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Basigin (CD antigen CD147)

 BASI_RABIT              Reviewed;         270 AA.
Q28740;
27-APR-2001, integrated into UniProtKB/Swiss-Prot.
01-NOV-1996, sequence version 1.
23-MAY-2018, entry version 109.
RecName: Full=Basigin;
AltName: CD_antigen=CD147;
Flags: Precursor;
Name=BSG;
Oryctolagus cuniculus (Rabbit).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae;
Oryctolagus.
NCBI_TaxID=9986;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Kidney;
PubMed=8603097; DOI=10.1016/0167-4889(95)00186-7;
Schuster V.L., Lu R., Kanai N., Bao Y., Rosenberg S., Prie D.,
Ronco P., Jennings M.L.;
"Cloning of the rabbit homologue of mouse 'basigin' and rat 'OX-47':
kidney cell type-specific expression, and regulation in collecting
duct cells.";
Biochim. Biophys. Acta 1311:13-19(1996).
-!- FUNCTION: Plays an important role in targeting the monocarboxylate
transporters SLC16A1, SLC16A3, SLC16A8 and SLC16A11 to the plasma
membrane. Plays pivotal roles in spermatogenesis, embryo
implantation, neural network formation and tumor progression.
Stimulates adjacent fibroblasts to produce matrix
metalloproteinases (MMPS). Seems to be a receptor for
oligomannosidic glycans. In vitro, promotes outgrowth of
astrocytic processes. {ECO:0000250|UniProtKB:P35613}.
-!- SUBUNIT: Forms homooligomers in a cis-dependent manner on the
plasma membrane. Forms a complex with MMP1 at the tumor cell
surface (By similarity). Interacts with AJAP1, ATP1B2, MAG and
L1CAM (By similarity). Interacts with SLC16A1, SLC16A7 and SLC1A3;
probably a BSG dimer is associated with a monocarboxylate
transporter dimer. Interacts with PPIL2; regulates BSG transport
to the cell membrane. Interacts with SLC16A11 (By similarity).
{ECO:0000250|UniProtKB:P18572, ECO:0000250|UniProtKB:P26453,
ECO:0000250|UniProtKB:P35613}.
-!- SUBCELLULAR LOCATION: Cell membrane
{ECO:0000250|UniProtKB:P35613}; Single-pass type I membrane
protein {ECO:0000250|UniProtKB:P35613}. Melanosome
{ECO:0000250|UniProtKB:P35613}. Note=Identified by mass
spectrometry in melanosome fractions from stage I to stage IV (By
similarity). In spermatozoa, localized on the principal piece of
caput and in the middle piece during transit in the corpus and
cauda epididymides (By similarity). {ECO:0000250|UniProtKB:P18572,
ECO:0000250|UniProtKB:P35613}.
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EMBL; U62398; AAB04759.1; -; mRNA.
PIR; S65739; S65739.
RefSeq; NP_001075843.1; NM_001082374.1.
UniGene; Ocu.1434; -.
ProteinModelPortal; Q28740; -.
SMR; Q28740; -.
PRIDE; Q28740; -.
GeneID; 100009229; -.
KEGG; ocu:100009229; -.
CTD; 682; -.
HOVERGEN; HBG008120; -.
InParanoid; Q28740; -.
KO; K06535; -.
Proteomes; UP000001811; Unplaced.
GO; GO:0005887; C:integral component of plasma membrane; ISS:UniProtKB.
GO; GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.
GO; GO:0005537; F:mannose binding; IEA:UniProtKB-KW.
GO; GO:0072659; P:protein localization to plasma membrane; ISS:UniProtKB.
Gene3D; 2.60.40.10; -; 2.
InterPro; IPR009151; Basigin.
InterPro; IPR007110; Ig-like_dom.
InterPro; IPR036179; Ig-like_dom_sf.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR003599; Ig_sub.
PANTHER; PTHR10075:SF12; PTHR10075:SF12; 1.
SMART; SM00409; IG; 2.
SUPFAM; SSF48726; SSF48726; 1.
PROSITE; PS50835; IG_LIKE; 1.
2: Evidence at transcript level;
Cell membrane; Complete proteome; Disulfide bond; Glycoprotein;
Immunoglobulin domain; Lectin; Mannose-binding; Membrane;
Phosphoprotein; Reference proteome; Signal; Transmembrane;
Transmembrane helix.
SIGNAL 1 21 {ECO:0000250}.
CHAIN 22 270 Basigin.
/FTId=PRO_0000014520.
TOPO_DOM 22 207 Extracellular. {ECO:0000255}.
TRANSMEM 208 228 Helical. {ECO:0000255}.
TOPO_DOM 229 270 Cytoplasmic. {ECO:0000255}.
DOMAIN 22 103 Ig-like C2-type.
DOMAIN 105 203 Ig-like V-type.
MOD_RES 252 252 Phosphoserine.
{ECO:0000250|UniProtKB:P35613}.
CARBOHYD 44 44 N-linked (GlcNAc...) asparagine.
{ECO:0000250}.
CARBOHYD 75 75 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 152 152 N-linked (GlcNAc...) asparagine.
{ECO:0000250}.
CARBOHYD 186 186 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 41 87 {ECO:0000255|PROSITE-ProRule:PRU00114}.
DISULFID 126 185 {ECO:0000255|PROSITE-ProRule:PRU00114}.
SEQUENCE 270 AA; 29078 MW; 1CB0737A7B5DA6D1 CRC64;
MAAVLFALLA LALLRAGGAS AAAGTVTTSV QSGDSWVQLT CTLNTSAAGV TGHRWLKGKE
VVKEDQLQGL HTEHNVTGDD RFGKYSCLFL PKDTGEATLT VDGPPRIKAV KKSEHANEGD
SVTLLCKSES FPFVTAWVWY KVADSGDQVI QNGSQSRFFI SHSEAQSELH IKDLDLTSDP
GEYACNGTSL QGTDAAVVTL RVRSRLAALW PFLGIVAEVL VLVTVIFIYE KRRKPDEVLD
DEDAGAAPLK SSGHHVNDDK GKNVRQRNAS


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