoSitePlus; P02812; -.
DMDM; 160409933; -.
PaxDb; P02812; -.
PeptideAtlas; P02812; -.
PRIDE; P02812; -.
ProteomicsDB; 51604; -.
TopDownProteomics; P02812; -.
Ensembl; ENST00000389362; ENSP00000374013; ENSG00000121335.
UCSC; uc010shk.2; human.
DisGeNET; 653247; -.
EuPathDB; HostDB:ENSG00000121335.11; -.
GeneCards; PRB2; -.
HGNC; HGNC:9338; PRB2.
MIM; 168810; gene.
neXtProt; NX_P02812; -.
eggNOG; ENOG410KCD2; Eukaryota.
eggNOG; ENOG4110P3B; LUCA.
InParanoid; P02812; -.
ChiTaRS; PRB2; human.
PRO; PR:P02812; -.
Proteomes; UP000005640; Chromosome 12.
Bgee; ENSG00000121335; Expressed in 71 organ(s), highest expression level in temporal lobe.
CleanEx; HS_PRB2; -.
ExpressionAtlas; P02812; baseline and differential.
Genevisible; P02812; HS.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
InterPro; IPR026086; Pro-rich.
PANTHER; PTHR23203; PTHR23203; 7.
Pfam; PF15240; Pro-rich; 6.
SMART; SM01412; Pro-rich; 2.
1: Evidence at protein level;
Complete proteome; Direct protein sequencing; Glycoprotein;
Phosphoprotein; Polymorphism; Pyrrolidone carboxylic acid;
Reference proteome; Repeat; Secreted; Signal.
SIGNAL 1 16 {ECO:0000255}.
CHAIN 17 416 Basic salivary proline-rich protein 2.
/FTId=PRO_0000022095.
CHAIN 17 112 Basic proline-rich peptide IB-1.
/FTId=PRO_0000097038.
CHAIN 52 112 Basic proline-rich peptide P-E.
/FTId=PRO_0000395485.
CHAIN 113 171 Basic proline-rich peptide IB-7.
/FTId=PRO_0000372439.
CHAIN 299 359 Basic proline-rich peptide IB-8c.
/FTId=PRO_0000022096.
CHAIN 361 416 Basic proline-rich peptide IB-4.
/FTId=PRO_0000372440.
REPEAT 53 72 1.
REPEAT 74 93 2.
REPEAT 94 113 3.
REPEAT 114 133 4.
REPEAT 135 154 5.
REPEAT 155 174 6.
REPEAT 176 195 7.
REPEAT 197 216 8.
REPEAT 217 236 9.
REPEAT 238 257 10.
REPEAT 259 278 11.
REPEAT 279 298 12.
REPEAT 300 319 13.
REPEAT 321 340 14.
REPEAT 341 360 15.
REGION 53 360 15 X 20 AA approximate tandem repeats of
P-P-G-K-P-Q-G-P-P-P-Q-G-[GD]-[NKS]-[KSQ]-
[PRS]-[QRS] [GPS]-[PSAR]-[PSR].
MOD_RES 17 17 Pyrrolidone carboxylic acid.
{ECO:0000269|PubMed:20879038,
ECO:0000269|PubMed:3521730}.
MOD_RES 24 24 Phosphoserine.
{ECO:0000269|PubMed:3521730}.
MOD_RES 52 52 Phosphoserine.
{ECO:0000269|PubMed:20879038}.
CARBOHYD 168 168 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 230 230 N-linked (GlcNAc...) asparagine.
{ECO:0000269|PubMed:20879038}.
CARBOHYD 232 232 O-linked (Hex) serine.
{ECO:0000269|PubMed:20879038}.
CARBOHYD 272 272 N-linked (GlcNAc...) asparagine.
{ECO:0000269|PubMed:20879038}.
VARIANT 233 233 Q -> R (in dbSNP:rs34305575).
/FTId=VAR_061693.
VARIANT 274 274 S -> P (may abrogate glycosylation at N-
272; dbSNP:rs10845349).
{ECO:0000269|PubMed:16541075,
ECO:0000269|PubMed:8554050}.
/FTId=VAR_019695.
CONFLICT 68 68 P -> S (in Ref. 2; BX484538).
{ECO:0000305}.
CONFLICT 88 88 K -> R (in Ref. 4; AA sequence and 5; AA
sequence). {ECO:0000305}.
CONFLICT 151 151 Q -> P (in Ref. 2; BX484538).
{ECO:0000305}.
CONFLICT 271 271 G -> D (in Ref. 8; AAA60189).
{ECO:0000305}.
SEQUENCE 416 AA; 40799 MW; 5CF67F42B368A622 CRC64;
MLLILLSVAL LALSSAQNLN EDVSQEESPS LIAGNPQGAP PQGGNKPQGP PSPPGKPQGP
PPQGGNQPQG PPPPPGKPQG PPPQGGNKPQ GPPPPGKPQG PPPQGDKSRS PRSPPGKPQG
PPPQGGNQPQ GPPPPPGKPQ GPPPQGGNKP QGPPPPGKPQ GPPPQGDNKS RSSRSPPGKP
QGPPPQGGNQ PQGPPPPPGK PQGPPPQGGN KPQGPPPPGK PQGPPPQGDN KSQSARSPPG
KPQGPPPQGG NQPQGPPPPP GKPQGPPPQG GNKSQGPPPP GKPQGPPPQG GSKSRSSRSP
PGKPQGPPPQ GGNQPQGPPP PPGKPQGPPP QGGNKPQGPP PPGKPQGPPP QGGSKSRSAR
SPPGKPQGPP QQEGNNPQGP PPPAGGNPQQ PQAPPAGQPQ GPPRPPQGGR PSRPPQ


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